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An editorial on a Frontiers Research Topic argues that smart biomaterials and additive manufacturing must be tied to measurable, reproducible functional validation.

A Nature Communications study finds large reasoning models make more accurate primary diagnoses than standard language models but produce over 34 percent more false positives, with physician collaboration improving outcomes.

A cell-culture study reports that prodigiosin reduced apoptosis and oxidative stress in BMSCs exposed to chemically induced hypoxia, with effects linked to HIF-1α/YAP-associated signaling.

Researchers report generating human chemically induced pluripotent stem cells from umbilical cord-derived mesenchymal stem cells using an optimized small-molecule protocol under normal oxygen conditions.

A 12-week randomized trial found that multi-strain probiotic supplementation did not improve arterial stiffness or central blood pressure beyond an energy-restricted diet in adults with hypertension and overweight or obesity.

A study of two Vojvodina farms finds regenerative management can match conventional yields, though short-term profits remain unstable.

A new review finds CRISPR engineering can sharply raise carotenoid yields in microalgae, yet these gains mostly redistribute carbon rather than increase net CO2 fixation.

An integrated blood and CSF multi-omics analysis of the SMART-MS randomized trial found that intrathecal mesenchymal stem cell therapy in progressive multiple sclerosis was associated mainly with compartmentalized CSF proteomic changes rather than broad systemic immune alterations.

A new Cellular Oncology study shows that the enzyme PLA2G2A drives gallbladder cancer progression by promoting cancer stemness through PLA2R1, FLNA and ERK1/2 signaling while inducing soluble PD-L1 secretion that sustains an immunosuppressive tumor microenvironment.

Scientists used CRISPR/Cas9 to disrupt the tyr and oca2 pigmentation genes in zebrafish, reducing melanophores and visibly altering coloration in F0 and F1 mutants.

A new narrative review argues that generative AI simultaneously produces, detects, corrects, and amplifies the consequences of health misinformation across a recursive lifecycle.

A new review argues that mushrooms and the antioxidant L-ergothioneine show anti-aging effects in laboratory models, while human evidence remains largely observational.

A case report describes a 64-year-old woman with multiple myeloma and an SCN5A overlap channelopathy who underwent autologous stem cell transplantation without arrhythmic events under a structured risk mitigation strategy.

Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state in vitro, with the effect reversible on drug withdrawal.

Silencing β-catenin1 in the flatworm Macrostomum lignano blocks tail regeneration and blastema formation, but unlike in planarians it never induces head regeneration, revealing that the head-rescuing response is a planarian specialization rather than an ancestral flatworm trait.

A new review argues that neural stem cells may aid spinal cord injury recovery mainly by reprogramming macrophages and other immune cells rather than replacing lost neurons.

The FDA says Calibrate IV Hydration marketed unapproved stem cell and exosome products. The warning highlights regulatory concerns and questions consumers should ask before receiving an infusion.

A retrospective study of 29 severe systemic sclerosis patients found that autologous hematopoietic stem cell transplantation reduced epidermal thickness and lowered several serum markers of epithelial activation six months after treatment.

A new review in Epigenetics & Chromatin argues that incomplete epigenetic reprogramming remains the main barrier to efficient mammalian cloning by somatic cell nuclear transfer.

A new study of 14 Microcoleus species finds that CRISPR–Cas systems are widespread but do not follow species phylogeny, pointing to repeated gain, loss and exchange of components through gene flow.

A mouse study found that hematopoietic stem cells engrafted during active bone marrow regeneration showed superior long-term reconstitution compared with cells engrafted after myeloablative conditioning.

A large EBMT registry analysis of 3385 adults with AML in remission and measurable residual disease found that haploidentical transplantation with post-transplant cyclophosphamide was associated with lower relapse incidence than matched sibling or matched unrelated donor transplants, though overall survival was similar across donor types.

A new study maps about 1,100 sites where PRC2 rapidly re-establishes itself in mouse embryonic stem cells after reversible depletion of the core subunit Suz12.

Engineered three-dimensional muscle bundles grown from pediatric patients with juvenile dermatomyositis, immune-mediated necrotizing myopathy, and arthritis-related weakness show measurable donor-specific functional and structural differences in a proof-of-concept study.

