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Researchers found that Wei-Mi-Shu Decoction reduced stomach injury and preserved regenerative stem cells in rat models of chronic gastritis.

A review in the Journal of Translational Medicine examines how mesenchymal stem cells may slow amyotrophic lateral sclerosis progression through immune modulation despite mixed clinical trial outcomes.

Stem cell-derived exosomes improved memory deficits in a rat model of Alzheimer’s disease, though adding the p38γ gene provided no additional benefit.

A narrative review evaluates engineering strategies, stability limits, and standardized benchmarks required to extend the storage of isolated mitochondria for clinical transplantation.

Researchers have identified a specific metabolic-inflammatory mechanism that drives follicular arrest in polycystic ovary syndrome (PCOS), a condition recognized as the leading cause of anovulatory infertility.

A systematic review of randomized controlled trials found that fecal microbiota transplantation does not show a statistically clear short-term benefit for intestinal decolonization of multidrug-resistant organisms.

A multinational study finds that ATTR-CM patients prioritize treatments that extend life and enable enjoyable activities over basic self-care, with once-daily oral administration being the most preferred mode.

Clinicians at the Royal Melbourne Hospital developed and evaluated an annual WhatsApp-based educational group to train nephrology fellows in assessing deceased donor organ offers.

Researchers in Uganda have developed a multitask multimodal artificial intelligence model that improves tuberculosis diagnosis, lesion detection, and report generation from chest radiographs.

A four-year field trial in Norway demonstrates that amending degraded agricultural soil with organic compost significantly increases wheat yields, replenishes soil organic carbon, and enhances beneficial microbial diversity compared to commercial organic fertilizer alone.

A commentary in Health Research Policy and Systems highlights that fewer than half of 3,560 surveyed United States hospitals use predictive artificial intelligence tools and that adoption is lower in high-need communities, arguing that learning health systems are necessary to support continuous evaluation, bias monitoring, and equitable integration.

Researchers at the Universidad de Chile have demonstrated that transplanting rhizosphere microbial communities from drought-tolerant tomato plants can significantly enhance the recovery of susceptible tomato varieties following a drought event.

The dominant forms of cancer therapy, chemotherapy and radiotherapy, induce senescence in cancer cells they cannot kill, as well as in non-cancerous cells exposed to the treatment. Entering the senescent state is a response to a high level of stress and damage that isn't sufficient to kill the cell. A senescent cancer cell no longer replicates, and so promoting senescence continues to be seen as an acceptable goal to hinder the cancer. Cancer survivors are left with a high burden of cellular senescence, however, and as a result exhibit accelerated aging: higher mortality, higher risk of age-related conditions, including other cancers. Senotherapeutics such as senolytic drugs to selectively destroy senescent cells offer the possibility of dramatically reducing the consequences of an increased burden senescence induced […]

A new study in Genes & Nutrition shows that short-term caloric restriction partially reprograms immune and microbial networks in mice with acute colitis, suggesting a potential non-pharmacological adjunct for inflammatory bowel disease.

arXiv:2611.09553v1 Announce Type: new Abstract: In clone-censor-weight (CCW) analyses, inverse probability of censoring weighting corrects selection from artificial censoring at protocol deviation. Balance diagnostics, such as the end-of-grace between-strategy standardised mean difference (SMD) and censoring balance, compare different populations, and their zero targets under a correct model are not formally stated. We show that, under positivity and a correct censoring model, the weighted retained individuals reconstruct the risk set before each censoring interval and the baseline population, and we propose risk-set reconstruction balance (RRB), which measures how far they depart from these two populations. Interval RRB has a zero target for every history function, including post-baseline covariates, for which between-strategy SMDs have none. Cumulative RRB keeps a zero target for baseline covariates after outcome events, whereas the end-of-grace SMD acquires a depletion term. In

arXiv:2611.09647v1 Announce Type: new Abstract: People increasingly bring mental-health concerns to consumer AI chatbots. In these conversations, clinically relevant information rarely arrives all at once. Instead, it unfolds over multiple turns, often in response to the questions the chatbot asks. Recognizing risk therefore depends on how a chatbot integrates newly disclosed information (inference) and on the questions it asks on each turn to elicit this information (context-seeking). Here we evaluated the conversational triage performance of 13 frontier AI chatbots tasked with engaging in 10-turn conversations with simulated users. Simulated users were grounded in one of 112 structured mental-health case files, each with an associated clinician-validated urgency level, from routine care to emergency. Chatbots failed to recognize one in five mental-health emergencies (20.3%), nearly four times the failure rate when all relevant clinical details were presented in a single message

