Life Extension

Researchers combined Raman microscopy with gene expression data at single-cell resolution from the same cells, and AI, to develop RamanOmics, a noninvasive way to detect biomarkers of cellular senescence as “barcodes." The post Cell Senescence ‘Barcodes’ Identified with Raman Microscopy and Gene Expression Data appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers at Johns Hopkins University found that lower bone mineral density in the spine was associated with faster cognitive decline and accelerated age-related white matter injury, according to a new study published today in Radiology, a journal of the Radiological Society of North America.

Smoking kills. But why does smoking seem more likely to kill now than a few decades ago? In 1987, a smoker had a 3.4% chance of dying within five years. By 2013, a smoker had a 4.9% chance of drying within five years.

A range of gene therapies are presently available in the medical tourism community of clinics outside the US and Europe, largely originating with a small number of companies such as BioViva Sciences and Triple Helix Science. These gene therapies tend to involve intramuscular (targeting muscle) or intranasal (targeting the brain) delivery of a modern adeno-associated virus (AAV) vector, such as AAV8 or AAV9. While AAV therapies have exhibited a concerning risk of life-threatening immune response when injected systemically at high doses, lower doses used in conjunction with local delivery appear to be relatively safe. The genes delivered by these gene therapies include follistatin for muscle growth, VEGF for vascular growth, and some well-known genes hoped to improve the state of the aging body and brain […]

Senescent cells accumulate with age, likely largely because the aging of the immune system slows down the clearance of senescent cells, but the relative importance of different contributions to the growing burden of senescence in aging tissues is an area of ongoing discussion. Senescent cells secrete inflammatory signals that are disruptive to tissue structure and function when sustained over the long term. Separately, cells throughout the body accumulate mutations over the course of aging. Much of this has little to no effect, occurring in cells with few replications remaining, or in genes not used by the cell. However, a growing burden of mutation in stem cell populations spreads slowly into the tissues they support via the daughter somatic cells generated to replace those cells lost […]

Stem cell transplants helped regenerate stroke-damaged brain tissue in mice, producing new neurons and restoring lost motor function. The treatment also improved blood vessels, inflammation, and the blood-brain barrier, raising hopes that a similar approach could eventually help repair the human brain after stroke.

A new review was published in Volume 18 of Aging on August 31, 2026, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework."

Marine scientists have been amazed to discover an endangered sea cucumber can live for decades, with some animals living more than 100 years, in a first-of-its-kind genetic mark-recapture study. Australian Institute of Marine Science (AIMS) Senior Principal Research Scientist Dr. Sven Uthicke said the findings suggested black teatfish sea cucumber populations recover much more slowly than previously thought and that this had implications for commercial fishery catch limits.

Researchers identified genes that enable the regeneration of dopamine-producing neurons in planarians. This provides a roadmap for investigating whether similar pathways can be activated in humans and potentially leveraged to treat traumatic brain injuries and neurodegenerative diseases. The post Genes Involved in Flatworm Brain Regeneration Identified appeared first on GEN - Genetic Engineering and Biotechnology News.

Radicals, atoms or molecules that readily react with other substances to form new bonds, are useful tools for building complex substances such as pharmaceuticals. But even when a radical is generated efficiently, the reaction cannot continue unless the catalyst returns to its original state.

As we age, some of the cells in our body enter a state of senescence, in which they stop dividing but do not die. Those senescent cells can contribute to age-related disorders such as cancer, tissue degeneration, and inflammatory diseases.

A study by the Faculty of Sport and Health Sciences at the University of Jyväskylä, Finland, found that a high adolescent body mass index (BMI) may be linked to accelerated biological aging in adulthood.

As we age, some of the cells in our body enter a state of senescence, in which they stop dividing but do not die. Those senescent cells can contribute to age-related disorders such as cancer, tissue degeneration and inflammatory diseases. In an advance that could lead to better ways to diagnose and treat those diseases, MIT researchers have developed a noninvasive way to detect biomarkers of senescence. Their method is based on Raman microscopy, which can reveal the biochemical composition of cells without harming them.

