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Researchers continue to identify compounds that marginally affect aging in short-lived species. The Interventions Testing Program at the NIA continues to show that most of these have no effect on life span when rigorously assessed in mice. The few points of comparison we do have between mice and humans suggest that effects on life span in mice resulting from manipulation of metabolism become much smaller in humans. Long lived species do not have the same flexibility in metabolic determination of the pace of aging as exists in short lived species. This entire branch of longevity science, focused on exercise mimetics, calorie restriction mimetics, and other similar approaches, should not be expected to deliver meaningful results to human medicine in terms of years of life gained. […]

BOSTON — Serif Biomedicines, a startup launched last month by Flagship Pioneering, believes it has solved two technical challenges that have long prevented gene therapy from being delivered without troublesome viruses. Viruses are ...

MOZAIC leverages deep learning to optimize fecal microbiota transplantation, enhancing treatment efficacy through precise donor-recipient microbiome matching.

The new strategy also holds promise for lung and colon tumors. Here’s how scientists discovered it.

Researchers from the Hebrew University of Jerusalem and the Weizmann Institute of Science have identified a previously unrecognized defense mechanism in the intestine, showing that intestinal stem cells can actively respond to Salmonella infection and help protect the gut from bacterial invasion.

For highly aggressive types of blood cancer, stem cell transplantation is often the only potentially curative therapy, yet even after a transplant, these cancers often return. Now a clinical trial, led by researchers at Washington University School of Medicine in St. Louis, shows that a stem cell transplant in which the donor cells have been genetically engineered to remove a particular protein helps prevent toxic side effects and potentially improves the effectiveness of therapies given after a transplant to help prevent cancer recurrence.

Ditto, an Amsterdam-based health-tech building AI-generated summaries of medical appointments for patients, has raised €7.6m, the company said on Monday. The round is led by Heal Capital with participation from Rubio Impact Ventures. Earlier backer Chris Oomen, chair of Optiverder, has also participated. The funding will support expansion into Germany, the UK, and Spain this […] This story continues at The Next Web

A team led by researchers from Tokyo Metropolitan University, in collaboration with Tohoku University and Orbray Co., Ltd., using heteroepitaxial diamond materials developed by Orbray, have shown that lab-grown diamonds might realize a radiation dosimeter compatible with both medical diagnosis and radiation therapy.

A blood stem cell donation can save the lives of people with leukemia. To collect these cells from the bloodstream, donors are given medication that mobilizes blood stem cells from the bone marrow. A pilot study now suggests that physical exercise could specifically support stem cell donation.

Artificial intelligence (AI) is rapidly transforming the tools that are central to global health decision-making in areas like disease control policies, financing and vaccination strategies, such as infectious disease modeling. This brings new opportunities to the modeling landscape, but could also exacerbate existing disparities, according to Matt Ferrari, professor of biology and director of the Center for Infectious Disease Dynamics at the Huck Institutes of Life Sciences at Penn State.

Researchers at Technische Universität Berlin have discovered that teaching Large Language Models (LLMs) to mimic human intuition and reasoning significantly improves their ability to provide accurate medical care-seeking advice.

Researchers at Technische Universität Berlin have discovered that teaching Large Language Models (LLMs) to mimic human intuition and reasoning significantly improves their ability to provide accurate medical care-seeking advice. The study, published in JMIR Biomedical Engineering, suggests a paradigm shift in prompt engineering: moving away from computer-focused instructions toward strategies rooted in applied psychology.

In a groundbreaking development that could redefine antiviral therapy, researchers have engineered a CRISPR-Cas13d based system to combat hepatitis E virus (HEV) infection with remarkable specificity and efficacy. Unlike the widely known Cas9 nuclease, which targets DNA, Cas13d operates at the RNA level, cleaving viral RNA sequences. This unique property positions Cas13d as a powerful […]

An enzymatic scissors recognizes and cuts viral RNA, but leaves the host cell unharmed. This opens up new antiviral strategies against hepatitis E.

Surgery is a complicated endeavor. Even a successful surgery can lead to complications, and even the best surgeons sometimes have unsuccessful surgeries. A surgeon must rely on visual cues and their own experience to avoid hitting a nerve or a blood vessel, mistakes that can turn a simple surgery into a much more challenging one.

