Transplantation

Recent advancements in medical technology have ushered in a new era for organ transplantation, particularly in kidney transplants. As the world grapples with organ shortages, the demand for effective and non-invasive ways to monitor transplant health has skyrocketed. A recent comprehensive review titled “Non-Invasive Biomarkers for Kidney Transplant Monitoring,” authored by Damas, Caeiro, Ramirez-Bajo, and […]

A research team led by Prof. Dr. Christian Hinze, senior physician at the MHH Clinic for Kidney and Hypertension Diseases at Hannover Medical School (MHH), has gained new insights into the treatment of kidney transplant patients. The team has discovered properties of kidney cells that, after rejection, provide information about how well a transplant will recover in the long term.

Bone and skeletal injuries cause extensive and long-term functional impairments worldwide. In a new study, researchers at Lund University in Sweden show how a cell-free cartilage structure can safely guide bone repair without triggering strong immune responses. The transplant has been successfully tested in animal models, and the next step is to evaluate the tissue engineering approach in humans. The study is published in the journal Proceedings of the National Academy of Sciences.

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bmj;391/dec15_1/r2604/FAF1faCredit: WhisypyhistoryTerence English was a dynamic force with disparate talents and a penchant for wild extravagance. He performed Britain’s first successful heart transplant at Papworth Hospital in 1979—this ensured the future of one of Europe’s leading heart and lung programmes after the UK’s first three cardiac transplant recipients, in 1968 and 1969, survived for only 45, 2, and 107 days. These results and poor international survival rates led to a moratorium on further UK operations—which English defied. His uncompromising life mantra was “tenacity of purpose.”English was equally at ease in the wilds of Canada and Africa, the operating theatre, and St Catharine’s College, Cambridge, where he was master for seven years. He began his working life in South Africa’s diamond mines having won an engineering scholarship after drilling a record 42 metres with a single bit at the age of just 17. He thrived in the mines’ heavy drinking,

In a groundbreaking study poised to revolutionize the field of organ transplantation, researchers have harnessed the power of deep learning techniques to enhance the prediction of transplant recipient outcomes and improve pathology assessments through rapid analysis of procurement kidney biopsies. This innovative approach, detailed in the forthcoming publication in Scientific Reports, promises to address critical […]

A new study shows that giving the chemotherapy drug cyclophosphamide after allogeneic hematopoietic cell transplantation, a curative treatment for common types of blood cancer, can make the procedure safe and effective even when donors and recipients are unrelated and have extensive genetic mismatches.

Researchers have uncovered and then overcome an obstacle that has led to the failure of pioneering efforts in xenotransplantation, in which an animal kidney is transplanted into a human.

The current kidney transplant waitlisting criterion is based on a single measurement of kidney function (estimated glomerular filtration rate [eGFR] ≤20 ml/min/1.73m2) and does not consider an individual's risk of progressing to kidney failure.

Bernie Kosar vowed to keep fighting despite he latest health setback. The former Cleveland Browns quarterback awaits a liver transplant and recently underwent two surgeries.

A groundbreaking advancement in regenerative medicine has been achieved by researchers at the Institute for Bioengineering of Catalonia (IBEC), in partnership with the Biomedical Research Institute of A Coruña (INIBIC) and numerous international collaborators. Their innovative approach enables the scalable production of human kidney organoids that can be integrated with porcine kidneys using ex vivo […]

A research team led by the Institute for Bioengineering of Catalonia (IBEC) and collaborating with the Biomedical Research Institute of A Coruña (INIBIC), as well as other international research groups, has developed pioneering technology that enables human kidney organoids to be produced in a scalable manner.

ABO-incompatible kidney transplantation has emerged as a pivotal solution to address the mounting demand for organ transplants globally. The approach, however, poses various challenges that can complicate the recipient’s healthcare journey. While current desensitization strategies primarily focus on the recipient, relying heavily on antibody depletion methods such as plasmapheresis, these techniques are not without their […]

The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed at the University of British Columbia to help prevent a mismatch and rejection of the organ.

Discover how turning organs into glass could revolutionize crucial transplant logistics.

Posidonia seagrass meadows, veritable underwater forests, play a major ecological role. Under constant pressure from human activity, scientists are looking for ways to ensure their survival, in particular by carrying out restoration campaigns.

