Life Extension

Knee osteoarthritis (KOA) affects more than 1 in 10 people over 40 years of age, impairing patients' mobility and quality of life.

Using nanoscale electron microscopy, McMaster researchers found a 71-million-year-old dinosaur fossil shares a feature with modern human bone.

Higher residential nighttime light exposure was associated with contrasting biological aging patterns in nearly 300,000 UK Biobank participants, depending on the aging algorithm used. PhenoAge and homeostatic dysregulation suggested a potentially adverse aging pattern, while KDM-BA showed the opposite association, underscoring uncertainty about how nighttime light relates to biological aging.

Scientists are shedding new light on a little-known biological system that could help unlock the full potential of stem cell therapy, one of the most promising areas of modern medicine.

The global rise in obesity and population aging represents a major public health challenge, with growing evidence suggesting that excess body fat not only increases the risk of chronic disease but may also accelerate the biological aging process.

A new research perspective was published in Volume 18 of Aging on July 24, 2026, titled "A brief history of the hyperfunction theory of aging and future directions."

Anti-aging medicine has long been a small specialty field of practice culturally adjacent to sports medicine, but considerably less rigorous and more derided by the mainstream. The present development of a longevity industry, based on means to slow and reverse aspects of aging conclusively demonstrated in laboratory animals and now slowly making their way towards the clinic, is going to have interesting effects on the field of anti-aging medicine. Over some period of time, anti-aging medicine will become reputable, a field in which physicians manage the delivery of treatments for aging that actually work. The field will swell to become the majority of all medical practice, as the majority of all serious illness and death is age-related. Initially, this growth and takeover of mainstream medicine […]

Questions regarding the relative importance of different mechanisms and dysfunctions to the progression of aging and eventual mortality are hard to answer definitively. Even given a straightforward class of therapies to target one specific mechanism of aging in isolation of all others, such as senolytics to clear lingering senescent cells, one still has to look at a lot of different studies, extrapolate from mice to humans, and the answer is fuzzy. The other sort of fuzzy answer comes from statistical techniques applied to large longitudinal human epidemiological data sets: compare humans who exhibited different levels of the mechanism in question, and see what happened to them over time. That is the approach taken here in the matter of the chronic inflammation as a driver of […]

The brain's immune system has long been thought to exist independently from the rest of the body, complete with its own specialized immune cells and a blood-brain barrier that limits what can travel into the brain.

The cerebral cortex is densely packed with different nerve cells that enable us to perceive, think and act. Yet how these cell types arise while the brain develops is still not fully understood.

For decades, scientists have accepted that the immune system naturally weakens with age. Georgia Tech biomedical engineer and Carl Ring Family Professor Ankur Singh wasn't convinced. Then the COVID-19 pandemic made the stakes impossible to ignore.

Cells become senescent throughout life, because of stress or damage or reaching the Hayflick limit on replication, but senescent cells only begin to accumulate with age. When a cell becomes senescent, it grows in size, ceases to replicate, and turns its energies to creating signals promoting inflammation and growth. The immune system is responsible for destroying senescent cells after they have served their purpose, which is usually to attract the attention of immune cells to locations where they are needed to prevent or repair issues. While clearance of senescent cells is efficient in young people, it becomes much less efficient with age, allowing a population of lingering senescent cells to grow over time in tissues throughout the body. The pro-growth, pro-inflammatory signals that are helpful […]

A growing body of scientific insight is drawing attention to cellular senescence as a central force in the progression of intervertebral disc degeneration (IDD), a leading contributor to chronic low back pain worldwide.

Among patients with primary CNS lymphoma who respond to induction therapy, high-dose chemotherapy with stem cell transplant improves survival compared with nonmyeloablative chemotherapy.

Aging clocks of many varieties have been produced in recent years by applying machine learning techniques to a wide range of biological data that changes with age. This approach yields a tool that is disconnected from our understanding of the mechanisms of aging; links between the forms of cell and tissue damage and dysfunction that drive aging and the measures making up the clocks have yet to be determined. This makes it hard to interpret results, and hard to make practical use of a clock to assess the quality of any given approach to slowing or reversing aging. We have no idea in advance as to whether a given clock will perform well for a given intervention, and finding out is a slow process. The […]

George R.R. Martin reveals personal struggles with depression and grief, shedding light on the delay of 'The Winds of Winter'. Fans remain frustrated as they await updates on the long-anticipated novel.

