Headlines

A preclinical study reveals that verbascoside curbs glioblastoma malignancy and triggers cellular senescence in part through the downregulation of Skp2.

A Johns Hopkins Medicine phase I clinical trial in ten healthy adults showed that transplanted volar fibroblasts increased skin thickness and elasticity.

A systematic review of 81 studies indicates that advanced cell therapies and biomaterial scaffolds promote intervertebral disc regeneration in experimental models, although hostile disc microenvironments and limited long-term clinical data remain major hurdles.

In an in vitro study, hybrid iron oxide and zinc oxide nanoparticles combined with porphyrin-mediated photodynamic therapy significantly reduced Salmonella enterica serovar Typhimurium biofilm formation.

A review examines how programmable CRISPR-Cas RNA circuits unite transcriptome sensing, molecular computation, and therapeutic execution into single theranostic platforms.

An open-label pilot trial found that fecal microbiota transplantation combined with conventional therapy was associated with higher composite response rates in children with refractory functional abdominal pain disorders.

Researchers found that prevascularized composite stem cell sheets reduced tooth movement distance and accelerated periodontal repair in an orthodontic model.

High levels of LDL cholesterol and triglycerides, which are types of blood fats, are major contributors to atherosclerotic cardiovascular disease. Gene-editing technologies offer a potential alternative to lipid-lowering medications. In a new CRISPR experiment, a single infusion of a gene-editing treatment kept triglyceride levels low in monkeys for three years. The findings support the possibility of controlling blood fats with a lasting DNA change, potentially replacing daily doses of medication.

Researchers engineered a CRISPR Cas12a multiplex plasmid system capable of expressing up to ten guide RNAs to reliably introduce multiple marker-free gene deletions simultaneously in Aspergillus niger.

Pharma Meets Medical AI in China When a Chinese doctor asks Alibaba Health’s Hydrion app about a treatment,

A global data science competition showed synthetic cohorts can support post-transplant survival modeling, though equity gains attenuated under domain shift to real clinical data.

Eliminating the cGAS innate immune sensor in African turquoise killifish attenuates molecular and cellular signatures of aging but fails to prolong organismal lifespan.

A magnesium metal-organic framework scaffold promoted vascular infiltration and accelerated new bone formation in a critical-sized rat cranial defect model.

A narrative review evaluates how mesenchymal stromal cell-derived extracellular vesicles and engineered hydrogels address uterine scarring while highlighting remaining clinical translational gaps.

A study in Singapore reveals marine biofilm assembly on plastics is driven primarily by temporal succession rather than substrate type.

The study, published in Discover Artificial Intelligence, evaluated a hybrid ensemble model combining Support Vector Machine (SVM) and Gaussian Process (GP) algorithms against standard machine learning benchmarks.

Researchers using human cell models found that small extracellular vesicles released by senescent cells transmit growth-arrest signals to neighboring cells without triggering classical inflammatory pathways.

Researchers established a health education pathway for allogeneic hematopoietic stem cell transplantation patients comprising eight primary and 48 secondary indicators based on the LEARNS model.

A clinical review highlights the Mediterranean diet as an evidence-based lifestyle strategy that modulates the gut microbiome to alleviate chronic gastrointestinal and metabolic disorders.

A controlled evaluation of three large language models found that artificial intelligence systems were more than twice as likely to commit diagnostic boundary failures when users expressed escalating self-diagnostic conviction rather than presenting genuine clinical evidence.

Jessica Hagen / MobiHealthNews: Charta Health, which offers AI-powered tools to automate medical chart review, billing, and coding workflows, raised a $55M Series B led by Insight Partners  —  The round is the company's third in less than two years and brings its total funding to $85 million.  —  Global Investing

Supported by a federal grant, University of Illinois Chicago researchers are investigating how dentin phosphophoryn protects pulp stem cells to support natural tooth regeneration.

The world’s first attempt to edit genes inside a child’s brain, which killed a six-year-old girl in Shanghai last year, has led to the firing of scientists following an official investigation that found they had broken research rules and taken money from her family. The investigation, ordered by the Communist Party’s Shanghai municipal committee and the local government, concluded on Friday that the researchers had not shared worrying results from monkey tests with the girl’s doctors beforehand....

Surgeons successfully combined a lateral parapatellar approach, semi-active robotic assistance, and a specialized patellar template in ten knees with severe valgus deformity.

Researchers established that calibrating the enzymatic degradation rate of methacrylated type I collagen hydrogels regulates stem cell proliferation, construct contraction, and cartilage defect repair in laboratory and animal models.

A comprehensive genomic investigation in Swiss dairy cattle revealed a recessive nonsense mutation in the HYAL1 gene that triggers polysynovitis and accelerates early culling in Holsteins.

A systematic review and exploratory meta-analysis found artificial intelligence models achieved high sensitivity and specificity in detecting skeletal Class III malocclusion in pediatric patients.