The addition of an off-the-shelf pooled stem cell product to a single unit of umbilical cord blood conferred favorable outcomes among people with hematologic malignancies, according to phase 2 trial results.Nearly all treated patients remained alive by data cutoff and none developed severe acute or chronic graft-versus-host disease.“The outcomes are very solid,” lead author Filippo Milano, MD, PhD, director of the cord blood transplant program at Fred Hutch Cancer Center, told Healio. “I cannot deny that there is always an element of luck when you conduct a clinical trial, but to see results

A fluid that women with advanced ovarian cancer know all too well - ascites, the buildup of liquid in the belly - may be doing more than causing discomfort.

Drug developers are racing to make gene therapies that could replace chronic GLP-1 injections and pills with a one-and-done treatment. Now, a company based just outside of Boston is poised to become ...

Sleep apnea is correlated with cardiovascular disease, among other conditions. It induces a state of hypoxia in tissues when regular breathing is interrupted. Here, researchers induce a similar degree, duration, and intermittency of hypoxia in mice to examine the effects it has on vascular tissue. They find that this sort of hypoxia exposure increases the burden of senescent cells in the vasculature, alongside worsened measures of cardiovascular dysfunction. The researchers further show that clearing senescent cells from the vasculature improves cardiovascular function in the mice exposed to intermittent hypoxia, suggesting that this strategy should be tried in human patients. Obstructive Sleep Apnea (OSA) is a pervasive cardiovascular risk factor linked to accelerated aging and systemic inflammation. Intermittent hypoxia (IH), a hallmark of OSA, induces cardiovascular […]

Lawyers for the US state of Pennsylvania have filed a lawsuit against a company it alleges is allowing a chatbot to impersonate a doctor.1Pennsylvania filed the action against the tech company Character.AI after a state investigator posing as a patient was told by an AI chatbot that it was licensed to practise medicine in Pennsylvania and the UK and provided a fake Pennsylvania medical licence number.“We will not allow companies to deploy AI tools that mislead people into believing they are receiving advice from a licensed medical professional,” said Josh Shapiro, governor of Pennsylvania, in a statement announcing the lawsuit.2Character.AI allows users to interact with themed AI personas that can pose as particular people, members of certain professions, or fictional characters. Responding to the lawsuit, a Character.AI spokesperson said, “We have taken robust steps to make that clear, including prominent disclaimers in every chat to remind users that a Character...

Whoop, the screen-free fitness wearable with a subscriber base of more than 2.5 million, is about to put

Barcelona, 08 May 2026 – The field of cellular therapies has reached a significant milestone with the successful completion of the first-ever inspection under the third edition Immune Effector Cells (IEC) Standards by JACIE at Guy’s and St Thomas’ NHS Foundation Trust. This achievement not only confirms the robustness of these newly established standards but […]

A Chinese barbecue stall owner paused his business to donate stem cells to a three-year-old toddler and was rewarded by long queues of customers. Shao Sanhu, 33, from central China’s Anhui province, put his barbecue stall on hold for 13 days to carry out the Good Samaritan deed. He put a notice on the tarpaulin that covered his stall on April 18, saying that the business was on hold for a week because of a “family matter”. He also posted on his social media account, indicating that he was going...

arXiv:2605.06696v1 Announce Type: new Abstract: Collections of interacting AI agents can form coalitions, creating emergent group-level organization that is critical for AI safety and alignment. However, observing agent behavior alone is often insufficient to distinguish genuine informational coupling from spurious similarity, as consequential coalitions may form at the level of internal representations before any overt behavioral change is apparent. Here, we introduce a practical method for detecting coalition structure from the internal neural representations of multi-agent systems. The approach constructs a pairwise mutual-information graph from the hidden states of agents and applies spectral partitioning to identify the most salient coalition boundary. We validate this method in two domains. First, in multi-agent reinforcement learning environments, the method successfully recovers programmed hierarchical and dynamic coalition structures and correctly rejects false positives