An AI-based method uses MRI scans to generate detailed maps highlighting how different areas of the brain age, and shedding light on how patterns of brain changes correlate with changes in cognitive function across lifespan. The post AI Uses MRIs to Generate Brain Aging Maps for Neurodegenerative Disease Research appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers find that soil aging of polyethylene microplastics has only a limited effect on their interactions with organic contaminants. Scientists have long worried that aging microplastics in soil could become increasingly effective at interacting with organic contaminants.

The ability to accurately determine the composition of the gut microbiome via 16S rRNA sequencing is resulting a great deal of very interesting data on differences in the gut microbiome that are characteristic of aging, age-related diseases, and long-lived individuals. Here, researchers report that centenarians tend to have more Clostridium scindens in their gut microbiome, and demonstrate in aged mice that a metabolite produced by this bacterial species reduces intestinal barrier dysfunction. That the intestinal barrier becomes more leaky with age is an important contributing cause of chronic inflammation and other forms of dysfunction caused by the presence of unwanted bacteria, metabolites, and other molecules in the circulatory system and tissues throughout the body. Microbial networks and keystone taxa play pivotal roles in maintaining gut […]

As spirometry requires coordinated deep breathing and can be challenging for children to perform, researchers from the USA, as part of the TRANSPIRE study investigating lung complications in children undergoing hematopoietic stem cell transplantation (HSCT), explored the potential of oscillometry, a simple and child-friendly lung function test.

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aging is an inevitable biological process marked by progressive functional decline and elevated risk of cardiovascular diseases (CVDs).

A review finds that restricting protein, particularly methionine, isoleucine, and valine, may improve metabolism and influence key aging pathways, largely in experimental models. Short human studies suggest metabolic benefits, but effects on lifespan remain unknown and restriction may harm people with unmet or increased protein needs.

3D bioprinting allows scientists to build custom tissue structures for medicine, but printing soft tissues like the human brain remains a major challenge. The strong pushing forces required to squeeze biological materials through tiny printer nozzles often crush and damage sensitive cells, leading to low survival rates and weak printed structures.

USC researchers have developed an approach that uses artificial intelligence to generate detailed maps that highlight differences in how distinct parts of the brain age.

In southeastern Madagascar, patches of forest that were once cut down to make way for farms are slowly regenerating naturally after being left to lie fallow. But recovering a native forest needs more than just gaining tree cover. The animals that once lived in these forests also need to make their way back so that the forest can function the way it used to.

New research reveals that cells of the same chronological age can follow dramatically different biological aging paths, offering new insights into cancer, neurodegeneration and the fundamental biology of aging. Rather than aging uniformly, tissues become a mosaic of biologically younger and older cells, with some individual cells aging much faster than others—a discovery that could reshape how scientists understand aging and the earliest origins of age-related disease.

Scientists have identified a molecular switch that may help explain why aging makes the brain more vulnerable to diseases such as ALS and Huntington’s. In worms, the protein EPS8 builds up with age and triggers signaling that encourages toxic proteins to clump together, damaging neurons and shortening lifespan. Reducing EPS8 activity prevented these harmful aggregates and preserved nerve function.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

A sweeping review of more than 350 studies suggests that the protein boom may be overselling what many people actually need. Eating less protein appears to improve metabolism, reduce inflammation and cellular damage, and activate pathways linked to healthier aging and longer life.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Enhanced Aquaporin 4 Activity Improves Glymphatic Drainage of Cerebrospinal Fluid in Mice A Novel View of Age-Related Mitochondrial Dysfunction as a Failure of […]

A protein best known for protecting the ends of chromosomes also helps muscle stem cells preserve their identity and repair damaged tissue, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

A person’s sleeping brain may reveal warning signs of dementia long before memory problems begin. Researchers used machine learning to analyze EEG recordings from about 7,000 adults and found that an older-than-expected “brain age” was tied to a sharply higher dementia risk. Every additional 10 years of brain aging raised that risk by nearly 40%.