arXiv:2611.08662v1 Announce Type: new Abstract: We consider the nonlinear Hardy-H\'enon parabolic equation $ u_t=\Delta u+|x|^l|u|^\alpha u,$ $t>0,$ $x\in\mathbb{R}^N$ or $x\in\mathbb{R}^N\setminus\{0\}$, with $N\ge1$, $l>-\min\{2,N\}$, $\alpha>0$, with nonnegative initial datum $u_0$. We first establish new criteria for finite-time blow-up. We then derive optimal upper bounds for the life-span $T_{\max}(\lambda\varphi)$ of solutions arising from the initial datum $u_0=\lambda\varphi$. These estimates establish a precise dependence of $T_{\max}(\lambda\varphi)$ on both the initial profile $\varphi$ and the parameter $\lambda$ in the small and large-amplitude regimes.

arXiv:2611.09371v1 Announce Type: new Abstract: We consider offline imitation learning (IL), which aims to train an agent to imitate from the dataset of expert demonstrations without online interaction with the environment. Behavioral Cloning (BC) has been a simple yet effective approach to offline IL, but it is also well-known to be vulnerable to the covariate shift resulting from the mismatch between the state distributions induced by the learned policy and the expert policy. Moreover, as often occurs in practice, when expert datasets are collected from an arbitrary state distribution instead of a stationary one, these shifts become more pronounced, potentially leading to substantial failures in existing IL methods. Specifically, we focus on covariate shift resulting from arbitrary state data distributions, such as biased data collection or incomplete trajectories, rather than shifts induced by changes in dynamics or noisy expert actions. In this paper, to mitigate the effect of the

arXiv:2611.09298v1 Announce Type: new Abstract: Long-term particle physics experiments face critical operational challenges: monitoring non-stationary machine data streams and preserving tacit expert knowledge. We present the "Helmholtz Co-Pilot," a hybrid Multi-Agent System (MAS) acting as an autonomous experiment steward. The system can be triggered interactively by human operators or autonomously by an asynchronous causal diagnostics engine that runs independently of the MAS reasoning core. Continuously monitoring live hardware streams such as data acquisition and slow control, this engine performs dynamic causal discovery to trace cascading alarms back to their root causes and applies adaptive model selection to keep forecasts reliable across shifting machine states; upon detecting an anomaly, it hands a structured diagnostic report to the MAS. The reasoning layer itself relies on a high-throughput C++ core and a Python edge architecture orchestrating a directed acyclic graph

arXiv:2611.08854v1 Announce Type: new Abstract: While there is an abundance of research into large language model (LLM) biases against LGBTQ+ communities, far less research has examined how and why LGBTQ+ people choose to make use of AI chatbots. In this work, we examine how LGBTQ+ people choose (not) to use AI chatbots across three domains in which LGBTQ+ users have unique needs: relationship support, mental health support, and gender or sexual health support. We surveyed 73 people (60 LGBTQ+; 13 non-LGBTQ+) on how they interact with AI chatbots and find that participants' access to external resources, privacy concerns, and perceptions of chatbot capabilities shape whether and how they choose to make use of AI chatbots. For instance, some LGBTQ+ participants felt that chatbots might actually be less biased against LGBTQ+ people than the people they know offline. We also find that LGBTQ+ participants report using AI chatbots less frequently than non-LGBTQ+ participants across 15

arXiv:2611.08721v1 Announce Type: new Abstract: Evaluations of large language models (LLMs) for mental health support commonly focus on the clinical appropriateness of individual responses, potentially overlooking failures that emerge across extended interactions. As AI assistants accumulate memory of users' circumstances and prior disclosures, this raises an accountability question: Do AI chatbots provide appropriate support as users' needs evolve? We investigate by analyzing 14,256 longitudinal simulations grounded in donated chatbot histories from 22 users, examining how a memory-equipped assistant responds to suicidal ideation, self-harm, and anxiety crises across recovery trajectories and communication styles. We introduce the Context-Aware and Readiness-Evaluative (CARE) framework, developed with mental health professionals, to assess the timing and quality of advice, including omissions. Advice was less aligned with users' readiness after a crisis than in matched control

Google and Israel’s Clalit Health Services join forces on artificial intelligence for five million patients, bridging health gaps in diverse communities.

