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A Japanese claims-based cohort study of 1,520 women treated for cervical cancer found that only 22.0 percent started hormone replacement therapy within six months, with use falling steeply with age and continuing for a median of about two years.

arXiv:2610.38496v1 Announce Type: cross Abstract: Behavior Cloning (BC) of expert controllers for multiscale dynamical systems is challenging: state variables evolving at widely separated timescales induce highly nonlinear couplings that a shared latent space may fail to adequately represent, degrading closed-loop generalization. We propose Structured Representation Learning for Behavior Cloning (SRLBC), an architecture designed to leverage the physical knowledge of multiscale systems in which slow state variables, fast (stiff) state variables, and predictable exogenous inputs evolve at different timescales. On 500 long-horizon roll-outs of a pressurized water reactor (PWR) load-following benchmark -a high-dimensional, stiff industrial system with challenging safety constraints -and across 20 training seeds, separated embeddings systematically outperform shared embedding baselines on cumulative cost, imitation accuracy and constraint satisfaction. The resulting standalone policies

arXiv:2610.37815v1 Announce Type: new Abstract: We consider the general mother-dependent neutral mutation model defined in Blancas, Fittipaldi and Hern\'andez-Torres (2026), consisting of a multitype branching process in which every individual carries one of $d$ alleles and each mutant child acquires a type different from that of its mother, according to a prescribed distribution. We assume that the total offspring distribution is critical and belongs to the domain of attraction of an $\alpha$-stable law, with $\alpha\in(1,2)$, while mutations are rare. Extending the results of Blancas and Rivero (2018), we prove the finite-dimensional convergence of the rescaled Markov chain that records, in each allelic generation, the sizes of the type-specific clone subfamilies and the mutant populations they produce. The limiting clone masses form a multitype Ji\v{r}ina process driven by stable subordinators with drift, whose branching mechanism combines the stable reproduction law with the

Frontiers in Medicine has retracted a 2020 mouse study on exosomal miR-25 and fracture healing after image integrity concerns and missing raw data.

While artificial intelligence (AI) holds great potential to transform health care, its clinical adoption in Korea remains slow due to inadequate reimbursement and limited access to medical data, experts said. The remarks came during a symposium hosted by Eulji University Medical Center to mark its 70th anniversary, under the theme "Future Healthcare with AI," in Seoul. AI has already been transforming Korea's health care system. It has significantly improved public access to medical information, while helping physicians at primary and secondary health care institutions stay up to date with the latest medical research and developments. Despite these advances, AI adoption in clinical settings remains slow. While AI-based medical devices have gained regulatory approval in Korea, few are covered by national health insurance. Based on Ministry of Food and Drug Safety data, 549 AI medical devices have received regulatory approval until the first half of this year, but only 49 are covered by

A new review maps how mutations in more than twenty genes weaken bone in osteogenesis imperfecta and surveys therapies from bisphosphonates to CRISPR gene editing.

A zinc-chelating dye that stains insulin-producing beta cells red allowed researchers to locate and retrieve otherwise invisible islet grafts transplanted under the skin of mice.

A new study shows that the RNA-binding protein MSI1 stabilizes the ferritin-like transcript Fthl17c, preserving the ferrous iron supply that TET enzymes need to keep DNA hypomethylated and mouse embryonic stem cells pluripotent.

A vision-language AI agent built by CU Anschutz researchers identified correct diagnoses in 99.6% of reviewed right upper quadrant ultrasound reports and drafted reports that experts could not distinguish from radiologist-edited work.

A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and combining the autophagy inhibitor GNS561 with AZD5305 slowed tumors and improved survival in mouse models.

Abstracts from the 34th Portuguese Dental Association Annual Meeting present case reports and early studies spanning odontogenic cyst management, regenerative endodontics, implant bone regeneration, antimicrobial resistance, and diagnostic artificial intelligence.

The FDA's draft guidance could streamline approval of gene-editing therapies tailored to individual mutations, while families and experts weigh safety, affordability, evidence requirements, and access challenges.

Researchers developed an in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes, which showed normal karyotype, intact p53, and responses to thirteen reference substances consistent with published genotoxicity reports.

A retrospective study of 3,884 emergency brain CT scans found two FDA-cleared AI haemorrhage detectors traded sensitivity against specificity, with neither dominating across all metrics.

