Life Extension

In this webinar, two experts will show how ultra-sensitive, multiplexed proteomics can measure both the pace of aging and the effects of interventions designed to change it. The post The Aging Proteome: Clocks, Cohorts, and Clinical Trials appeared first on GEN - Genetic Engineering and Biotechnology News.

A new review was published in Volume 13 of Oncoscience on September 30, 2026, titled "Extracellular vesicles in health, aging and disease."

Do we need to fully understand aging, how exactly it works in fine detail, in order to create rejuvenation therapies that are effective enough to make the effort worthwhile? One would expect not, based on the present state of field, but also expect that the process of creating rejuvenation therapies should become ever easier as knowledge accumulates. One can find dead ends and failures by falling into them, or by knowing in advance not to go that way. The former requires considerably greater effort and expense. The present understanding of aging is much advanced over past decades, but still woefully incomplete: it is impossible to determine in advance whether any given mechanism is more or less important than any other; everything interacts with everything else, […]

NASA and Canadian astronauts have completed a five-year upgrade to the International Space Station, installing its final solar array after briefly resolving an unexpected electrical reading.

A surprising new study suggests that an anti-aging drug could help protect people genetically predisposed to Alzheimer's disease. Researchers found that just four weeks of low-dose rapamycin improved brain blood flow in healthy middle-aged adults carrying the high-risk APOE4 gene variant, with women showing the strongest benefits. Because declining blood flow can occur years before Alzheimer's symptoms appear, the discovery raises hopes for preventing or delaying the disease before memory loss begins.

Fatty liver disease, or at least the non-alcohol induced side of fatty liver disease, more properly known as metabolic dysfunction-associated steatotic liver disease (MASLD) is largely an outcome of obesity. Obesity is now known to promote an accelerated age-related accumulation of senescent cells in many tissues. It is not surprising to find cellular senescence in liver cells as an important mechanism in the progression of MASLD to more severe and ultimately fatal liver conditions. Treating the consequences of obesity with senotherapeutics does not appear a priority for the research and development community, but in fairness a great many more severe conditions have not yet made it onto that still short priority list either. There are only so many researchers and entrepreneurs in the field, and […]

A narrative review published in Applied Sciences examined how urbanisation, time constraints, food costs, and changing lifestyles have contributed to declining adherence to the Mediterranean diet. Drawing on 116 references, the authors identified workplace and school interventions, nutrition education, physical activity, and Mediterranean-inspired convenience foods as potential strategies for adapting this dietary pattern to modern life.

Researchers analyzed approximately 12.8 million gut microbial genetic variants in 10,781 individuals across six cohorts, identifying 940 independent associations with 69 human health characteristics and environmental exposures. Nearly two-thirds of these associations were not accompanied by significant differences in bacterial species abundance, suggesting that microbial genetics can reveal relationships overlooked by conventional microbiome analyses, although causality remains unproven.

A new $6.9 million grant from the California Institute for Regenerative Medicine (CIRM) will support preclinical development of an investigational cell therapy for the heart created by USC Stem Cell scientists.

Hormone replacement therapy is a popular treatment for women leading up to or following menopause. Manipulating sex hormones is a very blunt strategy, with potentially significant downsides, and a high variation in outcomes between patients, but the medical community has accumulated a great deal of experience in delivering this class of therapy. In the matter of assessing how this sort of approach affects aging, the research community is presently engaged in a process of gathering as much data as possible on how aging clocks interact with various therapies thought to influence aging or age-related disease. The accuracy of the clocks in the environment of any given therapy is unknown, and the effect of the therapy on the clock is unknown, and so the way forward […]

It is by now well established that senescent cells promote senescence in neighboring cells. This is a useful and necessary part of the benefits of the transient presence of senescent cells in the contexts of cancer suppression and coordination of wound healing. But when senescent cell clearance falters in later life, and senescent cells begin to linger and accumulate, this promotion of further senescence makes matters worse. One of the ways in which senescent cells promote senescence is via relatively well mapped and well understood inflammatory signaling. Here, however, researchers note that there are other pathways involved, in which the signaling involves the contents of small extracellular vesicles. Interfering in senescent cell signaling as a basis for therapy is likely a more challenging path forward […]