The human brain is terrible at healing itself from injury or disease. But some animals can harness their own cellular abilities not only to repair injuries but also to regrow their brains entirely. Researchers from the University of Georgia have pinpointed several of the genes that make brain regeneration possible in one type of flatworm.

​About 1.2 million people in the United States are living with HIV, or human immunodeficiency virus. Because of major advances in medical treatment and technology, people with HIV are living long, healthy lives.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Midlife Growth Hormone Receptor Ablation Modestly Slows Aging in Mice Telomerase Expression in the Immortal Hydra The Most Powerful Economic Productivity Lever of […]

FRIDAY, Sept. 18, 2026 — Healthy eating might help slow the speed at which you age, and there’s more than one diet that works, a new study says.Ten different healthy dietary patterns are linked to slower biological aging, researchers reported...

Scientists found that declining levels of the brain protein Menin may help drive aging, with lower levels in mice linked to inflammation, cognitive decline, weaker bones, and thinner skin. Restoring Menin reversed several age-related changes, while the amino acid D-serine improved cognition, hinting at a potentially intriguing new target for healthy aging.

Researchers developed 38 sex-specific biological aging clocks across 15 organ systems, finding differences between females and males in genetic architecture, molecular signatures, disease associations, and mortality patterns. Brain aging clocks were linked to progression from mild cognitive impairment to Alzheimer’s disease in both sexes and to sex-dependent cognitive trajectories among solanezumab-treated A4 participants, while the authors stressed that sex-pooled and sex-interaction models remain complementary approaches.

Apple’s Rebuilt Health App Apple Watch owners testing iOS 27.2 can now see a Health Age score, an

Most older adults would rather stay in their own homes as they get older than move into care.

Enhertu, which can give patients an extra seven months to live on average, has been prescribed in Scotland for more than two years and is available.

Japan has recorded 99,763 people aged 100 and over, extending a 55-year rise, while longevity and demographic ageing increase pressure on public finances and services.

PD-L1 and PD-L2 are components of immune checkpoints, widely expressed in tissues throughout the body. They act by binding to the PD-1 receptor on immune cells to suppress immune activation, and are part of the panoply of biochemical interactions that provide self-tolerance to prevent the immune system from inappropriately attacking healthy cells. Autoimmunity is a breakdown of these mechanisms. Cancerous cells abuse the strategies by which normal somatic cells are shielded from immune cell attention, and thus most research into immune checkpoints has taken place in the cancer research community. Inhibition of checkpoint interactions to unleash the immune system now forms the foundation for a number of cancer therapies, albeit that most work has focused on PD-1 and PD-L1 rather than on PD-L2. In today's […]

With an $11 million award from the National Institute on Aging, University of Michigan researchers will build and share national data that track how neighborhood conditions change over time, helping scientists study how local environments affect older adults' health.

Twelve candidate indicators, based on studies in mice, could make developing anti-aging interventions faster-while offering new insights into age-related diseases.

NICE has reversed its decision and approved Enhertu for NHS use in England, benefiting around 1000 women with advanced breast cancer.

Damage to nuclear DNA occurs constantly, and near all of it is immediately repaired. A tiny fraction lingers, however, and over time a burden of mutational damage builds up in tissues throughout the body. It is an open question as to how large a component of degenerative aging is a direct result of this damage, under normal circumstances. High rates of mutation in individuals with disabled DNA repair mechanisms shorten life span and accelerate the onset of age-related conditions, sometimes dramatically, but that doesn't necessarily mean the DNA damage is important in aging at levels exhibited in normal individuals. The best approach to firm data is to find a way to suppress or repair mutations without affecting other mechanisms, but the life-extending interventions that are […]

Sports medicine is somewhat focused on specific functional aspects of health, and so it was probably inevitable that factions in that community found the measures of life span and even health span to be lacking. Here, for example, a researcher proposes movement span as a useful concept, the period of life in which one is capable of navigating the world easily - the inverse of physical frailty, more or less. Interestingly, life span and health span in nematode worm studies of aging and longevity are already in practice forms of movement span, as manual or automated measures of worm movement is how researchers assess that the worms remain healthy and alive. How we conceptualize aging shapes how we measure it, how we respond to it, […]

More than 100,000 people in the country are over 100 years old

Scientists have discovered that some severe genetic disorders linked to rapid aging may be driven not just by damaged DNA, but by the body’s overreaction to that damage. When broken DNA fragments leak into the wrong part of a cell, an immune sensor called cGAS can mistake them for signs of a viral infection, triggering chronic inflammation and even interfering with DNA repair itself.