The first patient received a dose of the high-precision gene editor in a new clinical trial for Wilson disease. Researchers hope it's a one-and-done fix. The post CRISPR Prime Editing Rewrites DNA in the Human Body for the First Time appeared first on SingularityHub.

A new review in Cell Regeneration explains why transient senescent cells support muscle repair while persistent senescence in aged or dystrophic muscle undermines it.

A new review summarizes how processed human amniotic membrane is being applied across orthopaedics, obstetrics and gynaecology, and dermatology.

An international study reports 60% progression-free survival at 10 years after autologous bone marrow transplantation, adding important evidence on sustained positive clinical outcomes and long-term safety in patients treated for early severe systemic sclerosis.

A new study proposes the contextual palimpsest, a temporally layered design framework in which past traces and present interventions coexist in regenerated cultural buildings.

New work shows that loss of the chromatin-binding protein Prospero leaves fly CNS cells of mixed identity that fail to divide or divide once extra, without dedifferentiating into stem cells.

When a patient arrives in the emergency department with severe abdominal pain, every minute counts. Researchers at the University of Colorado Anschutz School of Medicine are investigating ways to streamline the work of radiologists and make it more efficient.

A comprehensive review of more than 200 peer-reviewed publications examines how communication protocols, security frameworks, AI, blockchain and quantum technologies could shape the future of the Internet of Medical Things.

An international study reports 60% progression-free survival at 10 years after autologous bone marrow transplantation, adding evidence of sustained positive clinical outcomes and long-term safety in patients treated for early severe systemic sclerosis.

More than 65% of approved medicines work by binding to proteins on the surface of human cells. Yet scientists developing new treatments face a fundamental problem: Major biological databases disagree about which proteins are actually found on cell surfaces.

For people with kidney failure, access to transplantation can mean better survival and quality of life.

A planetary-scale mining of public metagenomes collected 794 million CRISPR spacers and 1.18 billion virus and plasmid hits, revealing high spacer turnover and evidence that some targeting reflects viral genomes entering non-host cells.

In rat bone marrow stem cells, the TLR4 inhibitor TAK-242 suppressed LPS-induced inflammatory gene expression while leaving osteogenic differentiation largely unimpaired by day 14.

A new review argues that stem cell grafts can protect tissue and communicate with host circuits in selected spinal cord injury models, but no study has yet linked product molecular features to recovery in one experiment.

Scientists can now edit genes in precise locations deep in the brain and body without the use of invasive surgery or implants, thanks to new work from researchers at the Wu Tsai Neurosciences Institute. The team demonstrated its technique, which uses a combination of ultrasound, light-emitting nanoparticles and photo-controllable gene-editing proteins, by successfully altering genes in mouse brains at selected locations.

A 2024 survey at Universidad Ricardo Palma found 92.4 percent of 278 medical students reported previous AI use for academic activities, with ChatGPT the most cited tool.

A new review summarizes how basal stem cells sustain lifelong olfactory epithelium renewal and how single-cell and organoid technologies are reshaping the field.

VIENNA — In a phase 2 study, SAR402663 gene therapy for wet age-related macular degeneration showed positive efficacy and safety interim results with a single in-office intravitreal injection.With a medium dose of SAR402663, there was a 97% reduction in treatment burden, with more than 90% of patients not needing supplemental anti-VEGF injections, Arshad M. Khanani, MD, MA, FASRS, said at the Euretina congress.Researchers have observed positive functional and anatomic results with the therapy, and the safety profile appears good.SAR402663 (Sanofi) is an investigational AAV2 gene therapy

's Kevin Davies, PhD, reports from ESGCT where patient safety, expanding access to gene therapy, and progress towards an HIV vaccine were prominent themes among the early talks at ESGCT 2026. The post Hamburg Hosts 2026 European Gene Therapy Conference appeared first on GEN - Genetic Engineering and Biotechnology News.

This eBook brings together perspectives from across the AAV development and manufacturing continuum. It explores how early commercial planning can help avoid costly delays, how standardized platform approaches and off-the-shelf plasmids can streamline development, and how next-generation innovations are helping overcome long-standing manufacturing bottlenecks. The post Building the Future of AAV Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.

A survey of 1,218 consumers in Spain, Germany and the UK found that conventional pesticides draw stronger rejection than precision-bred watermelon, with zero-residue pesticides commanding the highest premiums.

