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Little Giant is recalling about 3.66 million ladders after 19 injury reports, including head injuries, from sudden retractions. How to check yours.

A multi-tissue metabolomic analysis reveals that five distinct lifespan-extending interventions induce shared metabolic reprogramming in male mice well before survival differences emerge.

A study of more than 53,000 participants and experimental animal models found that elevated circulating ANGPTL4 predicts chronic kidney disease risk and accelerates disease progression by inducing tubular cell senescence.

A comparative study found that generative AI tools produced preliminary literature summaries on social determinants of periodontal disease in U.S. adults but did not match human-led systematic review fidelity.

A structured review of clinical evidence from 2024 through 2026 evaluates the oncological outcomes, functional preservation, and implementation requirements of robotic platforms, perfusion imaging, and advanced reconstruction in colorectal cancer surgery.

Researchers have demonstrated that chemically recycled ABS shows a cytocompatibility profile comparable to certified medical-grade ABS for fused deposition modeling of non-implantable medical devices.

A large retrospective study of kidney transplant recipients followed for over a decade found that long-term rapamycin treatment was not associated with improved human longevity after adjusting for patient differences.

A multi-stage study reveals that resistant hypertension is linked to cellular senescence and vascular stiffening driven by dysregulated PTEN and AKT signaling.

A randomized trial in lung transplant recipients found that switching from twice-daily to once-daily extended-release tacrolimus does not reduce objective or subjective tremor severity over two years.

Thicker right anterior perirenal fat on routine pre-transplant CT scans was independently associated with post-transplant diabetes mellitus in a retrospective cohort of 202 kidney transplant recipients.

Researchers found that the SF3a factor AtATO interacts with AtWDS1 to negatively regulate developmental and dark-induced leaf senescence in Arabidopsis thaliana.

The US ⁠Food and Drug Administration said ⁠on Friday it was investigating a ⁠risk of neoplasia, or tumour formation including malignancy, associated with Novartis’ gene therapy Zolgensma. The Swiss drug maker earlier in the day disclosed two cases in which tumours in children showed evidence of being linked to its gene therapy drug used to treat patients less than ‌two years old with spinal muscular atrophy. Novartis said that it had received nine reports overall of tumours in patients...

Ultragenyx will eliminate about 250 jobs, end Angelman and Wilson disease programs, and reduce research spending while continuing launches of two approved gene therapies.

Following a sizable release last month, Google Health is rolling out another big update with version 5.12. more…

A systematic review examines how deep learning algorithms analyze gigapixel whole-slide images to classify tumors and predict transcriptomic profiles directly from tissue morphology.

"Two cases to date have shown evidence of vector integration into the DNA of the patients. In both cases, the patients underwent treatment and continue to be monitored,” Novartis said in a statement. The post Novartis Confirms Nine Cases of Tumors in Children Treated with Gene Therapy Zolgensma appeared first on GEN - Genetic Engineering and Biotechnology News.

A prospective study of older elective cardiac surgery patients reveals that preoperative levels of cellular senescence proteins IGFBP-1 and IGFBP-4 independently predict multi-organ complications.

A review examines how CRISPR-edited mesenchymal stromal cells could advance bone and cartilage repair while noting that clinical translation remains hindered by safety challenges and a lack of trials.

The New England Journal of Medicine has published a study on the long-term efficacy of AAV8-mediated gene therapy (GNT0003) in patients with Crigler-Najjar syndrome, an extremely rare congenital liver disorder affecting approximately 500 people in Europe. It is caused by a deficiency of UGT1A1, an enzyme required for bilirubin metabolism. The accumulation of this substance can lead to irreversible neurological damage and, in the most severe cases, death.

Researchers report that restoring the chemical tag lysine crotonylation through sodium crotonate rejuvenates aging adipose-derived stem cells and improves their anti-inflammatory performance in a mouse model of colitis.

A transient thidiazuron flooding protocol stimulates high-frequency direct shoot regeneration across four recalcitrant grain legume species without producing visible intermediate callus.

Nanopit arrays promote greater cell spreading, focal adhesion maturation, and early osteogenic RUNX2 expression in human adipose-derived stem cells compared to nanopillar arrays.

