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Gastric cancer surgery has traveled an extraordinary distance since Theodor Billroth performed the first successful gastric resections in the nineteenth century. What was once a brutal open operation, carried out in traditional operating theaters with limited visualization and high morbidity, has become a field defined by keyhole incisions, high-definition cameras, robotic arms, and increasingly, artificial […]

A single infusion of genetically corrected autologous hematopoietic stem cells can provide lasting clinical benefits for patients with Wiskott-Aldrich syndrome, a rare genetic disorder that impairs immune and platelet function, exposing affected children from an early age to severe infections, bleeding episodes, eczema and autoimmune complications.

Katie Roof / Business Insider: Sources: OpenEvidence, an AI search engine for doctors, raised $250M at a $15B valuation, up from $12B in January; it could be open to selling itself  —  OpenEvidence, an AI search engine for doctors, is the latest AI darling to raise back-to-back funding rounds.

More than 90% of children born with the rare bone marrow condition Shwachman-Diamond syndrome (SDS) survive beyond age 20. But fewer than 30% live beyond age 50. Long-term survival could improve if clinicians act on early signs of high risk, according to a study published, in The New England Journal of Medicine.

A study has raised a question that many women would understandably want answered: Could hormone replacement therapy (HRT) protect against dementia? The research found that women who had used HRT were less likely to receive a dementia diagnosis during follow-up, particularly if they had undergone surgery involving their reproductive organs. But the results do not establish that HRT caused the difference.

A new review was published in Volume 18 of Aging on September 8, 2026, titled "How to live for centuries: common denominators of organisms with exceptional longevity."

Targeting senescence decreases fibrosis and boosts the response of cancer cells to immunotherapy

Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide metabolism, amplified by dietary fat, initiates colorectal ...

Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are conserved drivers of fibrosis and therapeutic targets, yet ...

Scientists have known for years that neural activity in the brain's motor cortex doesn't just happen when people perform actions. Neurons associated with actions—reaching with a hand to grasp an object, for example—also fire when a person watches someone else perform an action. This observational activity, which underlies a concept known as "mirror neurons," may play a role in how humans and other primates learn to perform physical tasks.

When it comes to balancing hormonal changes during the transition to menopause, less can be more. Researchers at the University of São Paulo (USP) in Brazil demonstrated this when testing an alternative to conventional therapy. Rather than replacing estrogen, the team activated only one type of estrogen receptor in cells. This approach had broad metabolic benefits without stimulating the growth of reproductive tissues, such as the uterus and breasts. That is important for individuals with a genetic predisposition to developing tumors.

At a time of rampant medical misinformation online, artificial intelligence can do a good job of correcting falsehoods, but the tone of the correction is key, according to new research led by Washington State University.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which motor neurons are gradually lost, leading to muscle weakness and, as the disease advances, difficulty breathing and swallowing. Existing medicines can slow disease progression to some extent, but no treatment has been established that fundamentally reverses the disease process. Mitochondrial dysfunction is considered a potential therapeutic target because mitochondria play a central role in cellular energy production and are frequently impaired in ALS.

Plus news about Frazier Life Sciences, BigHat Biosciences, Kasvu Therapeutics, Arcturus Therapeutics, Oruka Therapeutics and Viking Therapeutics. Sarepta Therapeutics settles gene therapy suit: Sarepta has agreed to pay Regenxbio $39 million to

AI doomsday predictions could put the brakes on health tech innovation. At least one healthcare company — electronic health record giant Epic, which offers AI tools for hospitals and clinicians — has

Scientists at Stanford University have unveiled a detailed laboratory protocol for a high-throughput drug screening platform designed to find compounds capable of treating cardiac fibrosis, the stiffening of heart tissue that accompanies heart attacks, genetic cardiomyopathies, diabetes and aging. Writing in Nature Protocols, the team led by Hao Zhang and Joseph C. Wu describes a […]

As AI tools play an ever larger role in healthcare, one question remains: How will doctors get paid for using them?