Voice phishing, or vishing, used to depend on a convincing script and a confident caller. In 2026 it

A stable-pool strategy can move cell line development off the critical path to Phase I while preserving a path to a conventional clonal cell line as a program matures. The post Rethinking the Clone-First Paradigm for First-in-Human Biologics appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers found that the gene preserves bone stem cell supply throughout life, and say the discovery advances understanding of stem cell biology and could indicate potential therapeutic approaches to improve bone healing and regeneration in aging and disease. The post Gene That Preserves Bone Stem Cell Supply Throughout Life Identified appeared first on GEN - Genetic Engineering and Biotechnology News.

It is easier and less costly to theorize about aging than it is to run studies in mice and cells. Uncertainty also tends to inspire the generation of hypotheses, and our understanding of the fine details of degenerative aging remains in a state of considerable uncertainty. For all that biological data can now be accumulated with a level of accuracy and at rates that would shock the last generation of researchers, assembling that data into a coherent whole - in which it is fully understood and concretely proven as to how mechanisms of aging interact with one another, what is cause, what is consequence, what is more important, and what is less important - remains beyond present capabilities. There are certainly consensus views, but they […]

Tuesday, November 17, 2026 In an effort to reach an elusive continuity of the self, some far-thinking technologists are working on ways to keep your brain going—even beyond death. Join science editor Mary Beth Griggs and senior editor for biomedicine Antonio Regalado for a conversation exploring possible paths to keep your mind going, including gradual…

Scientists have discovered a compound that transforms a natural muscle-repair protein into a more powerful version dubbed "Super HGF," more than doubling its ability to bind to a key receptor while protecting it from age-related chemical damage. The breakthrough, supported by early mouse experiments, could eventually help combat muscle loss and preserve strength as people age.

The state of the gut microbiome is at least as influential on long term health as lifestyle choices like exercise. The composition of the gut microbiome changes with age for reasons yet to be fully explored. Inflammatory populations grow at the expense of populations producing metabolites necessary for tissue function. Connections can be drawn between near every organ and system in the body and specific metabolites or specific microbial populations influencing them. In turn the immune system and other organs influence the gut microbiome. Fortunately, it is possible to produce the lasting restoration of a more youthful gut microbiome via strategies such as flagellin immunization and fecal microbiota transplantation. Unfortunately, probiotic and related strategies are as yet incapable of producing such sizable and lasting changes, […]

Women with HIV who achieve sustained virologic suppression live longer than demographically similar men, a difference resembling the female longevity edge in the general population.

The only viable way to definitively establish the importance of any given mechanism of action is to create a therapy that selectively prevents or repairs that mechanism without touching the other mechanisms of aging, and then observe the outcomes in aged animals. This is a challenge, and typically the results are a surprise; until the development of senolytic therapies, no-one expected clearance of senescent cells to be so very effective at reversing age-related disease in animal models, for example. Because it is hard to determine the relative importance of mechanisms of aging, much of the aging research community often resembles a collection of small fiefdoms, each advocating for the importance of their small portion of degenerative aging, in the absence of concrete proof of that […]

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the country, and collaborators have pioneered a new approach to preventing dangerous bloodstream infections in patients receiving donor stem cell transplants for blood cancers.

A study led by researchers from the Germans Trias i Pujol Research Institute (IGTP) and the Blood and Tissue Bank (BST) has developed and validated a manufacturing platform for extracellular vesicles that meets pharmaceutical quality requirements, marking a key step toward their clinical application.

A longitudinal study of 5,423 adults in England found that cardiovascular disease was associated with faster cognitive decline, with the strongest association observed among participants with consistently low depressive symptoms. Those with persistent moderate or high depressive symptoms generally experienced poorer cognitive performance and faster overall deterioration, despite showing a weaker additional association between cardiovascular disease and cognitive decline.

