Life Extension

If the activities of a cell appear precisely engineered and highly efficient, it is because every layer of cellular activity is monitored by some form of quality control mechanism. A cell is a collection of molecules moving at incredible speeds, where every possible collision happens countless times per second. All of the damaging, unwanted reactions that can occur between molecular structures in the cell do in fact happen constantly. Breakage happens constantly. Manufacture of new structures produces flawed outcomes constantly. But all of these issues are cleaned up as they occur. The processes of quality control and maintenance that undertake this cleanup work are collectively vital to cell health and cell function. Messenger RNA is manufactured as the first stage of gene expression. The transcriptional […]

We know that a person’s outlook can have a huge effect on their health, and it’s no different when it comes to ageing. Columnist Graham Lawton looks at new evidence of just how powerful our attitude is – and how to use it to age better

Aging can be split up into specific categories in many different ways; age-related diseases as collections of symptoms, specific forms of cell and tissue damage that accumulate, dysfunctions separated by organ, and so forth. None of these categories exist in isolation from the others, however. All aspects of aging interact with one another. Kidney dysfunction affects the brain. Mitochondrial dysfunction influences the burden of cellular senescence. There are a hundred other interactions one might consider that blur the lines of any attempt at categorization of the progression of aging. Nothing is neat and contained, everything interacts. Aging is accompanied by conserved hallmarks including genomic instability, epigenetic alterations, loss of proteostasis, and mitochondrial dysfunction, but how these processes emerge and become mechanistically linked remains unclear. Here […]

The standard view of the evolution of aging is that aging exists because natural selection operates more strongly on features of young animals than on features of old animals. A faster time to reproductive success will be selected over a slower time to reproductive success. This leads to the evolution of biological systems that are front-loaded for early efficiency, but that decay to become dysfunctional over time. Aging is near universal but not actually universal, however. For example, varieties of hydra are in fact immortal, exhibiting no loss of function over time. How to explain the existence of the few immortal species in the presently dominant view of the evolution of aging? Here, researchers build a model of the evolution of aging in which a […]

An increasing number of cells in aged tissues enter a senescent state, ceasing replication and generating pro-inflammatory signals that are disruptive to tissue structure and function. In the case of innate immune cells, however, there is some question as to whether they are in fact senescent or just adopting features of senescence, and that leads to debate over whether these cells are in fact harmful. Neutrophils, also known as polymorphonuclear leukocytes, are an important cell type in the innate immune system. Here, researchers show that neutrophils in aged individuals exhibit features of cellular senescence, but stop short of calling them senescent cells. They also show that this behavior is harmful, as it impedes the immune response to infection. Aging drives increased susceptibility to respiratory infections […]

Cycling might be one of the simplest ways for older adults to stay healthier, longer. A 10-year study in Japan found that seniors who rode bicycles had lower risks of needing long-term care and dying—especially those who didn’t drive. Continuing or even starting cycling later in life still delivered noticeable benefits. The results highlight biking as a surprisingly powerful tool for maintaining independence and well-being.

Worse financial well-being in midlife and older age -and especially declines over time-are associated with lower memory scores and faster cognitive decline, reports a new study at Columbia University Mailman School of Public Health.

Most programs aiming to produce therapies that treat aging involve some form of manipulation of cellular metabolism, usually via small molecules initially derived from screens that showed effects on function or survival in lower animals. Effect sizes are usually modest, and decrease relative to species life span as species life span increases; large increases in function and life span in a nematode worm translate to modest gains in a mouse. Where we have the ability to compare mice and humans, in the matter of growth hormone metabolism and calorie restriction, we know that sizable gains in mice do not translate to sizable gains in humans. Researchers, particularly Brian Kennedy's team, have shown that most combinations of this sort of intervention fail to be useful. Any […]

The role of the thymus in our long-term immunity and health is poorly understood. A new study suggests we need to pay attention

Autophagy is the name given to a collection of cellular processes responsible for recycling damaged or otherwise unwanted proteins and structures. The materials to be recycled are conveyed to a lysosome where they are broken down into raw materials that can be reused for further protein synthesis. Many of the most well studied approaches to slowing aging in laboratory species involve increased autophagy. Greater autophagy improves cell function and is demonstrated to reduce the pace at which cells in aged tissues enter the harmful senescent state. Nothing in biology is simple, however. Here, researchers discuss the role of excessive autophagy in sustaining the inflammatory, disruptive signaling that is generated by lingering senescent cells in aged tissues. Autophagy and cellular senescence are fundamental stress-response programs that […]