Architectural researchers have formulated a theoretical framework and classification system that reframes the neglected in-between spaces of intermediate cities as vital resources for community-driven public space regeneration.

Dyania Health today announced a collaboration with NVIDIA to put AI clinical reasoning to work inside health systems, on their own infrastructure, at the scale of their entire patient population.

Andelyn Biosciences (Andelyn), a leading US-based patient-focused cell and gene therapy Contract Development and Manufacturing Organization (CDMO), and Celliaz Co., Ltd., a South Korean biotechnology company developing next-generation regenerative therapeutics for retinal degenerative diseases, today announced a strategic partnership to advance CLZ002, an investigational adeno-associated virus (AAV)-based gene therapy for retinitis pigmentosa (RP).

A comparative study in AAPS Open evaluates two AI-based tools for predicting drug-excipient compatibility, revealing significant discrepancies that highlight the need for a hierarchical screening framework in pharmaceutical preformulation.

Insilico Medicine will showcase its generative AI drug discovery platforms and automated robotics at upcoming international healthcare and technology conferences in London and Dubai.

A reflexive thematic analysis of 37 studies reveals that artificial intelligence in global health risks reproducing structural inequities unless upstream power asymmetries in design and governance are restructured.

A new study finds artificial intelligence language tools miss critical expressions of psychological distress despite scoring well on standard accuracy metrics.

Professor Philippe Lambin delivered a special lecture at Korea University College of Medicine outlining the future of medical artificial intelligence, foundation models, and digital twin precision medicine.

A comprehensive mechanistic review evaluates how chromatin regulation, RNA modifications, and noncoding RNA networks govern cancer stem cell plasticity and therapeutic resistance.

A medical review indicates that host immune responses represent an intrinsic component of gene therapy pharmacology across viral and non-viral delivery platforms.

A retrospective study of 300 simulation encounters shows multimodal AI requires audio-inclusive video to reliably score physical examinations in medical training.

Three doctoral researchers at the Institute of Science and Technology Austria have been awarded Google PhD Fellowships for their research in machine learning, model efficiency, and privacy.

Researchers developed a three-phase diagnostic framework integrating Building Information Modeling to guide precision renovations across aging residential buildings in China.

Researchers have optimized an ex-vitro hairy root transformation protocol in soybean to enable high-throughput CRISPR gene editing and greenhouse cyst nematode bioassays within fifty-three days.

A comprehensive cross-organ review reveals that while exogenous mitochondrial transplantation mitigates ischaemia–reperfusion injury across diverse animal models, controlled trials in humans have not yet demonstrated reproducible clinical efficacy.

Bioengineers at the University of California San Diego have developed a technology that allows drugs to control when cells produce therapeutic proteins, which could potentially make gene therapies safer and more adaptable for treating chronic diseases.

A comprehensive review analyzes how human pluripotent stem cells are transforming regenerative medicine, disease modeling, and drug discovery while confronting manufacturing and biological hurdles.

Researchers developed a four-stage in vitro micropropagation system for the succulent Haworthia emelyae var. major, achieving high shoot regeneration and acclimatization success.

Research using stem cell-derived models of early human development suggests that PFOS, a persistent substance belonging to the PFAS group, can interfere with processes critical for early germ cell and embryonic development. The study, from Karolinska Institutet, is published in the journal Human Reproduction Open.

Having an older heart age estimated using artificial intelligence (AI) ultrasound analysis compared with actual age was associated with worse outcomes, according to results presented today at the ESC Digital & AI Summit 2026.

A phase 2b trial demonstrates that a two-dose adjuvanted RSV vaccine regimen induces higher neutralizing antibody titers than a single dose in kidney and lung transplant recipients.

A prescription drug warning can be accurate and still be difficult for a patient to use. What matters is not only the information itself but also how and where people receive it. This becomes especially important as patients increasingly use AI systems to find answers about medications, sometimes without visiting the original source.

A comprehensive scientific review evaluates how cellular senescence and secretome signaling drive benign prostatic hyperplasia while analyzing the therapeutic potential and clinical hurdles of senolytics.

Researchers analyzed a five-stage participatory regeneration initiative in Geumsan-gun that paired local residents with university designers to address rural streetscape decline.

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A comprehensive genomic review reveals how cancer stem cells, viral integration, and clonal signaling pathways drive hepatocellular carcinoma, highlighting emerging precision therapies to improve patient outcomes.

Researchers discovered that secondary metabolites from Paenarthrobacter nicotinovorans YYH-1, a bacterium isolated from the Epimedium rhizosphere, alleviate oxidative senescence in cultured human ovarian granulosa cells.

Researchers restored gene dosage and reversed cellular and functional deficits in human brain organoids and neurons carrying autism-associated mutations using enhancer-targeted CRISPR activation.