In a groundbreaking advancement for the treatment of brittle type 1 diabetes, physicians at the University of Illinois Chicago Health (UI Health) have successfully performed the first FDA-approved islet cell transplant using Lantidra, marking a pivotal milestone in diabetes management. This development signifies the transition of islet transplantation from an experimental procedure to an established […]

Enhanced Recovery After Surgery (ERAS) programs have revolutionized the approach to liver transplantation, providing a comprehensive framework aimed at improving patient outcomes, minimizing complications, and expediting recovery. The recent review article by Guzzi, Strand, Hussain, and their colleagues showcases the pivotal enhancements ERAS brings to liver transplant procedures. This initiative encompasses a series of protocols […]

The recent advancements in single-cell sequencing and spatial transcriptomics have revolutionized the field of kidney transplantation, as discussed in a groundbreaking study by Paul, Atkinson, and Malone. This pivotal research sheds light on how these innovative technologies can enhance our understanding of kidney transplant biology, revealing the cellular dynamics and spatial organization of tissues that […]

Surgeons think the first transplantation of a pig lung in a human is an exciting step forward for the field, but many questions remain open

In a groundbreaking development in reproductive medicine, a recent study has reported a second clinical pregnancy following repeat ovarian tissue transplantation in a survivor of acute leukemia. This remarkable case highlights not only the advances in fertility preservation techniques for patients with cancer but also the intricate biological mechanisms that contribute to success in such […]

In a landmark achievement that could profoundly impact the future of regenerative medicine, scientists at Kumamoto University have successfully engineered functional ureteral tissue in vitro using pluripotent stem cells. This pioneering work, led by Professor Ryuichi Nishinakamura and his team at the Institute of Molecular Embryology and Genetics, marks the first time a ureteral structure […]

In an unprecedented advancement in cardiac surgery, a recent case series has highlighted the safety and feasibility of partial heart transplantation as a revolutionary treatment for patients with complex congenital heart disease. This novel surgical approach is not just a temporary fix but holds the potential to fundamentally alter how valve replacements are managed, especially […]

Scientists in China achieved the first pig lung transplant into a human patient, with the genetically modified organ showing no signs of rejection during monitoring.

TUESDAY, Aug. 26, 2025 — Doctors in China transplanted a genetically modified pig lung into a man, where it functioned for nine days, according to a new study published in the journal Nature Medicine.Researchers at Guangzhou Medical University’s Fir...

First-ever pig-to-human lung transplant attempted in brain-dead person in China  Live SciencePig-to-human lung xenotransplantation into a brain-dead recipient  NatureScientists Perform First Pig-to-Human Lung Transplant  The New York TimesFor the first time, a genetically modified pig lung was transplanted into a brain-dead man  CNNGene-edited pig lung transplanted into a brain-dead patient for first time  statnews.com

First-ever pig-to-human lung transplant attempted in brain-dead person in China  Live SciencePig-to-human lung xenotransplantation into a brain-dead recipient  NatureScientists Perform First Pig-to-Human Lung Transplant  The New York TimesFor the first time, a genetically modified pig lung was transplanted into a brain-dead man  CNNGene-edited pig lung transplanted into a brain-dead patient for first time  statnews.com

In a first, scientists in China transplanted a lung from a pig into a human so they could see how the host immune system handled the procedure.

The genetically modified lung remained viable for nine days, but the recipient’s immune responses need more research, scientists say.

A Phase 1 clinical trial has shown that an antibody developed at Stanford Medicine can prepare patients for stem cell transplantation while avoiding toxic side effects. A phase 1 clinical trial has demonstrated that an antibody treatment created at Stanford Medicine can safely prepare patients for stem cell transplants without the need for busulfan chemotherapy [...]

In a groundbreaking advancement that may redefine transplant medicine, researchers at the Medical University of South Carolina (MUSC) have engineered a novel immunological tool capable of selectively suppressing the immune response responsible for organ rejection. Published in the prestigious journal Frontiers in Immunology, this pioneering work introduces genetically modified regulatory T cells equipped with chimeric […]

An innovative, antibody-based therapy enabled safe stem cell transplants in three children with Fanconi anemia, avoiding toxic chemotherapy and radiation, with positive outcomes after two years. The post Novel, Less Toxic, Stem Cell Transplant Prep Yields Successful Outcomes appeared first on GEN - Genetic Engineering and Biotechnology News.