arXiv:2609.27970v1 Announce Type: new Abstract: Although the Heil--Ramanathan--Topiwala conjecture is false in full generality, its failure makes the classification of positive geometric and arithmetic regimes more urgent. We settle the critical mixed-arithmetic regime for four time-frequency shifts. For \(z=(x,\omega)\) and \(w=(y,\eta)\), set \(\sigma(z,w)=x\eta-y\omega\). Let \(u,v\in\R^2\) satisfy \(\lvert\sigma(u,v)\rvert=1\), write \(\nu=\alpha u+\beta v\), and assume that \(0,u,v,\nu\) are distinct. If \(\dim_{\Q}\operatorname{span}_{\Q}\{1,\alpha,\beta\}=2\) then, for every nonzero \(f\in L^2(\R)\), the vectors \(f,\pi(u)f,\pi(v)f,\pi(\nu)f\) are linearly independent. This includes both four-point configurations in Chris Heil's Conjecture~9.2. The proof first converts a putative dependence into a scalar cocycle over an irrational rotation. On a positive-measure family of zero-free fibres, winding and continued-fraction returns force the periodic holonomy to be constant. The

arXiv:2609.27774v1 Announce Type: new Abstract: In a remarkable breakthrough, Faulhuber, Petersen, van Velthoven, and Voigtlaender disproved the Heil--Ramanathan--Topiwala conjecture by constructing twelve linearly dependent time--frequency shifts of a Schwartz function. The following day, the author compressed their vector-Zak and cohomological architecture to an explicit intrinsically subcritical four-point configuration, thereby attaining the minimum possible cardinality. Soon thereafter, Jasper and Mixon gave a transparent analytic refinement of the breakthrough mechanism and proved, for every Diophantine pair, that HRT counterexamples may be realized with windows in the Roumieu Gelfand--Shilov class $\mathcal S_1^1(\mathbb R)$; their theorem establishes the endpoint regularity phenomenon in broad arithmetic generality while leaving support cardinality unrestricted. The purpose of the present paper is to show that these two sharp advances can be attained simultaneously. We prove

arXiv:2609.27418v1 Announce Type: new Abstract: Systematic reviews underpin clinical guidelines, yet their data-extraction step is a major expert-labor bottleneck bound by a protocolized workflow: two reviewers extract each study independently, an adjudicator resolves disagreements, and the team keeps an auditable record of how every value was produced. Large language models can assist with extraction, but that assistance must fit established review protocols and preserve reproducibility. We present EviStreams, a live, open-source, no-code web platform that puts review teams in control of AI-assisted extraction at three key stages: program design (a structured decomposition approved before any code runs), field specification (typed field definitions calibrated from a pilot), and extracted predictions (reviewer-blinded dual review with adjudication). Working through a form builder, a domain expert defines typed fields rather than prompts, runs extraction over uploaded PDFs, inspects

Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine triphosphate (ATP) to power the cell. Reactive oxygen species react with and damage molecular machinery throughout the cell, damage that needs to be repaired. The cell reacts with an increase in repair and maintenance activities that address oxidative damage and other forms of damage, producing a net benefit to function. Here, researchers investigate one portion of how this response is regulated, looking at the metabolism of nematode worms. The reactive oxygen species superoxide is generated by mitochondria during the process of producing energy. While superoxide can cause oxidative damage to the cell, we and […]

Компания Anthropic объявила о первом научном результате своей биологической лаборатории: искусственный интеллект Claude самостоятельно выявил ранее не описанную ферментную систему, напоминающую по принципу действия механизм CRISPR. Об этом сообщает The Verge. Это не просто техническая демонстрация — речь идет о проверке того, способна ли языковая модель приносить реальную пользу в фундаментальной науке, причем накануне выхода компании на биржу. Как утверждают в Anthropic, участие человека в этом открытии было минимальным. Ученые лишь поставили первоначальную задачу и провели лабораторные исследования, тогда как сам поиск вел ИИ. За 21 час почти 950 агентов Claude обработали 210 млн токенов, прежде чем один из них обнаружил в массиве данных необычную повторяющуюся последовательность и пометил ее для проверки человеком. Дальнейший анализ подтвердил: найдена ранее не описанная ферментная система у бактериофагов — вирусов, поражающих бактерии. Именно масштаб обработки

Anthropic says its Claude AI system identified a previously uncharacterised enzyme system in bacteriophage DNA, but researchers are still investigating whether it can perform programmable genetic operations.

