Transplantation

A Phase 1 clinical trial has shown that an antibody developed at Stanford Medicine can prepare patients for stem cell transplantation while avoiding toxic side effects. A phase 1 clinical trial has demonstrated that an antibody treatment created at Stanford Medicine can safely prepare patients for stem cell transplants without the need for busulfan chemotherapy [...]

In a groundbreaking advancement that may redefine transplant medicine, researchers at the Medical University of South Carolina (MUSC) have engineered a novel immunological tool capable of selectively suppressing the immune response responsible for organ rejection. Published in the prestigious journal Frontiers in Immunology, this pioneering work introduces genetically modified regulatory T cells equipped with chimeric […]

An innovative, antibody-based therapy enabled safe stem cell transplants in three children with Fanconi anemia, avoiding toxic chemotherapy and radiation, with positive outcomes after two years. The post Novel, Less Toxic, Stem Cell Transplant Prep Yields Successful Outcomes appeared first on GEN - Genetic Engineering and Biotechnology News.

An antibody treatment developed at Stanford Medicine successfully prepared patients for stem cell transplants without toxic busulfan chemotherapy or radiation, a Phase I clinical trial has shown.

Researchers at the University of Pittsburgh have identified a new way of predicting whether a kidney donor and recipient are a good match for transplantation.

Advances in blood stem cell transplants now make it possible for people with blood cancers to get safe and effective "mismatched" transplants that will potentially cure their disease, new UVA Cancer Center research reveals. The advances will allow far more people to receive the lifesaving treatment.

In a groundbreaking advancement destined to reshape the future of organ transplantation, an international team of researchers has unveiled unprecedented insights into the immune dynamics following pig-to-human kidney xenotransplantation. Presented at the prestigious European Society for Organ Transplantation (ESOT) Congress 2025 in London, this pioneering study delves deep into the cellular interplay that underpins the […]

The patient, a 45-year-old man hospitalized for months with severe heart failure, became the first in the United States to receive a heart transplant using a minimally invasive, robot-assisted technique. Unlike traditional transplants that require splitting the breastbone to open the chest, this procedure uses a sophisticated surgical robot to...Read Entire Article

Fecal microbiota transplants (FMT) have emerged as a revolutionary therapeutic approach aimed at reshaping the gut microbiome to treat a variety of disorders, ranging from recurrent Clostridium difficile infections to chronic inflammatory diseases, metabolic conditions like obesity and type 2 diabetes, and even neurodevelopmental issues, including autism spectrum disorders. Yet, a groundbreaking new study from […]

A groundbreaking international study unveiled at the 62nd European Renal Association (ERA) Congress in Vienna challenges the long-standing notion that deceased-donor kidney transplantation universally confers a survival advantage for all recipients. Drawing on two decades of comprehensive data from over 64,000 adult dialysis patients across several European countries, the research utilizes a sophisticated analytical approach […]

Historic surgery opens the door for improved treatment of non-functioning bladders. Continue reading World’s first-ever human bladder transplant on Tech Explorist.

Multiple obstacles, including vascular connections and immune suppression, made the pioneering bladder transplant procedure a challenge.

MONDAY, May 19, 2025 — Doctors in Southern California have performed the first human bladder transplant, offering new hope to people with serious bladder problems.The surgery was done earlier this month by two doctors from the University of C...

Surgeons from Keck Medicine of USC and UCLA Health have performed the world's first-in-human bladder transplant.

Becoming an organ donor has never been easier. Registration is available online when renewing a driver's license or, for iPhone users, through an app.

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Current treatments to prevent organ transplant rejection focus mainly on suppressing T cells, part of the adaptive immune system. However, the innate immune system—the body's first line of defense that triggers early inflammation after transplantation—has largely remained untargeted by modern therapies.

