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Contemporary hormone replacement therapy (HRT) was not associated with an increased risk of heart attack, stroke, blood clots or death among women ages 45 to 59, according to a large, long-term study of more than 52,000 women in Israel. The findings from this independent, preliminary research will be presented at the American Heart Association's Scientific Sessions 2026. The meeting is Nov. 6–9 in Chicago.

What does it mean to feel that a part of us will live on after we are gone? A new study of nearly 3,000 adults found that people who believed they would be remembered by others tended to report better mental health, a stronger sense of meaning and lower levels of problematic substance use and addictive behaviors. The findings point to a possible link between our sense of lasting significance and the way we cope with stress, uncertainty and mortality.

Doctors at Beilinson Medical Center perform a robotic lung transplant with minimal incisions, joining around 20 similar procedures worldwide; report rapid recovery and reduced need for painkillers.

arXiv:2610.38234v2 Announce Type: replace Abstract: We demonstrate the first zero-shot sim-to-real transfer for a surgeon-robot collaboration task in open surgery: retractor take-over. A robot arm takes a retractor from the surgeon's hand and preserves retraction at handoff, using a policy trained only on simulated demonstrations, without human demonstrations or real-world fine-tuning. Imitation learning from real demonstrations is limited by collection and labeling costs, and by performance degradation when the environment changes. Our framework, SimRetract, generates simulated demonstrations designed for transfer: the policy observes masked instrument images and grasp geometry, learns to recover from off-nominal states, and acts with margin for execution drift. Deployed zero-shot, it grasps the retractor in 90% of 50 surgeon-defined phantom presentations and preserves retraction at handoff in 78%. Results on unseen retractors suggest potential for generalization to instruments with

arXiv:2610.05533v3 Announce Type: replace Abstract: A harness search around a frozen longevity-tuned 1.7B model reported a rescue. An audit found that the gain came from rows the start left unparsed, that the caller sent each row's reference answer as an assistant turn, and that replication through the same pipeline missed it. Is a harness's gain more than a constant answer would give? We preregistered three studies and report every endpoint. In the first two, thinking off raised test accuracy over a capped thinking setting in 7 of 12 cells, mostly on rows the cap left unparsed. It was not meaningfully worse than a rescue in 7 of 9 small-model test cells or than four GEPA harnesses at 1.7B. Replication reproduced an injected defect's distortion in 9 of 20 evaluable cases (7 fixed by design). At 14B, two GEPA harnesses beat thinking off by 34 points on test but were not detectably above the strongest constant label, and answered "Yes" in 94.6% and 98.2% of parsed mortality answers on

arXiv:2610.42066v1 Announce Type: new Abstract: AI answers require more than apparent correctness: reviewers need to inspect their recorded basis. We introduce the Knowledge Layer Model (KLM), an open, implementation-neutral specification for inference records with versioned epistemic assessments, evidence relations, and explicit unknowns. SEDIM, the knowledge and evidence architecture of Nage AI OS, is a reference implementation. We reference KLM v0.3 (repository tag v0.3.0). Empirical material consists of separate internal experiments, not end-to-end validation. A historical platform-domain routing benchmark reports 137/150 classifications across 15 classes (91.3%; nominal 95% Wilson interval 85.7-94.9%); the numerator is recovered from a rounded summary, and historical example membership is unverified. A native-model weight-path configuration yielded 0/15 successful answers in a corrected two-source test. A capacity-growth comparison could not establish a reliable effect because of

arXiv:2610.41978v1 Announce Type: new Abstract: Automated endoscope guidance reduces the need for continuous manual camera control during minimally invasive surgery. However, the desired camera motion depends on the surgeon's immediate intentions and cannot always be inferred from the visual operative scene alone. We propose to automate the task using language-conditioned behavioral cloning; we define 6 clinically relevant guidance behaviors and collect 235 subtask demonstrations. In preliminary phantom experiments, our policy achieves 100% success on focus, overview, and stop, 80% on search-tip and follow-tip behaviors, and 50% on horizon leveling. These results demonstrate the feasibility of learning heterogeneous surgeon-requested camera behaviors with a single visuomotor policy, while the observed failure modes motivate future work on adding temporal context for more demanding guidance tasks.