AI is becoming part of everyday life, from helping people organise their schedules to answering questions and providing

Claude and the ART Enzyme System More than 200,000 enzymes went in, and one odd system came out.

Transluce: AI agents, including those from OpenAI, attempted to hack UNM's digital library, Data USA, and the Australian Institute of Health and Welfare in May and June  —  Jack Cable*,2, Daniel Chiu*, Francisco Pernice*,3, Selena Zhang*,1, James Anthony1, Tetiana Bas4, Gary Shen4, Conrad Stosz1, Jacob Steinhardt1

Current use of oral menopausal hormone therapy (commonly known as hormone replacement therapy or HRT) is associated with an increased risk of blood clots in legs / lungs regardless of dose or treatment duration, finds a large Danish study published by The BMJ today.

OpenAI: OpenAI releases MentalHealthBench, an open benchmark to evaluate AI responses in realistic mental health conversations, developed with 80+ licensed experts  —  An open benchmark developed with more than 80 licensed mental health experts to evaluate AI responses in realistic mental health conversations.

Medical image segmentation, the task of teaching computers to trace the exact outlines of organs and lesions inside CT scans, MRIs, and endoscopic images, sits at the heart of modern computer-aided diagnosis. Radiation oncologists use these digital contours to plan treatments, surgeons rely on them to navigate around critical structures, and clinical trials depend on […]

A sweeping new national consensus has just redrawn the rulebook for one of the fastest-growing frontiers in cancer surgery. The Robotic Surgery Group of the Colorectal Cancer Committee of the Chinese Medical Doctor Association has published the 2025 edition of its expert consensus on robotic surgery for colorectal cancer, updating guidelines first issued in 2015 […]

Ireland's Data Protection Commission has fined Google €403M ($463M) for mishandling users' location data under the EU's GDPR privacy rules.

Generative artificial intelligence has swept into hospitals and clinics with a seductive promise: liberate physicians from the tyranny of the keyboard. AI scribes now listen to patient encounters, draft clinical notes, and file documentation with a fluency that would have seemed fantastical only a few years ago. The dominant narrative has been one of relief […]

Allogeneic hematopoietic cell transplantation remains the single most powerful weapon in the fight against higher-risk acute myeloid leukemia, a cancer of the blood and bone marrow that can progress with terrifying speed. Now, one of the most comprehensive national analyses ever assembled has traced how the outcomes of this demanding procedure have evolved across nearly […]

Researchers trained an AI model to learn chemical patterns associated with stability in drug-like molecules and accurately predict where their hydrogen atoms should be positioned. The post Tautomer-Predictor AI Tool Identifies Stable Molecules for Drug Discovery appeared first on GEN - Genetic Engineering and Biotechnology News.

Sejong University researchers have developed a high-quality soybean with improved oxidative stability, reduced saturated fat and increased seed fatty acid content. The research team led by Hyun Uk Kim, a professor in the Department of Bio-Industrial Resources Engineering at Sejong University, created the soybean line containing up to 90.2% oleic acid using CRISPR/Cas9 gene-editing technology. The study is published in the Plant Biotechnology Journal.

Marina Temkin / TechCrunch: Colorado-based Enveda, which uses AI to discover new drugs in the natural world, raised a $311M Series E at a $2B valuation, double its valuation a year ago  —  Enveda, a biotech startup that uses AI to discover new drugs in the natural world, has raised a $311 million Series E at a $2 billion valuation.

