Headlines

For decades, the human endometrium—the dynamic lining of the uterus that governs embryo implantation, menstruation and the earliest moments of pregnancy—has remained one of the most difficult tissues in the human body to study. Now, a comprehensive review published in Nature Biomedical Engineering maps how a quiet revolution in tissue modelling, spanning organoids, assembloids and […]

Platelet-rich plasma, the amber-colored concentrate spun from a patient’s own blood and injected back into damaged tendons, joints, and wounds, has long occupied a curious place in medicine: widely used, vigorously marketed, yet scientifically underdefined. Now a team of researchers in Catalonia, Spain, has delivered one of the most detailed molecular portraits to date of […]

A team of researchers at Hassan II University of Casablanca has combined blockchain smart contracts with large language model agents to orchestrate crowdsourced pharmaceutical last-mile delivery, reporting that in matched simulations the AI-assisted workflow cut route time by 25 percent and planning time by nearly 79 percent compared with a human-operated baseline. The work addresses […]

Gotu kola, the humble creeping herb known scientifically as Centella asiatica, has quietly become one of the most sought-after plants on the planet. Its leaves contain a family of triterpenoid saponins called centellosides—including asiaticoside, madecassoside, asiatic acid, and madecassic acid—that drive wound healing, neuroprotection, and antioxidant defenses. The cosmetics industry alone has built a market […]

Skin is the body’s first line of defense and its most resilient mechanical shield, stretched, compressed, and sheared thousands of times a day without failing. Yet the cellular machinery that allows this outer organ to continuously remodel itself under physical load has remained remarkably opaque. A new study published in Nature Communications points to a […]

A single infusion of a gene therapy delivered within the first months of life continues to transform the course of one of the most devastating neuromuscular diseases of infancy, according to a comprehensive two-year analysis of real-world outcomes drawn from the Italian national registry. The new findings, published in Annals of Clinical and Translational Neurology, […]

COLLEGE STATION, Texas — Editing a plant’s genes is only half the battle. Before a new, improved trait can ever reach a farmer’s field, scientists must be able to grow a whole plant from just a few edited cells — a process that can be slow, unreliable and, for some plant species, impossible. A new […] The post New Gene-Editing Tool Speeds Regeneration of Hard-To-Breed Perennial Crops appeared first on Morning Ag Clips.

Google Health 5.08 is rolling out on Android and iOS as the smallest update since the May redesign. more…

ARPA-H picked teams to build AI agents that could adjust heart failure care, aiming for FDA authorization. Safety questions patients should ask.

Abdominal aortic aneurysm (AAA) is one of cardiovascular medicine’s most deceptive killers. The disease involves a localized, tumor-like dilation of the abdominal aorta that typically progresses without symptoms until the vessel wall thins to the point of catastrophic rupture. As the aneurysm expands beyond roughly 5 centimeters, the aortic wall undergoes progressive structural degradation, leaving […]

Researchers have taken an important step toward solving one of the biggest challenges in gene therapy for children with metabolic liver disorders: growth itself. As a child's liver grows, some gene therapies that once worked can gradually lose their effect because the treated cells are eventually outnumbered by new, untreated ones.

An international team of researchers, including those at the Earth-Life Science Institute (ELSI) at the Institute of Science Tokyo, has developed a protein language model that brings together two fundamental sources of information about proteins: their amino acid sequences and three-dimensional structures.

In 2024, surgeons at Northwestern Medicine completed the first awake kidney transplant.Led by transplant surgeons Satish N. Nadig, MD, PhD and Vinayak S. Rohan, MD and anesthesiologist Vicente Garcia Tomas, MD, the procedure was the first kidney transplant to be performed using single spinal/epidural anesthesia injection rather than general anesthesia at Northwestern Medicine.After the first surgery, Northwestern Medicine established the Accelerated Surgery Without General Anesthesia in Kidney Transplantation (AWAKE) program. Since then, the program has completed 25 transplant operations.

Artificial intelligence systems that can look at a surgical image and answer a clinician’s question are moving rapidly from research curiosity toward genuine clinical utility. But a persistent problem has haunted this field: these models often answer with unwavering confidence, even when that confidence is misplaced. Now, a team of researchers from Italy and the […]

On a sunny spring day at Penn State, Cristin Millett, professor of art in the College of Arts and Architecture's School of Visual Arts, inserted a catheter needle into the umbilical vein of a placenta.