Cells contain hundreds of mitochondria, constantly fusing together, replicating by splitting apart, and swapping component parts. Mitochondrial function is vital to cell health, and declining mitochondrial function is an important component of degenerative aging. Some of the answers as to why mitochondrial function declines with age are likely buried somewhere in the complex interactions of mitochondrial structure, the dynamics of mitochondrial fusion and fission, and the operation of the mitochondrial quality control processes of mitophagy. Mitophagy is both necessary to maintain function by destroying worn mitochondria, but it also seems quite sensitive to changes in structure and size of mitochondria, as happens when the dynamics of fusion and fission change. In today's open access paper, researchers demonstrate that compounds that improve the activity of mitofusin, […]

As cochlear implants go fully internal, the technology could pave the way for other sensory implants.

A review examines how pregnancy spacing affects maternal aging, proposing that insufficient recovery may lead to cumulative biological aging and health risks.

A surprising discovery suggests that rejuvenating the liver could help protect against Alzheimer’s disease and heart disease. USC researchers found that an experimental drug restored aging liver cells in rats, cutting levels of an Alzheimer’s-linked protein in half and bringing bad cholesterol down to youthful levels. The treatment also revived a previously unknown communication system that helps liver cells remove harmful substances from the bloodstream.

A major 24-year study involving more than 8,200 adults suggests that excess body weight may accelerate brain aging, leading to faster declines in memory, concentration, and decision-making skills. The connection was particularly strong among people over 65, raising concerns about the long-term effects of obesity on brain health.

A protein that helps build teeth may one day be used to allow damaged teeth to repair themselves.

Researchers at UC Santa Barbara, UC San Francisco and international collaborators are uncovering the cascade of molecular events that happen when women undergo menopause, a time of life marked by endocrine changes and symptoms like hot flashes, brain fog and sleep disturbances.

A cross-sectional study of 615 adults in the Loma Linda Blue Zone area and surrounding communities found that vegetarian diets were more common among older adults and Seventh-day Adventists, with vegetarians also reporting significantly lower BMI than non-vegetarians. The findings raise concerns about whether younger generations are maintaining the region's traditional dietary practices, although further research is needed to establish whether vegetarian adherence is declining over time.

Researchers at the German Cancer Research Center (DKFZ) and the HI-STEM Stem Cell Institute have discovered a group of particularly long-lived blood stem cells in mice. These cells remain in a dormant state for an exceptionally long time while retaining their ability to generate new blood cells. This newly discovered cell population may be responsible for sustaining blood regeneration and immune defense throughout a mouse's entire life.

Cells become senescent constantly throughout life, usually upon reaching the Hayflick limit to replication, but also in response to injury, high levels of cell stress, or potentially cancerous damage. Senescent cells cease to replicate, grow in size, and secrete pro-inflammatory signals to attract the attention of the immune system. In youth, the immune system clears senescent cells rapidly, but this becomes less efficient with advancing age for a range of reasons yet to be fully explored. Senescent cells appear to alter their biochemistry in ways that inhibit immune clearance, but the immune system as a whole also becomes less effective at all of its tasks. Senescent cells linger, accumulate, and disrupt tissue structure and function with their inflammatory signaling. The vascular system is vital to […]

What does it mean to feel that a part of us will live on after we are gone? A new study of nearly 3,000 adults found that people who believed they would be remembered by others tended to report better mental health, a stronger sense of meaning and lower levels of problematic substance use and addictive behaviors. The findings point to a possible link between our sense of lasting significance and the way we cope with stress, uncertainty and mortality.