An antibody treatment developed at Stanford Medicine successfully prepared patients for stem cell transplants without toxic busulfan chemotherapy or radiation, a Phase I clinical trial has shown.

Researchers at the University of Pittsburgh have identified a new way of predicting whether a kidney donor and recipient are a good match for transplantation.

Advances in blood stem cell transplants now make it possible for people with blood cancers to get safe and effective "mismatched" transplants that will potentially cure their disease, new UVA Cancer Center research reveals. The advances will allow far more people to receive the lifesaving treatment.

In a groundbreaking advancement destined to reshape the future of organ transplantation, an international team of researchers has unveiled unprecedented insights into the immune dynamics following pig-to-human kidney xenotransplantation. Presented at the prestigious European Society for Organ Transplantation (ESOT) Congress 2025 in London, this pioneering study delves deep into the cellular interplay that underpins the […]

The patient, a 45-year-old man hospitalized for months with severe heart failure, became the first in the United States to receive a heart transplant using a minimally invasive, robot-assisted technique. Unlike traditional transplants that require splitting the breastbone to open the chest, this procedure uses a sophisticated surgical robot to...Read Entire Article

Fecal microbiota transplants (FMT) have emerged as a revolutionary therapeutic approach aimed at reshaping the gut microbiome to treat a variety of disorders, ranging from recurrent Clostridium difficile infections to chronic inflammatory diseases, metabolic conditions like obesity and type 2 diabetes, and even neurodevelopmental issues, including autism spectrum disorders. Yet, a groundbreaking new study from […]

A groundbreaking international study unveiled at the 62nd European Renal Association (ERA) Congress in Vienna challenges the long-standing notion that deceased-donor kidney transplantation universally confers a survival advantage for all recipients. Drawing on two decades of comprehensive data from over 64,000 adult dialysis patients across several European countries, the research utilizes a sophisticated analytical approach […]

Historic surgery opens the door for improved treatment of non-functioning bladders. Continue reading World’s first-ever human bladder transplant on Tech Explorist.

Multiple obstacles, including vascular connections and immune suppression, made the pioneering bladder transplant procedure a challenge.

MONDAY, May 19, 2025 — Doctors in Southern California have performed the first human bladder transplant, offering new hope to people with serious bladder problems.The surgery was done earlier this month by two doctors from the University of C...

Surgeons from Keck Medicine of USC and UCLA Health have performed the world's first-in-human bladder transplant.

Becoming an organ donor has never been easier. Registration is available online when renewing a driver's license or, for iPhone users, through an app.

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Current treatments to prevent organ transplant rejection focus mainly on suppressing T cells, part of the adaptive immune system. However, the innate immune system—the body's first line of defense that triggers early inflammation after transplantation—has largely remained untargeted by modern therapies.

In a groundbreaking development that promises to transform the landscape of lung transplantation, researchers have demonstrated that the hypothermic oxygenated machine perfusion (HOPE) technique is a safe and effective method for preserving donor lungs outside the human body, even when total preservation times approach an unprecedented 20 hours. This advancement, presented by Jitte Jennekens, MSc, […]

In a landmark moment for cardiac transplantation, the International Society of Heart and Lung Transplantation (ISHLT) commemorated the tenth anniversary of the modern heart donation after circulatory death (DCD) technique at their recent Annual Meeting and Scientific Sessions in Boston. This innovative approach has revolutionized heart transplantation globally by substantially increasing the number of transplant […]

A baby girl named Amy Isabel has become the first child in the UK to be born to a mother who has had a womb transplant. Amy is one of around 65 children worldwide born as a result of pioneering research into the procedure.

Uterus transplantation, a surgery enabling birth for women with uterine issues, has seen over 135 transplants and 50+ births globally.

The liver performed basic functions but isn’t yet a full replacement. The post Scientists Just Transplanted a Pig Liver Into a Person for the First Time appeared first on SingularityHub.

Pig Liver Successfully Transplanted Into Human Patient in World First  ScienceAlertGene-modified pig-to-human liver xenotransplantation  Nature.comChinese researchers report a pig kidney transplant and a first-step liver experiment  The Seattle TimesSurgeons transplant genetically modified pig liver into Chinese patient  The GuardianSurgeons transplanted a pig’s liver into a human  Science News Magazine

Pig Liver Successfully Transplanted Into Human Patient in World First  ScienceAlertGene-modified pig-to-human liver xenotransplantation  Nature.comChinese researchers report a pig kidney transplant and a first-step liver experiment  The Seattle TimesSurgeons transplant genetically modified pig liver into Chinese patient  The GuardianSurgeons transplanted a pig’s liver into a human  Science News Magazine

It's the latest evidence to suggest that animal-to-human transplantation is feasible.

