Headlines

A new robotic system is drawing blood in adult patients, but its real-world impact may depend on how often it skips difficult veins.

arXiv:2609.07610v1 Announce Type: cross Abstract: We convert black-box clinical prediction models for tabular data into standalone nomograms that can be audited term by term. PRiSM (Partial Responses in Structured Models) takes the shape of each effect and interaction from the source model, not merely which variables mattered, and lets the outcome select and weight them. We tested this in 50,356 heart transplant recipients, with validation in a later era than training. Nomograms from all 5 source models - a public clinical risk score, logistic regression, neural networks, random forests and extreme gradient boosting - met a prespecified noninferiority criterion for discrimination before any further simplification, and generally preserved calibration and clinical net benefit. Those from the 3 machine-learning models showed no detectable difference in discrimination from de novo generalized additive and explainable boosting models, exceeded neural additive models, and carried fewer

arXiv:2609.05547v1 Announce Type: new Abstract: Breast cancer diagnosis commonly considers individual nuclear morphological characteristics, whereas their joint organization is less frequently evaluated. We developed the Morphological Network Disruption Index (MNDI), a patient-level measure of morphological abnormality relative to a benign reference state. Using the Wisconsin Diagnostic Breast Cancer dataset, ten nuclear characteristics were represented as network nodes, with MNDI summarizing disruption across 45 pairwise feature configurations. Performance was evaluated using repeated stratified five-fold cross-validation. Malignant lesions exhibited substantially higher MNDI than benign lesions (mean: 3.454 vs. 1.165; p = 2.94e-69). MNDI achieved an AUC of 0.941 (95% CI: 0.918-0.961), with 85.9% sensitivity and 91.6% specificity. A classifier using network-derived descriptors achieved an AUC of AUC of 0.928 +/- 0.024. Independent evaluation in the BreaKHis histopathology cohort

arXiv:2609.05453v1 Announce Type: new Abstract: Excitable and oscillatory responses are widespread in cell signaling, but how these arise in the same system is unclear. We propose a minimal model of a saddle node bifurcation on an invariant circle, where slow fluctuations modulate transitions between excitable and oscillatory states, and noise drives excitability. Fitting the model to cell signaling data from embryonic stem cells reveals that these cells operate close to the bifurcation. Proximity to the bifurcation allows the cell to tune different dynamic states, suggesting a general principle for versatile cell signaling.

arXiv:2609.05453v1 Announce Type: cross Abstract: Excitable and oscillatory responses are widespread in cell signaling, but how these arise in the same system is unclear. We propose a minimal model of a saddle node bifurcation on an invariant circle, where slow fluctuations modulate transitions between excitable and oscillatory states, and noise drives excitability. Fitting the model to cell signaling data from embryonic stem cells reveals that these cells operate close to the bifurcation. Proximity to the bifurcation allows the cell to tune different dynamic states, suggesting a general principle for versatile cell signaling.

Pharmaceutical companies have embraced artificial intelligence in drug research almost universally, yet few company executives expect AI to actually make drugs succeed, according to a Citi survey released on Tuesday. “The biggest risk to the AI-powered drug discovery thesis is not that AI fails to accelerate discovery,” said John Yung, head of Asia healthcare research at the US investment bank. “The stronger risk is that acceleration does not translate into better drugs or higher probability of...

arXiv:2609.08485v1 Announce Type: new Abstract: Whether artificial intelligence pays off for the firms that build it into their products is hard to establish, because AI innovation is itself hard to observe. The medical technology sector is a rare exception: an AI-enabled device must obtain clearance from a national health authority before it can reach a patient, leaving a dated, firm-attributable record of AI innovation output that can be observed directly rather than proxied. We exploit this setting with a three-stage recursive model estimated on a novel firm-level dataset linking FDA premarket clearances, USPTO patents, Scopus publications, and Orbis financials, tracing the full innovation chain from external collaboration through AI device introduction to firm performance. We find that external AI research collaboration is a robust driver of AI device introduction across firm sizes and estimators, with a larger effect for small firms, consistent with external knowledge ties

OutSee, a genomics and drug discovery company pioneering a unique AI-based predictive approach to uncover new drug targets, today announced it has been awarded funding through Innovate UK's Investor Partnership Grant, jointly provided by Innovate UK and Empirical Ventures.