AI can trawl vast amounts of health data which is not specifically related to migraines, but which can be used to identify people predisposed to the condition.

People with a progressive genetic eye disorder see more clearly after receiving engineered grafts that repair the damaged surfaces of their eyes, offering a glimpse at what future treatments could hold.

In lung transplant recipients, detecting nontuberculous mycobacteria in the first year after a transplant may signal heightened risks for death or a repeat transplant and for chronic graft decline.

Europe’s largest urban regeneration project, the Ellinikon, a 6.2 million-sq-m redevelopment of Athens’ former international airport, has completed its latest stage. Called the Courtyards, the 324-unit residential neighbourhood is formed… The post Checking in on Europe’s largest urban regeneration project appeared first on Global Construction Review.

arXiv:2609.11877v1 Announce Type: new Abstract: Many biological discovery problems require experiments to be selected sequentially under constrained budgets. CRISPR screening is a prominent example, as exhaustive perturbation testing is often infeasible and candidate perturbations must instead be prioritized over multiple experimental rounds. Despite the importance of this problem, existing benchmarks for adaptive hit discovery remain limited in scale and diversity. Here, we introduce AssayBench-Loop, a large-scale benchmark for adaptive hit discovery comprising 1,389 CRISPR screens across five phenotype categories. Beyond enabling systematic evaluation, its scale makes it possible to learn acquisition strategies across historical experiments. Building on this resource, we introduce AssayLoop, a sequential experimental design framework combining AssayFormer, a transformer-based amortized acquisition policy trained across historical screens to adapt from experimental feedback, with

arXiv:2609.11877v1 Announce Type: cross Abstract: Many biological discovery problems require experiments to be selected sequentially under constrained budgets. CRISPR screening is a prominent example, as exhaustive perturbation testing is often infeasible and candidate perturbations must instead be prioritized over multiple experimental rounds. Despite the importance of this problem, existing benchmarks for adaptive hit discovery remain limited in scale and diversity. Here, we introduce AssayBench-Loop, a large-scale benchmark for adaptive hit discovery comprising 1,389 CRISPR screens across five phenotype categories. Beyond enabling systematic evaluation, its scale makes it possible to learn acquisition strategies across historical experiments. Building on this resource, we introduce AssayLoop, a sequential experimental design framework combining AssayFormer, a transformer-based amortized acquisition policy trained across historical screens to adapt from experimental feedback, with

arXiv:2609.10595v1 Announce Type: new Abstract: The adoption of generative AI in software-intensive systems is proceeding rapidly, but current analytical instruments - principally unidimensional maturity models - compress important configurational variation into a single progressive axis. Drawing on an inductive interview study of eighteen senior practitioners across telecommunications, automotive, defence, aviation, banking, energy, government, and enterprise software services, this paper presents the Trustworthy Autonomy Health Check Model: a structured, multidimensional instrument for characterizing how organizations establish trust in GenAI-assisted software engineering. The model organizes eight empirically grounded dimensions into a system layer (Scope of Agent Authority, Assurance Mechanisms, Data Trustworthiness, Architectural Containment, Traceability & Comprehensibility) and an organizational layer (Governance, Human Oversight Posture, Workforce Capability Sustainability),

Pick your favorite zombie movie or television show and you’ll eventually be confronted with dialogue justifying the killing of the zombies with the idea that they are no longer human. “They aren’t people, Rick. They’re just bodies. We have to stop thinking of them as if they’re still alive.” – The Walking Dead “They’re not […]

Команда исследователей из Техасского университета A&M AgriLife Research, Мэрилендского университета и Министерства сельского хозяйства США (USDA) представила инновационную технологию CRISPR-Combo. Метод позволяет одновременно редакти...

Artificial intelligence is moving into hospitals, clinics, and classrooms at a pace that few predicted a decade ago, and the students training to become the next generation of physicians and nurses are watching it happen in real time. A new study published in BMC Nursing offers one of the most granular looks yet at how […]

Panelists at the 2026 TIME100 Health Leadership Forum discussed the latest in longevity research.

For Judy Donnelly, participating in a UConn Health research study meant driving from Windham to Farmington, drinking four packets of a supplement each day and undergoing a comprehensive series of tests designed to measure everything from her strength and body composition to her cognitive function.