A study by DZNE finds that healthy eating is associated with slower biological aging-and that there is more than one way to eat healthily.

Normal cell metabolism, particularly the activities of mitochondria, generates oxidizing molecules that react with proteins to disrupt their function. This damage occurs constantly, and is repaired constantly. Cells remove damaged proteins, undo oxidative changes, and make use of antioxidant enzymes such as SOD1 to prevent damage from occurring in the first place. With age, oxidation increases and becomes an important component of cell dysfunction. Here, researchers note that SOD1 itself can become oxidized and harmful, and discuss the importance of antioxidants disabled by oxidization in the growth of age-related oxidative stress in cells. The specific focus is on skin aging, but the points have relevance to all tissues. As the body's primary barrier against environmental insults, the skin is continually exposed to oxidative stress, which […]

After an injury, DNA not only alters its activity but also the way it is organized spatially within the cell nucleus.

A few species of hydra are immortal in their normal environmental conditions, meaning that function does not decline over time and mortality risk does not increase over time. Researchers spent a good deal of time taking care of hundreds of hydra some years ago to demonstrate that this is the case. Hydra are lower animals, essentially a bundle of stem cells capable of regenerating and replacing any part of their bodies, somewhat analogous to an ambulatory embryo. It is an open question as to whether anything we can learn from their biochemistry can be useful in human medicine. In today's open access paper, researchers report on the employment of telomerase by hydra. Telomeres are repeated sequences at the end of chromosomes that shorten with each […]

Insilico Medicine, a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced Longevity Vaccines, a research initiative developing treatments that direct a patient's own immune cells to eliminate the earliest cellular drivers of age-related disease.

The company anticipates its two pumps will work with a next-generation insulin dosing algorithm.

Persistent infections such as cytomegalovirus and other herpesviruses most likely accelerate aging, primarily via harmful effects on the immune system that lead to earlier immunosenescence and chronic inflammation than would otherwise be the case. A range of mechanistic and epidemiological research broadly supports this hypothesis. It remains challenging to completely clear persistent viral infections, however. If a strong antiviral therapy existed, epidemiological data would likely prove the point one way or another within five to ten years, as effects on aging would become apparent in older populations. As it stands, the present relatively weak antiviral therapies show some evidence for positive effects on late life risk of mortality and age-related disease, but not in all studies. Asymptomatic infections are traditionally considered harmless, reflecting effective immune […]

Cells become senescent constantly throughout life in response to various forms of damage and stress, ceasing replication and generating a potent mix of inflammatory signals. In youth, these cells are promptly cleared by the immune system, but with advancing age they begin to linger and accumulate. The inflammatory signaling becomes disruptive to tissue structure and function when sustained over the long term, and this is an important contribution to degenerative aging. Here, researchers show that macrophage cells in the kidney express increasing amounts of the P2RX7 receptor on the cell surface as they progress towards becoming senescent, and blocking this receptor with a suitable antagonist small molecule reduces macrophage senescence and improves kidney function. Macrophage senescence is a pathological feature in aging or diseased kidneys. […]

Researchers found that a standardized 30-second voice recording could predict chronological age with mean absolute errors of 3.95 years in females and 4.41 years in males. The resulting Voice Age measure also captured physiological information partly distinct from molecular, imaging, sleep, and lifestyle-based aging clocks, supporting its potential as a functional aging biomarker.

Nostradamus's ambiguous 16th-century verse is being linked to artificial intelligence, but the interpretation reflects modern fears rather than evidence of a specific prediction about machines.