How have the first patients fared after receiving organ transplants from genetically modified pigs? Roni Caryn Rabin, a health reporter on the Science desk of The New York Times, looks at the results so far.

How have the first patients fared after receiving organ transplants from genetically modified pigs? Roni Caryn Rabin, a health reporter on the Science desk of The New York Times, looks at the results so far.

How have the first patients fared after receiving organ transplants from genetically modified pigs? Roni Caryn Rabin, a health reporter on the Science desk of The New York Times, looks at the results so far.

Surgeons and teams with Vanderbilt Lung Transplant performed 99 lung transplants in 2024, the most ever in one year. Two of the procedures involved combined organ transplants.

Hepatocellular carcinoma (HCC) represents about 80 to 90% of cases of primary liver cancer. On a global level, 905,700 new cases and 830,200 deaths were registered in 2020 according to the World Health Organization.

Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.

A recent clinical trial conducted at the Johns Hopkins Kimmel Cancer Center, in collaboration with approximately 20 other cancer centers across the United States and London, has shown promising results for a new bone marrow transplant procedure for adults suffering from sickle cell disease. This trial not only highlights the safety and curative potential of […]

Discover how biotech could solve the organ shortage crisis through xenotransplantation, 3D bioprinting and stem cells. The post The future of organ transplants: Xenotransplantation, 3D bioprinting and stem cells appeared first on Labiotech.eu. © Labiotech UG and Labiotech.eu. Unauthorized use and/or duplication of this material without express and written permission from this site’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Labiotech UG and Labiotech.eu with appropriate and specific direction to the original content.

Surgeons at Massachusetts General Hospital have successfully performed the fourth pig kidney transplant in the U.S.

MONDAY, Feb. 10, 2025 -- Surgeons at Massachusetts General Hospital have successfully performed the fourth pig kidney transplant in the U.S. The recipient of the genetically modified pig organ was a 66-year-old man with kidney failure, surgeons...

"This man literally saved my life by giving me his kidney." The post Former Celtics guard Nate Robinson has successful kidney transplant appeared first on Boston.com.

x The post Former Celtics guard Nate Robinson has successful kidney transplant appeared first on Boston.com.

Ex-Knick Robinson's kidney transplant successful  ESPNFormer NBA player Nate Robinson undergoes kidney transplant  CNNNate Robinson, former NBA dunk king, undergoing kidney transplant after dealing with renal failure - The Athletic  The AthleticNate Robinson successfully undergoes kidney transplant, family focuses on recovery  KING5.comFormer Celtics Star Announces Life-Saving Kidney Transplant  Sports Illustrated

Ex-Knick Robinson's kidney transplant successful  ESPNFormer NBA player Nate Robinson undergoes kidney transplant  CNNNate Robinson, former NBA dunk king, undergoing kidney transplant after dealing with renal failure - The Athletic  The AthleticNate Robinson successfully undergoes kidney transplant, family focuses on recovery  KING5.comFormer Celtics Star Announces Life-Saving Kidney Transplant  Sports Illustrated

This study highlights the first successful cases of robot-assisted kidney transplantation following cystectomy, paving the way for innovative ESRD treatments.

A woman with heart failure was kept alive long enough to receive a heart transplant, in part thanks to newly developed stem-cell-derived heart tissue grafts.

An Alabama grandmother who was the first patient to receive a new kind of genetically modified pig kidney more than two months ago is now the longest surviving recipient of a pig organ.

ProCure On-Demand's 500th transplanted organ, being announced today, is emblematic of the gaps and inefficiencies in the current transplant system that the organ recovery, technology and logistics company is regularly solving.

Researchers from NYU Langone Health and NYU Grossman School of Medicine are part of a major undertaking that will bring together more than 40 scientists, doctors, and industry experts from around the country to make vision-restoring whole-eye transplants a reality.

Researchers have published a prospective, randomized and controlled study on the use of extracorporeal photopheresis (ECP) in lung transplantation. The findings could significantly change the standard procedure for rejection reactions after lung transplants.