AI has been making its way into video game development for a while now, but the recent developments have started raising some serious concerns. Popular games are being reverse-engineered with AI assistance, recreated for web browsers, and made playable on platforms they were never released for. Between all that, indie developers have started pulling down […]

Guy Penrod seeks prayers after disclosing a serious blood and bone marrow illness, telling Mark Lowry a transplant is the only potential fix.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents How Important is Lipid Metabolism Dysfunction in the Aging of Microglia? Reviewing What is Known of How the Aging Gut Microbiome May Contribute […]

Lysosomes are structures within cells packed full of enzymes capable of breaking down proteins and structures into raw materials; they serve as recycling centers. Lysosomes are the final destination of damaged or unwanted proteins and structures flagged for destruction by the cellular maintenance processes of autophagy. Lysosomes are known to become dysfunctional with age, for reasons that are not fully explored. Some of it is a matter of changes in the expression of relevant genes, some of it is a matter of the accumulation of persistent metabolic waste that lysosomes cannot effectively break down. Given enough of that waste, lysosomes become bloated and inefficient. If a cell cannot effectively recycle, it becomes dysfunctional, inflammatory, and eventually dies. The more that this happens, the more that […]

Cells are very particular about the proper locations of their contents. For example, DNA is packaged in the nucleus in a highly specific way, but researchers are still trying to understand how this happens. For stem cells in the brain of a larval fruit fly—a model organism used to study processes such as early development—the DNA is organized so that the center of each strand, called the centromere, is at the top of the nucleus.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Researchers here propose that greater efforts should be devoted to considering the variety of G-protein coupled receptors (GPCRs) as a regulatory network in the matter of aging and age-related disease. Aging produces sweeping changes in protein levels, gene expression, protein function and interactions, and one can thus make similar arguments for many different classes of molecule found in cells. The question is always whether one can justify intervention in a given mechanism on the basis of its importance to aging: where does it sit in the interacting network of cause and consequence? Is it causing a great deal of downstream harm, or is it more of an end stage consequence? How close is it to root causes of aging? This is a lot harder to […]

An international study reports 60% progression-free survival at 10 years after autologous bone marrow transplantation, adding important evidence on sustained positive clinical outcomes and long-term safety in patients treated for early severe systemic sclerosis.

Eggs follow a very different developmental path from sperm. Once a male hits puberty, sperm cells are produced continuously throughout his life.

Studies conducted in various countries indicate that approximately 60% of people over the age of 65 currently live with two or more chronic conditions simultaneously.

Stem cell therapies involve a stage of expansion of cells in culture prior to injecting them into the patient. The research community has realized that both the state of the original source cells and small variations in the subsequent cell culture environment can result in large differences in the quality of the transplanted cells. For example, how many of the cells in the culture have become senescent, and are thus now generating pro-inflammatory signals. There are other possible variations in cell state that could contribute negatively to outcomes, diminishing any benefits resulting from the therapy, however. Differences in cell state and behavior may be the cause of much of the well-known and undesirable variability of outcomes in stem cell therapy. Some clinics may have started […]

A study of nearly 13,000 adults found that people consuming the most artificial sweeteners experienced a 62% faster decline in memory and thinking skills, equivalent to approximately 1.6 additional years of brain aging. Six popular sweeteners were linked to faster cognitive decline, raising concerns about the long-term brain health effects of common sugar substitutes, although causation was not established.

Peripheral nerves are capable of regeneration to restore connections across gaps caused by injury, but the larger the gap the less likelihood of a successful outcome. The medical community has developed approaches that help by laying guides along the path that regrowth must take, often composed of donor nerve tissue, which may be taken from elsewhere in the patient, but these are far from optimal. There is considerable research interest in the development of entirely artificial nerve regrowth guides that have a low cost and high rate of success in stimulating the necessary regeneration for a complete restoration of function. The paper here is an example of this sort of research and development, focused on bioprinting an implantable path for nerve regrowth. Conventional cell-laden electro-direct […]

AI Clauses in Fashion Contracts A draft Calvin Klein contract asked a model to accept, for no extra

WEDNESDAY, Oct. 28, 2026 — Older people with autism are more likely to develop symptoms of Parkinson’s disease, a new study says.About 3.8% of people 45 and older with autism wind up with tremors and movement problems linked to Parkinson’s disease...