After an injury, DNA not only changes its activity but also the way it is organized spatially within the cell nucleus. In this process, certain regions of DNA establish new physical contacts through chromatin loops that act as bridges, bringing together sequences that are far apart in the genome's linear sequence. Now, a study has identified—in an animal model—the formation of these loops as an essential step in tissue regeneration after an injury.

Despite considerable and growing effort put towards the development of novel means to slow and reverse aging over the past thirty years, the longest lived laboratory mice remain those lineages first established in the 1990s with mutations that disable growth hormone metabolism, such as via knockout of growth hormone or growth hormone receptor genes. These mice are small and vulnerable to cold, but live as much as 70% longer than their unmodified peers. It seems likely that this has little relevance to human aging, as Laron syndrome is the analogous human inherited condition, usually caused by a growth hormone receptor loss of function mutation. Laron syndrome patients may have a lower incidence of some age-related conditions, but do not appear to live meaningfully longer than […]

Cancer rates are rising in adults under 55, and new research suggests accelerated biological aging may be one piece of the puzzle. Scientists found that people from more recent generations tended to have bodies that appeared biologically older than those of earlier generations at the same chronological age. Greater biological age acceleration was linked to a higher risk of early onset cancers, with specific patterns seen for lung, gastrointestinal, uterine and colorectal cancers.

Researchers here run a much larger than usual mouse study to show a ~10% slowing of aging, depending on how one slices the data, in mice genetically engineered to exhibit a growth hormone mutation that changes the interaction of circulating growth hormone with the growth hormone receptor on cell surfaces. Growth hormone is switched from a receptor agonist (binds with and activates the receptor) to a receptor antagonist (binds with the receptor without activating it, blocking other molecules from activating it). This extension of life is entirely expected given all of the long-lived mouse lineages in which growth hormone metabolism is in some way sabotaged. This specific form of sabotage had not been tested rigorously, however. While interesting, it is worth noting that humans with […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents The Challenge of Cheap Interventions and Expensive Clinical Trials The Adaptive Cost Hypothesis of Aging, a Viewpoint on Antagonist Pleiotropy Semaglutide to Reduce […]

Semaglutide helped older healthy mice live longer while improving memory, muscle function, blood sugar control, and several biological signs of aging. Its effects went beyond those seen with calorie restriction, raising the possibility that GLP-1 drugs could tap into a separate biological pathway linked to longevity.

Mitch McConnell's expected Senate return after a three month health absence is reviving America's debate over age and term limits for ageing lawmakers.

The aging Michigan power plant was set to retire. Then the Trump administration intervened in a way that overstepped its authority, a court ruled.

A remarkably detailed study of Maria Branyas, who lived past 117, reveals that extreme longevity may involve both intense aging and powerful biological protection at the same time. Researchers found signs of advanced aging, but also low inflammation, beneficial gut bacteria, protective genetic features, and a biological age younger than her chronological age. Because she avoided major disease, the study offered a rare look at aging itself rather than the illnesses that often accompany it.

On a sunny spring day at Penn State, Cristin Millett, professor of art in the College of Arts and Architecture's School of Visual Arts, inserted a catheter needle into the umbilical vein of a placenta.

People with a progressive genetic eye disorder see more clearly after receiving engineered grafts that repair the damaged surfaces of their eyes, offering a glimpse at what future treatments could hold.

A new study looked at gray matter in the brain during puberty, pregnancy and menopause, finding distinct changes at different life stages.

Aging is a complex stochastic process of damage accumulation, shaped at the detail level by choices made, environments encountered, and the responses and interactions of countless cells. As the paper here notes, this gives rise to a sizable variance between individuals, even those with the same genetics or similar lifestyles. The research and medical community largely react to this variance with a drive towards developing personalized medicine, but the underlying mechanisms of aging are the same from individual to individual, even if outcomes vary. A therapy that addresses one underlying mechanism in one tissue will tend to produce differing levels of benefit from person to person, but in principle it should always produce benefit. Undergoing some degree of repair should always result in better outcomes […]

Europe’s largest urban regeneration project, the Ellinikon, a 6.2 million-sq-m redevelopment of Athens’ former international airport, has completed its latest stage. Called the Courtyards, the 324-unit residential neighbourhood is formed… The post Checking in on Europe’s largest urban regeneration project appeared first on Global Construction Review.