Editing a plant's genes is only half the battle. Before a new, improved trait can ever reach a farmer's field, scientists must be able to grow a whole plant from just a few edited cells—a process that can be slow, unreliable and, for some plant species, impossible.

Researchers have unveiled a lithium-ion battery separator that pairs the workhorse durability of polypropylene with the rapid biodegradability of poly(butylene adipate-co-terephthalate), better known as PBAT, and manufactured it using an industrial gravure printing process. The study, published in the Journal of Materials Science: Polymers, reports that the printed, chain-extended PBAT–polypropylene membrane achieves an ionic conductivity […]

Every leaf, tassel, and ear of corn traces its origin to a dome of actively dividing cells smaller than a millimeter across, hidden at the growing tip of the plant. Scientists have long known that this structure, the shoot apical meristem, depends on elegant genetic circuits such as the CLAVATA-WUSCHEL signaling pathway to keep its […]

Today, the National Comprehensive Cancer Network® (NCCN®)-an alliance of leading cancer centers-published updated data on the current impact of generic cancer medication shortages in the United States.

A team of researchers has unveiled a printing technology that takes its cue from one of nature’s most overlooked design tricks: foam. In a study published in Nature, the group describes “deep-foam photolithography,” a light-driven process that turns ordinary photosensitized polymer films into intricate, sponge-like structures whose pores can be created, grown, and even collapsed […]

Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy, the functional significance of rRNA levels remains ...

Every field of specialist knowledge consists of a series of concentric circles, the greatest knowledge at the center, the scientists advancing the state of the art, and the least knowledge at the outskirts, the public at large. In between we find lesser scientists, patient advocates, laypeople with a strong interest in the field, and so forth - various gradations of knowledge. The members of any given ring engage in an educational dialog with the next ring out, and themselves learn from the education efforts of the more knowledgeable neighboring inner ring. The more distant any two rings are, the less they tend to engage with one another directly. Thus we end up with the edifice of public messaging, simplifications of scientific knowledge intended for people […]

Artificial intelligence (AI) holds profound potential to reshape public health. Although its application accelerates threat detection and targeted interventions, the rapid deployment has outpaced the regulatory, validation, and equity safeguards standard to traditional health interventions.

An AI-designed lung drug lowered blood-protein aging clock readings in 42 patients. The study cannot show that it slows aging, and the drug is unapproved.

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Kidney transplantation remains the gold-standard treatment for patients living with end-stage chronic kidney disease, but the surgery is only half of the story. The other half is pharmacological: for the rest of the patient’s life, the transplanted organ must be shielded from immune attack with carefully calibrated doses of immunosuppressive drugs. Among these, tacrolimus stands […]

More than three-quarters of donated lungs offered for transplantation are not used, according to the UK's National Institute for Health and Care Excellence, contributing to a chronic shortage of organs for patients with end-stage lung disease.

Abiotic stresses—drought, salinity, extreme temperatures, and heavy metal toxicity—are responsible for an estimated 40 to 70 percent of yield losses in the world’s primary food crops, and a new comprehensive review argues that the tools to fight back already exist, if scientists can weave them together. Writing in the open-access journal Discover Plants, researchers Richa […]

A phase 2 trial evaluates whether posttransplant cyclophosphamide can support the use of mismatched unrelated donor transplants in patients needing reduced-intensity or non-myeloablative conditioning.

In 1997, IBM’s Deep Blue computer beat the reigning world chess champion Garry Kasparov. After the match, a visibly angry Kasparov said through gritted teeth: “The computer hasn’t proved anything yet.” That “yet” would take another 20 years.In the wake of his defeat, Kasparov developed what he called “centaur” chess, with humans and computers working as a team. This new approach consistently beat even the best computer models. Then in 2017, a pure AI model named AlphaZero started beating these new hybrid centaur teams. Fast forward less than 10 years and today any smartphone can beat the current world chess champion, Magnus Carlsen.A recent perspective in JAMA warns us that an analogous moment to 2017 has already been and gone for medicine.1 And we didn’t even notice. It was thought that doctors could use a similar centaur model in medicine, where human judgment steers the machine for the better. Yet...