arXiv:2610.41348v1 Announce Type: new Abstract: Robots deployed in unstructured environments are susceptible to actuator-authority degradation, which reduces the effective control authority of individual actuators and can cause reinforcement learning policies trained under nominal dynamics to fail. Existing robustness approaches rely on discrete fault labels, broad domain randomization, or global latent variables, often without explicitly modeling continuous per-joint residual actuation capability. We propose a joint-health-aware reinforcement learning framework for robust robot control under simulated actuator degradation. Our framework encodes actuator condition in a continuous joint-health vector and models degradation as multiplicative attenuation of executed actions. A dedicated HealthNet estimator infers per-joint health from recent observations and actions, allowing the policy to redistribute control effort across healthy and degraded joints. We evaluate the method on Walker,

Shares of gene editing therapy companies mostly surged this past week on two growth catalysts: Data readouts at the European Society of Gene and Cell Therapy’s 33rd ESGCT Annual Congress, and the FDA's new draft guidance for personalized gene therapies. The post StockWatch: Gene Editing Shares Jump on ESGCT Data, FDA Draft Guidance appeared first on GEN - Genetic Engineering and Biotechnology News.

AI has been making its way into video game development for a while now, but the recent developments have started raising some serious concerns. Popular games are being reverse-engineered with AI assistance, recreated for web browsers, and made playable on platforms they were never released for. Between all that, indie developers have started pulling down […]

Cailey Gleeson / Fierce Healthcare: AI-powered medical search engine Vera Health, which says it is used by 800,000+ clinicians in 190 countries, raised a $28.5M Series A led by Threshold Ventures  —  Artificial Intelligence funding round series A venture capital (VC)  —  Clinical artificial intelligence search engine Vera …

A Pew survey of 3,488 U.S. adults found that 60% are uncomfortable with doctors using AI for diagnoses and treatment, while most want human oversight of medical decisions.

Will Maddox / Axios: Midstream Health, whose AI tools help 250 hospitals recover revenue from rebates and vendor and payer underpayments, raised a $20M Series A led by Valtrius  —  Midstream Health, an AI financial system for hospitals, raised a $20 million Series A round to expand its platform …

Sen. Bill Cassidy's PATIENT AI Act discussion draft would direct Medicare to test paying for autonomous clinical AI while requiring patient notice and preserving appeal rights.

An AI Agent Injected Drugs Into a Live Mouse’s Brain  WIREDA Claude model autonomously chose a gene therapy and operated on a mouse brain with no human decision-making  The DecoderAI agent used to perform controversial brain surgery on a mouse, Anthropic Sonnet-controlled motorized surgery rig — Opus 5.5 refused to conduct biological experiment, Sonnet given free rein to treat epilepsy with a range of gene therapy vectors after  Tom's HardwareExin Therapeutics Uses Anthropic Sonnet to Guide Mouse Brain Surgery  news.lavx.huAI Agent Autonomously Performs Gene Therapy Injection on Live Mouse Brain  The Tech Buzz

Guy Penrod seeks prayers after disclosing a serious blood and bone marrow illness, telling Mark Lowry a transplant is the only potential fix.

Microsoft's AI diagnostic system identified 83% of complex medical cases in a study, more than doubling the 36% accuracy of generalist doctors.

In the third of a four-part Health Matters wellness series on frontier medicine in Hong Kong, Fiona Sun examines how a local start-up is testing a gene-editing therapy that could tackle a group of inherited eye diseases at their genetic source and what it will take to turn it into a treatment patients can access. For 15 years, Professor Zheng Zongli has worked to make gene-editing therapies safe enough to treat diseases with limited treatment options. His path has taken him from a PhD in medical...

TechNode: Shanghai-based NeuroXess, which is developing BCI technology for movement support, speech decoding, and control of external devices, raised a ~$105M Series B  —  Chinese brain-computer interface startup NeuroXess has raised RMB 700 million in Series B funding, co-led by SDIC Juli, Shenzhen Capital Group and Qinzhi Capital.