As researchers continue to map the changing composition of the gut microbiome in aging and disease, in ever more detail, they increasingly uncover the problematic activities of specific microbial species and specific mechanisms by which the aging of the gut microbiome can contribute to age-related loss of function throughout the body. This opens the door to the development of means of targeted adjustment of the gut microbiome's composition, and also to the development of therapies that interfere in specific interactions between the microbiome and tissues that cause issues. Ageing is accompanied by declining memory function, with extremely heterogeneous manifestation in the human population. Brain-extrinsic factors influencing cognitive decline, such as gastrointestinal signals, have emerged as attractive targets for peripheral interventions, but the underlying mechanisms remain […]

A two-drug combination frequently used in anti-aging research causes brain damage in mice, University of Connecticut researchers report in the March 16 issue of PNAS.

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The aging of the brain is characterized by the formation of solid aggregates of misfolded amyloid-β peptides. This is a foundation for later loss of cognitive function and the development of the more severe, inflammatory dysfunction of late stage Alzheimer's disease. Researchers here provide data from cell studies to suggest that the innate immune cells known as microglia maladaptively manufacture amyloid-β aggregates in the process of attempting to clear amyloid. Microglia have been the target of increasing interest in the context of the aging of the brain and development of neurodegenerative conditions, though much of that has focused on growing inflammation driven by this cell population. It seems we might have to consider that the normal operation of microglia becomes pathological when faced with protein […]

On the matter of cellular senescence as a contributing cause of degenerative aging, there is a school of thought whose members argue that at least some senescent cells are doing something useful by existing, despite their problematic behavior. Therefore therapeutic approaches should focus on prevention of senescence (senostatics) or reducing the harmful senescence-associated secretory phenotype (SASP) (senomorphics) rather than on outright destruction of senescent cells (senolytics). Within the array of possible ways to reduce the pace at which cells become senescence, sabotaging the ability of senescent cells to encourage their neighbors to also become senescent has been little explored, so it is interesting to note recent work on this topic. Today's open access paper represents is an early step on the path to finding ways […]

Researchers here provide data on the correlations between (a) secreted proteins circulating in blood that are distinct to senescent cells of various types, and (b) a number of different age-related conditions. Some cell types are better than others when it comes to the strength of correlation between the burden of senescence as assessed by circulating proteins and status of given age-related condition. This process of mapping the landscape of senescence and aging sets the stage for the development of better assays that can inform patients as to the risk resulting from the burden of senescence, and later the degree of improvement produced by therapies capable of reducing the burden of senescent cells. Senescence is characterized in part by proteomic expression changes, including the secretion of […]

Senescent cells accumulate in tissues with age to promote degenerative aging. Senescent cells cause harm via the signals that they send to other cells, the senescence-associated secretory phenotype (SASP). The SASP is by no means fully understood, and while it clearly contains many pro-inflammatory and pro-growth signals, it probably has many other effects as well. Here, researchers provide evidence for one specific SASP signal molecule to interfere in the benefits of exercise. Clearance of senescent cells should therefore produce an enhanced response to exercise in old individuals, in addition to the other benefits already demonstrated in a sizeable number of animal studies. Adaptation to physiological stress is fundamental to health but varies widely among individuals. In humans, this heterogeneity is evident in markedly different gains […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Complement System Biomarkers Change with Age, and More So in Dementia Patients ANKRD1 Gene Therapy Improves Memory Function in Aged Mice A Better […]

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A video of Israeli PM Netanyahu has sparked clone theories, with claims of an 'extra finger' suggesting AI manipulation amid the Israel-Iran crisis.

A new Tasmanian Institute of Agriculture (TIA) study has found that while regenerative agriculture practices can improve soil health and reduce emissions on sheep farms, farmers often face trade-offs between environmental and economic goals. The article, "Regenerative agriculture improves productivity and profitability while reducing greenhouse gas emissions on Australian sheep farms," has been published in Nature Food.

The speculation began after users shared screenshots from a 12 March address by Netanyahu, zooming in on his left hand while he gestured mid-sentence.