Sun safety is always in season. It's important to protect your skin from sun damage throughout the year, no matter what the weather.

Blocking PD-L2 reduced senescent cell accumulation in aged mice and improved measures tied to metabolic function and physical strength. The post PD-L2 Blockade May Reduce Harmful Aging Cell Buildup appeared first on GEN - Genetic Engineering and Biotechnology News.

Editing a plant's genes is only half the battle. Before a new, improved trait can ever reach a farmer's field, scientists must be able to grow a whole plant from just a few edited cells—a process that can be slow, unreliable and, for some plant species, impossible.

Longstanding aging metrics have focused on how long people live and how long they live free of chronic disease, but both overlook a core component of daily well-being: the ability to move through the world with ease and confidence.

Brain tumors develop within an organ that changes substantially with age. A new review in Ageing and Cancer Research & Treatment examines evidence that the aging brain microenvironment may influence brain tumor progression, treatment resistance, and cognitive outcomes.

Every field of specialist knowledge consists of a series of concentric circles, the greatest knowledge at the center, the scientists advancing the state of the art, and the least knowledge at the outskirts, the public at large. In between we find lesser scientists, patient advocates, laypeople with a strong interest in the field, and so forth - various gradations of knowledge. The members of any given ring engage in an educational dialog with the next ring out, and themselves learn from the education efforts of the more knowledgeable neighboring inner ring. The more distant any two rings are, the less they tend to engage with one another directly. Thus we end up with the edifice of public messaging, simplifications of scientific knowledge intended for people […]

Aging clocks built using machine learning techniques applied to biological data are colloquially said to measure biological age, or at least aspire to measure biological age. Biological age is nebulous and debated at the detail level, but a rigorous definition is the increase over time in risk of mortality from intrinsic causes. A greater mortality risk implies a greater biological age, regardless of chronological age. Regarding clocks, it would be more accurate to say that they may measure some reflection of biological age, or factors that correlate with biological age, and it is actually far from clear that any given clock does this in a useful way. The lengthy review and discussion noted here is a good one, and digs into many of the subtle […]

The accumulation of senescent cells is an important contribution to degenerative aging; the inflammatory secretions of senescent cells actively degrade tissue structure and function. Animal studies have shown that selective destruction of senescent cells produces a meaningful degree of rejuvenation in old animals, alongside reversal of the pathology and progression of many age-related conditions. Senescent cells exhibit a sizable number of metabolic differences from normal cells, and researchers continue to explore these differences in search of novel ways to selectively destroy senescent cells. Here find an example of a novel finding, in which researchers explore the increased glycolysis that supports senescent cell energy metabolism and find a way to sabotage it. Aging is a complex biological process, which is affected by several factors, lifestyle, diet, […]

Researchers applied six proteomic aging clocks to serum samples from a phase 2a trial of rentosertib in people with idiopathic pulmonary fibrosis and found treatment-associated shifts toward younger predicted biological-age profiles, particularly with the 30 mg twice-daily regimen. Additional proteomic analyses linked treatment to changes in senescence, metabolism, growth-factor signaling, and fibrosis-related pathways, although the study could not determine whether these effects reflected genuine geroprotection rather than disease modification.

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it.

Without careful study design, studies in which the use of GLP-1 receptor agonists such as semaglutide lowered calorie intake significantly via suppression of appetite might be expected to teach us little that we did not already know. Reducing calorie intake without compromising minimum necessary levels of essential nutrients slows aging and extends life, whether achieved via limiting food availability or by limiting appetite. Researchers know this, and they know a great deal about the fine details of the metabolic response to reduced nutrient availability. The effects of reduced calorie intake readily overpowers the effects of other mechanisms that may or may not be operating as a result of GLP-1 receptor agonism, particularly in short-lived species. One has to look more carefully to see any more […]

Scientists found that caffeine activates an ancient cellular energy system involved in stress resistance, DNA repair, and growth. The discovery could help explain caffeine’s links to healthier aging and may point toward new ways to target the same pathway.