North Korea urged its people to intensify efforts toward this year's grain harvest, state media reported Monday, as the country continues to grapple with food shortages. In an editorial, the Rodong Simnun, the ruling Workers' Party's main newspaper, called on the public to "concentrate all efforts on rice transplanting and completing it in a timely manner" in order to meet annual grain targets. The paper described rice transplanting as "a key business" in achieving production goals and fulfilling directives from the party's key congress, held in February. It stressed agricultural output is central to the party's agenda, invoking leader Kim Jong-un's stated priority that "the most urgent job facing us is to resolve people's food problems by farming the land well." North Korea typically begins rice farming in mid-March, with the transplanting phase wrapping up by late May or early June. It routinely deploys soldiers and students alongside civilian laborers during the transplanting

Nobel Peace laureate and activist Narges Mohammadi has been transferred to a Tehran hospital more than a week after collapsing in prison, her foundation said on Sunday. Her transfer comes after days of pleading by her family and others who described her condition as critical. Her foundation said she has been granted a prison sentence suspension on bail. It was not clear for how long her sentence is suspended, the foundation said. Mohammadi had been imprisoned since December in Zanjan prison. She...

A viral video of Trump at the LIV Golf tournament has sparked body double rumors, with online sleuths noting differences in his mannerisms and hair parting.

A team led by researchers from Tokyo Metropolitan University, in collaboration with Tohoku University and Orbray Co., Ltd., using heteroepitaxial diamond materials developed by Orbray, have shown that lab-grown diamonds might realize a radiation dosimeter compatible with both medical diagnosis and radiation therapy.

Alongside its new Fitbit Air, Google this week announced that the Fitbit app is dead, to be replaced by “Google Health.” If you’d told me this would happen a few months ago, I’d be worried, but the end result actually seems like an overall win for everyone involved. Let’s take a closer look. more…

Scientists are uncovering surprising links between aging and the trillions of microbes living in the human gut. Scientists are investigating whether the key to aging well may lie in the gut microbiome. Early findings suggest microbes could affect everything from inflammation to lifespan, opening new possibilities for future treatments. People once searched for the Fountain [...]

Scientists at the University of Rochester pulled off a remarkable experiment: they transferred a longevity-related gene from the famously long-lived naked mole rat into mice, and the mice ended up healthier and lived longer. The special gene boosts production of a substance called high molecular weight hyaluronic acid, which appears to protect against cancer, reduce inflammation, and support healthier aging. The modified mice showed stronger resistance to tumors, healthier guts, and lower levels of age-related inflammation.

Residents living near data centers are raising concerns about noise pollution, as these massive sites operate 24/7 and generate low-frequency sounds that disturb the neighborhood's peace.

Nearly 3,000 peer-reviewed medical papers have fake citations, AI-assisted audit finds  Phys.orgFraudulent citations, blamed on AI hallucinations, are becoming more common in research papers  statnews.comReview uncovers rising rate of fake references in published biomedical papers  CIDRAPNearly 3,000 peer-reviewed medical papers have fake citations, a Columbia Nursing AI-assisted audit finds  EurekAlert!'Tip of the Iceberg': Study Uncovers AI-Fabricated Citations in Research Papers  MedPage Today

Nearly 3,000 peer-reviewed medical papers have fake citations, AI-assisted audit finds  Phys.orgFraudulent citations, blamed on AI hallucinations, are becoming more common in research papers  statnews.comReview uncovers rising rate of fake references in published biomedical papers  CIDRAPNearly 3,000 peer-reviewed medical papers have fake citations, a Columbia Nursing AI-assisted audit finds  EurekAlert!'Tip of the Iceberg': Study Uncovers AI-Fabricated Citations in Research Papers  MedPage Today

Clashes erupted in Barcelona after counter-protesters interfered with Victory Day celebrations marking the defeat of Nazi Germany Read Full Article at RT.com

Engineered microorganisms are widely used in industrial biotechnology and biopharmaceutical applications, including the production of biofuels, sustainable chemicals, and therapeutic compounds. However, concerns remain regarding the unintended environmental release and uncontrolled proliferation of genetically engineered microbes. For this reason, biocontainment technologies, which are designed to prevent microorganisms from surviving outside controlled environments, have become increasingly important in both academia and industry.

Researchers have successfully regenerated skeletal and connective tissue, although the new tissue was not perfectly formed. The result demonstrates a critical step forward in limb regeneration. For centuries, scientists have viewed the inability to regrow lost body parts as a major biological limit for humans and other mammals. Salamanders and some other animals can regenerate [...]