In a groundbreaking development that promises to transform the landscape of lung transplantation, researchers have demonstrated that the hypothermic oxygenated machine perfusion (HOPE) technique is a safe and effective method for preserving donor lungs outside the human body, even when total preservation times approach an unprecedented 20 hours. This advancement, presented by Jitte Jennekens, MSc, […]

In a landmark moment for cardiac transplantation, the International Society of Heart and Lung Transplantation (ISHLT) commemorated the tenth anniversary of the modern heart donation after circulatory death (DCD) technique at their recent Annual Meeting and Scientific Sessions in Boston. This innovative approach has revolutionized heart transplantation globally by substantially increasing the number of transplant […]

A baby girl named Amy Isabel has become the first child in the UK to be born to a mother who has had a womb transplant. Amy is one of around 65 children worldwide born as a result of pioneering research into the procedure.

Uterus transplantation, a surgery enabling birth for women with uterine issues, has seen over 135 transplants and 50+ births globally.

The liver performed basic functions but isn’t yet a full replacement. The post Scientists Just Transplanted a Pig Liver Into a Person for the First Time appeared first on SingularityHub.

Pig Liver Successfully Transplanted Into Human Patient in World First  ScienceAlertGene-modified pig-to-human liver xenotransplantation  Nature.comChinese researchers report a pig kidney transplant and a first-step liver experiment  The Seattle TimesSurgeons transplant genetically modified pig liver into Chinese patient  The GuardianSurgeons transplanted a pig’s liver into a human  Science News Magazine

Pig Liver Successfully Transplanted Into Human Patient in World First  ScienceAlertGene-modified pig-to-human liver xenotransplantation  Nature.comChinese researchers report a pig kidney transplant and a first-step liver experiment  The Seattle TimesSurgeons transplant genetically modified pig liver into Chinese patient  The GuardianSurgeons transplanted a pig’s liver into a human  Science News Magazine

It's the latest evidence to suggest that animal-to-human transplantation is feasible.

How have the first patients fared after receiving organ transplants from genetically modified pigs? Roni Caryn Rabin, a health reporter on the Science desk of The New York Times, looks at the results so far.

How have the first patients fared after receiving organ transplants from genetically modified pigs? Roni Caryn Rabin, a health reporter on the Science desk of The New York Times, looks at the results so far.

How have the first patients fared after receiving organ transplants from genetically modified pigs? Roni Caryn Rabin, a health reporter on the Science desk of The New York Times, looks at the results so far.

Surgeons and teams with Vanderbilt Lung Transplant performed 99 lung transplants in 2024, the most ever in one year. Two of the procedures involved combined organ transplants.

Hepatocellular carcinoma (HCC) represents about 80 to 90% of cases of primary liver cancer. On a global level, 905,700 new cases and 830,200 deaths were registered in 2020 according to the World Health Organization.

Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.

A recent clinical trial conducted at the Johns Hopkins Kimmel Cancer Center, in collaboration with approximately 20 other cancer centers across the United States and London, has shown promising results for a new bone marrow transplant procedure for adults suffering from sickle cell disease. This trial not only highlights the safety and curative potential of […]

Discover how biotech could solve the organ shortage crisis through xenotransplantation, 3D bioprinting and stem cells. The post The future of organ transplants: Xenotransplantation, 3D bioprinting and stem cells appeared first on Labiotech.eu. © Labiotech UG and Labiotech.eu. Unauthorized use and/or duplication of this material without express and written permission from this site’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Labiotech UG and Labiotech.eu with appropriate and specific direction to the original content.

Surgeons at Massachusetts General Hospital have successfully performed the fourth pig kidney transplant in the U.S.

MONDAY, Feb. 10, 2025 -- Surgeons at Massachusetts General Hospital have successfully performed the fourth pig kidney transplant in the U.S. The recipient of the genetically modified pig organ was a 66-year-old man with kidney failure, surgeons...

"This man literally saved my life by giving me his kidney." The post Former Celtics guard Nate Robinson has successful kidney transplant appeared first on Boston.com.

x The post Former Celtics guard Nate Robinson has successful kidney transplant appeared first on Boston.com.