One of the above images is real; the other is AI-generated. Can you tell which is which? The images depict intestinal polyps, often benign growths on the inside of the colon or rectum. Polyps are usually removed because some can develop into bowel cancer over time.

In a finding that could reshape how ornamental plant breeders harness radiation to create novel varieties, researchers in Iran have mapped the precise dose-dependent effects of gamma irradiation on two popular cultivars of Begonia rex, one of the world’s most beloved foliage plants. The study, published in BMC Plant Biology, provides the first detailed account […]

The game, 'Build the Wall,' filtered classic block-stacking mechanics through the Trump administration's immigration policies.

In a 50-year follow-up study, men with low cardiovascular risk in their 40s maintained their functional capacity, happiness and quality of life better than others as they aged.

Elderly mice on the popular weight-loss drug semaglutide aged slower and lived longer, mimicking the longevity effects of caloric restriction. The post Could GLP-1 Drugs Help You Live a Longer, Healthier Life? appeared first on SingularityHub.

Researchers from the University of Miami Miller School of Medicine and collaborating institutions have published a comprehensive review examining the rapidly evolving field of intra-arterial stem cell therapy for ischemic stroke, highlighting its potential to improve recovery for patients who continue to face disability despite major advances in stroke treatment.

Sponsored content brought to you by Artificial intelligence is dramatically accelerating early drug discovery. Models can screen chemical space, predict structures, optimize properties, and propose new molecules at speeds that were unimaginable […] The post AI Drug Discovery Hits a New Bottleneck: Experimental Validation appeared first on GEN - Genetic Engineering and Biotechnology News.

A breakthrough pancreatic cancer drug won approval. They still struggle to access it  STATOncologists say newly approved pancreatic cancer drug is a breakthrough for treatment  Healthcare BrewPancreatic cancer drug may hold promise for lung cancer as well, early study suggests  ABC News - Breaking News, Latest News and VideosFDA approves landmark pancreatic cancer drug that's shown to improve survival  WUSA9David Gandara: Daraxonrasib Marks a Major Advance in Pancreatic Cancer Care  Oncodaily

A breakthrough pancreatic cancer drug won approval. They still struggle to access it  STATOncologists say newly approved pancreatic cancer drug is a breakthrough for treatment  Healthcare BrewPancreatic cancer drug may hold promise for lung cancer as well, early study suggests  ABC News - Breaking News, Latest News and VideosFDA approves landmark pancreatic cancer drug that's shown to improve survival  WUSA9David Gandara: Daraxonrasib Marks a Major Advance in Pancreatic Cancer Care  Oncodaily

Zack Zwiezen / Kotaku: The White House has quietly removed Build The Wall, a Tetris clone on its arcade.gov website, after Tetris said it takes “copyright infringement very seriously”  —  It seems the Trump administration doesn't want to tempt a lawsuit from The Tetris Company

Bone repair depends on skeletal progenitor cells (SPCs) moving to injured areas and developing into bone-forming cells, but how these cells respond to their surroundings remains unclear.

It’s time for human doctors to get serious about AI.

Trump admin's propaganda "arcade" hits some apparent legal limits.

Cellular senescence has long been one of biology’s most paradoxical phenomena. In healthy tissue, senescent cells—those that have permanently exited the cell cycle in response to stress, DNA damage, or telomere shortening—act as a safeguard against cancer, halting division before damage can accumulate. Yet as these cells linger, they secrete inflammatory signals that can, over […]

The field of regenerative medicine is gaining momentum. Mesenchymal stem cells (MSCs) remain central to this field, with expanding applications as direct therapies and as producers of MSC-derived extracellular vesicles (MSC-EVs). This article examines the biological and regulatory factors shaping their promise. The post Regenerative Medicine in the Bronze Age: MSCs and MSC-EVs Leading the Way appeared first on GEN - Genetic Engineering and Biotechnology News.