In a groundbreaking exploration of human longevity and health, researchers have unveiled pivotal insights into the developmental origins that underpin exceptional health and survival across multiple generations. This expansive four-generation family cohort study, recently published in Nature Communications, charts new territory in understanding how genetic, epigenetic, and environmental factors intertwine within familial lines to sculpt […]

NEW ORLEANS — Patients with Medicare Advantage plans may have lower odds of receiving a kidney transplant referral than patients with traditional Medicare, data presented at the National Kidney Foundation Spring Clinical Meetings show.More than 50% of Medicare-eligible patients receiving dialysis are enrolled in Medicare Advantage plans as of 2024, according to Adam S. Wilk, PhD, associate professor of surgery at Indiana University School of Medicine, and colleagues. The researchers aimed to assess whether Medicare Advantage plans, compared with traditional Medicare, may help or hinder access

Google wants to be your go-to fitness coach and wellness adviser… even if you have an Apple Watch. The tech giant announced a slew of health updates on Thursday that put its AI coach front and center, part of a broader strategy to compete with OpenAI, Microsoft and a wave of other tech companies racing … The post Google’s plan to win the AI health race? Play nice with Apple and other rivals appeared first on Egypt Independent.

  Google launched a 99 dollar screenless fitness tracker and a 9.99 dollar per month AI health coach powered by Gemini. One day later, Whoop announced that it would add on-demand video consultations with licensed clinicians to its app. Google is betting that artificial intelligence can interpret your health data. Whoop is betting that you […] This story continues at The Next Web

In a groundbreaking advancement poised to revolutionize regenerative medicine, researchers have unveiled an innovative nanoparticle-based strategy to fine-tune cell density and thereby enhance cellular adhesion and tissue repair processes. This cutting-edge approach, described in a recent publication in Nature Communications (2026), holds immense promise for accelerating wound healing and restoring damaged tissues with unprecedented precision […]

Седые волосы давно перестали быть чем-то, что нужно скрывать любой ценой. Сегодня серебристые оттенки -...

In a landmark advancement poised to revolutionize radiation dosimetry, researchers from Tokyo Metropolitan University, in partnership with Tohoku University and the tech company Orbray Co., Ltd., have engineered a diamond-based detector that challenges existing paradigms in medical radiation measurement. The team’s innovative approach harnesses heteroepitaxial diamond materials, lab-grown with atomic precision, to create a compact […]

An Iranian knowledge-based company has unveiled a next-generation synthetic bone graft designed to accelerate bone regeneration while reducing surgical risks.

If you own a Whoop fitness-tracking wearable, you’ll want to check out these new updates surrounding medical records and AI insights.

As cell and gene therapy programs move from early clinical stage development into global commercialization, any gaps in system-level orchestration can translate directly into compliance and operational risk. The post How Digital Orchestration Is Redefining Regulatory Infrastructure for Cell and Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.

Google Launches $99 Fitbit Air, a Screenless Wearable for Health Tracking  eWeekIntroducing the all-new Fitbit Air  blog.googleGoogle’s plan to win the AI health race? Play nice with Apple and other rivals  CNNThe New Google Fitbit Air and Other Fitness Bands Are Losing Screens—and Gaining Fans  WSJGoogle Fitbit Air preorders come with a second band for free  The Verge

Google Launches $99 Fitbit Air, a Screenless Wearable for Health Tracking  eWeekIntroducing the all-new Fitbit Air  blog.googleGoogle’s plan to win the AI health race? Play nice with Apple and other rivals  CNNThe New Google Fitbit Air and Other Fitness Bands Are Losing Screens—and Gaining Fans  WSJGoogle Fitbit Air preorders come with a second band for free  The Verge

Bloomberg: Sources: Isomorphic Labs, an AI-powered drug discovery company spun out of Google DeepMind, is in advanced talks to raise $2B+ led by Thrive Capital  —  Isomorphic Labs, an AI-powered drug discovery company spun out of Alphabet Inc.'s Google DeepMind, is in advanced discussions to raise …

Google is turning the Fitbit app into Google Health, adding Gemini-powered coaching, medical record tools, and the new screenless Fitbit Air tracker. The post Google Rebrands Fitbit App as ‘Google Health’ in Major AI Wellness Push appeared first on TechRepublic.