In a remarkable advancement for xenotransplantation, a surgical breakthrough at the University of Maryland Medical Center has showcased the potential for genetically-modified pig organs to save human lives. In 2023, Lawrence Faucette, a 58-year-old patient suffering from end-stage heart failure, became the second recipient globally of a pig heart, a groundbreaking procedure aimed at addressing […]

An Alabama woman is free from dialysis and in better health after surgeons at NYU Langone Health performed a gene-edited pig kidney transplant last month.

A woman from Alabama is the latest to receive a gene-edited pig kidney in a recent xenotransplantation at NYU Langone Health, according to a university press briefing.“We know much now about what the pig kidney can do and what it cannot do in terms of all of the functions that the human kidney is responsible for,” Robert A. Montgomery, MD, DPhil, FACS, H. Leon Pachter, MD, Professor of Surgery; chair of the NYU Grossman Schoolof medicine department of surgery; and director of the NYU Langone Transplant Institute, said during the briefing. “We know what rejection looks like

Three people in the US received a genetically modified pig kidney in 2024, marking another step towards animal-to-human organ transplants becoming routine

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.

CU Anschutz researchers launch “moonshot” to cure blindness through eye transplants  The Denver PostUniversity of Colorado Anschutz Medical Campus-Led Team Receives Up to $46 Million to Develop Innovative Treatment to Cure Blindness  University of Colorado Anschutz Medical CampusBascom Palmer Receives Multimillion Dollar Award to Support Functional Whole-Eye Transplant  University of MiamiMoran Researcher Joins Elite Team Working to Make Human Eye Transplantation Possible  University of Utah Health CareNew funding could make whole-eye transplants a reality  Northwestern Now

CU Anschutz researchers launch “moonshot” to cure blindness through eye transplants  The Denver PostUniversity of Colorado Anschutz Medical Campus-Led Team Receives Up to $46 Million to Develop Innovative Treatment to Cure Blindness  University of Colorado Anschutz Medical CampusBascom Palmer Receives Multimillion Dollar Award to Support Functional Whole-Eye Transplant  University of MiamiMoran Researcher Joins Elite Team Working to Make Human Eye Transplantation Possible  University of Utah Health CareNew funding could make whole-eye transplants a reality  Northwestern Now

A Michigan man can blink, swallow, smile and breathe through his nose for the first time in a decade thanks to a face transplant performed at Mayo Clinic. This transformative and complex procedure underscores Mayo Clinic's skilled multidisciplinary surgical team who provide hope to patients with complex medical needs.

In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers at Johns Hopkins Medicine say they have significantly expanded scientific understanding of how some of these transplants may succeed and work.

For the first time, scientists have tracked what happens to stem cells decades after a transplant, lifting the lid on the procedure that has been a medical mystery for over 50 years.

A drug that suppresses the immune system shows promise in treating Type 1 diabetes.

The world’s first combined face and whole-eye transplant success started with innovations in transplant blood flow. The world’s first combined face and whole-eye transplant utilized personalized surgical cutting guides and an innovative “shortcut” technique to maintain blood flow to the transplanted eye. These advanced methods ensured optimal blood circulation to the retina, crucial for preserving [...]

Fecal microbiota transplants, or FMTs, are a magic bullet for patients with recurring infections from Clostridioides difficile (C. diff), but researchers are only beginning to understand why. A new in-depth study of pre- and post-transplant microbiomes shows that FMTs result in an increase of bacteria that inhabit the same niche within the gut as C. diff, but without the negative consequences. The work could be an important step toward isolating more targeted treatments for patients with recurrent C. diff infections.

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Three years ago, Aaron James, a utility lineman, lost half of his face and his arm when he was struck by a high-voltage electrical cable.

The bioengineering company Ossium Health has created a new program that offers deep-frozen bone marrow from deceased organ donors -- and a Michigan woman has received the first transplant.

A man who received a partial face and eye transplant after a serious accident does not have any vision in the transplanted eye, but the eye itself is still alive

The recipient of the world's first combined whole-eye and partial face transplant is doing well more than a year out from his groundbreaking surgery, NYU Langone doctors report.

Aaron James has been able to resume normal life after receiving a partial-face and whole-eye transplant.

Aaron James has been able to resume normal life after receiving a partial-face and whole-eye transplant.

A man who received a partial face transplant that included an eye can’t see out of the eye, but there is blood flow to it.