Researchers are exploring fetal gene editing to treat rare genetic disorders before they cause lasting damage.

The first University of Dodoma scientific conference on health compiled research showing major gains in maternal survival and kidney transplantation alongside persistent gaps in diabetes control, postnatal care and health system infrastructure across Tanzania.

Fatty liver disease, or at least the non-alcohol induced side of fatty liver disease, more properly known as metabolic dysfunction-associated steatotic liver disease (MASLD) is largely an outcome of obesity. Obesity is now known to promote an accelerated age-related accumulation of senescent cells in many tissues. It is not surprising to find cellular senescence in liver cells as an important mechanism in the progression of MASLD to more severe and ultimately fatal liver conditions. Treating the consequences of obesity with senotherapeutics does not appear a priority for the research and development community, but in fairness a great many more severe conditions have not yet made it onto that still short priority list either. There are only so many researchers and entrepreneurs in the field, and […]

arXiv:2611.07918v1 Announce Type: new Abstract: Reasoning trajectories generated for the same problem often arrive at conflicting answers. These disagreements reveal alternative intermediate decisions that can be reused to explore new solutions. We introduce Adaptive Semantic Branching (ASB), a training-free inference procedure that turns cross-trajectory disagreement into targeted candidate generation. ASB first groups independently sampled trajectories by extracted final answer, selects a representative from each group, and aligns their reasoning steps with a monotonic dynamic program. A persistent-divergence objective identifies the point at which initially similar reasoning paths develop different continuations. For each selected directed pair, ASB retains the source trajectory's textual prefix, extracts a short reasoning window from a competing donor trajectory, and generates a fresh solution conditioned on both. A diversity-aware policy allocates up to three additional

A review in Clinical Epigenetics outlines experimental considerations and unresolved challenges for designing CRISPR-dCas9 epigenetic editing studies.

The study indicates AI can enhance cardiac MRI analysis and mortality prediction, yet its clinical benefits and cost-effectiveness need further investigation.

Hazırda 50-dən çox şəxs ürək transplantasiyası üçün gözləyir. Day.Az Trend-ə istinadən xəbər verir ki, bu barədə cümə günü ürək-damar cərrahı Kamran Musayev Ürək Transplantasiyası Həftəsi çərçivəsində Səhiyyə Nazirliyi tərəfindən media nümayəndələri üçün təşkil edilən seminarda çıxışı zamanı deyib.

A new review describes how reactive oxygen species promote regeneration at physiological levels but inhibit it at pathological concentrations.

A new study in Built Heritage proposes an analytical framework that treats Umbria's water mills as nodes of a historical territorial energy system and identifies paradigmatic models for their multifunctional regeneration.

A density gradient equilibrium analytical ultracentrifugation method using rubidium chloride achieved high-resolution separation and accurate quantification of the two highly similar full capsids in dual-AAV drug products.

An international analysis of 5218 liver transplant recipients across 61 centres shows that recipient characteristics, cold ischaemia time and centre volume predict survival, while donor factors have a minor impact.

A comprehensive expert review concludes that manual chamber counting and microscopic examination remain the gold standards for cerebrospinal fluid cytology, while artificial intelligence and telecytology require validated workflows before routine adoption.

A new study in Aging Cell shows that the DNA-remodeling enzyme TOP2A sustains Lamin B1 expression to preserve heterochromatin, and that its loss drives senescence in human mesenchymal stem cells and aging-like changes in mouse brain.

A new review highlights how CRISPR-based SHERLOCK diagnostics could bring rapid, highly sensitive testing for African trypanosomiases to remote clinics.

A new ex vivo platform derives temozolomide- and radiation-selected glioblastoma stem-like cells from the same primary tumor, exposing mismatch-repair loss, drug tolerance, adaptive DNA damage response and receptor tyrosine kinase remodeling as distinct resistance routes.