In a groundbreaking advancement at the intersection of genome engineering and biocontainment, researchers at Seoul National University have developed a pioneering technology enabling irreversible and precise control over engineered bacterial survival. Published in the prestigious journal Nucleic Acids Research, this study unveils a multiplexed CRISPR base editing system that activates in pulses and permanently disables […]

Google trusts Gemini to coach your health; Whoop is putting a licensed doctor on your screen. Here's what each approach actually means for your wallet and your wellbeing.

Partial cell reprogramming as a basis for rejuvenation therapies is an area of great interest in the research and development communities. It has received greater funding in recent years than any other part of the field, with the founding of Altos Labs and a number of other unusually well-funded biotech companies. Reprogramming involves expression of some or all of the Yamanaka factors. Full reprogramming of a somatic cell slowly transforms that cell into a pluripotent stem cell, a recreation of the process of early embryonic development. Partial reprogramming for a shorter period of time only restores youthful epigenetic patterns of gene expression without changing cell state, and this, if it can be made to work in a living organism, is the basis for potential rejuvenation […]

HundredsThe hundredth anniversary of the birth of Sir David Attenborough on 8 May 1926 is being celebrated today, justifiably, not merely because of the achievements of the man himself, but also because it reminds us that more people than ever before are living to the age of 100 years and over. Another example, in the medical field, was Harold Ellis, the surgeon whose textbook, Clinical Anatomy, in its 14 editions, has been so influential in teaching generations of medical students, and who died recently having just attained the age of 100. I have just tucked a copy of his obituary into my copy of the 3rd edition of 1966, which opened my eyes to the clinical relevance of the anatomy that I had been struggling to understand in the dissecting room.Those who live to be 100 years old are called centenarians, from the classical Latin adjective centenarius, referring to something...

Organ transplantation remains the cornerstone treatment for end-stage organ failure. While conventional broad-spectrum immunosuppression effectively controls acute rejection, it fails to address chronic rejection and carries long-term side effects including infection, malignancy, and metabolic disorders.

CRISPR-Cas измельчила ДНК заданных клеток и уничтожила их

Researchers at National Taiwan University have developed a liver-directed IL-10 gene therapy that strengthens cancer-fighting immune cells and suppresses liver tumors in mice. The treatment also generated long-lasting immune memory cells that remained in the liver after tumors disappeared.

The U.S. Food and Drug Administration (FDA) has granted accelerated approval to Regeneron Pharmaceuticals’ Otarmeni™ (lunsotogene parvec-cwha) as the first gene therapy designed to restore a neurosensory function to normal levels. The post Gene Therapy Briefs: Regeneron Wins FDA Approval for First Neurosensory Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.

Brandon Gomez / CNBC: Whoop plans to offer on-demand video consultations with licensed clinicians for US users, and adds electronic health records and AI-powered health guidance  —  Wearable fitness tracker Whoop announced on Friday it will introduce in-app access to on-demand licensed clinicians for users in the United States.

Fitness bands can’t be as simple as they once were before the AI health boom. | Photo by Amelia Holowaty Krales / The Verge This is Optimizer, a weekly newsletter sent every Friday from Verge senior reviewer Victoria Song that dissects and discusses the latest gizmos and potions that swear they're going to change your life. Opt in for Optimizer here. A fitness band is for bettering yourself, but casually. It's lightweight, easy to wear, and not something you have to think too hard about. It's cheaper than a smartwatch. You get your steps, basic heart rate, and some sleep tracking. Maybe you can see the time, maybe you can't. But unlike many wearables today, a fitness tracker wasn't truly meant to be a companion for your phone and all the overwhelm that comes wit … Read the full story at The Verge.

RIO DE JANEIRO — Mazdak Abulnaga should be the poster child for the type of employee pharma companies want to hire this year. Abulnaga, a 33-year-old postdoctoral fellow at MIT and Harvard Medical School, is building ...

In several nations, being a descendant of those who defeated Nazism and expressing affiliation with the Russian World can often be fraught with difficulties, and in some cases, even criminal penalties, Gennady Ovechko said

A new Columbia University School of Nursing AI-assisted audit reveals nearly 3,000 peer-reviewed medical papers have fake citations that do not exist in scientific databases. The results highlight an alarming trend in academic publishing as the use of AI grows.