The relationship between creativity and mental health has attracted the interest of many psychologists over the past decades. Some past studies have found that creativity is sometimes linked to mental health difficulties, while others collected opposing or inconsistent results.

Anthropic's Opus 5.5 model blocking attempts at videogame recreation — users also claim their non-malicious generic reverse-engineering tasks are block

Archaea Behind Complex Life The microbes closest to the ancestor of complex life turn out to be plain

The team had to use Sonnet after Opus 5.5 outright refused to run the experiment, while Opus 5 warned that it could stop working in the midst of the operation.

A biotech startup let an agent choose a gene therapy and successfully inject the treatment, offering a startling glimpse of the future of research labs.

Liu ensured that his return visit to ESGCT (having spoken at the congress in Barcelona in 2019) would be one of the highlights of the conference. The “meta lesson” of the past few years in therapeutic genome editing is that different scientific approaches and applications can synergize with regulatory, manufacturing, and economic advances “to achieve the mission we’re on.” The post No Nonsense: David Liu Lauds Progress in Disease-Agnostic Gene Editing at ESGCT appeared first on GEN - Genetic Engineering and Biotechnology News.

California to Texas migration is reshaping Texas politics as Democratic transplants bring progressive values to the once ruby red McKinney, Texas.

Dr. Jue Wang, Head of Global Business Development at Insilico Medicine, has been invited to attend the China Healthcare Summit in Shanghai. On the afternoon of November 3 at 16:45, she will deliver a keynote speech in the panel titled: "THE COMMODITIZATION TRAP: WHO WINS WHEN EVERYONE HAS THE SAME AI?"

A patient has undergone pioneering stem-cell therapy to treat Parkinson's disease, the Japanese drugmaker behind the treatment said on Friday, in a world first following its conditional approval in the country.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Cells are very particular about the proper locations of their contents. For example, DNA is packaged in the nucleus in a highly specific way, but researchers are still trying to understand how this happens. For stem cells in the brain of a larval fruit fly—a model organism used to study processes such as early development—the DNA is organized so that the center of each strand, called the centromere, is at the top of the nucleus.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Healthy eating may help cancer survivors live longer and lower their risk for ischemic heart disease, heart failure or stroke, according to data published in JACC: Advances.Implementing or maintaining a high-quality, heart-healthy diet such as the Mediterranean, Dietary Approaches to Stop Hypertension (DASH) or Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet after a cancer diagnosis may have cardioprotective benefit and enhance overall survival, researchers reported.In addition, the reduced risk for CV events was not observed with high intake of a healthy

An automated insulin delivery system substantially improved time in range and HbA1c at 3 months for youths with type 1 diabetes, according to data published in Diabetes Technology & Therapeutics.The iLet bionic pancreas (Beta Bionics) is an automated insulin delivery that replaces carbohydrate counting and manual bolus calculations with qualitative meal announcements, according to Elizabeth R. Sullivan-Ingram, DO, pediatric endocrinology fellow at University of Alabama at Birmingham and Children’s of Alabama. In a single-center real-world study of youths who initiated the device,

By: Victoria Tenor In January 2026, Canada took a step forward in agricultural biotechnology by approving the country’s first gene-edited (GE) mammal for human consumption. … The post Canada Approves its First Gene-edited Pig for Human Consumption appeared first on SAIFood.

Researchers here propose that greater efforts should be devoted to considering the variety of G-protein coupled receptors (GPCRs) as a regulatory network in the matter of aging and age-related disease. Aging produces sweeping changes in protein levels, gene expression, protein function and interactions, and one can thus make similar arguments for many different classes of molecule found in cells. The question is always whether one can justify intervention in a given mechanism on the basis of its importance to aging: where does it sit in the interacting network of cause and consequence? Is it causing a great deal of downstream harm, or is it more of an end stage consequence? How close is it to root causes of aging? This is a lot harder to […]

In part three of our series, I spoke with Ryan Confer, President and CEO of Genprex, about the company’s move from cancer into diabetes. The post Genprex bets on a one-time gene therapy for diabetes (Part 3 of 3) appeared first on Labiotech.eu. © Labiotech UG and Labiotech.eu. Unauthorized use and/or duplication of this material without express and written permission from this site’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Labiotech UG and Labiotech.eu with appropriate and specific direction to the original content.