“Build the Wall” was pulled days after the White House launched its “arcade.” | Screenshot: The Verge The White House has taken down its racist Tetris ripoff days after launching a website dedicated to "arcade games," as spotted earlier by Kotaku. The Tetris clone, called "Build the Wall," involved stacking different-sized blocks to prevent a "zombie border siege." It's not clear why the White House removed the title, though the Tetris Company previously said that it's looking into the situation. "For more than 40 years, Tetris has brought people together across generations and cultures through play and joy," Tetris spokesperson Kerri Brusca told The Verge last week. "The objective of the game has always been to stack with purpose to clear … Read the full story at The Verge.

For nearly a decade, the Beacon platform has advanced from integrated single-cell cloning to earlier productivity, product-quality, and stability measurements, with AI-assisted clone evaluation pointing toward the next step. Bringing richer evidence forward helps teams focus resources on the candidates most likely to succeed. The post Measuring Cell Line Development Quality Within Days of Single-Cell Cloning, Not Months Later appeared first on GEN - Genetic Engineering and Biotechnology News.

Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age.

Traditional gene editing rewrites DNA. But a new approach, called epigenome editing, aims to treat the molecular scars we collect throughout our lives.

Six proteomic aging clocks found rentosertib lowered predicted biological age in 42 lung fibrosis patients. The smaller dose gave the broadest signal.

Micah Barkley / Bloomberg: Forus, which uses AI to help patients get prescribed drugs more quickly by navigating steps like insurance coverage, raised a $150M Series C at a $3B valuation  —  Healthcare automation startup Forus has raised $150 million at a $3 billion valuation just months after completing a previous funding round.

I recently competed in the British Transplant Games in Sheffield, as the event reached its 48th year.1 More than 1000 transplant recipients and live donors took part, and hundreds of volunteers supported. I’ve always encouraged exercise as part of health, especially for people with health conditions. But since this year’s games I’m also encouraging people to register their decisions on organ donation and sign up to be a stem cell donor.23The event shone with community. Children whose organs had been failing were running, laughing, and thriving. Siblings bonded over sport after coping with more turmoil than any child should bear. Their parents connected with others who had shared experiences.There was a standing ovation as donor families entered for the opening ceremony. I listened to powerful stories from people at the games—people determined to make something positive from the grief of losing a loved one, by allowing organ and tissue donation....

Study Suggests AI-Generated Drug Could Slow Aging  GizmodoIntegration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment  NatureEarly Data Indicates an A.I.-Generated Drug Could Slow Aging  The New York TimesInsilico’s Co-CEO Has Big Hopes That Fibrosis Drug Can Reverse Aging Too  WSJInsilico's IPF candidate rentosertib shows anti-aging promise  FirstWord Pharma

Study Suggests AI-Generated Drug Could Slow Aging  GizmodoIntegration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment  NatureEarly Data Indicates an A.I.-Generated Drug Could Slow Aging  The New York TimesInsilico’s Co-CEO Has Big Hopes That Fibrosis Drug Can Reverse Aging Too  WSJInsilico's IPF candidate rentosertib shows anti-aging promise  FirstWord Pharma

In children with metachromatic leukodystrophy, early gene therapy preserved motor function and survival in long-term follow-up.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Traditional gene editing rewrites DNA. But a new approach, called epigenome editing, aims to treat the molecular scars we collect throughout our lives.

What’s the Face/Off?I mean AI enhanced faces. It’s your dream face, a visage with no pimples or wrinkles, possessing gorgeous cheekbones, the perfect nose and jawline, and immaculate symmetry, whatever you desire.But now plastic surgeons say that they are increasingly being asked by patients to replicate them in real life.Some 15% of members of the British Association of Aesthetic Plastic Surgeons (BAAPS) say they have met patients who show up for consultation appointments with AI beautified faces.1Facing reality?“We can improve and enhance features, but we cannot rewrite anatomy or guarantee a digitally perfect outcome,” BAAPS president Nora Nugent said.“The image can feel like a realistic representation of what patients could look like after surgery, but it may bear very little relation to what is anatomically or surgically possible.”Unlike traditional inspiration images, AI generated photographs can be particularly powerful because they depict the patient themselves—creating the

A new study suggests Insilico Medicine’s AI-designed lung drug may slow biological aging, though more research is needed.