Stem cell therapies involve a stage of expansion of cells in culture prior to injecting them into the patient. The research community has realized that both the state of the original source cells and small variations in the subsequent cell culture environment can result in large differences in the quality of the transplanted cells. For example, how many of the cells in the culture have become senescent, and are thus now generating pro-inflammatory signals. There are other possible variations in cell state that could contribute negatively to outcomes, diminishing any benefits resulting from the therapy, however. Differences in cell state and behavior may be the cause of much of the well-known and undesirable variability of outcomes in stem cell therapy. Some clinics may have started […]

Mars-owned Royal Canin and ingredients supplier Roquette will co-invest in the farms from which they source that wheat. The post Agrifood corporates find a new model for financing regenerative agriculture via Soil Capital partnership appeared first on AgFunderNews.

A study of 41 male renal transplant recipients found mean IIEF-5 scores rose significantly at six months, with recovery shaped by baseline ED severity, diabetes, hypertension, smoking and dialysis duration.

A systematic review of 26 studies finds AI models diagnosing multiple sclerosis with over 95 percent accuracy in some cases, but limited external validation and poor interpretability keep most tools out of the clinic.

A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting major standardization and validation hurdles.

A new review evaluates preclinical evidence that adipose-derived stem cell extracellular vesicles could multitarget the pathological processes driving diabetic microangiopathy.

Researchers show that GPT-5 and Gemini can extract and classify policy framing quotes from German news articles with F1-scores near 80 percent against an expert reference standard.

A ten-year retrospective study of 18 children with inflammatory bowel disease found fecal microbiota transplantation cleared recurrent C. difficile infection in most patients and was generally well tolerated.

Researchers fine-mapped and functionally validated CauYL, a magnesium chelatase H subunit gene essential for chlorophyll accumulation and normal leaf coloration in cauliflower.

A randomized controlled trial of 90 patients found that AI-facilitated, individualized nutritional guidance improved 30-day energy and protein intake adequacy and reduced patient-reported symptoms compared with standard discharge advice, though the trial could not isolate the effect of AI itself.

Researchers generated eyeless F0 CRISPR-Cas9 pax6 mutants in the slipper limpet Crepidula fornicata using a de novo transcriptome instead of an assembled genome.

The Biomolecular Nanotechnology research group led by Ikerbasque research professor Aitziber L. Cortajarena has developed a new iron-based contrast agent for magnetic resonance imaging that can be used for both diagnosis and treatment. In a study carried out on lab-grown human heart tissue, it was proven that the contrast agent accumulates in the fibrotic tissue, that its signal intensity on the MRI image increases with the severity of the disease, and that it slows disease progression.

Researchers built a human blood-brain barrier model combined with antiviral testing, validated it with anti-HIV drugs, showed TBEV crosses an intact barrier to infect astrocytes, and identified a barrier-permeable antiviral candidate.

CRISPR Prime Editing: First In Vivo Trial for Wilson’s Disease For years, scientists have been working on ways to treat genetic disorders that cause serious health problems. Now, a Phase 1/2 clinical trial is testing an experimental prime-editing treatment called PM577a. So far, only one patient has received the treatment, and the first clinical results […] The post CRISPR Breakthrough: First In Vivo Prime Editing Treatment Tested in Humans appeared first on BioTecNika.

Drug Development with Claude Imagine generating 35,000 antibody designs in just one month. Sounds ambitious, doesn’t it? Well, according to Anthropic, its AI assistant Claude helped researchers at Divergence Labs do exactly that. These were early-stage antibody candidates, not finished medicines, but the scale of the work is worth paying attention to. And that’s only […] The post Drug Development with Claude: Anthropic Reports 35,000 AI-Designed Antibody Candidates in a Month appeared first on BioTecNika.

A systematic review finds that only 47 human studies address fusion between mesenchymal stem/stromal cells and tissue-specific cells, suggesting regenerative potential in the cardiovascular, muscular, and nervous systems while noting that spontaneous fusion is rare.

A Thai single-center cohort study of 292 kidney transplant recipients found 6.8 percent developed de novo malignancies, with urothelial cancer most common and reduced patient survival.

A new narrative review details how hyperglycemia, Schwann cell dysfunction, and disrupted calcium and iron balance impair peripheral nerve regeneration after traumatic injury.