SK Biopharmaceuticals, a Korean firm focused on developing original prescription drugs, has built a massive artificial intelligence (AI) dataset of more than 7 million chemical entries to streamline candidate screening for new therapies. The project is part of the Ministry of Science and ICT’s program to develop AI foundation models for specific fields. A foundation model is a large AI model trained on vast amounts of data that can be adapted for many tasks. SK Biopharmaceuticals belongs to a medical and health care consortium led by medical AI firm Lunit, along with Trillion Labs, Kakao Healthcare and other companies, universities and hospitals. The consortium built a base model specialized in medical science. It then developed versions focused on three areas: drug development, covering chemical compounds and proteins; omics, the large-scale study of genes and other biological molecules; and clinical research. SK Biopharmaceuticals put together the drug discovery dataset based on what

A meta-analysis of fourteen observational studies found no statistically significant difference in prostate cancer risk between men with high and low Mediterranean diet adherence.

Acute full-sib mating in a black soldier fly strain colonized for over 64 generations caused no production collapse, but inbred adults lived shorter lives and larvae used feed less efficiently.

Researchers propose spatial path superposition, a no-cloning-compatible analogue of MIMO spatial diversity in which a quantum carrier is coherently delocalized over multiple links, enhancing fidelity and generating entanglement during propagation.

A narrative review published in Applied Sciences examined how urbanisation, time constraints, food costs, and changing lifestyles have contributed to declining adherence to the Mediterranean diet. Drawing on 116 references, the authors identified workplace and school interventions, nutrition education, physical activity, and Mediterranean-inspired convenience foods as potential strategies for adapting this dietary pattern to modern life.

A mouse study finds that conditioning transplant recipients, not donors, under chronic hypoxia prolongs heart allograft survival through a HIF2-dependent shift in circulating monocytes.

Genome editing is not designed to replace neurons or retinal cells that have already been lost. In this article, experts from four companies—eGenesis, Epicrispr, KOMO Biosciences, and Sumitomo Pharma America—discuss how they are moving beyond conventional CRISPR to develop novel approaches for treating disease. The post Beyond Conventional CRISPR appeared first on GEN - Genetic Engineering and Biotechnology News.

Personalized grafts, bioinks, and off-the-shelf tissues are advancing regenerative medicine toward broader clinical use. The post Tissue Engineering Takes Shape appeared first on GEN - Genetic Engineering and Biotechnology News.

The nonprofit biotech evaluates potential therapies based on unmet medical need, clinical evidence of safety and efficacy, and the compatibility of institutional partners. Its funding model combines initial seed investment with commercial revenue and non-traditional funding sources. The post Orphan Therapeutics Accelerator In-Licenses Its First Gene Therapy, Eyes Pipeline Expansion appeared first on GEN - Genetic Engineering and Biotechnology News.

A rat study reports that intravenous human umbilical cord mesenchymal stem cells improved liver function, reduced steatosis and fibrosis, and shifted serum metabolites linked to propanoate metabolism.

A new review argues that senescent cells and their inflammatory secretions may sustain chronic skin inflammation, with the strongest evidence in chronic and diabetic wounds and largely associative findings in psoriasis, atopic dermatitis, lupus, scleroderma, and vitiligo.

A new review outlines how CRISPR-based tools are being used to modify stress-responsive genes in rice and what still limits their use.

Bioethicist Jeremy Sugarman has outlined a seven-criterion ethical framework to guide the assessment, oversight, and conduct of basic stem cell-related research.

Patient-derived gallbladder cancer organoids faithfully reproduced tumor genetics and showed drug sensitivities that tracked with patient survival in a preliminary analysis.

A case report describes how calcineurin inhibitor-free, mTOR-based immunosuppression enabled successful CD19 CAR T-cell therapy in a kidney-pancreas transplant recipient with relapsed post-transplant lymphoproliferative disorder.

A new review maps how artificial intelligence could overcome resistance and safety barriers in cancer stem cell-targeted cellular immunotherapy, while stressing that most applications remain computational or preclinical.

AI chatbots are directing users to potentially misleading health information pushed by private medical providers, according to a new Simon Fraser University study published in BMJ Connections Digital Health & AI.

The human doctor and the artificial intelligence (AI) tool they are using more and more frequently are not always going to agree.