Advanced AI systems are approaching physicial-level reasoning in diagnostic tasks.

Bacteria fend off invading viruses with molecular scissors that slice up viral DNA—a system called CRISPR that's become indispensable to gene editing. But viruses can fight back with a molecular trick that stops the scissors from ever being made.

Organ transplantation has long been the definitive treatment for patients suffering from end-stage organ failure, yet the journey post-transplant has been fraught with challenges. Traditional immunosuppressive therapies, while effective in curtailing acute rejection episodes, fall short in preventing chronic rejection and often impose a heavy toll in the form of opportunistic infections, malignancies, and debilitating […]

The integration of artificial intelligence (AI) into robotic surgery marks a transformative era in the field of minimally invasive procedures. Surgical outcomes following robotic interventions have historically varied considerably, a variability largely attributable to differences in surgeon skill and intraoperative decision-making. As the complexity and precision required for these operations escalate, AI emerges as a […]

Google has announced the Google Health Coach, a Gemini-powered personal wellness assistant baked into a rebranded Google Health app. Here's everything you need to know about pricing, features, and availability.

Google’s Screenless Fitbit Air Relies on Gemini to Be Your Personal Health Coach  GizmodoIntroducing the all-new Fitbit Air  blog.googleGoogle’s plan to win the AI health race? Play nice with Apple and other rivals  CNNGoogle Launches $100 Fitbit Air Without a Screen to Rival Whoop  Bloomberg.comGoogle's Biggest Health Announcements: New Fitbit Air, Goodbye Fitbit App and Hello 'Coach'  CNET

Google’s Screenless Fitbit Air Relies on Gemini to Be Your Personal Health Coach  GizmodoIntroducing the all-new Fitbit Air  blog.googleGoogle’s plan to win the AI health race? Play nice with Apple and other rivals  CNNGoogle Launches $100 Fitbit Air Without a Screen to Rival Whoop  Bloomberg.comGoogle's Biggest Health Announcements: New Fitbit Air, Goodbye Fitbit App and Hello 'Coach'  CNET

Many cancer patients turn to biotin supplements hoping to restore hair lost during treatment, but experts warn the popular vitamin may do more harm than good. While biotin is often marketed for stronger hair and nails, there’s little evidence it actually helps cancer-related hair loss—and it can dangerously interfere with lab tests. Doctors say the supplement can distort key blood markers, potentially masking cancer recurrence or delaying treatment decisions.

Google unveils screenless Fitbit Air and Google Health app to replace Fitbit  Ars TechnicaIntroducing the all-new Fitbit Air  blog.googleNew $100 Fitbit is just a band, and that’s the point  Morning BrewGoogle’s plan to win the AI health race? Play nice with Apple and other rivals  CNNGoogle's Biggest Health Announcements: New Fitbit Air, Goodbye Fitbit App and Hello 'Coach'  CNET

Google unveils screenless Fitbit Air and Google Health app to replace Fitbit  Ars TechnicaIntroducing the all-new Fitbit Air  blog.googleNew $100 Fitbit is just a band, and that’s the point  Morning BrewGoogle’s plan to win the AI health race? Play nice with Apple and other rivals  CNNGoogle's Biggest Health Announcements: New Fitbit Air, Goodbye Fitbit App and Hello 'Coach'  CNET

arXiv:2605.06438v1 Announce Type: new Abstract: Traditional multi-population models, such as the Li-Lee framework, rely on the assumption of mean-reverting country-specific deviations. However, recent data from high-longevity clusters suggest a systemic break in this paradigm. We identify a stationarity paradox where mortality residuals in countries like Sweden and West Germany exhibit persistent unit roots, leading to a systematic mispricing of longevity risk in linear models. To address these non-linearities, we propose Hybrid-Lift, a neural-actuarial framework that combines Hierarchical LSTM networks with a Mean-Bias Correction (MBC) anchoring mechanism. Positioned as a governance-friendly model challenger rather than a replacement of classical approaches, the framework exhibits selective superiority on out-of-sample validation (2012-2020): it outperforms Li-Lee by 17.40% in Sweden and 12.57% in West Germany, while remaining comparable for near-linear regimes such as Switzerland