A new review argues that the hip's cotyloid fossa fat pad is a promising but still uncharacterized source of therapeutic stem cells, using the knee's well-studied infrapatellar fat pad as its benchmark.

A new open-access study reports that fusing attribute features with graph structure and training classifiers collaboratively reached 0.724 accuracy on MIMIC-III data with only 10% annotation, an 18.3% relative improvement over support vector machines.

Researchers surveyed 24,132 students in England and found that 2.7% had used general-purpose AI for mental health support during the previous year. Among users who answered the relevant questions, 55.9% rated the support helpful, yet 63.2% wanted additional assistance, with greater unmet needs reported among adolescents experiencing mental health difficulties and social adversity.

A hybrid classical-quantum support vector machine trained on more than 14,000 maternal records from Uganda and Pakistan predicted mental health risk competitively with the best classical models while SHAP explanations identified clinically meaningful predictors.

A new Perspective proposes VERSION-AI, a two-axis framework for deciding when updates to medical AI systems require renewed clinical evidence.

A new review synthesizes the signaling pathways, extracellular matrix cues, metabolic switches and transcription factors that govern cardiomyocyte proliferation and cardiac repair after injury.

A genomic survey of thirteen complete Kluyvera genomes found that only Kluyvera ascorbata strain SK carries a complete type I-E CRISPR-Cas locus, whose spacers mostly match plasmid sequences from related enteric bacteria.

Researchers developed AMHART, a clinician-informed tool that found chatbot responses covered more guideline-informed criteria for anxiety than depression and for moderate rather than severe adolescent presentations.

A new review examines how Schwann cells grown from human pluripotent stem cells are being used to model peripheral neuropathies and where the platform still falls short.

A WHO forum meeting report argues that global data standards such as FHIR, SNOMED CT, LOINC, and ICD are essential for pandemic intelligence and cross-border health data exchange.

A mini review used Swiss Target Prediction to map the probable protein targets of seven major classes of antidiabetic drugs used in type 2 diabetes.

Researchers built a seven-gene tumor stemness signature from single-cell and bulk transcriptomic data that predicts survival, immunotherapy response, and oxaliplatin sensitivity in hepatocellular carcinoma.

An engineered compact Cas12m variant enables multiplexed CRISPR gene activation from a single AAV vector in mouse models.

The EXTRA Trial will test whether 24 weeks of supervised aerobic and resistance training improves fitness, immune markers, and graft-related outcomes in kidney transplant recipients.

A new graph-based framework groups similar learners and augments sparse data to improve cognitive diagnosis predictions across three public datasets.

Braided electrospun PU/ALMA scaffolds carrying decellularized tendon ECM and umbilical cord stem cells showed stronger mechanics, slower degradation and better tendon regeneration in rabbits.

A new MCDA-CRISPR/Cas12a assay detects the aminoglycoside resistance gene armA in about 70 minutes with 100 percent concordance on 129 sequenced clinical isolates.

The FDA has outlined steps drugmakers can take to seek regulatory approval for gene editing medicines tailored to fix a single person's disease-causing mutation. The announcement is part of an ongoing ...

CDMOs already play a critical role in the cell and gene therapy development and manufacturing space and, says Rose Biosolutions, with emerging bioprocessing technologies, production methods, and strategies, are creating even more opportunities for contractors. The post Decentralization, AI, and Gene Editing are Opportunities for CGT Contractors appeared first on GEN - Genetic Engineering and Biotechnology News.

Disorders of the small intestine are often difficult to diagnose and treat. More than 20 feet (6.1 meters) long, an inch (2.5 centimeters) in diameter and located deep within the body, this organ is harder to access than other parts of the digestive tract, such as the colon or stomach.

AI Clauses in Fashion Contracts A draft Calvin Klein contract asked a model to accept, for no extra

A Hiroshima University researcher outlines advantages of Japan's new law that prohibits the transfer of genome-edited human embryos or germ cells into the human reproductive tract and imposes criminal penalties for violations.

A team from the Research Institute of the McGill University Health Center (The Institute) have discovered a new type of extracellular vesicle released by migrating cancer cells, revealing a previously unknown way in which these cells shed their DNA as they move. Published today in the journal Nature Cell Biology, the findings show that these cells release tiny structures called motile vesicles (MoVes), which carry their genetic material, including cancer-associated mutations. The discovery raises important questions about the role these vesicles may play in cancer progression.