Senescent cells accumulate with age in tissues throughout the body. These cells cease replication and secrete a potent mix of pro-growth, pro-inflammatory signaling that is disruptive to tissue structure and function when maintained over the long term. Cells become senescent throughout life in response to various circumstances, but in youth are efficiently destroyed by the immune system. With old age, the immune system falters in this task for reasons that are still being explored in detail. While the increased damage and disarray found in aged cells and tissues likely accelerates the pace at which cells become senescent, present evidence suggests that immune dysfunction in the matter of senescent cell clearance is the dominant factor in the increased presence of lingering senescent cells in later life. […]

While “protein maxxing” is all the rage, reducing your protein intake could add years to your life

Diabetic foot ulcers are among the most serious complications of diabetes because prolonged inflammation, poor circulation, and defective angiogenesis can leave wounds open for months and increase the risk of infection and amputation.

Bryan Johnson's latest health experiment involves storing his girlfriend's menstrual blood for analysis, sparking debate over its invasiveness and potential to advance women's health research.

Microglia are innate immune cells of the brain, very similar to the macrophages found elsewhere in the body outside the central nervous system. Both microglia and macrophages do much more than defend against pathogens; both are deeply involved in tissue maintenance, function, and regeneration. It is by now well established that microglia become inappropriately inflammatory in old age, and researchers increasingly see this as an important component of age-related neurodegeneration. Here, researchers present provocative data to argue that the microglia of old age are not the same cell type as the microglia of youth; they are instead more like macrophages, derived from circulating monocytes outside the brain. This is a sizable departure from the present understanding, a wrench thrown into the works for several possible […]

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

A structured multidomain lifestyle intervention slows increases in free water, an early MRI marker of white matter injury, in adults younger than 70 years at risk for cognitive decline.

An international research team led by the Medical University of Vienna reports on a new treatment strategy that has made a kidney transplant possible for a patient with no realistic chance of receiving a suitable donor organ.

Clonal hematopoiesis of indeterminate potential (CHIP) is arguably the most studied form of somatic mosaicism, in which stem cells accumulate mutations over time, and thus patterns of those mutations spread out into the tissue supported by those stem cells. In this case, the "tissue" is the immune system, made up of immune cells descended from the hematopoietic stem cell population that is resident in the bone marrow. There is evidence for CHIP to contribute to forms of age-related disease and aspects of aging more generally, which is an argument for somatic mosaicism in all tissues to contribute to degenerative aging. Aging is associated with organ and tissue function deterioration and consequent increased risk of disease occurrence and mortality. Recent scientific advancements have succeeded in increasing […]

The vessels of the glymphatic system run parallel to blood vessels entering the brain. Glymphatic vessels provide a path for drainage of cerebrospinal fluid into the body. This is a way to remove metabolic waste from the brain, such as the protein aggregates that contribute to neurodegenerative conditions. Loss of glymphatic flow is a feature of aging, allowing the build up of metabolic waste in the brain and consequent cellular dysfunction. Researchers here report on interesting results from a relatively simple approach to restore a greater drainage of cerebrospinal fluid through the glymphatic system, intermittently changing gas levels known to affect blood vessel contraction and dilation in order to encourage fluid flow in the glymphatic system close to those vessels. It remains to be seen […]

An upgrade transformed the beleaguered virtual assistant into a modern chatbot. It’s imperfect but worth trying.

Researchers tracked sleep-wake changes over five years in 704 women in their 80s and 90s using wrist actigraphy. Declining nighttime sleep and increasing 24-hour sleepiness were associated with approximately twice the hazard of all-cause mortality.

In many animal tissues, stem cells continually divide to create new cells that replace old or damaged ones. However, this capacity requires strict regulation, as uncontrolled stem cell proliferation can disrupt tissue homeostasis and contribute to tumorigenesis.

Sleep quality is well established to decline with age and age-related disease. A sizable medical and supporting industry is devoted to attempts to improve sleep quality via what are essentially compensatory approaches to intervention. As researchers note here, the evidence to hand does not demonstrate that reduced sleep quality causes an acceleration in the pace of aging. That the evidence for poor sleep to cause accelerated aging is very mixed suggests a complex relationship between this dysfunction and the broader scope of aging, in which only some of the circumstances and mechanisms associated with poor sleep may accelerate aging. Otherwise it is likely a downstream consequence of aging. Sleep gets worse with age and is correlated with risk for disease and mortality. The possibility that […]

The spacecraft rushing to the rescue of an aging and sinking NASA telescope has run into its own problem.