A Japanese claims-based cohort study of 1,520 women treated for cervical cancer found that only 22.0 percent started hormone replacement therapy within six months, with use falling steeply with age and continuing for a median of about two years.

arXiv:2610.38496v1 Announce Type: cross Abstract: Behavior Cloning (BC) of expert controllers for multiscale dynamical systems is challenging: state variables evolving at widely separated timescales induce highly nonlinear couplings that a shared latent space may fail to adequately represent, degrading closed-loop generalization. We propose Structured Representation Learning for Behavior Cloning (SRLBC), an architecture designed to leverage the physical knowledge of multiscale systems in which slow state variables, fast (stiff) state variables, and predictable exogenous inputs evolve at different timescales. On 500 long-horizon roll-outs of a pressurized water reactor (PWR) load-following benchmark -a high-dimensional, stiff industrial system with challenging safety constraints -and across 20 training seeds, separated embeddings systematically outperform shared embedding baselines on cumulative cost, imitation accuracy and constraint satisfaction. The resulting standalone policies

arXiv:2610.37815v1 Announce Type: new Abstract: We consider the general mother-dependent neutral mutation model defined in Blancas, Fittipaldi and Hern\'andez-Torres (2026), consisting of a multitype branching process in which every individual carries one of $d$ alleles and each mutant child acquires a type different from that of its mother, according to a prescribed distribution. We assume that the total offspring distribution is critical and belongs to the domain of attraction of an $\alpha$-stable law, with $\alpha\in(1,2)$, while mutations are rare. Extending the results of Blancas and Rivero (2018), we prove the finite-dimensional convergence of the rescaled Markov chain that records, in each allelic generation, the sizes of the type-specific clone subfamilies and the mutant populations they produce. The limiting clone masses form a multitype Ji\v{r}ina process driven by stable subordinators with drift, whose branching mechanism combines the stable reproduction law with the

Frontiers in Medicine has retracted a 2020 mouse study on exosomal miR-25 and fracture healing after image integrity concerns and missing raw data.

While artificial intelligence (AI) holds great potential to transform health care, its clinical adoption in Korea remains slow due to inadequate reimbursement and limited access to medical data, experts said. The remarks came during a symposium hosted by Eulji University Medical Center to mark its 70th anniversary, under the theme "Future Healthcare with AI," in Seoul. AI has already been transforming Korea's health care system. It has significantly improved public access to medical information, while helping physicians at primary and secondary health care institutions stay up to date with the latest medical research and developments. Despite these advances, AI adoption in clinical settings remains slow. While AI-based medical devices have gained regulatory approval in Korea, few are covered by national health insurance. Based on Ministry of Food and Drug Safety data, 549 AI medical devices have received regulatory approval until the first half of this year, but only 49 are covered by

A new review maps how mutations in more than twenty genes weaken bone in osteogenesis imperfecta and surveys therapies from bisphosphonates to CRISPR gene editing.

A zinc-chelating dye that stains insulin-producing beta cells red allowed researchers to locate and retrieve otherwise invisible islet grafts transplanted under the skin of mice.

A new study shows that the RNA-binding protein MSI1 stabilizes the ferritin-like transcript Fthl17c, preserving the ferrous iron supply that TET enzymes need to keep DNA hypomethylated and mouse embryonic stem cells pluripotent.

A vision-language AI agent built by CU Anschutz researchers identified correct diagnoses in 99.6% of reviewed right upper quadrant ultrasound reports and drafted reports that experts could not distinguish from radiologist-edited work.

A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and combining the autophagy inhibitor GNS561 with AZD5305 slowed tumors and improved survival in mouse models.