An independent review of NHS productivity and future ringfenced spending on prevention have been announced in the government’s 2026 budget, the first under prime minister Andy Burnham.An additional £190m was announced to support the NHS response to winter pressures. But no direct share of this pot has been set aside to support general practices.Unveiled by chancellor John Healey on 28 October, the budget had, overall, much less on the NHS and adult social care than in previous years, with the main focus instead on household bills.The BMA’s chair of council, Tom Dolphin, said, “For a government that claims to put the NHS at the heart of its priorities, this budget falls worryingly short.“The failure to set out meaningful action to tackle crumbling buildings or ensure we have enough doctors to meet future demand raises serious questions about the government’s commitment to the health service’s long term future.”David Williams, deputy director...

A one-hour exposure to activated protein C keeps human blood stem cells quiescent and improves their short-term serial engraftment in mice, while thrombin acts on the same receptor to drive differentiation and impair transplantation outcomes.

A new review in Biological Research surveys cardiac stem and progenitor cell populations, finding that classic markers c-kit and Sca-1 mostly label endothelial cells without cardiomyogenic potential.

A new review maps how 3D bone marrow models, from spheroids to bioprinted and organ-on-chip systems, are being used to study multiple myeloma and its drug resistance.

In the Drosophila ovary, Notch activation upregulates the E2 enzyme Ubc10, which teams with the E3 ligases Ari-1 and Cul3 to degrade the Hedgehog effector Ci and specify cap cells that form the germline stem cell niche.

A new closed-tube RT-RAA-CRISPR/Cas12a assay detects Schmallenberg virus within 50 minutes and outperformed RT-qPCR on simulated bovine nasal swab samples, though validation with authentic clinical specimens is still pending.

Flagship Pioneering is combining three of its portfolio companies, including one that has been around for a decade, in an effort to compete in the bustling AI drug discovery field. The Cambridge, MA-based incubator and ...

Peripheral nerves are capable of regeneration to restore connections across gaps caused by injury, but the larger the gap the less likelihood of a successful outcome. The medical community has developed approaches that help by laying guides along the path that regrowth must take, often composed of donor nerve tissue, which may be taken from elsewhere in the patient, but these are far from optimal. There is considerable research interest in the development of entirely artificial nerve regrowth guides that have a low cost and high rate of success in stimulating the necessary regeneration for a complete restoration of function. The paper here is an example of this sort of research and development, focused on bioprinting an implantable path for nerve regrowth. Conventional cell-laden electro-direct […]

Japanese researchers have established the first patient-derived organoid model of canine nasal carcinoma, showing variable drug sensitivities among tumor lines and identifying S100A2 as a promoter of cancer cell proliferation and invasion.

A dynamic bicellular in vitro model linked by a fluidic circuit reproduced vascular disruption and fibroblast changes when endothelial cells were stimulated with immune complexes from systemic sclerosis patients.

A phase-adaptive deep learning pipeline automatically quantified five liver indices from gadoxetic acid-enhanced MRI without inter-phase co-registration, matching manual measurements and distinguishing cirrhotic from non-cirrhotic patients.

An editorial on a Frontiers Research Topic argues that smart biomaterials and additive manufacturing must be tied to measurable, reproducible functional validation.

A Nature Communications study finds large reasoning models make more accurate primary diagnoses than standard language models but produce over 34 percent more false positives, with physician collaboration improving outcomes.

A cell-culture study reports that prodigiosin reduced apoptosis and oxidative stress in BMSCs exposed to chemically induced hypoxia, with effects linked to HIF-1α/YAP-associated signaling.

Researchers report generating human chemically induced pluripotent stem cells from umbilical cord-derived mesenchymal stem cells using an optimized small-molecule protocol under normal oxygen conditions.

A 12-week randomized trial found that multi-strain probiotic supplementation did not improve arterial stiffness or central blood pressure beyond an energy-restricted diet in adults with hypertension and overweight or obesity.

A study of two Vojvodina farms finds regenerative management can match conventional yields, though short-term profits remain unstable.

A new review finds CRISPR engineering can sharply raise carotenoid yields in microalgae, yet these gains mostly redistribute carbon rather than increase net CO2 fixation.

An integrated blood and CSF multi-omics analysis of the SMART-MS randomized trial found that intrathecal mesenchymal stem cell therapy in progressive multiple sclerosis was associated mainly with compartmentalized CSF proteomic changes rather than broad systemic immune alterations.

A new Cellular Oncology study shows that the enzyme PLA2G2A drives gallbladder cancer progression by promoting cancer stemness through PLA2R1, FLNA and ERK1/2 signaling while inducing soluble PD-L1 secretion that sustains an immunosuppressive tumor microenvironment.