The International Society for Stem Cell Research (ISSCR) today announced the launch of Stem Cell Medicine: Parkinson's Disease, a new continuing education course designed to equip clinicians with an evidence-based understanding of emerging stem cell therapies for Parkinson's disease (PD).

Researchers identified in mice a microbiome–gut–brain pathway in which age-associated changes in gut microbes increase medium-chain fatty acids that impair vagal sensory signaling and hippocampal activity. These interoceptive disruptions weaken memory formation, revealing a microbial mechanism that contributes to cognitive decline during aging.

Scientists tracking the entire life of the African turquoise killifish have discovered that behavior alone can predict whether an animal will live a long or short life.

To better understand aging’s role in neurodegeneration, Salk researchers and their collaborators built an atlas of the aging mouse brain, revealing region- and cell-type–specific changes in DNA methylation, genome organization, and gene activity. The post Brain Atlas Maps Epigenetic Changes Associated with Aging in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.

Species capable of exceptional regeneration also tend to have longer life spans and slowed aging relative to similar species with less proficient regenerative capabilities. Various closely related species of spiny mouse have been studied in the context of mammalian regeneration because of their ability to shed a large amount of skin and supporting tissues as a defensive mechanism, and later regrow that tissue without scarring. This exceptional regenerative capacity extends to at least some internal organs as well. Spiny mice have been used in past studies that pointed to differences in the activity of macrophage cells as one of the important determinants of complete regeneration versus scar formation. Macrophages are innate immune cells that are deeply involved in ongoing tissue maintenance and regeneration from injury. […]

Technologies that convert carbon dioxide (CO₂) emitted from factories and power plants into useful chemical feedstocks are considered key to achieving carbon neutrality. However, rapid degradation of catalyst performance has long hindered commercialization. KAIST researchers have now developed a "self-regenerating" catalyst that restores its activity during operation, offering a potential solution to this challenge.

Some of the organs in the body do not have to be in their current location, nor structured in a single mass of tissue, in order to carry out all of their functions. The liver is one of these organs. Many (not all, but many) of the functions of the liver could be carried out by small amounts of liver tissue distributed throughout the body. Thus the existence of companies like Lygenesis, shepherding clinical trials of liver tissue organoid transplantation into lymph nodes to help restore lost function. Here, researchers report on the early stages of development for an alternative approach that is even less like normal liver tissue, essentially just an injection of cells and hydrogel rather than any production of structured tissue for […]

Researchers here mount an argument for aging to have evolved due to the interaction between (a) limited nutrient availability in the environment and (b) the options a cell has for generating the vital chemical energy store molecule adenosine triphosphate (ATP). Broadly, ATP can be generated via glycolysis in the cytoplasm or oxidative reactions in mitochondria, at least in eukaryotes such as mammals. Mitochondrial ATP production is slower and more energy-efficient, but both avenues decline with age. Loss of ATP production is harmful to cell and tissue function, most prominently in tissues with high energy needs such as muscle and the brain. Why does ATP production decline with age? The argument advanced here is that this decline evolved in part because it helps the survival of […]

For some women with de novo metastatic breast cancer, surgical resection of the primary tumor is associated with longer survival.

Nanogel integrated spheroids increase cell retention and repair injured swallowing muscles.

We all know cats represent a major threat to native animals and birds. Australia's 5.3 million domestic cats kill a total of 546 million animals each year in Australia. What's less well known is allowing your domestic cat to roam outside exposes them to considerable danger—and the risk of a short life.

For sexual reproduction to yield healthy offspring, newly generated oocytes—immature egg cells—must receive the correct amount of DNA after cell division. This process of segregating chromosomes becomes more prone to failure as we age. Now, RIKEN researchers have identified a strategy that could help to prevent such errors and restore healthy production of oocytes.

A communication pathway between the brain and the gut may be integral to how well the brain holds on to memories

We become forgetful as we age. This is often seen as a universal truth, but in fact it is far from universal: some people remain incredibly sharp at 100 years old, while others experience memory loss starting in middle age.

Swallowing is a fundamental human function that supports nutrition and communication. Damage to swallowing muscles can reduce quality of life and even lead to aspiration pneumonia or malnutrition. Many patients suffer from swallowing difficulties after being treated for head or neck cancer, and swallowing disorders are also common in older adults, yet effective therapies have been limited.

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years.