Abstracts from the 34th Portuguese Dental Association Annual Meeting present case reports and early studies spanning odontogenic cyst management, regenerative endodontics, implant bone regeneration, antimicrobial resistance, and diagnostic artificial intelligence.

The FDA's draft guidance could streamline approval of gene-editing therapies tailored to individual mutations, while families and experts weigh safety, affordability, evidence requirements, and access challenges.

Researchers developed an in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes, which showed normal karyotype, intact p53, and responses to thirteen reference substances consistent with published genotoxicity reports.

A retrospective study of 3,884 emergency brain CT scans found two FDA-cleared AI haemorrhage detectors traded sensitivity against specificity, with neither dominating across all metrics.

The first patient received a dose of the high-precision gene editor in a new clinical trial for Wilson disease. Researchers hope it's a one-and-done fix. The post CRISPR Prime Editing Rewrites DNA in the Human Body for the First Time appeared first on SingularityHub.

A new review in Cell Regeneration explains why transient senescent cells support muscle repair while persistent senescence in aged or dystrophic muscle undermines it.

A new review summarizes how processed human amniotic membrane is being applied across orthopaedics, obstetrics and gynaecology, and dermatology.

An international study reports 60% progression-free survival at 10 years after autologous bone marrow transplantation, adding important evidence on sustained positive clinical outcomes and long-term safety in patients treated for early severe systemic sclerosis.

A new study proposes the contextual palimpsest, a temporally layered design framework in which past traces and present interventions coexist in regenerated cultural buildings.

New work shows that loss of the chromatin-binding protein Prospero leaves fly CNS cells of mixed identity that fail to divide or divide once extra, without dedifferentiating into stem cells.

When a patient arrives in the emergency department with severe abdominal pain, every minute counts. Researchers at the University of Colorado Anschutz School of Medicine are investigating ways to streamline the work of radiologists and make it more efficient.

A comprehensive review of more than 200 peer-reviewed publications examines how communication protocols, security frameworks, AI, blockchain and quantum technologies could shape the future of the Internet of Medical Things.

An international study reports 60% progression-free survival at 10 years after autologous bone marrow transplantation, adding evidence of sustained positive clinical outcomes and long-term safety in patients treated for early severe systemic sclerosis.

More than 65% of approved medicines work by binding to proteins on the surface of human cells. Yet scientists developing new treatments face a fundamental problem: Major biological databases disagree about which proteins are actually found on cell surfaces.

For people with kidney failure, access to transplantation can mean better survival and quality of life.

A planetary-scale mining of public metagenomes collected 794 million CRISPR spacers and 1.18 billion virus and plasmid hits, revealing high spacer turnover and evidence that some targeting reflects viral genomes entering non-host cells.

In rat bone marrow stem cells, the TLR4 inhibitor TAK-242 suppressed LPS-induced inflammatory gene expression while leaving osteogenic differentiation largely unimpaired by day 14.

A new review argues that stem cell grafts can protect tissue and communicate with host circuits in selected spinal cord injury models, but no study has yet linked product molecular features to recovery in one experiment.

Scientists can now edit genes in precise locations deep in the brain and body without the use of invasive surgery or implants, thanks to new work from researchers at the Wu Tsai Neurosciences Institute. The team demonstrated its technique, which uses a combination of ultrasound, light-emitting nanoparticles and photo-controllable gene-editing proteins, by successfully altering genes in mouse brains at selected locations.

A 2024 survey at Universidad Ricardo Palma found 92.4 percent of 278 medical students reported previous AI use for academic activities, with ChatGPT the most cited tool.

A new review summarizes how basal stem cells sustain lifelong olfactory epithelium renewal and how single-cell and organoid technologies are reshaping the field.