A survey of eighty-nine medical students revealed that daily chatbot use reached up to 87.64 percent, driven primarily by self-selected tools rather than an instructor-provided chatbot.

FRIDAY, Nov. 13, 2026 — Most Americans are comfortable with artificial intelligence (AI) weighing in on their healthcare, so long as it doesn’t take the wheel, a new survey says.In fact, they’re more comfortable with AI-driven medicine than are...

MDCalc's CrossCover screens clinicians' AI questions for patient identifiers and compares generated answers with medical references, while experts caution that its safeguards remain untested.

Bioprinting uses living cells and molecular signals to produce biological tissues and even whole organs, building them layer by layer in the lab. To keep the bioink, or blend of cells and materials that power this printing, correctly aligned to grow a target tissue, researchers use electricity. However, this typically requires bulky electronic interfaces and invasive wiring.

Surgeons successfully managed sudden complete obstruction of the right bronchus intermedius following bilateral lung transplantation using an interlobar sleeve resection that preserved lung parenchyma.

Gene editing has spent the last decade proving what's possible in the lab. The next decade is about proving it can reach the patients who need it most. The post Inside Arbor’s CNS pipeline and next-generation gene editing appeared first on Labiotech.eu. © Labiotech UG and Labiotech.eu. Unauthorized use and/or duplication of this material without express and written permission from this site’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Labiotech UG and Labiotech.eu with appropriate and specific direction to the original content.

The American Medical Association adopted a policy seeking liability protections for physicians who reject AI recommendations and greater responsibility for vendors and health systems when clinical AI causes harm.

A validated mortality score outperformed the current six-status system, potentially reshaping US donor heart allocation and prioritizing sicker patients.

Vancomycin-resistant Enterococcus faecium is listed by the World Health Organization as one of the highest-priority bacteria in its 2024 Bacterial Priority Pathogens List, ahead of MRSA, due to its ability to transfer resistance genes between humans, animals and the environment.

NEW ORLEANS — In this video, Robert A. Sisk, MD, FACS, FASRS, of Cincinnati Eye Institute, highlights a trial that assessed the use of an adeno-associated viral vector gene therapy for the treatment of wet age-related macular degeneration.In a phase 1/2a dose escalation trial presented at the American Academy of Ophthalmology meeting, patients with wet AMD received an injection of subretinal NG101 (Elisigen) in low, mid and high doses.With the lower doses of NG101, “there was an excellent safety and tolerability profile,” Sisk said.In addition, he reported there were no

A new score using data from routine lab tests and heart support devices may rank heart transplant candidates based on the short-term risk for death more accurately than the current six-status system.

Researchers here report on the development a senostatic treatment, one that reduces the pace at which cells become senescent in aged tissues. This allows the immune system to catch up on its clearance of senescent cells, and thus the overall burden of senescence is reduced over time. The big question regarding this sort of approach is whether it will still allow senescence to occur when it should occur, such as in wound healing and potentially cancerous cells. Senostatics that act through upregulated autophagy, such as rapamycin, are demonstrated to be quite safe in this regard in mice. Novel mechanisms would need the same sort of proof, but since this mechanism involves SIRT1 activity one might be optimistic that it will be beneficial. The deacetylase SIRT1 […]

A new conceptual framework called the Regenerative Hexagon integrates host health, biomechanics, and cellular energetics with traditional regenerative medicine components to explain variability in musculoskeletal treatment outcomes.

A three-database bibliometric analysis shows research on fecal microbiota transplantation for inflammatory bowel disease expanded rapidly after 2015 and shifted toward strain engraftment and biosafety.

arXiv:2611.15769v1 Announce Type: new Abstract: Anti-cancer drug response prediction (DRP) is critically important for precision oncology and therapeutic development. Currently, most DRP models are developed using drug screening data from immortalized cancer cell lines, which can differ substantially from patient tumors at the genomic and molecular levels, even though patient tumor response is the ultimate prediction target. To help bridge this gap and bring DRP models closer to their intended clinical application, we conducted four drug screening studies using patient-derived organoids (PDOs), which more faithfully recapitulate patient tumors than immortalized cell lines. These studies generated data for improving and evaluating DRP models, including multi-omics profiles of PDO lines, drug feature data, and treatment response measurements. Using these data, we retrained and evaluated multiple publicly available DRP models under three model-building scenarios: training models using

Extracellular vesicles from umbilical cord stem cells attenuated urethral stricture narrowing in rats and suppressed fibroblast fibrosis by delivering microRNA let-7i-5p to target TGFBR1.

A multicenter French cohort study of 6,935 kidney transplant recipients found that infections, cancers, and cardiovascular diseases accounted for nearly two-thirds of deaths, with distinct shifts in leading causes over time and an elevated mortality risk immediately following graft failure.