WEDNESDAY, March 11, 2026 — A researcher is disputing a recent high-profile study claiming that people who live in multilingual countries show healthier brain aging.The study, published in Nature Aging last year, found that knowing more than one l...

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

A Spanish review suggests vaccines — influenza, RSV, COVID, pneumococcal, zoster, and others — may help preserve immune function in older adults and reduce hospitalizations.

The study focused on safety, but the results offer hope the approach could give kids a chance to walk. The post In a First, Researchers Use Stem Cells and Surgery to Treat Spina Bifida in the Womb appeared first on SingularityHub.

A new biotech company forged through an Australian and Danish partnership will accelerate treatments for children and adults with heart disease. Harnessing cellular therapies, the company aims to conduct human clinical trials within three to five years.

Dental pulp injury caused by trauma or deep caries often leads to inflammation, tissue necrosis, and eventual loss of tooth vitality.

TUESDAY, March 10, 2026 — The health boost from daily multivitamins might actually extend to how quickly a person ages, a new study says.Researchers found slower “wear and tear” biological aging among seniors after two years on a multivitamin, resea...

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Researchers have demonstrated that many forms of mild, repeated stresses can improve cell function and slow aging. Lack of nutrients, lack of oxygen, heat, cold, oxidative damage, and others have been demonstrated to be beneficial in animal studies. Here, researchers discuss what is known of the response to hypoxia specifically, but note that many of the mechanisms involved are the same as those involved in other forms of stress response. The cell increases maintenance activities, for example, such as the processes of autophagy responsible for recycling damaged proteins and structures. This in turn helps to reduce the risk of cells becoming senescent. A fair amount of effort has been devoting to finding ways to trigger increased autophagy and other beneficial responses to mild stress using […]

The study of aging is an ongoing project, as is the study of cellular metabolism. The research community remains some way from a complete understanding, and as such there is a great deal of ongoing empirical discovery. Popular areas of study exist because someone demonstrated that a particular approach to therapy produced a slowing or reversal of measurable aspects of aging. Others then join in to try to understand how it works. None of these existing approaches are yet fully understood, in part because they produce complex changes in complex systems. Layered atop considerations of aging in laboratory mice and humans is the point that the world contains thousands of species that researchers might plausibly study, many of which exhibit quite different patterns of aging […]

University of Houston professor of psychology Arturo Hernandez is disputing a high-profile study published in the journal Nature Aging claiming that people who live in multilingual countries show healthier brain aging.

A new study shows that taking a daily multivitamin could boost longevity, but the results aren’t conclusive

Taking a multivitamin every day might slightly slow the rate of ageing, but the extent to which this is relevant to our health is unclear

ARPA-H will “build the train tracks” for first large clinical studies of aging interventions

An analysis led by Mass General Brigham investigators found slower aging in older adults after two years of a daily multivitamin, with greater benefits for those who began the trial with accelerated biological age.

MONDAY, March 9, 2026 — Spending time with someone who constantly causes problems may do more than just ruin your mood. Over time, those stressful relationships could also affect your health and even speed up aging, a recent study s...

Age is more than just one number. While neuroscientists used to think of cognitive aging as a single trendline, they now realize that vast individual differences require a more predictive and personalized approach. As they uncover more factors that affect cognition over time, they are realizing that modeling the aging brain requires more diverse data than traditionally captured.

A large longitudinal study of U.S. adults found that many older people improve in cognitive function or walking speed over time, challenging the idea that aging inevitably leads to decline. Positive beliefs about aging were associated with higher odds of improvement in both cognitive and physical health.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents The Relevance of Clonal Hematopoiesis to Degenerative Aging Remains Uncertain Distinct Nuclear DNA Structure in Immune Cells from Centenarians A Fair Amount of […]

The human body hosts countless viruses in addition to the other forms of microbe such as bacteria and fungi. Most of these viruses are commensal species, most likely harmless throughout much or all of the life span, playing their parts in the microbial ecosystems that exist within and around the body. At the present time there is considerable enthusiasm for the study of the gut microbiome, and this is one avenue of research in which viruses are being cataloged and their activities considered by researchers. Another avenue is the study of persistent infectious viruses, primarily herpesviruses, and their effects of health over the course of aging. Persistent viruses may contribute meaningfully to age-related immune dysfunction and various age-related diseases. Consider what is known of the […]

A researcher dives into the latest research on how the health of the gut microbiome can influence the aging process.