Depressive symptoms may be prevalent for kidney transplant recipients before and after transplantation, according to study data published in Kidney360.About 40% of patients with end-stage kidney disease experience depressive symptoms, which may be associated with adverse outcomes like CV events and mortality, according to Mara McAdams-DeMarco, PhD, professor in the departments of surgery and population health at New York University Grossman School of Medicine, and colleagues. However, studies evaluating the prevalence of depressive symptoms throughout the kidney transplant process are

Foaming photopolymers as a high-resolution biomimetic printing platform  NatureSee more headlines & perspectives on Google News

Foaming photopolymers as a high-resolution biomimetic printing platform  NatureSee more headlines & perspectives on Google News

A well-connected family’s fight to access a potential treatment for their son highlights the barriers most rare disease patients struggle to overcome.

A well-connected family’s fight to access a potential treatment for their son highlights the barriers most rare disease patients struggle to overcome.

The accumulation of senescent cells is an important contribution to degenerative aging; the inflammatory secretions of senescent cells actively degrade tissue structure and function. Animal studies have shown that selective destruction of senescent cells produces a meaningful degree of rejuvenation in old animals, alongside reversal of the pathology and progression of many age-related conditions. Senescent cells exhibit a sizable number of metabolic differences from normal cells, and researchers continue to explore these differences in search of novel ways to selectively destroy senescent cells. Here find an example of a novel finding, in which researchers explore the increased glycolysis that supports senescent cell energy metabolism and find a way to sabotage it. Aging is a complex biological process, which is affected by several factors, lifestyle, diet, […]

Korea's medical tourism industry is on the cusp of its next leap, driven by artificial intelligence (AI) and anti-aging care converging to reshape treatment across specialties. Panelists at the Medicon Black Roundtable on Tuesday said Korea already has skilled medical staff and technology and AI now makes possible what wasn't before. Hosted by The Korea Times and the Korea Medical Tourism Promotion Association (KMTPA), the roundtable brought together specialists from Korea's five key medical tourism fields: ophthalmology, plastic surgery, dermatology, dentistry and health checkups. Panelists examined how AI and anti-aging could fuel Korea's medical tourism leap, from diagnosis to treatment. "Combine Korea's clinical strengths with AI, K-beauty, wellness and its national brand, and medical tourism can go beyond simply attracting foreign patients," said Kim Jae-kyoung, managing director of Content and Business Planning at The Korea Times. With anti-aging drawing growing interest,

Korea's medical tourism industry is on the cusp of its next leap, driven by artificial intelligence (AI) and anti-aging care converging to reshape treatment across specialties. Panelists at the Medicon Black Roundtable on Tuesday said Korea already has skilled medical staff and technology and AI now makes possible what wasn't before. Hosted by The Korea Times and the Korea Medical Tourism Promotion Association (KMTPA), the roundtable brought together specialists from Korea's five key medical tourism fields: ophthalmology, plastic surgery, dermatology, dentistry and health checkups. Panelists examined how AI and anti-aging could fuel Korea's medical tourism leap, from diagnosis to treatment. "Combine Korea's clinical strengths with AI, K-beauty, wellness and its national brand, and medical tourism can go beyond simply attracting foreign patients," said Kim Jae-kyoung, managing director of Content and Business Planning at The Korea Times. With anti-aging drawing growing interest,

In a development that blurs the line between synthetic materials and living tissue, researchers have unveiled a new class of self-assembling, 3D-printable materials that closely mimic the architecture and behavior of biological tissues. Known as jammed interconnected bilayer emulsions, or JIBEs, these materials can be produced in remarkable quantities—up to deciliter-scale volumes within minutes—and contain […]

Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, today announced that it has dosed the first patient with Rentosertib (known as ISM001-055 / INS018_055) in GENESIS-IPF-3, a Phase III clinical trial (NCT07687459, CTR20262475) at Peking Union Medical College Hospital, while Shanghai Pulmonary Hospital has also enrolled its first patient on the same day.

Tim Bradshaw / Financial Times: The AI boom is fueling a resurgence in VC bets in “moonshot” sectors such as BCI; Dealroom says non-AI deeptech funding has topped $150B since the start of 2024  —  Tech investors are rediscovering the kind of long-shot sci-fi bets that helped build Silicon Valley.