Cancer medicine is saving more lives than ever, but the treatments themselves are quietly taking a toll on one of the body’s most vulnerable organs. A sweeping new review published in Holistic Integrative Oncology maps the growing problem of anticancer therapy-related renal injury, or ATRI, and examines whether cell-based and cell-derived therapies could finally give […]

Breast cancer is not one disease. Under the microscope, tumors may look similar, but at the molecular level they split into distinct subtypes that respond differently to treatment and carry very different prognoses. Clinicians have long relied on a 50-gene signature known as PAM50 to sort breast tumors into categories such as Luminal A, Luminal […]

Компания Anthropic заявила, что её ИИ Claude «самостоятельно обнаружил» новую ферментную систему, схожую с механизмом, лежащим в основе мощного инструмента редактирования генов CRISPR. Об этом пишет The Verge. Источник изображения: Anthropic

Компания Anthropic объявила о первом открытии, сделанном в её недавно запущенной лаборатории: модель Claude автономно обнаружила в генетических данных новую ферментную систему, напоминающую механизм редактирования генов CRISPR. Участие людей в процессе ограничилось постановкой задачи и проверкой результата.

Anthropic says Claude has found a previously undescribed enzyme system in the DNA of bacteriophages, the viruses that infect bacteria. Next to the enzyme’s gene sits a long run of repeating DNA that resembles a CRISPR array. The company does not yet know what the system does. Anthropic announced the result on Wednesday in a […] This story continues at The Next Web

The round valued the AI biotech at $2 billion. It is currently testing drugs that treat skin conditions and preserve weight loss after stopping GLP-1s.

Robert Hart / The Verge: Anthropic says Claude autonomously discovered a new enzyme system in the DNA of bacteriophages, somewhat similar to CRISPR, the first result from its new biolab  —  It took nearly 1,000 Claude agents 21 hours and 210 million tokens to uncover the ‘novel enzyme system.’

The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. The cGAS-STING interaction produces some fraction of the maladaptive chronic inflammation characteristic of aging, as, among other reasons, mitochondrial dysfunction tends to spill mitochondrial DNA fragments into the cell cytoplasm. Nothing in the cell has only one purpose, however, and cGAS is also involved in the regulation of the DNA damage response in the cell nucleus. It is known to inhibit homologous recombination of double strand breaks, for example. An examination of cGAS in different species suggests that different variants can aid or hinder late life health via their actions in either the DNA repair context or […]

OXFORD, England — The world's first therapy designed to fix a patient's unique genetic mutation cost $1.65 million to make, a key facilitator of the project revealed Wednesday at a rare disease conference in the UK. ...

Years before bladder cancer is diagnosed, faint warning signs may already be accumulating across a patient’s medical history. Bladder cancer causes about 220,000 deaths worldwide each year, but finding it early remains difficult. Blood in the urine is its best-known warning sign, yet the same symptom can result from kidney stones, prostate problems, and other [...]

A blood stem cell molecule revealed how some childhood brain tumor mutations disrupt CoREST and led researchers to existing drugs worth testing further. A molecule used to help blood stem cells multiply has led researchers to an unexpected connection with childhood brain cancer. Scientists at Lund University found that the molecule produces a cellular effect [...]

A New York transplant surgeon’s experience waiting for a heart transplant laid bare the challenges of a system he had spent decades trying to fix.

China supplies over 90% of the technology fueling Vladimir Putin's war machine while buying billions in Russian oil under new U.S. sanctions scrutiny.

According to Basecamp, EDEN offers the ability to design long and complex DNA sequences with large serine recombinases capable of delivering those sequences precisely. The post Anthropic-, Nvidia-Backed Basecamp Research Raise $140M Series C Financing Toward Advancing AI-Designed Drugs appeared first on GEN - Genetic Engineering and Biotechnology News.

Chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease, or COPD, remain among the world’s most persistent killers. In the European region alone, they account for nearly 400,000 deaths every year, with COPD responsible for roughly 80 percent of that toll, and globally respiratory illnesses rank as the third leading cause of death. […]

Generative artificial intelligence has become remarkably good at dreaming up molecules. Feed a model a protein pocket or a desired property profile, and it will happily pour out thousands of candidate structures that look, on a screen, like the next blockbuster drug. There is a catch that has haunted computational chemistry for years: a large […]

New York University researchers have trained an AI model to learn chemical patterns associated with stability in drug-like molecules and accurately predict where their hydrogen atoms should be positioned.

The Abigail Wexner Research Institute at Nationwide Children's Hospital celebrated the Food and Drug Administration's (FDA) approval of FAYUVI for Sanfilippo syndrome type A, following years of research in its Jerry R. Mendell Center for Gene Therapy to help patients with devastating diseases.

Dozens of trans activists protested outside NYU Langone and took hormone replacement therapy after the hospital agreed to end gender-affirming treatment for patients under 19.

Researchers here take a very broad tour of the established literature on the comparative biology of aging in long lived species of all sorts, picking from those that can live more than 250 years, whether plant or animal, and comparing reported differences in biochemistry both between species and between individuals of the same species. It seems just as interesting to ask which mechanisms are important in individual variation in pace of aging in a long-lived species as to ask why the species is long-lived in the first place. The usual challenges exist, in that one can identify differences in biochemistry that seem reasonably likely to contribute to differences in longevity, but establishing the relative importance of each contribution is near impossible without some form of […]

OpenEvidence, an AI tool used by American doctors, is now being offered in countries with limited access to medical literature. Reuters reported that the company is working with Anthropic to give clinicians in low- and middle-income countries free access to a specialized version of its platform. The initiative is being introduced in around 100 countries, […] This story continues at The Next Web

New York University researchers have trained an AI model to learn chemical patterns associated with stability in drug-like molecules and accurately predict where their hydrogen atoms should be positioned.

Large language models are being welcomed into hospitals at a pace that has outstripped nearly every safety discipline in modern medicine. They draft discharge summaries, suggest differential diagnoses, and increasingly sit beside clinicians during time-critical decisions. Yet the yardstick most commonly used to judge them—aggregate accuracy on standardized benchmarks—may be quietly concealing the very failures […]

AI video platform Synthesia is among the companies shipping tools that translate video into other languages using AI.

arXiv:2609.25043v1 Announce Type: cross Abstract: Quantum encrypted cloning encodes an unknown state into several encrypted components, each offering an alternative way to recover it later. We show that this redundancy can also serve for one-shot fault diagnosis: instead of inspecting the encrypted state, we measure relational Pauli observables testing consistency conditions imposed by the encoding. The canonical Yamaguchi--Kempf scheme encodes the input into \(n\) signal--key pairs, all carrying the same coherent Bell label, plus a transformed copy of the input qubit. Comparing the labels of two pairs yields a deterministic check that localizes an anomalous pair and identifies its Pauli-error class without revealing the label. Such checks cannot tell whether the signal or the key of that pair is faulty, and no measurement on the pairs can (we prove that they already generate the whole group of deterministic state-blind observables supported there, of rank \(2(n-1)\)). This ambiguity

arXiv:2609.26072v1 Announce Type: new Abstract: Inter-agent communication is essential to multi-agent language-model systems, yet a single message may combine task-critical information with instructions not authorized by the original request. Prompt-based defenses leave enforcement to models exposed to adversarial messages, while indiscriminate message removal discards useful information. We introduce Executable Semantic Commitments with Clean-Room Recovery (ESC-CR), a policy-backed framework for secure inter-agent code generation and recovery. It separates message claims from authorization, constructs executable commitments from trusted tasks, evidence, and policy, and enforces them at an external release boundary. Upon a violation, ESC-CR taints the responsible message and rejected artifact, reconstructs a clean context from evidence-backed task information, and regenerates under the same policy. We evaluate ESC-CR across communication-essential and standard code-generation