A new $6.9 million grant from the California Institute for Regenerative Medicine (CIRM) will support preclinical development of an investigational cell therapy for the heart created by USC Stem Cell scientists.

WASHINGTON — The U.S. Department of Agriculture (USDA) in Maryland has announced additional eligible practices for farmers participating in the Regenerative Pilot Program in fiscal year 2027, providing local agricultural producers with more opportunities to adopt conservation systems that improve soil health, water quality, and long-term farm resilience. Producers can now apply for assistance with […] The post NRCS Offers Additional Practices for Maryland Farmers Participating in the Regenerative Pilot Program appeared first on Morning Ag Clips.

A new review concludes that segment regeneration in polychaete annelids depends on both mesodermal regeneration cells and regenerating nerve fibres acting on the segment addition zone.

Targeting CRISPR–Cas9 at centromeric retrotransposons in hexaploid bread wheat reconfigured up to 11 chromosomes in a single generation, yielding translocations, isochromosomes and aneuploids.

Researchers report a dual-branch gated U-Net that removes motion artifacts from wearable ECG recordings while measurably preserving P and T wave morphology.

A retrospective study of 815 kidney transplant recipients found that primary care visits were associated with improved LDL cholesterol control and statin prescription, though not with mortality, hospitalization, or graft failure.

Ellipsis Health, a startup developing voice AI for healthcare, has acquired another company as demand for AI that can call patients heats up, Endpoints News learned exclusively. Ellipsis, which uses voice AI to screen and ...

Potential Sciences, a startup backed by the UK government, is betting that training AI models on computer-generated biochemical data can speed up the plodding process of developing new drugs.

Hormone replacement therapy is a popular treatment for women leading up to or following menopause. Manipulating sex hormones is a very blunt strategy, with potentially significant downsides, and a high variation in outcomes between patients, but the medical community has accumulated a great deal of experience in delivering this class of therapy. In the matter of assessing how this sort of approach affects aging, the research community is presently engaged in a process of gathering as much data as possible on how aging clocks interact with various therapies thought to influence aging or age-related disease. The accuracy of the clocks in the environment of any given therapy is unknown, and the effect of the therapy on the clock is unknown, and so the way forward […]

The update is expected to reduce false positives and allow game developers to use the tool for their own legitimate projects without getting blocked.

It is by now well established that senescent cells promote senescence in neighboring cells. This is a useful and necessary part of the benefits of the transient presence of senescent cells in the contexts of cancer suppression and coordination of wound healing. But when senescent cell clearance falters in later life, and senescent cells begin to linger and accumulate, this promotion of further senescence makes matters worse. One of the ways in which senescent cells promote senescence is via relatively well mapped and well understood inflammatory signaling. Here, however, researchers note that there are other pathways involved, in which the signaling involves the contents of small extracellular vesicles. Interfering in senescent cell signaling as a basis for therapy is likely a more challenging path forward […]

Voice phishing, or vishing, used to depend on a convincing script and a confident caller. In 2026 it

arXiv:2611.05127v2 Announce Type: replace Abstract: General-purpose generative AI (GenAI) models are being rapidly adopted in healthcare, but they are challenging to assess with traditional evaluation frameworks. These conceptual, methodological, and practical challenges parallel decades of work in evaluating clinician and health system quality and safety. We describe the adaptation of methods from several fields, combined with emerging technical approaches, into a structured, multi-method evaluation framework designed to give well-rounded assessments of GenAI in health at scale. The approach first anchors evaluation to Critical User Journeys (CUJs) to help prioritize out of a large choice space, and maps these to a phased AI system lifecycle (base model development, product development, and post-deployment monitoring), since evaluation at each stage requires different methodological approaches. In this context, the approach then integrates three distinct evaluation methods

arXiv:2611.04507v2 Announce Type: replace Abstract: AI agents can make incorrect decisions or waste resources even when their tools and infrastructure work normally. Their nondeterministic behavior makes these problems difficult to reproduce and diagnose. We developed Signals to identify such problems from agentic traces and suggest concrete remediations. We built the method around a taxonomy of 45 problem types across eight families, with definitions and evidence requirements for each type. The method distinguishes realized failures, risk exposures, and inefficiencies, groups related findings into engineering issues called Signals, and assesses their severity from the supporting evidence. Each Signal includes actions a developer can take and checks for evaluating the change. Further executions can add evidence to an existing Signal or reveal a new problem. We evaluated the method on public agent executions and achieved 91.43% F1 when matching Signals to reference issues, about 18