Korea's medical tourism industry is on the cusp of its next leap, driven by artificial intelligence (AI) and anti-aging care converging to reshape treatment across specialties. Panelists at the Medicon Black Roundtable on Tuesday said Korea already has skilled medical staff and technology, and AI now makes possible what wasn't before. Hosted by The Korea Times and the Korea Medical Tourism Promotion Association (KMTPA), the roundtable discussion brought together specialists from Korea's five key medical tourism fields: ophthalmology, plastic surgery, dermatology, dentistry and health checkups. Panelists examined how AI and anti-aging could fuel Korea's medical tourism leap, from diagnosis to treatment. "Combine Korea's clinical strengths with AI, K-beauty, wellness and its national brand, and medical tourism can go beyond simply attracting foreign patients," said Kim Jae-kyoung, managing director of Content and Business Planning at The Korea Times. With anti-aging drawing growing

arXiv:2609.10197v1 Announce Type: new Abstract: We show that on any closed orientable real-analytic Riemannian surface, any smoothly immersed closed immortal curve-shortening flow converges to a unique non-constant closed geodesic.

arXiv:2609.09735v1 Announce Type: new Abstract: Healthcare systems, mental health, and public well-being are increasingly affected by cyberbullying and harmful online interactions. This paper presents CareGuard, an early-warning framework designed to support healthcare-driven mental health protection and proactive online safety through the detection of cyberbullying-related content using advanced natural language processing techniques. CareGuard integrates zero-shot semantic labeling with fine-tuned transformer-based models, including BERT, DistilBERT, and RoBERTa, to enable robust and context-aware classification across sensitive cyberbullying categories. To improve efficiency and reduce unnecessary computation in healthcare-oriented monitoring settings, the framework incorporates an emotion-aware filtering mechanism alongside cosine similarity-based semantic screening, allowing the system to focus on semantically relevant and emotionally salient content. Experimental results on

arXiv:2609.09533v1 Announce Type: new Abstract: Clinician review of every AI output is often proposed as a safeguard in mental healthcare, but vigilance research suggests this approach fails at scale and may paradoxically reduce safety. Drawing on our experience deploying an AI coaching tool across 350,000+ conversations between therapy sessions, we describe how we arrived at a three-layer human-on-the-loop oversight framework combining preventive design, real-time monitoring, and continuous clinician evaluation. We show how specific findings from clinical review drove iterative improvements, and offer practical recommendations for mental health professionals evaluating AI systems.

Hair loss affects nearly half of all men and up to a third of women worldwide, yet the treatments available to them have barely changed in decades. Now, a comprehensive review published in Materials Today Bio argues that a quiet revolution is underway at the intersection of materials science and dermatology: intelligent microneedle systems capable […]

Sarah Perez / TechCrunch: Apple unveils a new Health app with Apple Intelligence, featuring an Insights tab, “readiness” and Health Age metrics, and more, rolling out later in 2026  —  Alongside the new Apple Watch Series 12 and Ultra 4, Apple on Wednesday introduced a redesigned Apple Health app …

Intravenous gene therapy extended lifespan, reduced neurological symptoms, and improved disease markers in a Sandhoff disease cat model, supporting further investigation of systemic AAV gene therapy for this disorder. The post Gene Therapy Extends Lifespan and Reduces Symptoms in Sandhoff Disease Cat Model appeared first on GEN - Genetic Engineering and Biotechnology News.

In a two-year head-to-head trial, researchers found that two very different dietary approaches produced similar changes in body weight. A Mediterranean-style eating plan adapted to Southern food preferences helped participants lose about as much weight as WeightWatchers over two years, but it produced substantially greater improvements in reported diet quality. The comparison was part of [...]

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it.

Zac Hall / 9to5Mac: Apple unveils the Apple Watch Series 12 and Ultra 4, with a new S11 chip, upgraded health tracking, an Audio Intelligence feature, a readiness feature, and more  —  Apple Watch Series 12 and Apple Watch Ultra 4 are official.  Apple has announced its two new Apple Watch models as part of its product event today.

When surgeons remove a portion of a cancerous lung, one of the most frustrating complications they can face is air. A persistent leak from the lung’s cut surface or staple lines — known as prolonged air leak — keeps chest tubes in place far longer than anyone would like, extends hospital stays, inflates costs, and […]

An AI-designed drug, rentosertib, reduced biological age markers by up to six years in a small study, offering potential insights into treatments for ageing.

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it. Most mutations are harmless, but when they disrupt genes, they can cause cancer and other diseases.