In many animal tissues, stem cells continually divide to create new cells that replace old or damaged ones. However, this capacity requires strict regulation, as uncontrolled stem cell proliferation can disrupt tissue homeostasis and contribute to tumorigenesis.

In the much-loved 1980s sitcom, still in perpetual reruns, the four wisecracking women who share a house in Miami met through an ad on a supermarket bulletin board.

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Scientists have identified a compound that may help preserve muscle in aging mice. Someday, this may help people with muscle atrophy.

TUESDAY, July 28, 2026 — Shirley Jennett, a retired nurse, loves her spacious ranch-style house in Denver, with its big backyard and gazebo.“I want to stay here,” she vowed. “And die here.”She might pull that off. In relatively good health, Jennett...

As global climate change intensifies, heatwaves are becoming more frequent, longer, and more severe, emerging as an important environmental stressor for human health.

A new study reveals that lignin - a natural plant polymer - can be transformed into a bioactive material that promotes the formation of bone-like minerals while supporting the growth of bone-forming cells.

University of California, Davis Professor of Neurology Sarah Tomaszewski Farias has been awarded a $3.3 million five-year grant from The National Institute on Aging to study if cultural differences affect how people perceive cognitive changes as they age.

Eating within a shorter daily window may help protect certain thinking skills as people age. In a small six-month trial, older women who limited eating to about 8 to 9 hours a day performed better on planning and problem-solving tests than those who ate over 12 hours. Both groups lost similar amounts of weight, hinting that when people eat could matter in addition to how much they eat.

King Charles says 'it gets much harder' as he ages and continues cancer treatment in the UK, renewing his push on early diagnosis and warning millions are missing vital screenings.

The immune system and its supporting organs and structures throughout the body, such as bone marrow, spleen, lymphatic system, and thymus, are collectively make up a very complex system. The way in which the immune system ages is thus also very complex. Different specialized cell populations change in number and function. Immune cells are influenced into maladative inflammatory behavior by some combination of internal molecular damage and disarray on the one hand coupled with external damage to tissue on the other. The supply of many types of immune cell is much reduced from youthful levels, allowing malfunctioning and senescent immune cells to accumulate. The immune system is crucial to health, not just as a defense against pathogens and potentially cancerous cells, but also due to […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents CLC-1 Inhibition Improves the Function of Neuromuscular Junctions in Aging Muscle The Aging Immune System Disrupts Maintenance of Bone Tissue Quantifying the Risk […]

The longevity-linked APOE2 gene appears to protect brain cells by reducing DNA damage and helping neurons recover from stress. The finding could open a new path toward treatments that mimic APOE2’s defenses in people at higher genetic risk for Alzheimer’s.

A sulfur-based compound called LASSS appears to protect and supercharge a key protein involved in repairing damaged muscle. The discovery could eventually lead to new ways to slow muscle loss and preserve strength as people age.

Researchers aim to evaluate the effectiveness of ASCT as consolidation therapy for patients with advanced-stage natural killer/T-cell lymphoma who have attained their first complete remission.

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Supercooled kidneys have been transplanted into pigs in a “landmark achievement”  When it comes to organ donation, time is everything. As soon as an organ has been removed from a donor’s…

One of the hallmarks of dysfunctional lipid metabolism in the brain the context of age-related neurodegenerative disease is an increase in lipid droplets in brain cells. This is seen in a number of different neurodegenerative conditions. Evidence suggests lipid metabolism dysfunction to be involved in the inflammatory behavior of the innate immune cells known as microglia, thought to be an important contributing cause of neurodegeneration. Here, researchers provide evidence for lipid droplet formation to be associated with cellular senescence, a state in which cells cease to replicate and secrete inflammatory signals. Senescent cells are not cleared efficiently in aged tissues, and their numbers grow to disrupt tissue structure and function. It is already known that some fraction of overly inflammatory microglia in the aging brain […]

Decades of UK data show chronic financial hardship, not one-off setbacks, drives worse midlife cognition and brain shrinkage.