AI-Discovered Drug Reverses Aging Markers In Study, Biotech Says  Bloomberg.comEarly Data Indicates an A.I.-Generated Drug Could Slow Aging  The New York TimesIntegration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment  NatureInsilico’s Co-CEO Has Big Hopes That Fibrosis Drug Can Reverse Aging Too  WSJAI-designed drug candidate reverses biological age in clinical study  News-Medical

AI-Discovered Drug Reverses Aging Markers In Study, Biotech Says  Bloomberg.comEarly Data Indicates an A.I.-Generated Drug Could Slow Aging  The New York TimesIntegration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment  NatureInsilico’s Co-CEO Has Big Hopes That Fibrosis Drug Can Reverse Aging Too  WSJAI-designed drug candidate reverses biological age in clinical study  News-Medical

In a development that could reshape how surgeons train for some of the most dangerous operations in medicine, a multidisciplinary team of neurosurgeons and engineers in Spain has built and validated a patient-specific, 3D-printed skull base model that replicates the delicate anatomy encountered during endoscopic endonasal surgery, including the internal carotid arteries, the optic nerves […]

Without brain surgery guided by live AI assistance, Rhys Hibbert could have lost his sight to a tumour.

A man has lived for a record nine months with a transplanted pig kidney while waiting for a human transplant.

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the stem cells—unspecialized cells that can develop into specific cell types—that give rise to the body's tendons and ligaments, the tissues connecting muscles and bones.

A genetically modified kidney from a pig has worked in a patient with kidney failure for nine months—the longest period yet recorded—US doctors have reported.The transplant kept Tim Andrews, 66, free of dialysis for 271 days, and demonstrated for the first time that a pig kidney can be used as a temporary “bridge” until a human transplant becomes available, according to a case study report published in the Lancet.1Andrews had kidney failure caused by type 2 diabetes. He had just a 9% chance of receiving a human kidney within five years, against a more than 40% risk of dying or being removed from the waiting list for a transplant, the researchers noted.The pig kidney he received worked for nine months before it failed and was removed. After a short period of dialysis, he received another kidney from a deceased human donor.Researchers at Mass General Brigham hospital, Massachusetts—who carried out the...

Insilico Medicine ("Insilico"), a clinical-stage company focused on generative AI-driven drug discovery and development, today announced the publication of a new study conducted in collaboration with an international team of scientists from Harvard Medical School, Stanford University, The Broad Institute, RWTH Aachen University, Peking University and Westlake University.

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the unspecialized stem cells that give rise to the body's tendons and ligaments, the tissues connecting muscles and bones.

Blood samples from a small lung-disease trial have been run through six independently built ageing clocks, and all six returned the same answer: the patients on the drug looked biologically younger than the patients on placebo. “More lifetimes than humanity lost in all the wars ever fought. If you manage to add 3 years to […] This story continues at The Next Web

Cade Metz / New York Times: Insilico, which uses AI to accelerate drug discovery, says early data shows that rentosertib, a drug developed to treat a chronic lung disease, could slow aging  —  Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Dr. Annu Navani shares four low-cost longevity habits rooted in sleep, stress management, nutrition and resistance training for a longer healthspan.

A miniature human bladder with flowing urine revealed that a standard UTI antibiotic struggled where lab tests said it should work.

Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age.

Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age.