By MANUEL PINILLA Every few months a new study reports that an AI model has outperformed doctors on a set of diagnostic cases. The latest one I’ve read came out in ScienceContinue reading...

Researchers have successfully extruded biodegradable polyhydroxybutyrate composite filaments blended with modified starch to fabricate three-dimensional scaffolds using fused deposition modeling.

Hwang Woo-suk, the disgraced South Korean scientist dismissed from Seoul National University over a stem cell research fabrication scandal, has lost his Korean citizenship after acquiring nationality in the United Arab Emirates (UAE), it was belatedly revealed. His loss of Korean citizenship took effect seven months ago, in April. According to the government's electronic gazette on Monday, Hwang's name appeared on a list of individuals who had lost their Korean nationality, published by the Cheongju Immigration Office under the Ministry of Justice on Aug. 13. The list included a man named Hwang Woo-suk, born in 1953 in Buyeo, South Chungcheong Province. His birthplace and year of birth strongly suggest that he is the former Seoul National University professor. The notice listed April 9 as the date he lost his Korean citizenship, citing his acquisition of UAE nationality. Under Article 15 of Korea's Nationality Act, Korean citizens automatically lose their nationality upon voluntarily

Marine scientists monitoring commercial Atlantic salmon pens in Scotland have demonstrated that automated artificial intelligence systems can detect the emergence of debilitating gill disease by tracking shifts in collective swimming behaviour.

A retrospective four-patient case series suggests balloon flotation pacing may offer a feasible rescue strategy for severe post-reperfusion cardiovascular collapse during adult liver transplantation.

Researchers found that the conserved gene Djvcp coordinates neoblast proliferation and apoptosis to maintain tissue homeostasis and enable blastema formation during planarian regeneration.

A cross-sectional study of 6,717 US adults finds that serum total bilirubin statistically mediates 13.2% of the association between obesity and leukocyte telomere shortening.

A study examining 9,000 Google search results across 30 European countries found that 36.3% of links to online medicine sellers led to illegal vendors, rising to nearly 77% for controlled substances. Countries that permitted legitimate online medicine sales generally had fewer illegal vendors among highly ranked search results than countries that prohibited such sales, although the observational findings do not establish causation.

A systematic review and meta-analysis found that exosome-functionalized scaffolds significantly improved bone volume fraction and bone mineral density in preclinical bone defect models.

A new artificial intelligence framework improves connected vehicle predictive maintenance by fusing internal diagnostic telemetry with external environmental and behavioural signals.

A study in the Journal of Translational Medicine reveals that Realgar eliminates triple-negative breast cancer stem cells by degrading the epigenetic repressor ANP32A, thereby triggering ferroptosis.

Researchers developed titanium-spongin composites by metallizing marine sponge scaffolds, showing enhanced osteoblast activity and cytocompatibility for tissue engineering.

A scientific review details how CRISPR-Cas9 gene editing is advancing through preclinical models and early clinical trials to regenerate insulin-producing beta-cells and provide immune protection in diabetes.

A decade-long seed bank study of native Korean Rhododendron species reveals that identical deep-freeze conditions produce starkly different rates of viability loss among closely related orthodox seeds.

An in vitro study demonstrates that transplanted healthy mitochondria integrate into MELAS endothelial cells, improving cellular energetics and reducing mutant mitochondrial DNA load.

Researchers discover that tailoring hydrogel stiffness to specific native tissues suppresses cellular senescence through integrin alpha-1 and YAP signaling pathways.

A study finds a near-zero gene-level rank association between hypothalamic stem cell microRNA targets and hypothalamic aging transcriptomes.

In the final instalment of a four-part Health Matters wellness series on frontier medicine in Hong Kong, Elizabeth Cheung examines a dual-arm surgical robot that could remove gastrointestinal tumours in about half the usual time, and the hurdles between its first human trials and wider patient access. Ho Man-wai underwent a colonoscopy in late August, during which doctors identified three polyps that needed to be removed before they could develop into cancer. Two were removed during the initial...