Samsung partners with Lark Health to offer eligible US seniors AI diabetes prevention coaching through Samsung Health, with Medicare eligibility restrictions. The post Samsung Health to Offer Free AI Diabetes Prevention Coaching for Seniors appeared first on TechRepublic.

A Hiroshima University researcher contends that Japan's newly enacted law regulating human genome-edited embryos and germ cells marks a significant advance in the governance of reproductive genome editing. Tsutomu Sawai, professor at Hiroshima University's Graduate School of Humanities and Social Sciences, praises the new law for defining prohibited activities and penalties for violation but also stresses the need for stronger international coordination to prevent the prohibitions from being circumvented by individuals seeking procedures abroad.

A Chinese biotech startup has raised more than $100 million in Series A funding for its AI-driven protein design. BioGeometry, a 4-year-old company headquartered in Beijing, said in a statement Wednesday ...

A JAMA study found epidural steroid injections fell 15% among Original Medicare patients in six states after an AI-assisted prior authorization pilot began, but patient benefits and harms remain unclear.

Artificial intelligence can be helpful in analyzing medical images and support radiotherapy planning workflows. However, huge amounts of sensitive patient data are needed to train robust AI models. Researchers at the Karlsruhe Institute of Technology (KIT) have investigated how hospitals can jointly develop AI models for radiation therapy applications without exchanging such data. In their project, they use federated learning, a process in which a single model is trained at a decentralized location while the data remains in place. Their results demonstrate not only the technical feasibility of the approach but also its safe, more sustainable, and accessible use.

Four seriously ill Chinese boys who would almost certainly have died in their twenties from a rare inherited disease received the same highly anticipated gene-editing drug. More than a year later, a set of cruel and contradictory data emerged. Two boys gained the strength to walk farther. One boy showed no improvement in gait and subsequently withdrew from the trial. And the fourth boy’s heart stopped beating 81 hours after receiving the medication intravenously, owing to a severe systemic...

A qualitative study of 45 stakeholders in Shenzhen finds concerns about safety, regulatory clarity, responsibility allocation and cross-sector cooperation in medical AI governance.

A year ago, Endpoints Signal surveyed almost 1,500 biopharma insiders about the very near-term prospects of AI accelerating drug discovery. Scientists, interestingly, were the most skeptical. Now, as we revisit the question in our

For decades, stroke prevention has revolved around a list of separate—and often separately treated—risk factors: blood pressure, cholesterol, diabetes, smoking and inactivity. According to Dr. Gustavo Saposnik, it's time to start considering biological age as a risk factor for stroke.

Researchers cloned a 1,874-bp ABCD4 cDNA from Ujimqin sheep liver, expressed the recombinant protein in E. coli, and generated a polyclonal antibody for future studies.

“This is the first documented instance of large- scale automated/bot interference in a formal public health consultation,” the researchers write.

Interim Phase 3 results from 80 women suggest Humacyte's lab-grown blood vessel provided usable dialysis access sooner than fistulas, reducing catheter time, though independent review is still pending.

A new review paper proposes a Regenerative Resource Governance framework that integrates safety, circular economy principles, and community stewardship, illustrated through India's Chilika Lagoon.

A case-control study of 180 infertile women found no statistically significant associations between polycystic ovary syndrome, personality traits, and adherence to the Mediterranean diet.

Mice with transplanted human brain organoids improved their gait and maze abilities. The resulting cells suggest new ways to study cerebral palsy, epilepsy, and autism.

A two-stage AI framework uses a large language model and evolutionary feature selection to halve the symptom set for Traditional Chinese Medicine respiratory syndrome differentiation without a statistically detectable performance cost.

A gene-edited Monascus strain fermented for 21 days showed the strongest glucose uptake and lipid improvements in insulin-resistant liver cells, though the mechanisms remain candidate associations.

Researchers report a lightweight, imbalance-aware intrusion detection system achieving up to 0.9998 accuracy on IoT and medical IoT benchmark datasets.

Deleting the strigolactone biosynthesis gene MAX1 in lettuce produces a strong stay-green phenotype in darkness while redirecting part of the senescence transcriptional program toward a distinct stress-associated state.