For three years, the case for ambient artificial intelligence in healthcare was told through one scene: a physician

A team of engineers and surgeons in China has built a handheld surgical robot that brings robotic dexterity to laparoscopic surgery in a package small enough to hold in one hand, and their prototype has now shown laboratory performance figures that could challenge the dominance of the multimillion-dollar operating room robots that currently define surgical […]

Lung cancer tumors that respond well to targeted drugs often harbor a hidden population of cells that the drugs cannot touch, and new research reveals that neighboring support cells actively reprogram those survivors into a drug-resistant state. A study published in the Journal of Experimental & Clinical Cancer Research shows that mesenchymal stromal cells educated […]

The Gerontological Society of America has thrown its institutional weight behind a sweeping new review of respiratory vaccine evidence, endorsing findings released on September 2, 2026 by the Vaccine Integrity Project in collaboration with the American Medical Association. The endorsement arrives at a moment of heightened public scrutiny of immunization policy, and it places one […]

That number on your vehicle's battery signals four key facts about it. Ignore it at your peril - batteries are less interchangeable than you may think.

Kidney organoids grown from human stem cells have transformed how researchers study kidney development and disease, but they have always shared one stubborn flaw: they lack blood vessels. Now a team at Maastricht University in the Netherlands has unveiled a 3D printed microfluidic chip that coaxes lab-grown kidney organoids to develop their own primitive capillary […]

Prostate cancer remains one of the most frequently diagnosed malignancies in men worldwide, and despite decades of progress in surgery, radiation therapy, and androgen-deprivation strategies, aggressive forms of the disease continue to claim hundreds of thousands of lives each year. A new study published in the Journal of Cellular and Molecular Medicine has now uncovered […]

Medical artificial intelligence systems are now capable of passing some of the most demanding examinations in medicine, yet a growing body of evidence suggests that these headline-grabbing achievements may say remarkably little about whether such systems are safe, effective, or appropriate for actual clinical deployment. A new commentary published in the Journal of Medical Systems […]

ABC News: Trump admin debuts arcade.gov with a deportation-themed Snake clone and a Tetris-like wall-building clone; Tetris says it takes IP infringement “very seriously”  —  In “Build the Wall,” players aim to “protect the border” from zombies.  —  Isabella Murray, Nicholas Kerr, and Michelle Stoddart

The collaboration brings together Synastra’s expertise in genomic engineering, AAV vector design, rare-disease gene therapy, and translational development with NewBiologix’s proprietary cell engineering and rAAV manufacturing technologies. The post NewBiologix and Synastra Join Forces to Advance rAAV Manufacturing for Duchenne Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.

Medical experts have stressed that Hong Kong’s next generation of healthcare professionals must combine clinical rigour with emotional resilience, an open-minded approach to artificial intelligence (AI) and the drive to transform the sector. The remarks came during a panel on the first day of the Global Education Summit, co-organised by the South China Morning Post and HSBC Premier. “We always talk about people going north, going to Shenzhen … for medical services. But I would say that it’s a...

AI evangelists’ bold predictions about the technology’s ability to cure all diseases are overblown and oversimplified, writes Arianna Huffington.

The FDA's TEMPO pilot now lists four devices, including an AI voice agent delivering therapy to Medicare patients without premarket authorization.

Artificial intelligence has transformed biomedical research over the past decade, but most AI systems in biology remain confined to narrow tasks, single data types, or one biological scale at a time. A new Perspective article published in Advanced Science proposes a radical conceptual remedy: a hypothetical “Full-Body AI Agent,” a supervisory multi-agent framework designed to […]

The durability of Meloni’s coalition has been a rarity in postwar Italy, where governments have often fallen before the end of their mandates.

The human gut is home to trillions of viruses, a sprawling community known as the virome, and yet it remains one of the least understood layers of the microbiome. A new review published in the journal Gut Pathogens argues that this viral darkness deserves far more clinical attention, particularly in patients undergoing hematopoietic stem cell […]

In a finding that could reshape how scientists think about repairing the damaged human heart, researchers at the University of Guelph have shown that the leopard gecko, a small terrestrial reptile best known as a popular pet, can regenerate its heart tissue after serious injury. Using a powerful technique known as quantitative proteomics, the team […]

In a development that could reshape how scientists probe the molecular machinery of legumes, researchers in Poland have created the first transgene-free knockout lines of a key transporter gene in the model legume Medicago truncatula, using a two-stage CRISPR/Cas9 strategy that promises to dramatically accelerate functional genomics in one of agriculture’s most important plant families. […]

The immune system is made up of specialized cells and proteins that help defend the body from pathogens and cancer. Most of the time, the immune system performs its job remarkably well. However, in some situations, the immune system doesn't work well enough or works in overdrive, causing disease.