Ex-Knick Robinson's kidney transplant successful  ESPNFormer NBA player Nate Robinson undergoes kidney transplant  CNNNate Robinson, former NBA dunk king, undergoing kidney transplant after dealing with renal failure - The Athletic  The AthleticNate Robinson successfully undergoes kidney transplant, family focuses on recovery  KING5.comFormer Celtics Star Announces Life-Saving Kidney Transplant  Sports Illustrated

Ex-Knick Robinson's kidney transplant successful  ESPNFormer NBA player Nate Robinson undergoes kidney transplant  CNNNate Robinson, former NBA dunk king, undergoing kidney transplant after dealing with renal failure - The Athletic  The AthleticNate Robinson successfully undergoes kidney transplant, family focuses on recovery  KING5.comFormer Celtics Star Announces Life-Saving Kidney Transplant  Sports Illustrated

This study highlights the first successful cases of robot-assisted kidney transplantation following cystectomy, paving the way for innovative ESRD treatments.

A woman with heart failure was kept alive long enough to receive a heart transplant, in part thanks to newly developed stem-cell-derived heart tissue grafts.

An Alabama grandmother who was the first patient to receive a new kind of genetically modified pig kidney more than two months ago is now the longest surviving recipient of a pig organ.

ProCure On-Demand's 500th transplanted organ, being announced today, is emblematic of the gaps and inefficiencies in the current transplant system that the organ recovery, technology and logistics company is regularly solving.

Researchers from NYU Langone Health and NYU Grossman School of Medicine are part of a major undertaking that will bring together more than 40 scientists, doctors, and industry experts from around the country to make vision-restoring whole-eye transplants a reality.

Researchers have published a prospective, randomized and controlled study on the use of extracorporeal photopheresis (ECP) in lung transplantation. The findings could significantly change the standard procedure for rejection reactions after lung transplants.

In a remarkable advancement for xenotransplantation, a surgical breakthrough at the University of Maryland Medical Center has showcased the potential for genetically-modified pig organs to save human lives. In 2023, Lawrence Faucette, a 58-year-old patient suffering from end-stage heart failure, became the second recipient globally of a pig heart, a groundbreaking procedure aimed at addressing […]

An Alabama woman is free from dialysis and in better health after surgeons at NYU Langone Health performed a gene-edited pig kidney transplant last month.

A woman from Alabama is the latest to receive a gene-edited pig kidney in a recent xenotransplantation at NYU Langone Health, according to a university press briefing.“We know much now about what the pig kidney can do and what it cannot do in terms of all of the functions that the human kidney is responsible for,” Robert A. Montgomery, MD, DPhil, FACS, H. Leon Pachter, MD, Professor of Surgery; chair of the NYU Grossman Schoolof medicine department of surgery; and director of the NYU Langone Transplant Institute, said during the briefing. “We know what rejection looks like

Three people in the US received a genetically modified pig kidney in 2024, marking another step towards animal-to-human organ transplants becoming routine

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.

CU Anschutz researchers launch “moonshot” to cure blindness through eye transplants  The Denver PostUniversity of Colorado Anschutz Medical Campus-Led Team Receives Up to $46 Million to Develop Innovative Treatment to Cure Blindness  University of Colorado Anschutz Medical CampusBascom Palmer Receives Multimillion Dollar Award to Support Functional Whole-Eye Transplant  University of MiamiMoran Researcher Joins Elite Team Working to Make Human Eye Transplantation Possible  University of Utah Health CareNew funding could make whole-eye transplants a reality  Northwestern Now

CU Anschutz researchers launch “moonshot” to cure blindness through eye transplants  The Denver PostUniversity of Colorado Anschutz Medical Campus-Led Team Receives Up to $46 Million to Develop Innovative Treatment to Cure Blindness  University of Colorado Anschutz Medical CampusBascom Palmer Receives Multimillion Dollar Award to Support Functional Whole-Eye Transplant  University of MiamiMoran Researcher Joins Elite Team Working to Make Human Eye Transplantation Possible  University of Utah Health CareNew funding could make whole-eye transplants a reality  Northwestern Now

A Michigan man can blink, swallow, smile and breathe through his nose for the first time in a decade thanks to a face transplant performed at Mayo Clinic. This transformative and complex procedure underscores Mayo Clinic's skilled multidisciplinary surgical team who provide hope to patients with complex medical needs.