Bryan Johnson reveals his stem cell clone, 'Baby Bryan', created from his blood cells to explore organ regeneration and longevity therapies, highlighting advancements in personalised regenerative medicine

A new collaborative research project between Murdoch University and Walailak University (WU) aims to restore seagrass meadows in Thailand using 3D-printed pods made from bioplastics.

Our population is aging. The United Nations reports that by 2050, the number of people over the age of 85 on our planet is set to triple.

Researchers have discovered that the human brain undergoes widespread age-related changes in genome regulation beginning in midlife that may help explain why aging is the greatest risk factor for neurodegenerative diseases such as Alzheimer's.

An analysis of aging human brains revealed widespread immune remodeling, blood-brain barrier deterioration, and genome architecture changes, challenging long-held assumptions about how the brain's resident immune cells are maintained. The post Midlife Brain Aging Linked to Immune Cell Remodeling, Blood-Brain Barrier Decline appeared first on GEN - Genetic Engineering and Biotechnology News.

The biochemistry of aging is enormously complex, and it is very hard to pick apart which changes are definitively cause versus effect, and which changes are definitively more important than others. The only robust approach is to build a therapy that fixes just one change in isolation, and observe the results. This is not always possible or practical. When it can be done, a great deal is learned, however. See the outcome of the development of the first senolytic drugs on the state of knowledge regarding the role and relative importance of senescent cells in degenerative aging, for example. But the lack of such targeted and relatively effective therapies for most other potentially important mechanisms of aging allows a wide diversity of viewpoints to arise, […]

Stem cell-derived dopamine cell transplantation appears feasible and may reduce medication needs in PD, but longer follow-up is needed to establish its clinical benefit and long-term safety.

This review finds that spermidine supports autophagy, mitochondrial function, and healthspan in experimental models, while observational studies link higher dietary intake to lower mortality. However, human trials have produced limited and mixed results, leaving its clinical role in healthy aging unresolved.

Sickle cell disease causes premature aging of blood stem cells, which scientists may be able to address with a special class of drugs, according to a new study from St. Jude Children's Research Hospital.

Adult-gerontology nurse practitioners might be the future of elder care as opportunities grow.

Bryan Johnson says reprogrammed stem cells could one day grow replacement organs and test treatments after his autoimmune diagnosis.

A biotech company called Revel Pharmaceuticals is looking into ways to reverse aging, and the company's science team, along with researchers from the company Calico and the University of Colorado, may be a step closer to realizing the so-called fountain of youth. The team recently published their study in Nature Communications detailing how they engineered an enzyme capable of reversing a particular form of age-related damage and demonstrated its competence with test results.

Health is like art; one knows it if one sees it. But that isn't good enough for the development of therapies. Health must be pinned down and actually measured. Numerous bodies have offered guidelines to this end, and those guidelines have been interpreted in countless different ways by the scientists who conduct studies. Everyone has their own definition at the detail level, which makes comparison between studies a sizable challenge. This is the usual picture for any area of human endeavor in which standards would be useful. Coordination is not a solved problem, and about the best one can hope for is a few competing standards that are fairly rigorously adhered to. In the matter of assessing and treating degenerative aging, even that remains an […]

A two-armed space robot blasted off on a private salvage operation Tuesday to slap life-extending jetpacks on old satellites running low on fuel thousands of miles up.

Researchers linked five epigenetic clocks to distinct blood gene-expression patterns and biological pathways in 3,227 Health and Retirement Study participants. TAGS derived from these patterns often showed stronger associations with frailty, functional measures, morbidity, and mortality than their parent clocks, although further validation is needed.

People with dementia, mild cognitive impairment, alcohol addiction, or psychiatric disorders such as schizophrenia show increased brain aging, each in specific patterns within the brain, according to a study published July 21st in the open access journal PLOS Medicine by Shile Qi from the Nanjing University of Aeronautics and Astronautics, China, and colleagues.