A Cleveland Clinic first-in-human clinical trial has shown that a one-time infusion of a gene-editing therapy using CRISPR-Cas9 was effective and safe in reducing LDL ("bad") cholesterol and triglycerides in people with medication-resistant lipid disorders through one year of follow-up across all doses.

A lab-grown micro bladder may explain why urinary tract infections (UTIs) return so frequently, according to a study led by researchers at UCL, the University of Oxford and the University of Leicester.

As the human brain takes shape before birth, a remarkable type of stem cell helps give it many of the features that make it distinctly human.

Federal and state regulators are drawing new boundaries around medical AI, from how the tools are vetted to who bears responsibility when they fail.

The latest news and headlines from Yahoo! News. Get breaking news stories and in-depth coverage with videos and photos.

This is far from the only study to indicate that the children of long-lived individuals tend also to be long-lived. The open question is the degree to which this is genetic versus cultural transmission. The construction of very large population databases over the past few decades has produced evidence for genetics to play only a small role in life expectancy for the vast majority of people. Similarly the weight of evidence for lifestyle choice, particularly physical fitness, to be the presently dominant influence on life expectancy is compelling. Against that background, the hypothesis that centenarians are centenarians because they have favorable gene variants that might form the basis for age-slowing therapies faces an uphill battle. Centenarian lifespan extension is frequently accompanied by delayed onset of […]

Unauthorized stem cell treatment may expose patients to medical and financial risks, reinforcing the role of physicians in counseling those considering such treatment abroad.

For more than a century, the adult human heart has been viewed as a terminally differentiated organ, incapable of meaningful self-repair. Cardiomyocytes, the contractile cells that make up the bulk of cardiac tissue, exit the cell cycle shortly after birth and never meaningfully return. When a heart attack destroys a section of muscle, the organ […]

Pig kidneys successfully transplanted into humans  Financial TimesPatient Who Received Pig Kidney Becomes First To Progress to Human Kidney Transplant  Harvard Medical SchoolUse pig organs while patients wait for donors, say scientists  The TelegraphPig kidney kept a man off dialysis for nine months in world first  New ScientistPig kidney works in human body for 271 days - is this the future of organ transplants?  BBC

Pig kidneys successfully transplanted into humans  Financial TimesPatient Who Received Pig Kidney Becomes First To Progress to Human Kidney Transplant  Harvard Medical SchoolUse pig organs while patients wait for donors, say scientists  The TelegraphPig kidney kept a man off dialysis for nine months in world first  New ScientistPig kidney works in human body for 271 days - is this the future of organ transplants?  BBC

arXiv:2609.03865v1 Announce Type: new Abstract: Deng et al. discovered that Drt3b synthesizes protein-primed poly(AC) DNA without a nucleic-acid template. The structures reveal a finite protein architecture and product-associated contacts, but not the renewable dynamical rule that converts a bounded pocket into a long period-2 sequence. We propose that Drt3b is a regenerating protein-substrate free-energy register. The framework specifies a sampled quantum mechanics/molecular mechanics (QM/MM) potential of mean force and a preregistered, within-domain first-order electronic-descriptor map for edge-specific activation barriers; physical curvature is admitted only through a training-frozen Taylor-remainder bound that widens uncertainty but never corrects a held-out mean. Conditional hazards derived from those barriers are averaged over unresolved conformational, hydration, protonation, and metal-coordination trajectories to yield a semi-Markov event kernel. Pointwise ratios of competing

Hydrogels have long been considered one of the most promising material platforms for implantable bioelectronics. Soft, water-rich, and chemically similar to living tissue, they promise a gentle interface between electronics and biology. Yet despite decades of enthusiasm, hydrogel-based implants have remained largely confined to laboratory demonstrations, largely because of a single, stubborn failure mode: swelling. […]