arXiv:2605.06168v1 Announce Type: new Abstract: Weekly healthcare activity data are typically non-negative counts with temporal dependence and occasional system-wide disruptions, settings in which Gaussian time-series models may be inadequate. Solid organ transplant (SOT) activity provides a representative case study of a count process affected by a large external shock. We analyse weekly SOT counts in the USA and Italy from 2014 to October 2024, stratified by donor type (deceased vs living) and organ (kidney and liver). We fit Poisson and negative-binomial count time-series models incorporating short-term dynamics, calendar effects (holiday weeks), and pre-specified pandemic-period level and/or slope indicators. Candidate specifications are screened within a pre-defined portfolio and selected using BIC within each training window. Forecasting performance is evaluated with an expanding-window design at horizons $h\in\{4,8,12\}$ weeks. Alongside RMSE, we report empirical coverage of

arXiv:2605.06438v1 Announce Type: cross Abstract: Traditional multi-population models, such as the Li-Lee framework, rely on the assumption of mean-reverting country-specific deviations. However, recent data from high-longevity clusters suggest a systemic break in this paradigm. We identify a stationarity paradox where mortality residuals in countries like Sweden and West Germany exhibit persistent unit roots, leading to a systematic mispricing of longevity risk in linear models. To address these non-linearities, we propose Hybrid-Lift, a neural-actuarial framework that combines Hierarchical LSTM networks with a Mean-Bias Correction (MBC) anchoring mechanism. Positioned as a governance-friendly model challenger rather than a replacement of classical approaches, the framework exhibits selective superiority on out-of-sample validation (2012-2020): it outperforms Li-Lee by 17.40% in Sweden and 12.57% in West Germany, while remaining comparable for near-linear regimes such as Switzerland

arXiv:2605.06226v1 Announce Type: cross Abstract: Accurate and timely diagnosis is essential for effective treatment, particularly in the context of rare diseases. However, current diagnostic workflows often lead to prolonged assessment times and low accuracy. To address these limitations, we introduce Hygieia, a multi-modal AI agent system designed to support precision disease diagnosis by integrating diverse data sources, including phenotypic features, genetic profiles, and clinical records. Hygieia features a router-based and knowledge-enhanced framework that mitigates hallucination and tailors diagnostic strategies to different disease categories. Notably, it prioritizes risk-related genomic factors for rare diseases and provides confidence scores to assist clinical decision-making. We conducted a comprehensive evaluation demonstrating that Hygieia achieves state-of-the-art performance across multiple diagnostic benchmarks. In collaboration with clinical experts from Yale School

arXiv:2605.06438v1 Announce Type: cross Abstract: Traditional multi-population models, such as the Li-Lee framework, rely on the assumption of mean-reverting country-specific deviations. However, recent data from high-longevity clusters suggest a systemic break in this paradigm. We identify a stationarity paradox where mortality residuals in countries like Sweden and West Germany exhibit persistent unit roots, leading to a systematic mispricing of longevity risk in linear models. To address these non-linearities, we propose Hybrid-Lift, a neural-actuarial framework that combines Hierarchical LSTM networks with a Mean-Bias Correction (MBC) anchoring mechanism. Positioned as a governance-friendly model challenger rather than a replacement of classical approaches, the framework exhibits selective superiority on out-of-sample validation (2012-2020): it outperforms Li-Lee by 17.40% in Sweden and 12.57% in West Germany, while remaining comparable for near-linear regimes such as Switzerland

arXiv:2605.06226v1 Announce Type: new Abstract: Accurate and timely diagnosis is essential for effective treatment, particularly in the context of rare diseases. However, current diagnostic workflows often lead to prolonged assessment times and low accuracy. To address these limitations, we introduce Hygieia, a multi-modal AI agent system designed to support precision disease diagnosis by integrating diverse data sources, including phenotypic features, genetic profiles, and clinical records. Hygieia features a router-based and knowledge-enhanced framework that mitigates hallucination and tailors diagnostic strategies to different disease categories. Notably, it prioritizes risk-related genomic factors for rare diseases and provides confidence scores to assist clinical decision-making. We conducted a comprehensive evaluation demonstrating that Hygieia achieves state-of-the-art performance across multiple diagnostic benchmarks. In collaboration with clinical experts from Yale School of