Researchers are engaged in finding alternative ways to induce the desirable epigenetic rejuvenation produced by exposing cells to the Yamanaka factors, without the risk of losing cell state to dedifferentiation and the creation of induced pluripotent stem cells that could give rise to tumors. Yamanaka factors are a challenging basis for many forms of therapy because it would be somewhere between difficult and impossible to reconcile the different requirements for dose and timing for different cell populations in a tissue. Here, screening leads researchers to a splicing factor that is capable of producing some degree of epigenetic rejuvenation in cells and extended healthy life in mice. Splicing factors are of interest because each influences the expression of many different genes, potentially thousands of genes, and […]

Mayo Clinic’s Zombie Cell Studies Not all aging cells cause the same harm, and scientists now have better

Researchers studying Bolotana, Sardinia, found that women had exceptionally high estimated late-life survival during 2021–2025, with their probability of surviving from age 70 to 100 exceeding regional and national averages by more than threefold. Earlier demographic estimates showed a much smaller survival advantage, prompting the authors to classify Bolotana as a candidate longevity blue zone that requires further investigation.

A new study published in Geromedicine has identified 17 plasma proteins associated with all-cause mortality in older adults and found that several of these proteins also track with measures of biological aging across multiple organ systems.

The gut microbiome is made up of thousands of distinct microbial species, interacting with one another to process food and generate a broad range of metabolite molecules that are varying degrees of necessary, helpful, and harmful to the tissues of the body. The balance of these microbial populations changes with age in detrimental ways; microbes that provoke chronic inflammation grow in number at the expense of microbes that manufacture beneficial metabolites. In recent years, researchers have mapped the microbiome in human populations, finding correlations with age-related diseases and specific microbial metabolites that contribute to specific forms of age-related dysfunction. We might expect near every common age-related disease to have many different meaningful connections to aspects of the composition of the gut microbiome and how that […]

Despite promising results in smaller trials, nicotinamide riboside fails to slow the progression of early Parkinson’s disease in a phase 3 study.

Mayo Clinic scientists have uncovered surprising new insights into “zombie cells,” aging cells that linger in the body and contribute to inflammation and disease. Seven studies reveal why these cells are harmful and identify new strategies for targeting them, including a natural compound found in tomatoes. In aging mice, experimental treatments reduced inflammation and improved physical and brain health. The findings could open the door to therapies that combat some of the biological processes behind aging.

The secret to aging more slowly may be hiding in your gut. Scientists discovered that certain gut bacteria are strongly linked to how quickly the body ages, with microbial differences accounting for about 15% of the variation in biological aging rates. Some bacterial species were associated with slower aging, while others were linked to accelerated aging.

Senescent cells accumulate with age to drive the onset and progression of age-related disease and loss of function. Over the past decade, a broad range of research and development efforts have emerged to attempt to address this cause of aging. Senostatic therapies reduce the pace at which senescent cells are created. Senolytic therapies selectively destroy senescent cells. Senomorphic therapies suppress aspects of the harmful behavior of senescent cells, principally the pro-inflammatory signaling that contributes to the chronic inflammation of aging and is disruptive to tissue structure and function. Researchers here describe the discovery of a senomorphic microRNA in the context of an attempt to reduce the burden of senescent cells generated by cancer therapy. Many forms of cancer treatment leave the patient with increased numbers […]

Microglia are innate immune cells of the brain, similar in behavior to tissue resident macrophages elsewhere in the body, but with an additional portfolio of duties relating to maintenance of neural networks. Like macrophages, microglia can adopt packages of behavior, and switch between them depending on environment cues; pro-inflammatory M1 focused on defense against pathogens versus anti-inflammatory M2 focused on tissue maintenance, for example. With age, the microglial population becomes more inflammatory, contributing to chronic inflammation of brain tissue and consequent disruption of normal function that contributes to the onset and progression of neurodegenerative conditions. Some of this inflammatory behavior is a consequence of an increased burden of cellular senescence in microglia and other supporting cells of the brain, but not all of it. Regardless, […]

MONDAY, Oct. 26, 2026 — Starting survivorship care for patients with cancer before or during treatment can help them live longer and avoid cancer recurrence, a new study says.Survivorship care focuses on maintaining a healthy lifestyle, managing...