A genome-wide CRISPR screen identifies UGCG-driven sphingolipid metabolism and protective autophagy as drivers of Niraparib resistance in ovarian cancer.

AI and Early Pancreatic Cancer Every scan in the study had already been read and cleared as normal.

Mayo Clinic’s Zombie Cell Studies Not all aging cells cause the same harm, and scientists now have better

arXiv:2609.33795v2 Announce Type: replace Abstract: Hydrogen-diesel dual-fuel (H2DF) combustion engines offer a promising pathway for decarbonising hard-to-electrify transport sectors, yet their highly nonlinear dynamics and coupled process variables demand constraint-aware control strategies. Model Predictive Control (MPC) meets these requirements but requires an online optimisation in every combustion cycle, which limits deployment on low-cost embedded hardware. This paper trains a feedforward deep neural network (DNN) by behaviour cloning (BC) to imitate an MPC expert, using 86,000 engine cycles of demonstration data collected at 1500 min-1 on a modified Cummins QSB 4.5-litre hydrogen dual-fuel engine. Two variants, one with process feedback and one without, are validated experimentally. Both track unseen fast-transient load steps (3-8 bar indicated mean effective pressure, IMEP) with normalised root mean square error (NRMSE) values of 7.80% and 9.03% against the expert's 8.01%,

arXiv:2610.37533v1 Announce Type: new Abstract: Failure diagnosers for robot manipulation are increasingly vision--language models (VLMs), trained and evaluated on single-arm failures produced by perturbing a successful demonstration. Bimanual tool use adds failures of other kinds: a tool that slips out of its socket while still held, two correct gestures made at different times, and attempts that fail for two reasons at once. On a simulated bimanual tool-use task whose failure causes are read from the recorded trace, we measure what each sensing channel lets a diagnoser tell. The tool's slip is read on the tool hand; which hand was late is read on both arms, while a sensor on one hand reads its own hand's delay and at most part of the other's; and whether a late attempt was also pushed too weakly is not identifiable from passive sensing when the tool hand is late. Within two attempts, a repair policy that escalates when the cause is not identifiable repairs as many failures as one

arXiv:2610.36852v1 Announce Type: new Abstract: Robot foundation models may generalize across tasks and embodiments, but their actions still depend on sensors that can fail. When the policy is frozen or inaccessible, can an external monitor diagnose and repair corrupted inputs without access to its internals? We test a structured surrogate that separates periodic gait from sensor-dependent corrections to guide input repair around a frozen locomotion policy. On simulated Go2, offline diagnosis raises walking success from 259/640 to 429/640 episodes; online repair reaches 382/640, with no triggers in 64 held-out fault-free episodes. A matched boosted-tree surrogate predicts clean actions similarly well but yields no detected repair improvement over no repair. Separate fits improve walking on Go1 and ANYmal C, although phase-aware gradients perform better. Evidence remains limited to one policy and a partly screened simulated fault suite; robot foundation model and hardware validation

arXiv:2610.36247v1 Announce Type: new Abstract: Offline-to-online reinforcement learning uses offline pretraining to accelerate subsequent online learning. While many methods assume the offline dataset remains available throughout fine-tuning, there are many settings where this is not the case. Prior work attributes failures in this setting primarily to critic recalibration under distribution shift. We identify a complementary actor-side failure: once the offline data disappears, continued behavioral cloning (BC) no longer preserves the offline behavior distribution and instead refits the behavioral model to the agent's limited, and nonstationary, online experience. We demonstrate that stopping online behavioral fitting while preserving the pretrained expressive prior substantially improves no-retention fine-tuning across implicit flow Q-learning (IFQL), flow Q-learning (FQL), and action-chunked RL (QC) on seven OGBench domains. We trace this failure to a behavioral feedback loop:

A new study identifies DPP4-positive zone 2 hepatocytes as mechanosensory cells that trigger liver regeneration through PIEZO1-mediated mechanotransduction.

Two LAMP-CRISPR diagnostic pipelines for Mycobacterium tuberculosis reached a limit of detection of 10 copies per microlitre, with the Cas12a version outperforming the Cas13a pipeline on clinical samples.

A narrative review finds AI and digital pathology show potential to improve adult CNS tumor diagnostics, while generalizability, transparency, and regulation remain barriers.