arXiv:2611.06306v1 Announce Type: cross Abstract: Spatial diversity is a key mechanism in classical Multi-Input Multi-Output (MIMO) communications, where multiple propagation alternatives provide redundant observations that improve reliability in noisy environments. A direct translation of this principle to quantum communications is forbidden by the no-cloning theorem, since an unknown quantum state cannot be copied and transmitted through independent links. In this Perspective article, we argue that spatial path superposition provides a no-cloning-compatible analogue of the spatial-diversity principle of MIMO. Rather than duplicating the transmitted quantum state, a quantum carrier is coherently delocalized over multiple communication links, so that alternative spatial evolutions are experienced in quantum superposition. In this framework, classical redundancy is replaced by spatial coherence, and the communication link itself becomes part of the quantum dynamics. Indeed, spatial

arXiv:2611.06296v1 Announce Type: new Abstract: Ambient sensors offer a privacy-preserving solution for activity recognition in smart homes, yet they face a critical challenge in multi-resident environments known as Data Association, which aims to identify the resident triggering a specific anonymous sensor event. Existing approaches fundamentally fail to maintain global consistency by often yielding conflicting associations for silent residents. Additionally, these methods frequently suffer from severe trajectory fragmentation caused by the ontological mismatch of applying continuous physical motion models to discrete logical behaviors. To address these limitations, we propose a novel framework that reformulates data association as a sequential decision-making task within a Markov Decision Process (MDP). We solve the defined MDP via Behavior Cloning (BC) to avoid complex reward engineering by directly learning from expert demonstrations. We instantiate the policy using two

arXiv:2611.05925v1 Announce Type: new Abstract: Quantifying glomerular inflammation in kidney-transplant biopsies is traditionally performed on single whole-slide sections using the Banff "most-severe section" rule, despite the inherently three-dimensional nature of lesion distribution. This 2D based assessment might lead to instability when inflammation varies across slices. This paper reports a feasibility study examining the technical feasibility and clinical relevance of extending Banff scoring into three dimensions. To this end, we propose a 3D Banff lesion-scoring framework that aligns serial sections, reconstructs glomerular identities across depth, and integrates inflammatory-cell counts in 3D under three scoring strategies: Compatible, Volumetric, and Deduplicated Volumetric. In the experiments, glomerulitis (g-scores) was used as an example Banff metric and applied to multi-section renal allograft biopsies. Our findings indicate that 3D Banff g-scores are more consistent

arXiv:2611.05638v1 Announce Type: new Abstract: Speaker-recognition benchmarks test how accurately a model recovers the speaker label of a recording, treating voice identity as a property of the person who produced it. However, these benchmarks do not evaluate how humans perceive voice identity. Whether a listener hears two voices as the same person has consequences for intellectual property rights, cybersecurity, and everyday life. We introduce the Voice Identity Perception benchmark (VIPBench), which contains 124,876 same-or-different judgments from 1,290 listeners on 9,800 recording pairs from 100 public figures. The pairs include real recordings, voice clones generated by a text-to-speech system, and morphs between two speakers' voices. We also define four tasks that evaluate the alignment between speaker-representation models and human identity perception. The first two tasks measure how well a model's similarity score predicts the proportion of listeners who respond "same" and

The system, MAI-DxO, was not only more accurate, but it also spent much less on tests to make its diagnoses. The post Microsoft’s Medical AI Is Over Twice as Good Diagnosing Diseases as Doctors appeared first on SingularityHub.

A UCLA-led team has described how they advanced an experimental CRISPR approach for sickle cell disease into a blood stem cell therapy that can be manufactured at the scale and quality required for a clinical trial.