arXiv:2609.25756v1 Announce Type: new Abstract: Precision medical robotics demands adaptive decision-making under strict safety, interpretability, and execution constraints. Although recent Vision-Language-Action (VLA) models show strong multimodal reasoning ability, their continuous action generation paradigm is not well suited for precision medical tasks, where reliable closed-loop operation may also depend on non-action system function calls. To address this gap, we propose MedVLA, a hierarchical framework that couples high-level multimodal reasoning with low-level function-constrained execution. We further introduce a scalable multi-agent pipeline to generate skill-oriented chain-of-thought(CoT) data for structured training. Built on different multimodal large-model backbones, MedVLA consistently improves performance after fine-tuning, demonstrating the effectiveness of the proposed framework across model variants. Under identical initial conditions, we perform 100 closed-loop

arXiv:2609.25642v1 Announce Type: new Abstract: Closed-loop evaluation of surgical robots requires tissue that deforms, can be grasped and lifted, and reproduces the anatomy in which the robot will operate. We present a simulator in which this tissue is reconstructed from a fixed-view RGB-D recording of the surgical field, composited to remove the instruments, closed into watertight volumes and tetrahedralised; the pipeline was applied unchanged to three specimens of two species (thirteen organs, 146,061 tetrahedra, no inverted elements). For one specimen, the organs are placed in a bimanual cell in which two Franka FR3 arms operate motorised instruments through 6 mm trocars. The core contribution is the numerical and contact design that keeps this cell stable: implicit integration, simulation meshes separate from collision meshes, numerical guards, and a grasp constraint captured at the live tissue pose. In 45 repeated grasp-lifts, a friction grasp held the tissue in 0 of 15 trials

Crohn’s disease is one of the most stubborn forms of inflammatory bowel disease, marked by chronic inflammation of the right colon and terminal ileum that brings diarrhea, abdominal pain, and sometimes life-threatening intestinal obstruction. Roughly twelve percent of patients carry a genetic predisposition, with certain populations showing heightened risk, and although corticosteroids, thiopurines, biologics, and […]

Sunlight leaves its signature on skin over decades: thickened, leathery patches, deepening wrinkles, broken capillaries, and uneven pigment that dermatologists collectively call photoaging. Beyond its cosmetic toll, chronic ultraviolet exposure can progress to precancerous actinic keratosis and even cutaneous malignancies, making it a genuine medical problem rather than a purely aesthetic one. Current remedies all […]

Bone marrow mesenchymal stem cells, or BMSCs, are the quiet workhorses of the skeleton. They replenish bone-forming osteoblasts throughout life, and their regenerative power underlies an expanding range of experimental therapies, from grafting cells into fracture sites to engineering scaffolds that coax new bone to grow. Yet these cells have a persistent enemy: oxidative stress. […]

High on the dry, sun-scorched slopes of the northwestern Himalayas grows one of the region’s most valuable and most vulnerable trees: Pinus gerardiana, the Chilgoza pine. Prized for its edible seeds, which fetch premium prices in local and international markets, and revered in traditional medicine, this endemic conifer is now classified as near-threatened on the […]

A team of researchers in China has developed a machine learning tool that can predict, before a single incision is made, whether a woman’s breast cancer has begun its silent spread through lymphatic and blood vessels. The finding, published in Cancer Reports, could change how surgeons plan operations and how oncologists tailor drug therapy, because […]

Cardiovascular disease remains the world’s deadliest health problem, claiming 19.2 million lives in 2023, with prevalent cases climbing to a record 626 million. Yet the tools scientists use to study the heart and test new drugs have lagged far behind this growing burden. A major new review published in Bioengineering & Translational Medicine argues that […]

Deep beneath the surface of coastal waters, colonies of a small marine invertebrate called Hydractinia symbiolongicarpus perform feats of regeneration that would make any mammalian tissue envious. These colonial cnidarians, related to jellyfish and corals, can regrow lost body parts throughout their lives, thanks to a population of adult stem cells known as interstitial cells, […]

Researchers combined Raman microscopy with gene expression data at single-cell resolution from the same cells, and AI, to develop RamanOmics, a noninvasive way to detect biomarkers of cellular senescence as “barcodes." The post Cell Senescence ‘Barcodes’ Identified with Raman Microscopy and Gene Expression Data appeared first on GEN - Genetic Engineering and Biotechnology News.