VIENNA — In a phase 2 study, SAR402663 gene therapy for wet age-related macular degeneration showed positive efficacy and safety interim results with a single in-office intravitreal injection.With a medium dose of SAR402663, there was a 97% reduction in treatment burden, with more than 90% of patients not needing supplemental anti-VEGF injections, Arshad M. Khanani, MD, MA, FASRS, said at the Euretina congress.Researchers have observed positive functional and anatomic results with the therapy, and the safety profile appears good.SAR402663 (Sanofi) is an investigational AAV2 gene therapy

's Kevin Davies, PhD, reports from ESGCT where patient safety, expanding access to gene therapy, and progress towards an HIV vaccine were prominent themes among the early talks at ESGCT 2026. The post Hamburg Hosts 2026 European Gene Therapy Conference appeared first on GEN - Genetic Engineering and Biotechnology News.

This eBook brings together perspectives from across the AAV development and manufacturing continuum. It explores how early commercial planning can help avoid costly delays, how standardized platform approaches and off-the-shelf plasmids can streamline development, and how next-generation innovations are helping overcome long-standing manufacturing bottlenecks. The post Building the Future of AAV Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.

A survey of 1,218 consumers in Spain, Germany and the UK found that conventional pesticides draw stronger rejection than precision-bred watermelon, with zero-residue pesticides commanding the highest premiums.

Stem cell therapies involve a stage of expansion of cells in culture prior to injecting them into the patient. The research community has realized that both the state of the original source cells and small variations in the subsequent cell culture environment can result in large differences in the quality of the transplanted cells. For example, how many of the cells in the culture have become senescent, and are thus now generating pro-inflammatory signals. There are other possible variations in cell state that could contribute negatively to outcomes, diminishing any benefits resulting from the therapy, however. Differences in cell state and behavior may be the cause of much of the well-known and undesirable variability of outcomes in stem cell therapy. Some clinics may have started […]

Mars-owned Royal Canin and ingredients supplier Roquette will co-invest in the farms from which they source that wheat. The post Agrifood corporates find a new model for financing regenerative agriculture via Soil Capital partnership appeared first on AgFunderNews.

A study of 41 male renal transplant recipients found mean IIEF-5 scores rose significantly at six months, with recovery shaped by baseline ED severity, diabetes, hypertension, smoking and dialysis duration.

A systematic review of 26 studies finds AI models diagnosing multiple sclerosis with over 95 percent accuracy in some cases, but limited external validation and poor interpretability keep most tools out of the clinic.

A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting major standardization and validation hurdles.

A new review evaluates preclinical evidence that adipose-derived stem cell extracellular vesicles could multitarget the pathological processes driving diabetic microangiopathy.

Researchers show that GPT-5 and Gemini can extract and classify policy framing quotes from German news articles with F1-scores near 80 percent against an expert reference standard.

A ten-year retrospective study of 18 children with inflammatory bowel disease found fecal microbiota transplantation cleared recurrent C. difficile infection in most patients and was generally well tolerated.

Researchers fine-mapped and functionally validated CauYL, a magnesium chelatase H subunit gene essential for chlorophyll accumulation and normal leaf coloration in cauliflower.

A randomized controlled trial of 90 patients found that AI-facilitated, individualized nutritional guidance improved 30-day energy and protein intake adequacy and reduced patient-reported symptoms compared with standard discharge advice, though the trial could not isolate the effect of AI itself.

Researchers generated eyeless F0 CRISPR-Cas9 pax6 mutants in the slipper limpet Crepidula fornicata using a de novo transcriptome instead of an assembled genome.

The Biomolecular Nanotechnology research group led by Ikerbasque research professor Aitziber L. Cortajarena has developed a new iron-based contrast agent for magnetic resonance imaging that can be used for both diagnosis and treatment. In a study carried out on lab-grown human heart tissue, it was proven that the contrast agent accumulates in the fibrotic tissue, that its signal intensity on the MRI image increases with the severity of the disease, and that it slows disease progression.

Researchers built a human blood-brain barrier model combined with antiviral testing, validated it with anti-HIV drugs, showed TBEV crosses an intact barrier to infect astrocytes, and identified a barrier-permeable antiviral candidate.

CRISPR Prime Editing: First In Vivo Trial for Wilson’s Disease For years, scientists have been working on ways to treat genetic disorders that cause serious health problems. Now, a Phase 1/2 clinical trial is testing an experimental prime-editing treatment called PM577a. So far, only one patient has received the treatment, and the first clinical results […] The post CRISPR Breakthrough: First In Vivo Prime Editing Treatment Tested in Humans appeared first on BioTecNika.