A stable-pool strategy can move cell line development off the critical path to Phase I while preserving a path to a conventional clonal cell line as a program matures. The post Rethinking the Clone-First Paradigm for First-in-Human Biologics appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers found that the gene preserves bone stem cell supply throughout life, and say the discovery advances understanding of stem cell biology and could indicate potential therapeutic approaches to improve bone healing and regeneration in aging and disease. The post Gene That Preserves Bone Stem Cell Supply Throughout Life Identified appeared first on GEN - Genetic Engineering and Biotechnology News.

Bloomberg: Sources: Google DeepMind spinout Isomorphic Labs is in talks to raise ~$5B at a ~$50B valuation; the AI drug discovery startup last raised $2.1B in May  —  Alphabet Inc.'s Isomorphic Labs is in talks to raise roughly $5 billion in new funds to support its efforts to use artificial intelligence …

A UCLA-led team has described how it advanced an experimental CRISPR approach for sickle cell disease into a blood stem cell therapy that can be manufactured at the scale and quality required for a clinical trial.

A new study protocol details the TACMONO-XL trial, which will randomize 306 kidney transplant recipients aged 60 and older to tacrolimus monotherapy or standard triple immunosuppression to test effects on infection-related death and quality of life.

A phase 1 trial found that a pill of 16 selected beneficial bacteria was safe for stem cell transplant patients and was associated with fewer bloodstream infections.

Researchers built a cell-lined silicone blood vessel large enough to hold a real stent and quantified how endothelial cells recolonize the device under controlled blood-flow conditions.

Kamau Therapeutics, which has stayed relatively quiet since its 2023 emergence, is sharing clinical data from its revamped sickle cell gene editing program for the first time. The startup is giving a ...

Utah has become the first state to let an artificial intelligence (AI) program prescribe medication without a doctor writing the prescription, starting with acne treatments.

Rice University's Han Xiao has used his AI-supported Sequence Display technology to expand the targeting abilities of CRISPR/Cas9. In a paper recently published in Nature Communications, Xiao evolved several variants of a compact Cas9 that could efficiently target stretches of DNA previously inaccessible for editing. The research included a proof-of-concept study in which the evolved Cas9s were successfully used to edit two genes found in coronary heart disease.

We all want a well-functioning immune system to help us fight invasive bacteria and viruses and recover faster from illness. Popular "immune-boosting" ideas, however, might be more of a hindrance than a help.

The action of a key gene is required to maintain a lifelong supply of stem cells that make bone healing possible, a new study finds.

Tuesday, November 17, 2026 In an effort to reach an elusive continuity of the self, some far-thinking technologists are working on ways to keep your brain going—even beyond death. Join science editor Mary Beth Griggs and senior editor for biomedicine Antonio Regalado for a conversation exploring possible paths to keep your mind going, including gradual…

Cryo-electron microscopy structures of the zebra finch R2 retrotransposon, alone and bound to Cas9, reveal how target-primed reverse transcription initiates and guided the engineering of an enhanced STITCHR gene-integration system.

A study of 56 end-stage non-CF bronchiectasis patients referred for lung transplantation evaluation found group 3 pulmonary hypertension in 73.2 percent and significantly higher mortality among those affected.

WEDNESDAY, Nov. 4, 2026 — Utah has become the first state to let an artificial intelligence (AI) program prescribe medication without a doctor writing the prescription, starting with acne treatments.New York City-based Nolla Health began offering...

An interpretable pathomics framework predicted BRAF V600E status in papillary thyroid carcinoma from routine Wright-stained cytology slides, reaching an AUC of 0.925 on pooled independent test data across two centers.

A multi-omics study shows that lactate produced by senescent breast cancer cells drives the SASP through histone H3 lactylation at inflammatory gene loci.

A CT-based AI system reduced benign interventions among treated kidney lesions from 40.3 percent to 16.4 percent in a randomized implementation trial while improving radiologist accuracy and reading speed.

A GIS and AI-assisted planning framework tested on aging districts in Sharjah and Ajman proposes walkable street networks, land-bank reuse, parking consolidation and pocket greens without greenfield expansion.

Chick satellite cells from breast and leg muscles show opposite patterns of proliferation and differentiation when cultured under identical conditions, a new study finds.