Energy storage is becoming critical to grid resilience and electricity affordability because battery systems can help balance supply

Past research has noted that socioeconomic status is a part of a web of correlations that include wealth, intelligence, education, lifestyle choices, and longevity. Untangling all of that to make definitive pronouncements on what exactly drives the observed variation in human life span has proven challenging. It is a reasonable assumption, based on animal studies, that lifestyle choices and consequent degree of physical fitness are the primary factor determining late life survival, however. Here, researchers take a more subtle approach to data analysis and conclude that socioeconomic and demographic status has very little influence on individual longevity. This is much as we might expect if lifestyle choice related to fitness is the primary influence, as will continue to be the case until the first therapies […]

Screening compound libraries for effects on aging in short-lived species has grown to become a significant area of interest in the aging research community. As a general rule, discoveries are modest in effect size, and largely take the form of novel ways to influence the beneficial maintenance and repair activities (such as autophagy) triggered by calorie restriction, heat, cold, and other forms of stress. These responses have a much larger effect on life span in short-lived species than in long-lived species, so in the long run are not all that interesting. Nonetheless, considerable effort has been made to find ways to make this screening process more efficient and automated. Research equipment has been constructed to house tens of thousands of nematode worms and use machine […]

A new UCLA Health study found that treatment of insomnia using cognitive behavioral therapy slowed the pace of biological aging in older adults.

Elderly mice on the popular weight-loss drug semaglutide aged slower and lived longer, mimicking the longevity effects of caloric restriction. The post Could GLP-1 Drugs Help You Live a Longer, Healthier Life? appeared first on SingularityHub.

At the high level, without delving into specific mechanisms, the consensus view on aging is that it exists in the shadow of natural selection. The selection pressure that drives the spread of changes in genes, systems, biology in general in any given species operates most strongly on early life reproductive success. This inevitably gives rise to systems that perform well initially, but which fall apart later. Expenditure of resources on long-term maintenance loses out to expenditure of resources on short-term reproductive fitness. Aging is a near universal side-effect of evolutionary competition, a race to the bottom that exists because early life reproductive success wins out over repeated reproductive success for a longer period of time. That a given aspect of an individual's biochemistry can be […]

Bone repair depends on skeletal progenitor cells (SPCs) moving to injured areas and developing into bone-forming cells, but how these cells respond to their surroundings remains unclear.

The field of regenerative medicine is gaining momentum. Mesenchymal stem cells (MSCs) remain central to this field, with expanding applications as direct therapies and as producers of MSC-derived extracellular vesicles (MSC-EVs). This article examines the biological and regulatory factors shaping their promise. The post Regenerative Medicine in the Bronze Age: MSCs and MSC-EVs Leading the Way appeared first on GEN - Genetic Engineering and Biotechnology News.

For nearly a decade, the Beacon platform has advanced from integrated single-cell cloning to earlier productivity, product-quality, and stability measurements, with AI-assisted clone evaluation pointing toward the next step. Bringing richer evidence forward helps teams focus resources on the candidates most likely to succeed. The post Measuring Cell Line Development Quality Within Days of Single-Cell Cloning, Not Months Later appeared first on GEN - Genetic Engineering and Biotechnology News.

Astronauts who undergo long-duration spaceflight aboard the International Space Station often return with health problems that resemble some age-related conditions in people on Earth.

Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age.

A new study suggests Insilico Medicine’s AI-designed lung drug may slow biological aging, though more research is needed.

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the stem cells—unspecialized cells that can develop into specific cell types—that give rise to the body's tendons and ligaments, the tissues connecting muscles and bones.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age.

Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents What Can Be Learned About Aging Clocks from Existing Clinical Trial Data for Longevity Interventions? Immune System Signatures Correlate with the Near Term […]

As the human brain takes shape before birth, a remarkable type of stem cell helps give it many of the features that make it distinctly human.