In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers at Johns Hopkins Medicine say they have significantly expanded scientific understanding of how some of these transplants may succeed and work.

For the first time, scientists have tracked what happens to stem cells decades after a transplant, lifting the lid on the procedure that has been a medical mystery for over 50 years.

A drug that suppresses the immune system shows promise in treating Type 1 diabetes.

The world’s first combined face and whole-eye transplant success started with innovations in transplant blood flow. The world’s first combined face and whole-eye transplant utilized personalized surgical cutting guides and an innovative “shortcut” technique to maintain blood flow to the transplanted eye. These advanced methods ensured optimal blood circulation to the retina, crucial for preserving [...]

Fecal microbiota transplants, or FMTs, are a magic bullet for patients with recurring infections from Clostridioides difficile (C. diff), but researchers are only beginning to understand why. A new in-depth study of pre- and post-transplant microbiomes shows that FMTs result in an increase of bacteria that inhabit the same niche within the gut as C. diff, but without the negative consequences. The work could be an important step toward isolating more targeted treatments for patients with recurrent C. diff infections.

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Three years ago, Aaron James, a utility lineman, lost half of his face and his arm when he was struck by a high-voltage electrical cable.

The bioengineering company Ossium Health has created a new program that offers deep-frozen bone marrow from deceased organ donors -- and a Michigan woman has received the first transplant.

A man who received a partial face and eye transplant after a serious accident does not have any vision in the transplanted eye, but the eye itself is still alive

The recipient of the world's first combined whole-eye and partial face transplant is doing well more than a year out from his groundbreaking surgery, NYU Langone doctors report.

Aaron James has been able to resume normal life after receiving a partial-face and whole-eye transplant.

Aaron James has been able to resume normal life after receiving a partial-face and whole-eye transplant.

A man who received a partial face transplant that included an eye can’t see out of the eye, but there is blood flow to it.

Surgeons in the US who last year carried out world’s first successful whole eye and partial face transplant say a year on the eye has survived and even shows indications of retinal response to light stimuli. Dr. Eduardo D. Rodriguez, a plastic and reconstructive surgeon at New York University Langone Health, says that while the […]

Researchers at the Terasaki Institute for Biomedical Innovation have been awarded a multi-million grant from the National Institutes of Health (NIH) to advance research in organ transplantation and antibody-mediated rejection.

Researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia and bone marrow failure disorders.

Researchers have achieved a significant advancement by developing lab-generated blood stem cells that mirror those found in the human embryo, offering hope for personalized treatments for children with leukemia and bone marrow failure. This breakthrough allows for the creation of transplantable blood cells from any cell of the patient, potentially transforming the lives of those [...]

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer's. The team had previously used another drug, SNC80, to achieve similar results in tadpoles and enhance the survival of whole mammalian hearts for transplants, but SNC80 is not approved for clinical use in humans because it can cause seizures. By contrast, DNP is already being used in the clinic, meaning it potentially could be rapidly repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital.

A discovery may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.

August 8, 2024—(BRONX NY)—A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body’s different blood cells. The findings, made in mice, were published today in […]

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.

A new national multicenter study offers hope for women who have undergone allogeneic hematopoietic cell transplantation (alloHCT).

A new study by Stanford Medicine highlights flaws in the U.S. pediatric heart transplant waitlist, showing that the current system fails to prioritize the sickest...

Although a new placebo-controlled trial failed to show symptom improvement, it yielded some interesting insights that may help in the design of future studies.

A surprising University of Minnesota study of stem cell transplants found that cancer patients were more likely to die if the cells they received came from donors who lived in poverty or low socioeconomic neighborhoods.

After allogeneic hematopoietic cell transplantation, pregnancies could be carried out and were successful.