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As for all tissues, bone derives its structural properties from the composition and structure of its extracellular matrix. This matrix constantly undergoes dynamic modification: osteoclast cells break down the matrix, while osteoblast cells build it up. Throughout much of adult life, a sufficient balance exists between these processes of creation and destruction to ensure that bones remain structurally sound. With old age, however, the balance shifts slowly to favor osteoclasts. The result is a loss of bone mineral density over time, leading eventually to osteoporosis, brittle bones, and fracture or breakage in an already frail elderly individual. The aging of the immune system is one of the contributing factors to this erosion of bone tissue maintenance. Chronic inflammation on the part of the immune system […]

Twenty years ago or so, researchers were investigating the possibility of building therapies based on upregulation of TFAM expression to improve mitochondrial function in aged tissues. While some initial results were promising, as it turned out the mitochondrial biochemistry of TFAM is complicated and too much is as bad as too little. This makes it a poor target for gene therapy, and a challenging target for small molecules. The field moved on to easier possibilities, as often happens. Still, nothing ever really stops entirely in the life sciences. Here find a review of the present state of knowledge regarding TFAM, and some speculation as to what future therapies might look like. Mitochondrial transcription factor A (TFAM) is a nuclear-encoded mitochondrial protein that directly binds mitochondrial […]

A hormone produced by the thymus helps tamp down age-related inflammation, a new study in mice found

Sarcopenia is the name given to later, more severe stages of the characteristic loss of muscle mass and strength that takes place with age. The loss is universal, ultimately leading to physical frailty. Since muscle is metabolically active, loss of muscle is also disruptive to overall metabolism, worsening insulin resistance and chronic inflammation. Like many aspects of degenerative aging, the underlying causes of sarcopenia form a web of interacting mechanisms. It is challenging to determine their relative importance, as well as which mechanisms are largely upstream versus largely downstream in the chain of cause and effect. As is usual, tracing a direct path from root causes of aging to proximate causes of disease is a work in progress, and very incomplete. Most research effort focuses […]

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Microglia are innate immune cells of the brain, analogous to macrophages elsewhere in the body. Both cell types are deeply involved in the intricate processes of tissue maintenance and regeneration. The central nervous system has only limited regenerative capacity, but it can regain some lost function following injury, such as that caused by a stroke. Researchers here find a way to improve the regenerative activities of microglia, and demonstrate that this intervention can improve outcomes following stroke in animal models. After a stroke, the brain launches a coordinated repair program that involves several types of cells. Among these, microglia, the brain's resident immune cells, play a pivotal role. Immediately after an injury, microglia are activated to trigger inflammation, but thereafter, they rapidly transition into a […]

Filtered coffee consumption was associated with slower biological aging, while instant coffee was linked to faster aging in UK Biobank participants. The cross-sectional findings do not prove causation, but they suggest that brewing method may influence coffee’s relationship with aging biomarkers.

Blood transfusions are crucial in human and veterinary medicine, yet human blood reserves are in constant need of donors, while blood bank systems in veterinary care are nearly nonexistent. This leaves canine transfusions largely reliant on donations from healthy dogs, but securing compatible blood remains a major challenge because dogs also have different blood types.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Increased SIRT3 Expression Improves Mitochondrial Function to Treat Intervertebral Disc Degeneration in Mice Proposing the Synergy of Therapeutic Plasma Exchange and Partial Epigenetic […]

Are GLP-1s for life? What we know about getting older on weight-loss drugs

Scientists may have uncovered one reason coffee is repeatedly associated with healthier aging and lower disease risk. Compounds in coffee appear to activate NR4A1, a receptor that helps protect cells from stress, inflammation, and damage. These protective effects disappeared when the receptor was removed, strengthening the connection. Surprisingly, plant-based compounds such as caffeic acid seemed far more active than caffeine itself.

A study in mice and in human cells found that blocking a single receptor on tissue-resident macrophages promoted clearance of accumulating senescent neutrophils, preserved the youthfulness of multiple organs in mice, and substantially slowed cognitive decline. The post Organ Aging Linked to Breakdown in Immune Cell Interaction and Senescent Neutrophil Clearance appeared first on GEN - Genetic Engineering and Biotechnology News.

Several popular sugar substitutes may not be as harmless as they seem. Adults who consumed the most artificial sweeteners showed substantially faster declines in memory and thinking, especially if they were under 60 or had diabetes. The highest intake was linked to cognitive aging roughly 1.6 years faster than the lowest intake. Researchers stressed that more studies are needed before concluding that sweeteners are the cause.