People's bodies may reflect their ages very differently at the molecular level, even when they are the same chronological age, according to a new study.

A substance found in edible sea squirts appeared to reverse several signs of aging in older mice. Plasmalogen supplements improved memory and learning, strengthened connections between brain cells, reduced inflammation, and even helped the mice grow thicker, darker hair. Researchers believe the compounds may encourage brain regeneration and protect aging synapses.

This is far from the only study to indicate that the children of long-lived individuals tend also to be long-lived. The open question is the degree to which this is genetic versus cultural transmission. The construction of very large population databases over the past few decades has produced evidence for genetics to play only a small role in life expectancy for the vast majority of people. Similarly the weight of evidence for lifestyle choice, particularly physical fitness, to be the presently dominant influence on life expectancy is compelling. Against that background, the hypothesis that centenarians are centenarians because they have favorable gene variants that might form the basis for age-slowing therapies faces an uphill battle. Centenarian lifespan extension is frequently accompanied by delayed onset of […]

Unauthorized stem cell treatment may expose patients to medical and financial risks, reinforcing the role of physicians in counseling those considering such treatment abroad.

Global disease burden is shifting toward aging-related conditions as people live longer, with these diseases now representing the largest expected lifetime health burden for newborns across all income groups. Modeling suggests that reducing aging-related disease could produce unusually large and progressively greater gains in both longevity and healthy life expectancy because improvements in survival and health reinforce one another.

JioPC Opens to Every Indian User Mukesh Ambani’s Reliance Jio has opened its cloud PC service to anyone

Researchers have demonstrated a series of biological tests that could serve as "proxies" for measuring how different regenerative agriculture practices could improve soil carbon—years before it would be possible to measure the carbon directly. The technique offers new insights into how effective various regenerative practices are at improving soil health.

Aging does not appear to follow the same molecular script for everyone, according to an eight-year study of 335 women.

Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is an important contributing cause of degenerative aging. A cell becomes senescent in response to damage induced by some form of stress, or more often when a somatic cell reaches the Hayflick limit on cellular replication. In youth senescent cells are efficiently cleared by the immune system, but immune system aging allows senescent cells to linger and grow in number. Immune cells themselves are prone to reaching the Hayflick limit and entering replicative senescence because they respond to a variety of issues with greater replication to multiply their efforts. Research into neurodegenerative conditions and the state of the aging brain has […]

Aging may be partly fueled by immune cells losing their ability to clear away damaged, inflammation-promoting cells. Blocking a single receptor restored that cleanup process in mice, reducing inflammation and helping their organs, muscles, and memory remain remarkably youthful.

Long-lived bats are extreme outliers in the normal mammalian relationships between species body size, metabolic rate, and life span. They are small, have a high metabolic rate, and unlike near all other mammals with those characteristics, many bat species are long-lived. But bat species do exhibit a very wide range of life spans; near neighbor species can have very different paces of aging. Researchers here sequence the genomes of a number of different bat species in search of insight into the mechanisms driving longevity in bats. As is usually the case, the distant end goal of this sort of comparative biology of aging research is to find potential approaches to the development of longevity therapies. That is a long road, and little progress has been […]

Semaglutide improved health, reduced aging-related changes, and extended lifespan in older female mice, sometimes outperforming caloric restriction. However, human longevity benefits remain unproven. The post GLP-1 Drug Semaglutide Slows Aging and Extends Lifespan in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.

The most common metabolic diseases, such as type 2 diabetes or fatty liver disease leading to metabolic dysfunction-associated steatohepatitis (MASH), a fibrotic condition of the liver, are consequences of the dysfunctional state of metabolism that results from being overweight and sedentary. These conditions are rare in thin, fit people, even in later life when the damage of aging makes metabolism more vulnerable and inflammatory. Excess visceral fat tissue is known to promote the accumulation of senescent cells. While cells become senescent throughout life, in youth they are promptly cleared by the immune system. That clearance falters with age, allowing senescent cells to linger and accumulate. The metabolic dysfunction produced as a consequence of being overweight accelerates this process. In today's open access paper researchers review […]