Research into the biochemistry of longevity does not proceed at a rapid pace, even now that the field has become popular. Much of this research takes the form of first discovering longevity-enhancing mutations in short-lived species and then painstakingly tracing chains of cause and effect from protein to protein and interaction to interaction. Since cellular metabolism is by no means fully understood, even in the extremely well studied nematode worm C. elegans, this takes a long time. For example, we can see that is has taken thirty years or so to move from the first C. elegans longevity-enhancing mutation to the discovery of many more, and now here finding that some of these mutations converge on the activity of the FMO-2 gene. This slow pace […]

Superagers’ memory capacity rivals that of younger adults. A new study suggests their brains’ robust production of new neurons may be why.

Other artists, including Britney Spears, Beyoncé, and Eminem, and most recently Selena Gomez, have also been referenced in similar internet narratives.

Mayo Clinic researchers have identified a drug-and-supplement combination therapy that is capable of reducing the harmful effects of senescent cells – also known as "zombie cells" – in diabetic kidney disease.

Discover how Singaporean photographer Chuando Tan maintains his youthful appearance at 60, captivating millions with his disciplined lifestyle and fitness routine.

The composition of the gut microbiome changes with age. Microbial species capable of provoking inflammation, by infiltrating tissues or via production of harmful metabolites, grow in number. This occurs at the expense of populations that produce beneficial metabolites, such as butyrate, known to promote function in a number of different tissues. The reasons for this shift of composition are not fully understood, especially since meaningful change starts to occur relatively early in adult life. Immune dysfunction likely plays a significant role, however, as the immune system is responsible for gardening the gut microbiome, keeping harmful species to a minimum. Rejuvenation of the aged gut microbiome via fecal microbiota transplantation from a young donor has been shown to improve health and extend life in animal studies. […]

A new ChromeOS Flex USB program from Google and Back Market aims to revive aging laptops by letting users easily install Google’s lightweight operating system. The post Google and BackMarket’s ChromeOS Flex USB drive wants to keep aging PCs alive appeared first on Digital Trends.

Teens who frequently lash out at others may face lasting physical health consequences later in life, according to research published by the American Psychological Association.

A recent study found reduced premature aging among childhood cancer survivors that adhered to established dietary guidelines.

Some gene sequences can give rise to circular RNAs when transcribed. As a class, circular RNAs are not as well studied as other classes of molecule in the cell, but it is becoming apparent that, as for just about everything one might find in a cell, some circular RNAs become relevant in the context of aging. Here, researchers discuss findings relating to circular RNAs generated from mitochondrial genes. In particular circular RNAs for MT-RNR2 appear to meaningfully affect mitochondrial function, and lower levels of MT-RNR2 in older individuals may be involved in the age-related decline of mitochondrial function. The best way forward to a greater understanding is to manipulate MT-RNR2 expression and see what happens as a result. In general, improved mitochondrial function should be […]

A new tool called My Music My Choice lets artists poison their songs before release, adding inaudible changes that break AI voice cloning while leaving the music untouched for human listeners. The post This invisible technique poisons songs so AI can’t clone them appeared first on Digital Trends.

A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large-scale gene-silencing structures inside cells, and what happens when that process breaks down. The findings, published today in Molecular Cell, identify a self-clustering mechanism in the Polycomb protein CBX2 that is essential for initiating the formation of gene-repressive condensates and guiding stem cells toward their proper fates.

The longevity industry will at some point diffuse into the broader pharmaceutical and biotech industries. It will cease to be so distinct in culture, technology, and regulation as to merit the drawing of firm lines. Treating aging as a medical condition is no longer looked upon as strange by the powers that be, even though the public at large has yet to catch up entirely to this new viewpoint. This relatively new environment of approval means that sizable funding is available, and indeed deployed in large amounts to advance the cause, both by private and public sources. One of the US government programs in which program managers have become very sympathetic to the cause of treating aging is ARPA-H, portions of which one might think […]

Cerebral palsy is a condition usually caused by brain damage before or during birth, resulting in impaired posture and movement.

Jim Carrey responds to bizarre clone conspiracy theories following his appearance at the César Awards in Paris.