A case report documents high-dose 131I-MIBG therapy followed by autologous stem cell transplantation in a 35-year-old man with metastatic neuroblastoma lacking an identifiable primary tumor, alongside a systematic review of only four prior adult cases.

A comparative study of six artificial intelligence chatbots found their pediatric oral health materials consistently exceeded recommended reading levels.

Human cortical organoids show that ASPM mutations prematurely displace and impair the specification of outer radial glia cells, explaining why humans are uniquely sensitive to microcephaly.

A cross-sectional survey of 310 health science students found frequent AI use linked to higher self-reported GPA, while 82.6% received no formal AI instruction and 61% voiced ethical concerns.

A new international study shows that early invasive procedures for stable heart disease do not improve long-term survival compared to drug therapy and lifestyle changes.

A review published in Med-X highlights advanced nanotechnology and cell-based delivery platforms designed to overcome the specificity and toxicity limitations of therapies targeting cellular senescence.

A review in Aging Cell proposes that senescent mesenchymal stromal cells drive stem cell aging by dysregulating chemokine synthesis, disrupting niche homeostasis and reducing regenerative capacity.

A comprehensive review details how smart biomaterials responsive to endogenous biochemical signals and external physical triggers modulate immune microenvironments to drive periodontal tissue regeneration.

A study of 163 FDA-cleared AI medical devices found that one-third received algorithm updates, while 85.7% of updated devices reported no clinical or organizational benefit data.

A retrospective cohort study found that a five-day catheter-based rectus sheath block was associated with significantly lower early postoperative fentanyl consumption after liver transplantation without increasing pain burden.

Weill Cornell says clinical information from some radiology patients was entered into AI tools without authorization during a June research study; the number affected and tools used remain unknown.

A study in Cellular and Molecular Neurobiology identifies hippocampal senescence-like alterations in a maternal deprivation rat model, linking them to candidate genomic instability and epigenetic pathways relevant to autism spectrum disorder.

Volume 43 of SLAS Discovery presents AI-guided screening, automated platforms and new cell-based assays that accelerate drug discovery across infectious disease, oncology and rare genetic disorders.

Whole-genome sequencing of human embryonic stem cells over 40 passages found low mutation burdens dominated by clock-like and oxidative stress signatures, with one unresolved BCOR frameshift variant detected late in culture.

Little Giant is recalling about 3.66 million ladders after 19 injury reports, including head injuries, from sudden retractions. How to check yours.

A multi-tissue metabolomic analysis reveals that five distinct lifespan-extending interventions induce shared metabolic reprogramming in male mice well before survival differences emerge.

A study of more than 53,000 participants and experimental animal models found that elevated circulating ANGPTL4 predicts chronic kidney disease risk and accelerates disease progression by inducing tubular cell senescence.

A comparative study found that generative AI tools produced preliminary literature summaries on social determinants of periodontal disease in U.S. adults but did not match human-led systematic review fidelity.

A structured review of clinical evidence from 2024 through 2026 evaluates the oncological outcomes, functional preservation, and implementation requirements of robotic platforms, perfusion imaging, and advanced reconstruction in colorectal cancer surgery.

Researchers have demonstrated that chemically recycled ABS shows a cytocompatibility profile comparable to certified medical-grade ABS for fused deposition modeling of non-implantable medical devices.

A large retrospective study of kidney transplant recipients followed for over a decade found that long-term rapamycin treatment was not associated with improved human longevity after adjusting for patient differences.

A multi-stage study reveals that resistant hypertension is linked to cellular senescence and vascular stiffening driven by dysregulated PTEN and AKT signaling.

A randomized trial in lung transplant recipients found that switching from twice-daily to once-daily extended-release tacrolimus does not reduce objective or subjective tremor severity over two years.

Thicker right anterior perirenal fat on routine pre-transplant CT scans was independently associated with post-transplant diabetes mellitus in a retrospective cohort of 202 kidney transplant recipients.

Researchers found that the SF3a factor AtATO interacts with AtWDS1 to negatively regulate developmental and dark-induced leaf senescence in Arabidopsis thaliana.