Maria Vorontsova has outlined Russian ambitions to extend human life, including possible anti-ageing treatments, while stressing childhood health and research into the social effects of longevity.

Scientists have uncovered a surprising new clue to why the Mediterranean diet is so good for the heart, brain, and healthy aging. Researchers at USC found that older adults who closely followed the diet had higher levels of two tiny proteins, humanin and SHMOOSE, produced by the mitochondria, the energy-producing structures inside cells. These proteins have been linked to protection against heart disease, Alzheimer's disease, and age-related damage.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Life Biosciences Reports Initial Results from the First Reprogramming Trial Creation of Chimeric Antigen Receptor Natural Killer Cells in Situ via Messenger RNA […]

Sustained low-level inflammation is a hallmark of the aging process. The accumulating damage persistently activates the innate immune system-the body's first line of defense-leading to what is known as inflammaging, functional decline and chronic diseases of old age.

Warhound says gene editing and cloning can fix why military dog candidates fail, but questions about genes and oversight remain.

The start-up is the brainchild of a founder of Anduril, the military tech firm, and Colossal Biosciences, a biotech company known for its de-extinction efforts

How can the identity of pluripotent stem cells be determined more reliably during their differentiation? Researchers from the IUF—Leibniz Research Institute for Environmental Medicine and Heinrich Heine University Duesseldorf have systematically validated marker genes for this purpose and developed a web-based application for the automated classification of early cell fates. The study has been published in Stem Cell Reports.

Researchers here identify the gene PLA2G2F as a regulator of compensatory responses to some of the damage and dysfunction of aging. The researchers were primarily investigating a population of neurons found in the hippocampus, involved in memory function, but find that the gene is relevant in supporting cells of the brain also, such as microglia. Expression of PLA2G2F increases with age, and artificially increasing expression over natural levels produces greater protection. PLA2G2F appears to be involved in maintenance of normal lipid metabolism. Evidence suggests that dysfunctions in lipid metabolism occur in the aging brain, and cause harm via provoking greater inflammatory behavior in a number of supporting cell populations. Cognitive reserve theory posits that compensatory mechanisms during aging stave off cognitive decline and lower risk […]

Of the common variants of the APOE gene, APOEε4 presents the greatest risk of Alzheimer's disease. APOE is involved in lipid metabolism, and APOEε4 is associated with lipid-related contributions to inflammation in microglia, suggesting a primarily inflammatory mechanism for the increased risk of neurodegeneration. Here, researchers find that APOEε4 also interferes in the ability of oligodendrocyte cells to maintain the myelin structures that sheath the axons that connect neurons into neural networks, again via lipid-related mechanisms. This myelin sheathing is required for effective communication between neurons. Myelin maintenance does falter to some degree in normal aging, and the consequent loss of myelin is thought to contribute to dysfunction in the aging brain. It is reasonable to hypothesize that greater myelin loss driven by APOEε4 is […]

Jesse Poganik, PhD, of the Division of Genetics within the Department of Medicine at Mass General Brigham, is the senior author of a paper published in Trends in Endocrinology & Metabolism, "The Postpartum Recovery Window as a Determinant of Maternal Aging." Stephen Albright, formerly of Mass General Brigham, is the lead author.

The presence of non-native trees is often seen as an obstacle to the recovery of tropical forests regrowing in previously deforested areas. To better understand the behavior of these plants over time in both humid and dry forests, researchers from approximately 60 institutions analyzed data from over 1,500 areas of forest regeneration across the Americas. The results, published in the journal Nature Plants, indicate that the initial dominance of exotic species is temporary. They multiply easily during the first 10 to 20 years, taking advantage of abundant sunlight in open areas. However, they decline as native trees grow and shade the forest.

The study of biological aging, how our cells, tissues, and organs change over time, independent of how many years have passed, is a growing area of research that aims to help scientists understand the root causes of chronic illnesses and find ways to enhance longevity.

Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a new class of light-activated compounds that could lead to safer and more versatile applications in 3D printing, cosmetics and medicine.

Conventional wisdom suggests that the long hours and pressures of entrepreneurship can take a toll on health. But new research by Cristiano Bellavitis, associate professor in the School of Business at Stevens Institute of Technology, and his collaborators finds that entrepreneurs tend to live longer than people who spend their careers working for others.

Elon Musk threatens legal action over Alex Gibney's documentary, which uses an AI-generated likeness and faces disputes over Starlink and the 2024 US election.

Why, mechanistically, is female reproductive aging so accelerated in relation to the rest of the aging process? Researchers here point to a role for a progressive loss of ribosomes in oocytes. Cells contain many ribosomes, vital components of the cell where messenger RNA is translated into protein, and usually synthesize more as needed. Oocytes do not tend to synthesize new ribosomes, however, one of many differences in behavior intended to retain a much higher standard of cell quality during the reproductive lifespan. Female germline cells are among the most protected of all cell types, and have to be in order to maintain a sufficiently low level of reproductive failure for evolutionary success. Here, it is suggested that this ribosomal approach to increased cell quality produces […]

Aging clocks can be produced from large databases of near any form of biological data that changes with age via the use of machine learning techniques that identify weighted combinations of measures that correlate strongly with chronological age, remaining life expectancy, mortality risk, and so forth. The true goal of developing clock technology is to find a way to rapidly assess the quality of any new potential therapy to slow or reverse aspects of aging, and thus greatly accelerate research and development, focusing attention on the best possible approaches. Unfortunately no clock can be trusted to perform accurately in the face of a new approach to treat aging. A clock could underestimate, overestimate, or be unaffected by biological changes that do have meaningful effects on […]

Current Good Manufacturing Practice (GMP) standards for cell therapies assess identity, viability, sterility, and genetic stability. For extracellular vesicle (EV) products, Minimal Information for Studies of Extracellular Vesicles (MISEV2023) guidance adds particle size, concentration, markers, morphology, contaminants, endotoxin, and assays.

If spreadsheets are your thing, but Microsoft Office isn’t, you might want to give the open-source clone, GridCraft, a try.

Naked mole rats are very long-lived in comparison to similarly sized rodents, undergo little to no age-related loss of function for much of their later life, and exhibit a near complete resistance to cancer. A sizable fraction of research into the comparative biology of aging is focused on this species, in an attempt to better understand which mechanisms of aging are more versus less important, and whether any of the unusual biochemistry of naked mole rats can be used as a basis for therapies to treat aging or cancer. Science moves slowly, and so only recently has the research community started to import a few naked mole rat genes into other species, a first step to validating whether or not therapies are possible. Early results […]

A study by DZNE finds that healthy eating is associated with slower biological aging—and that there is more than one way to eat healthily. The researchers examined ten dietary patterns considered healthy, including the Mediterranean, Nordic, and a plant-based diet, as well as the DASH diet, which is designed to help lower blood pressure. The findings are published in the journal Nature Communications. 

Scientists have turned blood cells from an 80-year-old into neural stem cells with a molecular age of less than 20, effectively reversing more than 60 years of cellular aging in the laboratory. The discovery offers a new way to investigate how cells become younger and could help researchers better understand age-related diseases such as Alzheimer's.

The presently available data and understanding of aging might be thought of as a jigsaw with more missing pieces than there are pieces in hand. There is a great deal of latitude to assemble what is known into a wide variety of views of the whole without being strongly contradicted in any of them. Thus theories of aging proliferate; it is always easier to theorize about existing puzzle pieces than to run a research program that will meaningfully add to the collection of puzzle pieces. Here, researchers present a framework for the relationship of the mechanisms of aging that places epigenetic change as the dominant (but not only) important process that drives loss of function, disease, and mortality. Age-related dysfunction is unlikely to arise from […]

Researchers found that a previously validated 67-metabolite blood signature of Mediterranean diet adherence was associated with lower long-term mortality across a Spanish trial population and three US cohorts. Participants with the highest signature scores had a 23% lower relative hazard of death than those with the lowest scores in both populations, although the findings do not establish a causal relationship.