Researchers at SingHealth Duke–NUS Academic Medical Center developed and evaluated AskADD, an AI-assisted chatbot designed to help faculty navigate complex promotion and tenure policies.

A validated clinical nomogram identifies five independent predictors to accurately forecast postreperfusion syndrome during pediatric living-donor liver transplantation.

A novel two-stage coagulation method rapidly isolates intact mitochondria that restore metabolic function and overcome drug resistance in cell models.

A review reports that CRISPR interference provides reversible, non-mutagenic gene silencing in insects, offering a targeted tool for functional genomics and prospective pest control.

A systematic review of 25 experimental studies reveals how photoacoustic imaging combines optical absorption with ultrasound detection to track stem cells and monitor tissue regeneration in real time.

Researchers integrated single-cell and spatial transcriptomics with machine learning to identify eight core risk genes in high-stemness malignant epithelial cells in bladder cancer.

Over an eight-year retrospective study conducted from January 2018 through October 2025 at Miguel Servet University Hospital in Zaragoza, Spain, clinical researchers identified a striking rise in a methicillin-susceptible Staphylococcus aureus lineage resistant to frontline topical antibiotics.

An experimental cell therapy was well tolerated in 10 people with chronic diabetic foot ulcers, according to first-in-human study led by researchers at Wake Forest Institute for Regenerative Medicine (WFIRM).

A study in Frontiers in Pharmacology shows that human iPSC-derived sensory neurons exhibit dominant calcitonin receptor signaling, supporting their use as a model for pain research.

A standardized enzymatic droplet isolation method enables scalable expansion of human dermal papilla cells while preserving key trichogenic signaling pathways and in vivo hair regeneration capacity.

An observational analysis of registry records reveals that regional lymph node spread differs sharply across histologic subtypes of extremity soft-tissue sarcoma and is linked to poorer cancer-specific survival.

A study in mice reveals that a high-fat diet leaves lasting DNA changes in intestinal stem cells, accelerating tumor development upon re-exposure.

A long downhill exposes a question that a peak-power figure cannot answer: how does the bike manage sustained

A study in EMBO Reports demonstrates that elevated mitochondrial metabolism in Down syndrome iPSCs accelerates proliferation, reducing primary cilia growth and delaying commitment to neuroectoderm.

Studies presented at the AMP 2026 Annual Meeting demonstrated artificial intelligence applications for cancer classification, clinical reporting, specimen triage, and genomic prediction.

A clinical study of 976 patients and experimental models demonstrate that donor-derived unlicensed natural killer cells accelerate hematopoietic recovery and improve survival after allogeneic stem cell transplantation.

Researchers at the National University of Singapore (NUS) have developed a catalyst-regeneration strategy that could make hydrogen production from ammonia more efficient and reliable. By tackling a major problem that causes catalysts to lose their effectiveness over time, the team sustained hydrogen production for over 2,000 hours in laboratory tests.

A comprehensive review synthesizes how enzymatic control of messenger RNA poly(A) tail lengths dictates post-transcriptional gene expression in mammalian stem cells and early embryogenesis.

Wildfires bring to mind a blazing sea of flames. But what happens to the smoke? Anyone observing a wildfire from a safe distance notices mainly the enormous clouds that tower above the fire. These rise several kilometers and then embark on journeys that can extend across continents and oceans. Pollutants from wildfires in Canada can still be detected, for example, at the Jungfraujoch in the Swiss Alps.

A fourteen-year panel analysis of thirty-eight OECD countries found no robust evidence that government effectiveness moderates the association between public healthcare expenditure and life expectancy.

A study of public hospital procurement in China shows medical AI diagnostic hardware converged geographically while concentrating heavily in tertiary facilities.

Researchers mapped direct transcriptional targets of the pluripotency factor Oct4 in mouse embryonic stem cells by combining auxin-inducible degron degradation with nascent RNA sequencing.

Fat that builds up in the pancreas is one of the lesser-known risk factors for diabetes and metabolic syndrome, but it turns out it can be targeted directly through what's on the plate.

This week, Google launched Gemini for healthcare. Google has long been a fixture in health, helping hospitals store data in Google Cloud, selling a wellness device through Fitbit and spinning out startups such as Verily ...

A sizable number of humans have received first generation stem cell therapies, with considerable variation in protocols and sources of cells. Only a small fraction of these patients and treatments resulted in data that was robustly recorded and made available to the rest of the world, as only a small fraction of those patients were participants in clinical trials. Stem cell therapies (and, given more time, likely exosome therapies as well) have an entirely justified reputation as being unreliable in outcome. The available evidence suggests a fairly reliable reduction in chronic inflammation for a period of months, but whether or not a patient exhibits improved function in tissues, and to what degree, is a roll of the dice. One of the reasons why the world […]

Tiny doses of GLP-1s are being marketed as antiaging drugs, but what evidence is there?