arXiv:2605.06018v1 Announce Type: new Abstract: In this paper, we conduct a detailed investigation on the effect of independent component (IC)-based noise rejection methods in neural network classifier-based decoding of electroencephalography (EEG) data in different task datasets. We apply a pipeline matrix of two popular different independent component (IC) decomposition methods (Infomax and Adaptive Mixture Independent Component Analysis (AMICA)) with three different component rejection strategies (none, ICLabel, and multiple artifact rejection algorithm [MARA]) on three different EEG datasets (motor imagery, long-term memory formation, and visual memory). We cross-validate processed data from each pipeline with three architectures commonly used for EEG classification (two convolutional neural networks and one long short-term memory-based model. We compare decoding performances on within-participant and within-dataset levels.Our results show that the benefit from using IC-based

arXiv:2605.05627v1 Announce Type: new Abstract: Sustainable forest management relies on precise species composition mapping, yet traditional ground surveys are labour-intensive and geographically constrained. While Uncrewed Aerial Vehicles (UAVs) offer scalable data collection, the transition to deep learning-based interpretation is bottlenecked by the severe scarcity of expert-annotated imagery, particularly in complex, visually heterogeneous regeneration zones. This paper addresses the dual challenges of data scarcity and extreme class imbalance in the semantic segmentation of fine-grained forest regeneration species by providing a scalable framework that reduces reliance on manual photo-interpretation for high-resolution, millimetre-level aerial imagery. Importantly, we leverage the large-scale vision-language Nano Banana Pro model to simultaneously generate high-fidelity images and their corresponding pixel-aligned semantic masks from prompts. We introduce WilDReF-Q-V2, an

arXiv:2605.05611v1 Announce Type: new Abstract: In this paper, we present X-Voice, a 0.4B multilingual zero-shot voice cloning model that clones arbitrary voices and enables everyone to speak 30 languages. X-Voice is trained on a 420K-hour multilingual corpus using the International Phonetic Alphabet (IPA) as a unified representation. To eliminate the reliance on prompt text without complex preprocessing like forced alignment, we design a two-stage training paradigm. In Stage 1, we establish X-Voice$_{\text{s1}}$ through standard conditional flow-matching training and use it to synthesize 10K hours of speaker-consistent segments as audio prompts. In Stage 2, we fine-tune on these audio pairs with prompt text masked to derive X-Voice$_{\text{s2}}$, which enables zero-shot voice cloning without requiring transcripts of audio prompts. Architecturally, we extend F5-TTS by implementing a dual-level injection of language identifiers and decoupling and scheduling of Classifier-Free Guidance

Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML).

A recent mouse model based study suggests that blocking TGF-β may improve osteoporosis treatment by helping quiescent osteoblasts in inactive bone surfaces return to an active state.

In a startling new revelation from the academic world, a comprehensive AI-assisted audit conducted by researchers at Columbia University School of Nursing has uncovered a burgeoning crisis in biomedical publishing. The investigative study, recently published in the prestigious journal The Lancet on May 7, 2026, reveals that nearly 3,000 peer-reviewed medical papers contain fabricated citations—references […]

Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). They show that there are not just one, but four different subtypes of leukemia stem cells. This diversity could explain why one of the most important AML drugs does not work sufficiently in some patients or loses its effectiveness over time—resulting in the return of leukemia.

Astellas reported promising results with its stem cell-derived therapy in an age-related eye disease, though data in a handful of high-dose patients in the early-stage study raised questions. The experimental stem cell therapy is made ...

In a groundbreaking study spearheaded by researchers at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), a pivotal mechanism underlying treatment failure in acute myeloid leukemia (AML) has been unraveled. This investigation reveals that AML does not arise from a single type of leukemia stem […]

Ahead of the Google Health app rolling out next week, the company has detailed what Fitbit features are going away or significantly changing. more…

Cancer immunotherapy is built on a simple but powerful idea: the immune system can recognize and destroy cancer cells if it is properly activated. In many patients, however, this response is too weak or too slow to be effective. Recently, a type of immune cell called invariant natural killer T (iNKT) cells has attracted attention because of their ability to act as coordinators of immune responses, rapidly activating and rallying other immune cells to fight cancer.

Klarna CMO David Sandström created an AI version of himself to handle angry comments after budget cuts.