Drug Development with Claude Imagine generating 35,000 antibody designs in just one month. Sounds ambitious, doesn’t it? Well, according to Anthropic, its AI assistant Claude helped researchers at Divergence Labs do exactly that. These were early-stage antibody candidates, not finished medicines, but the scale of the work is worth paying attention to. And that’s only […] The post Drug Development with Claude: Anthropic Reports 35,000 AI-Designed Antibody Candidates in a Month appeared first on BioTecNika.

A systematic review finds that only 47 human studies address fusion between mesenchymal stem/stromal cells and tissue-specific cells, suggesting regenerative potential in the cardiovascular, muscular, and nervous systems while noting that spontaneous fusion is rare.

A Thai single-center cohort study of 292 kidney transplant recipients found 6.8 percent developed de novo malignancies, with urothelial cancer most common and reduced patient survival.

A new narrative review details how hyperglycemia, Schwann cell dysfunction, and disrupted calcium and iron balance impair peripheral nerve regeneration after traumatic injury.

An independent review of NHS productivity and future ringfenced spending on prevention have been announced in the government’s 2026 budget, the first under prime minister Andy Burnham.An additional £190m was announced to support the NHS response to winter pressures. But no direct share of this pot has been set aside to support general practices.Unveiled by chancellor John Healey on 28 October, the budget had, overall, much less on the NHS and adult social care than in previous years, with the main focus instead on household bills.The BMA’s chair of council, Tom Dolphin, said, “For a government that claims to put the NHS at the heart of its priorities, this budget falls worryingly short.“The failure to set out meaningful action to tackle crumbling buildings or ensure we have enough doctors to meet future demand raises serious questions about the government’s commitment to the health service’s long term future.”David Williams, deputy director...

A one-hour exposure to activated protein C keeps human blood stem cells quiescent and improves their short-term serial engraftment in mice, while thrombin acts on the same receptor to drive differentiation and impair transplantation outcomes.

A new review in Biological Research surveys cardiac stem and progenitor cell populations, finding that classic markers c-kit and Sca-1 mostly label endothelial cells without cardiomyogenic potential.

A new review maps how 3D bone marrow models, from spheroids to bioprinted and organ-on-chip systems, are being used to study multiple myeloma and its drug resistance.

In the Drosophila ovary, Notch activation upregulates the E2 enzyme Ubc10, which teams with the E3 ligases Ari-1 and Cul3 to degrade the Hedgehog effector Ci and specify cap cells that form the germline stem cell niche.

A new closed-tube RT-RAA-CRISPR/Cas12a assay detects Schmallenberg virus within 50 minutes and outperformed RT-qPCR on simulated bovine nasal swab samples, though validation with authentic clinical specimens is still pending.

Flagship Pioneering is combining three of its portfolio companies, including one that has been around for a decade, in an effort to compete in the bustling AI drug discovery field. The Cambridge, MA-based incubator and ...

Peripheral nerves are capable of regeneration to restore connections across gaps caused by injury, but the larger the gap the less likelihood of a successful outcome. The medical community has developed approaches that help by laying guides along the path that regrowth must take, often composed of donor nerve tissue, which may be taken from elsewhere in the patient, but these are far from optimal. There is considerable research interest in the development of entirely artificial nerve regrowth guides that have a low cost and high rate of success in stimulating the necessary regeneration for a complete restoration of function. The paper here is an example of this sort of research and development, focused on bioprinting an implantable path for nerve regrowth. Conventional cell-laden electro-direct […]

Japanese researchers have established the first patient-derived organoid model of canine nasal carcinoma, showing variable drug sensitivities among tumor lines and identifying S100A2 as a promoter of cancer cell proliferation and invasion.

A dynamic bicellular in vitro model linked by a fluidic circuit reproduced vascular disruption and fibroblast changes when endothelial cells were stimulated with immune complexes from systemic sclerosis patients.