From algorithms to patient outcomes — lessons from one of the first randomized trials of AI in medicine  NatureMedicine Needs to Get Serious About AI  The AtlanticThink Machines Will Replace Doctors? See What’s Happening in These 3 Medical Specialties  inc.comCan AI fix health care? In the chaos of emergency rooms, the technology comes up short  STATSTETHOSCAPE  Telegraph India

From algorithms to patient outcomes — lessons from one of the first randomized trials of AI in medicine  NatureMedicine Needs to Get Serious About AI  The AtlanticThink Machines Will Replace Doctors? See What’s Happening in These 3 Medical Specialties  inc.comCan AI fix health care? In the chaos of emergency rooms, the technology comes up short  STATSTETHOSCAPE  Telegraph India

Blood cancer charities want NHS England’s blanket rule on second stem cell transplants changed to reflect modern practice and opinion.

EpilepsyGTx, a biotechnology company developing gene therapies for refractory epilepsy, and Viralgen, a leading contract development and manufacturing organization (CDMO) specializing in recombinant adeno-associated virus (AAV) gene therapies, today announced a partnership to support production of EpilepsyGTx's lead investigational gene therapy program targeting patients with focal refractory epilepsy (FRE), EPY201, ahead of first-in-human clinical trials.

FDA accepted a priority review for lonvo-z, a one-time CRISPR treatment for hereditary angioedema, with a decision target of March 10, 2027.

Past research has noted that socioeconomic status is a part of a web of correlations that include wealth, intelligence, education, lifestyle choices, and longevity. Untangling all of that to make definitive pronouncements on what exactly drives the observed variation in human life span has proven challenging. It is a reasonable assumption, based on animal studies, that lifestyle choices and consequent degree of physical fitness are the primary factor determining late life survival, however. Here, researchers take a more subtle approach to data analysis and conclude that socioeconomic and demographic status has very little influence on individual longevity. This is much as we might expect if lifestyle choice related to fitness is the primary influence, as will continue to be the case until the first therapies […]

Screening compound libraries for effects on aging in short-lived species has grown to become a significant area of interest in the aging research community. As a general rule, discoveries are modest in effect size, and largely take the form of novel ways to influence the beneficial maintenance and repair activities (such as autophagy) triggered by calorie restriction, heat, cold, and other forms of stress. These responses have a much larger effect on life span in short-lived species than in long-lived species, so in the long run are not all that interesting. Nonetheless, considerable effort has been made to find ways to make this screening process more efficient and automated. Research equipment has been constructed to house tens of thousands of nematode worms and use machine […]

A new robotic system is drawing blood in adult patients, but its real-world impact may depend on how often it skips difficult veins.

arXiv:2609.07610v1 Announce Type: cross Abstract: We convert black-box clinical prediction models for tabular data into standalone nomograms that can be audited term by term. PRiSM (Partial Responses in Structured Models) takes the shape of each effect and interaction from the source model, not merely which variables mattered, and lets the outcome select and weight them. We tested this in 50,356 heart transplant recipients, with validation in a later era than training. Nomograms from all 5 source models - a public clinical risk score, logistic regression, neural networks, random forests and extreme gradient boosting - met a prespecified noninferiority criterion for discrimination before any further simplification, and generally preserved calibration and clinical net benefit. Those from the 3 machine-learning models showed no detectable difference in discrimination from de novo generalized additive and explainable boosting models, exceeded neural additive models, and carried fewer

arXiv:2609.05547v1 Announce Type: new Abstract: Breast cancer diagnosis commonly considers individual nuclear morphological characteristics, whereas their joint organization is less frequently evaluated. We developed the Morphological Network Disruption Index (MNDI), a patient-level measure of morphological abnormality relative to a benign reference state. Using the Wisconsin Diagnostic Breast Cancer dataset, ten nuclear characteristics were represented as network nodes, with MNDI summarizing disruption across 45 pairwise feature configurations. Performance was evaluated using repeated stratified five-fold cross-validation. Malignant lesions exhibited substantially higher MNDI than benign lesions (mean: 3.454 vs. 1.165; p = 2.94e-69). MNDI achieved an AUC of 0.941 (95% CI: 0.918-0.961), with 85.9% sensitivity and 91.6% specificity. A classifier using network-derived descriptors achieved an AUC of AUC of 0.928 +/- 0.024. Independent evaluation in the BreaKHis histopathology cohort

arXiv:2609.05453v1 Announce Type: new Abstract: Excitable and oscillatory responses are widespread in cell signaling, but how these arise in the same system is unclear. We propose a minimal model of a saddle node bifurcation on an invariant circle, where slow fluctuations modulate transitions between excitable and oscillatory states, and noise drives excitability. Fitting the model to cell signaling data from embryonic stem cells reveals that these cells operate close to the bifurcation. Proximity to the bifurcation allows the cell to tune different dynamic states, suggesting a general principle for versatile cell signaling.