A Rhode Island grand jury indicted seven people tied to a Providence health agency over an alleged $2 million Medicaid fraud scheme involving AI-generated patient records and backdated training documents.

A new review finds stem cell and extracellular vesicle therapies show encouraging preclinical results for Alzheimer's disease, but published clinical trials have so far tested only safety and feasibility.

A zebrafish study shows that the ATP receptor P2RY11 sustains macrophage mitochondrial function through the SIRT1–PGC-1α axis and is required for fin regeneration.

A new review finds AI excels within single bone marrow modalities but genuine multimodal fusion systems remain unrealized.

A single-surgeon prospective study found that acetabular-only robot-assisted total hip arthroplasty was associated with a lower surgeon stress index and lower perceived workload than conventional surgery despite longer operative time.

A six-year internal evaluation of the fully virtual EDIT AI program reports 284 high school participants, improved self-reported familiarity with biomedical AI concepts, and 39 peer-reviewed publications.

A study in BMC Medical Genomics finds that miR-183-5p is upregulated in the serum of adolescent idiopathic scoliosis patients, shows diagnostic potential, and inhibits bone-forming differentiation of human bone marrow mesenchymal stem cells by negatively regulating GNG12.

A randomized trial found that injecting cefuroxime into bone before robotic-assisted knee replacement achieved far higher tissue concentrations than intravenous dosing, with 750 milligrams identified as a candidate dose for further evaluation.

University of Missouri researchers used the AI-designed, open-source gene editor OpenCRISPR-1 to create rice plants that resist bacterial blight, with commercial varieties still years away.

A new study combines LSTM-based deep learning with LIME and SHAP explainability to estimate EV battery state of health across an IoT–Fog–Cloud 6G architecture.

A retrospective single-center study of 163 Asian kidney transplant recipients found basiliximab induction offered no significant short-term benefit over no induction in one-year rejection, graft survival, function, or infection risk.

Researchers studying Bolotana, Sardinia, found that women had exceptionally high estimated late-life survival during 2021–2025, with their probability of surviving from age 70 to 100 exceeding regional and national averages by more than threefold. Earlier demographic estimates showed a much smaller survival advantage, prompting the authors to classify Bolotana as a candidate longevity blue zone that requires further investigation.

LANCASTER, PA — This spring, Lorraine and Mark Martin, a Mennonite family with a tax business, adopted a stubby-legged cow named Royal Lite. Lorraine, Mark and Royal Lite all have one thing in common: They ...

University of Missouri researchers have created rice plants that resist bacterial blight, a devastating disease that threatens one of the world's most important food crops. The advance could help farmers in parts of Asia and Africa, where the disease can destroy harvests and threaten livelihoods.

A four-tier wearable health monitoring framework combining multimodal deep learning, federated learning, differential privacy and blockchain auditability has reported strong benchmark results in preclinical simulation.

A qualitative interview study of hospital staff identified six ethical themes in AI-assisted clinical practice and led researchers to propose a lifecycle-based, multi-actor governance framework that has not yet been tested.

A systematic review and meta-analysis of 43 studies reports pooled diagnostic performance of artificial intelligence models for dengue, chikungunya, and Zika, while cautioning that most studies were at high risk of bias.

A retrospective international analysis found male metastatic urothelial carcinoma patients survived longer on enfortumab vedotin than females, with higher NECTIN-4 expression in male tumors.

Today, the National Comprehensive Cancer Network (NCCN)-an alliance of leading cancer centers in the United States responsible for guidelines that patients and providers rely on worldwide to improve outcomes-published its first-ever NCCN Guidelines for Patients focused specifically on how to support loved ones with cancer.

Hormone replacement therapy, or HRT, may lead to longer, more frequent migraines, according to research presented at The Menopause Society’s annual meeting.“Migraines can have a significant impact on quality of life, particularly during the menopause transition when many women experience changes in their symptoms,” Flavia Fairbanks Ruano, MD, PhD, lead author from the University of Miami Miller School of Medicine, said in a press release. “More research is needed to better understand the relationship between hormone therapy and migraine and to help guide individualized treatment decisions.”

A three-year review at a major US referral center found that 96% of completed uterine transplant applications were excluded on initial screening, with medical contraindications, age, and BMI the leading reasons.