TUESDAY, Oct. 20, 2026 — Older women might want to think twice before taking testosterone to treat their lagging libido, a new study says.Testosterone therapy appears to increase a woman’s risk of heart attack, stroke and other heart problems...

The aging brain may be undergoing a remarkable transformation rather than simply losing its abilities, shifting its focus from remembering details to understanding the bigger picture. Scientists suggest this change could be an evolutionary adaptation that helps older adults develop wisdom and share decades of knowledge with younger generations.

Could disruptions in the flow of energy through mitochondria cause everything from type 2 diabetes to Alzheimer’s?

Senescent cells accumulate with age, perhaps primarily because the aged immune system becomes less able to efficiently destroy senescent cells as it does in youth. When a cell becomes senescent it ceases to replicate, grows in size, and secretes a potent mix of pro-inflammatory, pro-growth signals that contribute to the chronic inflammation of aging and are disruptive to tissue structure and function. Here, researchers investigate some of the specific outcomes of an increased burden of cellular senescence in the aged liver. The liver is organized into tightly regulated zones with distinct metabolic functions but zonation erodes with age. Cellular senescence contributes to aging and liver diseases, however, its impact on aging biology is ill-defined. As part of The Cellular Senescence Network Consortium, we used multiple […]

For more than a decade, David Putnam and Lawrence Bonassar have been trying to build a better molecular

Researchers follow the children of centenarians to see what longevity and disease-resistance traits they may inherit. The results surprise them.

Scientists have discovered that a protein linked to youth helps protect the brain’s immune cells from age-related decline. Restoring the protein in older mice improved the cells’ ability to clear debris and reduced signs of inflammation, raising hopes for future treatments targeting brain aging and Alzheimer’s disease.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Age-Related Decline in Chaperone-Mediated Autophagy Impairs Clearance of Senescence Cells A Review of Differences Identified in Gut Microbiome Composition Between Young, Old, and […]

In a study of fingertip regeneration, a team led by JAX senior research scientist James Godwin found that some immune cells in mice can attack and kill cells needed to rebuild bone, while a subset of those same immune cells can protect the bone-making cells and allow regeneration to continue.

Scientists have uncovered a hidden biological mechanism that helps explain how exercise can reverse some of the damage caused by muscle aging. The key is a gene called DEAF1, which becomes overactive with age and interferes with the muscles’ ability to clear damaged proteins and repair themselves. Exercise can help restore this balance, allowing older muscles to rebuild and regain strength, although the benefits may diminish when the system becomes too disrupted.

Smaller dog breeds live for longer than larger dog breeds, which perhaps allows some insight into mechanisms of aging. Researchers here find that age-related change in the epigenetic regulation of nuclear DNA structure and gene expression proceeds more rapidly in larger dogs, particularly in regions containing transposable elements. Transposable elements are the remnants of ancient viral infections, capable of copying themselves across the genome when active, a form of damage that can break gene sequences. The virus-like particles created by expression of transposable elements provoke inflammatory responses, and thus loss of transposable element suppression contributes the disruptive chronic inflammation of aging. This study adds to the existing body of evidence suggesting that transposable element activation resulting from epigenetic change provides a meaningful contribution to mammalian […]

The aging of the immune system arises from the underlying causes of aging, but in and of itself causes significant further pathology. Here, for example, researchers discuss immune aging as a shared underlying cause of degenerative conditions of bone and joint tissues, and how this relates to the more traditional view of the cause of these conditions. In general, aging is not a neat straight line of cause and consequence, but rather a network of interacting processes of damage and dysfunction. In many cases the consequence can accelerate the cause. Consider senescent cells, for example, implicated in degenerative bone and joint conditions: the accumulation of senescent cells contributes to immune aging, which is a matter of both cellular senescence in immune cell populations and inflammatory […]