Scientists used CRISPR/Cas9 to disrupt the tyr and oca2 pigmentation genes in zebrafish, reducing melanophores and visibly altering coloration in F0 and F1 mutants.

A new narrative review argues that generative AI simultaneously produces, detects, corrects, and amplifies the consequences of health misinformation across a recursive lifecycle.

A new review argues that mushrooms and the antioxidant L-ergothioneine show anti-aging effects in laboratory models, while human evidence remains largely observational.

A case report describes a 64-year-old woman with multiple myeloma and an SCN5A overlap channelopathy who underwent autologous stem cell transplantation without arrhythmic events under a structured risk mitigation strategy.

Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state in vitro, with the effect reversible on drug withdrawal.

Silencing β-catenin1 in the flatworm Macrostomum lignano blocks tail regeneration and blastema formation, but unlike in planarians it never induces head regeneration, revealing that the head-rescuing response is a planarian specialization rather than an ancestral flatworm trait.

A new review argues that neural stem cells may aid spinal cord injury recovery mainly by reprogramming macrophages and other immune cells rather than replacing lost neurons.

The FDA says Calibrate IV Hydration marketed unapproved stem cell and exosome products. The warning highlights regulatory concerns and questions consumers should ask before receiving an infusion.

A retrospective study of 29 severe systemic sclerosis patients found that autologous hematopoietic stem cell transplantation reduced epidermal thickness and lowered several serum markers of epithelial activation six months after treatment.

A new review in Epigenetics & Chromatin argues that incomplete epigenetic reprogramming remains the main barrier to efficient mammalian cloning by somatic cell nuclear transfer.

A new study of 14 Microcoleus species finds that CRISPR–Cas systems are widespread but do not follow species phylogeny, pointing to repeated gain, loss and exchange of components through gene flow.

A mouse study found that hematopoietic stem cells engrafted during active bone marrow regeneration showed superior long-term reconstitution compared with cells engrafted after myeloablative conditioning.

A large EBMT registry analysis of 3385 adults with AML in remission and measurable residual disease found that haploidentical transplantation with post-transplant cyclophosphamide was associated with lower relapse incidence than matched sibling or matched unrelated donor transplants, though overall survival was similar across donor types.

A new study maps about 1,100 sites where PRC2 rapidly re-establishes itself in mouse embryonic stem cells after reversible depletion of the core subunit Suz12.

Engineered three-dimensional muscle bundles grown from pediatric patients with juvenile dermatomyositis, immune-mediated necrotizing myopathy, and arthritis-related weakness show measurable donor-specific functional and structural differences in a proof-of-concept study.

A new review argues that the hip's cotyloid fossa fat pad is a promising but still uncharacterized source of therapeutic stem cells, using the knee's well-studied infrapatellar fat pad as its benchmark.

A new open-access study reports that fusing attribute features with graph structure and training classifiers collaboratively reached 0.724 accuracy on MIMIC-III data with only 10% annotation, an 18.3% relative improvement over support vector machines.

Researchers surveyed 24,132 students in England and found that 2.7% had used general-purpose AI for mental health support during the previous year. Among users who answered the relevant questions, 55.9% rated the support helpful, yet 63.2% wanted additional assistance, with greater unmet needs reported among adolescents experiencing mental health difficulties and social adversity.

A hybrid classical-quantum support vector machine trained on more than 14,000 maternal records from Uganda and Pakistan predicted mental health risk competitively with the best classical models while SHAP explanations identified clinically meaningful predictors.

A new Perspective proposes VERSION-AI, a two-axis framework for deciding when updates to medical AI systems require renewed clinical evidence.

A new review synthesizes the signaling pathways, extracellular matrix cues, metabolic switches and transcription factors that govern cardiomyocyte proliferation and cardiac repair after injury.

A genomic survey of thirteen complete Kluyvera genomes found that only Kluyvera ascorbata strain SK carries a complete type I-E CRISPR-Cas locus, whose spacers mostly match plasmid sequences from related enteric bacteria.

Researchers developed AMHART, a clinician-informed tool that found chatbot responses covered more guideline-informed criteria for anxiety than depression and for moderate rather than severe adolescent presentations.

A new review examines how Schwann cells grown from human pluripotent stem cells are being used to model peripheral neuropathies and where the platform still falls short.

A WHO forum meeting report argues that global data standards such as FHIR, SNOMED CT, LOINC, and ICD are essential for pandemic intelligence and cross-border health data exchange.