The US ⁠Food and Drug Administration said ⁠on Friday it was investigating a ⁠risk of neoplasia, or tumour formation including malignancy, associated with Novartis’ gene therapy Zolgensma. The Swiss drug maker earlier in the day disclosed two cases in which tumours in children showed evidence of being linked to its gene therapy drug used to treat patients less than ‌two years old with spinal muscular atrophy. Novartis said that it had received nine reports overall of tumours in patients...

Ultragenyx will eliminate about 250 jobs, end Angelman and Wilson disease programs, and reduce research spending while continuing launches of two approved gene therapies.

Following a sizable release last month, Google Health is rolling out another big update with version 5.12. more…

A systematic review examines how deep learning algorithms analyze gigapixel whole-slide images to classify tumors and predict transcriptomic profiles directly from tissue morphology.

"Two cases to date have shown evidence of vector integration into the DNA of the patients. In both cases, the patients underwent treatment and continue to be monitored,” Novartis said in a statement. The post Novartis Confirms Nine Cases of Tumors in Children Treated with Gene Therapy Zolgensma appeared first on GEN - Genetic Engineering and Biotechnology News.

A prospective study of older elective cardiac surgery patients reveals that preoperative levels of cellular senescence proteins IGFBP-1 and IGFBP-4 independently predict multi-organ complications.

A review examines how CRISPR-edited mesenchymal stromal cells could advance bone and cartilage repair while noting that clinical translation remains hindered by safety challenges and a lack of trials.

The New England Journal of Medicine has published a study on the long-term efficacy of AAV8-mediated gene therapy (GNT0003) in patients with Crigler-Najjar syndrome, an extremely rare congenital liver disorder affecting approximately 500 people in Europe. It is caused by a deficiency of UGT1A1, an enzyme required for bilirubin metabolism. The accumulation of this substance can lead to irreversible neurological damage and, in the most severe cases, death.

Researchers report that restoring the chemical tag lysine crotonylation through sodium crotonate rejuvenates aging adipose-derived stem cells and improves their anti-inflammatory performance in a mouse model of colitis.

A transient thidiazuron flooding protocol stimulates high-frequency direct shoot regeneration across four recalcitrant grain legume species without producing visible intermediate callus.

Nanopit arrays promote greater cell spreading, focal adhesion maturation, and early osteogenic RUNX2 expression in human adipose-derived stem cells compared to nanopillar arrays.

Researchers are exploring fetal gene editing to treat rare genetic disorders before they cause lasting damage.

The first University of Dodoma scientific conference on health compiled research showing major gains in maternal survival and kidney transplantation alongside persistent gaps in diabetes control, postnatal care and health system infrastructure across Tanzania.

Fatty liver disease, or at least the non-alcohol induced side of fatty liver disease, more properly known as metabolic dysfunction-associated steatotic liver disease (MASLD) is largely an outcome of obesity. Obesity is now known to promote an accelerated age-related accumulation of senescent cells in many tissues. It is not surprising to find cellular senescence in liver cells as an important mechanism in the progression of MASLD to more severe and ultimately fatal liver conditions. Treating the consequences of obesity with senotherapeutics does not appear a priority for the research and development community, but in fairness a great many more severe conditions have not yet made it onto that still short priority list either. There are only so many researchers and entrepreneurs in the field, and […]

arXiv:2611.07918v1 Announce Type: new Abstract: Reasoning trajectories generated for the same problem often arrive at conflicting answers. These disagreements reveal alternative intermediate decisions that can be reused to explore new solutions. We introduce Adaptive Semantic Branching (ASB), a training-free inference procedure that turns cross-trajectory disagreement into targeted candidate generation. ASB first groups independently sampled trajectories by extracted final answer, selects a representative from each group, and aligns their reasoning steps with a monotonic dynamic program. A persistent-divergence objective identifies the point at which initially similar reasoning paths develop different continuations. For each selected directed pair, ASB retains the source trajectory's textual prefix, extracts a short reasoning window from a competing donor trajectory, and generates a fresh solution conditioned on both. A diversity-aware policy allocates up to three additional

A review in Clinical Epigenetics outlines experimental considerations and unresolved challenges for designing CRISPR-dCas9 epigenetic editing studies.