Women who undergo allogeneic hematopoietic cell transplantation can get pregnant and have healthy children, according to results of a retrospective study conducted in Germany.The findings are counter to long-held views that women cannot get pregnant after allogeneic hematopoietic cell transplantation (alloHCT).“Some study participants reported that they had not taken measures to prevent pregnancy because their doctor told them conception was not possible,” Katja Sockel, MD, senior physician at University Hospital Carl Gustav Carus in Germany, said in a press release. “Spontaneous

Despite treatment-related fertility challenges, female patients can become pregnant and give birth to healthy children after undergoing allogeneic hematopoietic cell transplantation (alloHCT), according to a study published in Blood.

'Unhealthy' gut microbiome patterns are linked to a heightened risk of death after a solid organ transplant, finds research published online in the journal Gut.

Northwestern surgeons perform one of the first 'awake' kidney transplant surgeries  Chicago Sun-Times

Northwestern surgeons perform one of the first 'awake' kidney transplant surgeries  Chicago Sun-Times

An interdisciplinary team of researchers from The Westmead Institute for Medical Research (WIMR) and the Sydney Precision Data Science Centre at the University of Sydney have, for the first time, identified molecular biomarkers for transplant rejection that are common to all the major transplanted organs: hearts, lungs, livers, and kidneys. The researchers say using machine learning, they can predict transplant outcomes with unprecedented accuracy.

Mahindra’s 6RO Paddy Walker Transplanter is equipped with a powerful and efficient engine and cutting-edge precision technologies to optimise paddy farming efficiency.

PLYMOUTH MEETING, PA [June 11, 2024] — New research in the June 2024 issue of JNCCN—Journal of the National Comprehensive Cancer Network highlights a promising approach for alleviating distress, enhancing quality of life, improving physical function, and reducing fatigue in patients with blood cancers who undergo hematopoietic stem cell transplantation (HSCT). The study used a […]

New research in the June 2024 issue of Journal of the National Comprehensive Cancer Network highlights a promising approach for alleviating distress, enhancing quality of life, improving physical function, and reducing fatigue in patients with blood cancers who undergo hematopoietic stem cell transplantation (HSCT).

CHICAGO — Interim results from a phase 2 study showed positive survival outcomes for individuals who underwent peripheral blood stem cell transplantation for hematologic malignancies.This is despite the ACCESS study using grafts from mismatched unrelated donors, which have had historically poor treatment outcomes, according to study investigators.Researchers also estimated that more than half of patients treated in the study will survive without relapse or developing graft-versus host disease (GVHD) one year after treatment with a regimen that included reduced-intensity conditioning and

The First Person to Receive a Pig Kidney Transplant Has Died  WIREDMassachusetts man dies 2 months after becoming first person to receive successful pig kidney transplant  Yahoo! VoicesWorld-first pig kidney transplant recipient has died  New AtlasRecipient of first-ever pig kidney transplant dies  The Associated Press

The First Person to Receive a Pig Kidney Transplant Has Died  WIREDMassachusetts man dies 2 months after becoming first person to receive successful pig kidney transplant  Yahoo! VoicesWorld-first pig kidney transplant recipient has died  New AtlasRecipient of first-ever pig kidney transplant dies  The Associated Press

The hospital that carried out the procedure two months prior says there’s “no indication” that the transplant was related to his death.

Massachusetts man dies 2 months after becoming first person to receive successful pig kidney transplant  Yahoo! VoicesPig-kidney transplant patient dies 7 weeks after surgery  USA TODAYPatient Dies Weeks After Kidney Transplant From Genetically Modified Pig  The New York TimesUpdate Mass. man who received kidney from pig dies, MGB confirms  The Boston Globe

Massachusetts man dies 2 months after becoming first person to receive successful pig kidney transplant  Yahoo! VoicesPig-kidney transplant patient dies 7 weeks after surgery  USA TODAYPatient Dies Weeks After Kidney Transplant From Genetically Modified Pig  The New York TimesUpdate Mass. man who received kidney from pig dies, MGB confirms  The Boston Globe