arXiv:2609.05453v1 Announce Type: cross Abstract: Excitable and oscillatory responses are widespread in cell signaling, but how these arise in the same system is unclear. We propose a minimal model of a saddle node bifurcation on an invariant circle, where slow fluctuations modulate transitions between excitable and oscillatory states, and noise drives excitability. Fitting the model to cell signaling data from embryonic stem cells reveals that these cells operate close to the bifurcation. Proximity to the bifurcation allows the cell to tune different dynamic states, suggesting a general principle for versatile cell signaling.

Pharmaceutical companies have embraced artificial intelligence in drug research almost universally, yet few company executives expect AI to actually make drugs succeed, according to a Citi survey released on Tuesday. “The biggest risk to the AI-powered drug discovery thesis is not that AI fails to accelerate discovery,” said John Yung, head of Asia healthcare research at the US investment bank. “The stronger risk is that acceleration does not translate into better drugs or higher probability of...

arXiv:2609.08485v1 Announce Type: new Abstract: Whether artificial intelligence pays off for the firms that build it into their products is hard to establish, because AI innovation is itself hard to observe. The medical technology sector is a rare exception: an AI-enabled device must obtain clearance from a national health authority before it can reach a patient, leaving a dated, firm-attributable record of AI innovation output that can be observed directly rather than proxied. We exploit this setting with a three-stage recursive model estimated on a novel firm-level dataset linking FDA premarket clearances, USPTO patents, Scopus publications, and Orbis financials, tracing the full innovation chain from external collaboration through AI device introduction to firm performance. We find that external AI research collaboration is a robust driver of AI device introduction across firm sizes and estimators, with a larger effect for small firms, consistent with external knowledge ties

OutSee, a genomics and drug discovery company pioneering a unique AI-based predictive approach to uncover new drug targets, today announced it has been awarded funding through Innovate UK's Investor Partnership Grant, jointly provided by Innovate UK and Empirical Ventures.

One of the above images is real; the other is AI-generated. Can you tell which is which? The images depict intestinal polyps, often benign growths on the inside of the colon or rectum. Polyps are usually removed because some can develop into bowel cancer over time.

In a finding that could reshape how ornamental plant breeders harness radiation to create novel varieties, researchers in Iran have mapped the precise dose-dependent effects of gamma irradiation on two popular cultivars of Begonia rex, one of the world’s most beloved foliage plants. The study, published in BMC Plant Biology, provides the first detailed account […]

The game, 'Build the Wall,' filtered classic block-stacking mechanics through the Trump administration's immigration policies.

In a 50-year follow-up study, men with low cardiovascular risk in their 40s maintained their functional capacity, happiness and quality of life better than others as they aged.

Elderly mice on the popular weight-loss drug semaglutide aged slower and lived longer, mimicking the longevity effects of caloric restriction. The post Could GLP-1 Drugs Help You Live a Longer, Healthier Life? appeared first on SingularityHub.

Researchers from the University of Miami Miller School of Medicine and collaborating institutions have published a comprehensive review examining the rapidly evolving field of intra-arterial stem cell therapy for ischemic stroke, highlighting its potential to improve recovery for patients who continue to face disability despite major advances in stroke treatment.

Sponsored content brought to you by Artificial intelligence is dramatically accelerating early drug discovery. Models can screen chemical space, predict structures, optimize properties, and propose new molecules at speeds that were unimaginable […] The post AI Drug Discovery Hits a New Bottleneck: Experimental Validation appeared first on GEN - Genetic Engineering and Biotechnology News.

A breakthrough pancreatic cancer drug won approval. They still struggle to access it  STATOncologists say newly approved pancreatic cancer drug is a breakthrough for treatment  Healthcare BrewPancreatic cancer drug may hold promise for lung cancer as well, early study suggests  ABC News - Breaking News, Latest News and VideosFDA approves landmark pancreatic cancer drug that's shown to improve survival  WUSA9David Gandara: Daraxonrasib Marks a Major Advance in Pancreatic Cancer Care  Oncodaily