A rare and devastating inherited immune disorder may have a new path toward treatment, thanks to a proof-of-concept study demonstrating that CRISPR base editors can correct disease-causing mutations in the Artemis gene outside the body. Artemis-deficient severe combined immunodeficiency, known as ART-SCID, leaves infants with almost no functional T and B cells, and current treatments […]

Deep in the pharmacopoeia of Tibetan medicine lies a vast library of plants whose correct identification can mean the difference between a healing remedy and a useless or even harmful preparation. For centuries, that identification has depended on the trained eyes of practitioners, but a research team in Qinghai, China, now reports a machine learning […]

Cirrhosis can recur after liver transplantation, according to a study published online Sept. 3 in Portal Hypertension & Cirrhosis.

Most medical devices do not enter the market through rigorous safety testing but by being deemed similar enough to something already approved—the "predicate" device—through a mechanism known as the FDA's 510(k) pathway. But similar is not a synonym for safe. While the assumption may be that substantial equivalence is a reasonable stand-in for a safety review, some devices cleared with this method are still recalled, and the FDA spends valuable time reviewing devices the same way, regardless of how risky they appear on paper.

Sony's filings describe AI-generated diagnostic code for connected devices, while one application faced a final rejection before publication

Lithium-ion batteries quietly age every time they charge and discharge, and knowing exactly how much life remains inside a cell has become one of the most consequential measurement problems in modern energy technology. Electric vehicles, grid-scale storage systems and consumer electronics all depend on accurate estimates of the state of health, the measure that links […]

Inside every bacterial cell, RNA molecules carry far more information than their sequence of bases alone. After transcription, the four nitrogenous bases of RNA can be chemically altered by specialized enzymes, and these modifications influence how stable the molecules are, how efficiently they are translated into protein, and how the cell copes with stress. The […]

Every year, the world applies millions of tonnes of agrochemicals to crops and consumes billions of doses of pharmaceuticals, yet the safety story rarely ends when these compounds do their intended job. Once released into soil, water, and the human body, pesticides, herbicides, fungicides, and drugs are transformed by sunlight, microbes, plants, and metabolism into […]

The global spread of highly pathogenic avian influenza has exposed a persistent weakness in the world’s diagnostic arsenal: the tools that are most sensitive tend to be locked inside well-equipped laboratories, while the faster, simpler tests sacrifice the specificity needed to track emerging viral lineages. A research team led by Yujia Huang and Andrew Guo […]

Glioblastoma remains the most feared diagnosis in neuro-oncology. Despite surgery, radiotherapy, and chemotherapy, the tumor almost invariably returns, driven in part by its extraordinary cellular diversity and by a microenvironment that actively shelters malignant cells from treatment. Gene therapy delivered directly into the resection cavity offers one possible route forward, and adeno-associated virus (AAV) vectors […]

Treatment resistance remains one of the most stubborn obstacles in modern oncology, and a comprehensive new review published in the journal Molecular Cancer argues that a humble laboratory tool — the patient-derived organoid — may finally offer researchers a way to see the full architecture of that resistance in a single, living system. Writing as […]

Drug-induced seizures remain one of the most disruptive safety failures in modern pharmaceutical research, derailing promising molecules across therapy areas as diverse as the central nervous system, cardiovascular medicine, gastroenterology, respiratory disease and inflammation. Traditionally, seizurogenic risk only surfaces late, during rodent and non-rodent toxicology studies or, worse, once a compound has already entered clinical […]