The study indicates AI can enhance cardiac MRI analysis and mortality prediction, yet its clinical benefits and cost-effectiveness need further investigation.

Hazırda 50-dən çox şəxs ürək transplantasiyası üçün gözləyir. Day.Az Trend-ə istinadən xəbər verir ki, bu barədə cümə günü ürək-damar cərrahı Kamran Musayev Ürək Transplantasiyası Həftəsi çərçivəsində Səhiyyə Nazirliyi tərəfindən media nümayəndələri üçün təşkil edilən seminarda çıxışı zamanı deyib.

A new review describes how reactive oxygen species promote regeneration at physiological levels but inhibit it at pathological concentrations.

A new study in Built Heritage proposes an analytical framework that treats Umbria's water mills as nodes of a historical territorial energy system and identifies paradigmatic models for their multifunctional regeneration.

A density gradient equilibrium analytical ultracentrifugation method using rubidium chloride achieved high-resolution separation and accurate quantification of the two highly similar full capsids in dual-AAV drug products.

An international analysis of 5218 liver transplant recipients across 61 centres shows that recipient characteristics, cold ischaemia time and centre volume predict survival, while donor factors have a minor impact.

A comprehensive expert review concludes that manual chamber counting and microscopic examination remain the gold standards for cerebrospinal fluid cytology, while artificial intelligence and telecytology require validated workflows before routine adoption.

A new study in Aging Cell shows that the DNA-remodeling enzyme TOP2A sustains Lamin B1 expression to preserve heterochromatin, and that its loss drives senescence in human mesenchymal stem cells and aging-like changes in mouse brain.

A new review highlights how CRISPR-based SHERLOCK diagnostics could bring rapid, highly sensitive testing for African trypanosomiases to remote clinics.

A new ex vivo platform derives temozolomide- and radiation-selected glioblastoma stem-like cells from the same primary tumor, exposing mismatch-repair loss, drug tolerance, adaptive DNA damage response and receptor tyrosine kinase remodeling as distinct resistance routes.

SK Biopharmaceuticals, a Korean firm focused on developing original prescription drugs, has built a massive artificial intelligence (AI) dataset of more than 7 million chemical entries to streamline candidate screening for new therapies. The project is part of the Ministry of Science and ICT’s program to develop AI foundation models for specific fields. A foundation model is a large AI model trained on vast amounts of data that can be adapted for many tasks. SK Biopharmaceuticals belongs to a medical and health care consortium led by medical AI firm Lunit, along with Trillion Labs, Kakao Healthcare and other companies, universities and hospitals. The consortium built a base model specialized in medical science. It then developed versions focused on three areas: drug development, covering chemical compounds and proteins; omics, the large-scale study of genes and other biological molecules; and clinical research. SK Biopharmaceuticals put together the drug discovery dataset based on what

A meta-analysis of fourteen observational studies found no statistically significant difference in prostate cancer risk between men with high and low Mediterranean diet adherence.

Acute full-sib mating in a black soldier fly strain colonized for over 64 generations caused no production collapse, but inbred adults lived shorter lives and larvae used feed less efficiently.

Researchers propose spatial path superposition, a no-cloning-compatible analogue of MIMO spatial diversity in which a quantum carrier is coherently delocalized over multiple links, enhancing fidelity and generating entanglement during propagation.

A narrative review published in Applied Sciences examined how urbanisation, time constraints, food costs, and changing lifestyles have contributed to declining adherence to the Mediterranean diet. Drawing on 116 references, the authors identified workplace and school interventions, nutrition education, physical activity, and Mediterranean-inspired convenience foods as potential strategies for adapting this dietary pattern to modern life.

A mouse study finds that conditioning transplant recipients, not donors, under chronic hypoxia prolongs heart allograft survival through a HIF2-dependent shift in circulating monocytes.

Genome editing is not designed to replace neurons or retinal cells that have already been lost. In this article, experts from four companies—eGenesis, Epicrispr, KOMO Biosciences, and Sumitomo Pharma America—discuss how they are moving beyond conventional CRISPR to develop novel approaches for treating disease. The post Beyond Conventional CRISPR appeared first on GEN - Genetic Engineering and Biotechnology News.