Induced pluripotent stem cells could help treat diseased hearts and brains

The shape and packaging of nuclear DNA is actively controlled by the cell via decoration of the DNA and supporting structures with additional molecular motifs, such as methyl groups. At any given time much of the genome is tightly spooled into regions known as heterochromatin that are inaccessible to the machinery of gene expression that surrounds nuclear DNA, constantly interacting with it. The structure of nuclear DNA determines gene expression, which regions are unspooled and accessible to translation machinery for the production of RNA from gene sequences versus which regions are spooled and the genes there silenced. Here researchers examine immune cells from centenarian blood samples and note a distinct pattern of structure in their DNA. Further investigation points to one specific transcription factor, ERG, […]

Jim Carrey's appearance at the César Awards fuelled widespread speculation about the actor's changing looks, prompting surgeons and officials to weigh in on the rumours. The debate highlights how quickly online theories can eclipse the event itself.

A rare Japanese ant is the only species known to lack female workers and males; all of its young develop into parasitic queens that try to take over other colonies.

Jim Carrey's appearance at the 2026 César Awards has ignited a viral row over whether the star was really there, after makeup artist Alexis Stone claimed to have impersonated him in a hyper‑realistic mask.

Experimental composer Holly Herndon says this technology isn’t here to replace artists—and that the future of creativity belongs to collective intelligence

A new study details how fecal transplants from older female mice significantly improve ovarian function and fertility in young mice. The surprising results reveal a direct link between the microbiome (the collection of all bacteria and other microbes present) of the gut and ovarian health and function.

Surviving cancer at a young age may come with an unexpected cost: faster aging at both the cellular and brain levels. Researchers found that survivors often show signs of being biologically older than their actual age, with chemotherapy accelerating the process most dramatically. This accelerated aging is linked to struggles with memory and focus, which can ripple into education and career outcomes. Encouragingly, scientists believe healthy habits like exercise may help turn back the clock.

The César Awards organizers refute claims of Jim Carrey being replaced by an impersonator, amidst ongoing plastic surgery speculation.

Scientists have discovered a key biological safeguard that helps one of nature's most impressive regenerators, the planarian flatworm, correctly rebuild its organs. The new research, published in Nature Communications, illuminates how these animals prevent their powerful stem cells from making mistakes during regeneration, a discovery that may eventually help scientists understand how to better control stem cell behavior in other species.

Jim Carrey's appearance at the César Awards in Paris led to wild conspiracy theories online, questioning if it was really him on stage.

"Glass" has a unique and distinct meaning in physics—one that refers not just to the transparent material we associate with window glass. Instead, it refers to any system that looks solid but is not in true equilibrium and continues to change extremely slowly over time. Examples include window glass, plastics, metallic glasses, spin glasses (i.e., magnetic systems), and even some biological and computational systems.

Somatic mosaicism in tissues occurs as a result of random mutational events in stem cell populations. Stem cells accumulate mutations randomly over time, a small fraction of the continual damage to nuclear DNA that slips past the highly efficient DNA repair machinery. Those mutations spread out into tissue via the daughter somatic cells generated by the stem cells. A tissue made up of somatic cells thus exhibits an ever more complex mosaic pattern of overlapping mutations over time. Somatic mosaicism in the immune system is known as clonal hematopoiesis. This is arguably the most studied form of somatic mosaicism, as the immune cells produced by hematopoietic stem cells are readily accessible via a blood sample. Somatic mosacism sets the stage for cancer by spreading mutations […]

Speculation about a 'fake Putin' arises after a call with Iran's President following missile strikes, amid Russia's internal and external challenges.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Relationships Between an Aged Oral Microbiome and Harms Done by Senescent Cells Podocytes in the Kidney Do Not Regenerate and Are Lost with […]

Jim Carrey's appearance at the César Awards has sparked discussions about cosmetic procedures and wild clone theories. Experts weigh in on the changes.

Aging muscles heal more slowly after injury — a frustrating reality familiar to many older adults. A new

Jim Carrey's rare turn at the 51st César Awards in Paris triggered fresh 'clone' rumors online, amplified by a viral 'I'm real' image—yet there's no verified evidence, and Carrey hasn't responded.

Polyamines—natural molecules found in every living cell—have become stars in the longevity world for their ability to boost cellular cleanup and support healthy aging. But there’s a dark twist: high levels of these same molecules are consistently seen in cancer, where tumors grow aggressively.

Targeting aging rather than individual diseases could add more than a decade of healthy life, researchers say, citing centenarian studies and drug repurposing efforts.