Life Extension

The sirtuin family of proteins has attracted research interest for its involvement in mechanisms that may influence the pace of aging. While the overhyped work on the effects of sirtuin 1 on aging unraveled to produce no practical applications, sirtuin 3, sirtuin 4, and sirtuin 5 are localized in the mitochondria and there is a range of more convincing evidence to suggest that they can be manipulated to meaningfully adjust mitochondrial function in later life. Sirtuins, colloquially termed "longevity proteins," are central regulators in the intricate molecular networks of aging. These proteins function as nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases or adenosine diphosphate (ADP)-ribosyltransferases, operating within multiple cellular regulatory pathways crucial to the aging process. The mammalian sirtuin family comprises seven members (SIRT1-7), with SIRT3, SIRT4, […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents A Novel Approach to Improve Mitochondrial Function in Aged Tissues via G Proteins An Example of Continued Efforts to Correlate Gut Microbiome Features […]

Excessive amounts of visceral fat - the hidden fat surrounding organs - is linked with faster aging of the heart, a new study has found.

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Translation is the process by which cells manufacture many copies of a protein from one messenger RNA sequence encoding that protein. This takes place in one of the many ribosomes present in the cell, after which a newly assembled protein is folded within the endoplasmic reticulum. Translation is important, and so has evolved to be highly efficient. Errors nonetheless occur, and are corrected by various processes that identify broken, misfolded, and other problem proteins and ensure they are broken down for recycling. Those quality assurance processes have also evolved to be highly efficient. Correctly formed proteins are necessary for cell function, and malformed proteins will tend to cause harm in proportion to their numbers. Nonetheless, different species exhibit different degrees of efficiency in translation. A […]

Using stem cells from mice, researchers from Kyoto University tested the potential damage spaceflight can have on spermatazoa stem cells and the resulting offspring. After six months aboard the ISS, the stem cells were used to successfully produce healthy offspring.

Author(s): Yi-fan Wang, Chun-lai Ren, and Yu-qiang MaAging of biomolecular condensates, a phenomenon increasingly recognized in recent experiments, is a multiscale phenomenon that can impact the condensate’s biological function. The authors employ coarse-grained simulations integrated with machine learning techniques to analyze structural and sequence-specific effects underlying the liquid-to-solid transition associated with the aging process. #TimelyTopic #BiophysicsSpotlight [Phys. Rev. E 112, 024412] Published Thu Aug 21, 2025

A multicenter study shows increased arterial stiffness among patients who have COVID.

A new study by USC Leonard Davis School of Gerontology researchers shows that Americans with less education are aging faster than their peers with more schooling, and the gap has grown over the last 30 years.

People want to stay healthy and active for as long as possible. But how young and resilient is our body actually? Researchers at ETH Zurich, Empa, Caltech and the University Hospital Basel now want to make our biological age precise and easy to measure.

Apple’s Vision Pro is a very nice piece of kit, but the $3,400 price means that even CEO Tim Cook has acknowledged it’s a niche product, and the 600g plus weight also means many find it uncomfortable to wear for longer than an hour. Chinese brand Vivo has attempted to address both issues in a design which looks remarkably like a direct copy of Apple’s spatial computer … more…

A new critical review, published in the journal CABI Agriculture and Bioscience, highlights the emergence and scientific basis of regenerative agriculture—proposing a working definition centered on ecological cycles and farm system outcomes.

Circulating oxytocin levels decline with age, and researchers have shown that restoring oxytocin to youthful levels has beneficial effects in aged animal models. Oxytocin is produced in the hypothalamus, and thus a range of different delivery mechanisms could work to replace this source. Here, researchers use an intranasal route for the introduction of replacement oxytocin, and show that it produces the expected benefits in aged mice. While it is well-documented that plasma oxytocin (OXT) levels decline with age, the underlying mechanisms remain elusive. This study aimed to elucidate the physiological mechanisms contributing to this age-related decrease in plasma OXT and the possible use of OXT supplementation on improving age-related decline of neural function. Comparing young (9 weeks) and aged (older than 45 weeks) mice, aged […]

Parents are spending thousands of pounds to bank stem cells from their children's milk teeth – but the recipient companies' claims about their future medical value are unproven and potentially misleading, reveals an investigation by The BMJ, published today.

Scientists at UCSF have uncovered a surprising culprit behind brain aging: a protein called FTL1. In mice, too much FTL1 caused memory loss, weaker brain connections, and sluggish cells. But when researchers blocked it, the animals regained youthful brain function and sharp memory. The discovery suggests that one protein could be the master switch for aging in the brain — and targeting it may one day allow us to actually reverse cognitive decline, not just slow it down.

Research shows COVID-19 accelerates vascular aging, especially in women, with implications for long-term cardiovascular health and recovery strategies.

A population-based NHANES survey showed accelerated markers of aging in adults with wheezing and emphysema.

Two new studies from Karolinska Institutet in Sweden have investigated how mutations that occur in muscles and blood vessels over time can affect aging.

While all tissues age into dysfunction, the primary cause of human mortality is the aging of the cardiovascular system into heart failure, stroke, and heart attack, combined with the consequences of progressively worsening cardiovascular function in other organs. The way in which cardiovascular aging manifests is well documented, and the underlying processes of aging that contribute to the observed outcomes are also fairly well understood at the high level. The challenge lies in establishing exactly how the low-level mechanisms of aging give rise to changes and loss of function in the heart and vasculature. This is a task that may not even be needed, if instead the research community focused on ways to repair the molecular damage of aging. We don't need to fully understand […]

Persistent infection via HIV, herpesvirus, or a range of other pathogens capable of evading or subverting the immune system might reasonably be thought of as producing accelerated aging. The dysfunction produced by these infections usually centers around the immune system, but this in turn negatively affects the function of tissues and systems throughout the body. Aging is an accumulation of damage, and persistent infection produces forms of damage that overlap with those generated during the normal course of aging. Here, researchers discuss the range of mechanisms thought to be involved. Many models of aging assume that processes such as cellular senescence or epigenetic alteration occur under sterile conditions. However, humans sustain infection with viral, bacterial, fungal, and parasite pathogens across the course of a lifetime, […]

Researchers discovered that early puberty or childbirth doubles women’s risk for major diseases and accelerates aging, while later timing offers protective benefits. Genetic analysis reveals evolutionary tradeoffs, where reproductive advantages early in life create health burdens later.

Scientists developed a 3D printing method that creates hydrogels with tissue-like properties, paving the way for personalized implants and adaptive soft robotics.

Researchers discovered that gut microbes, including Lactobacillus reuteri and L. johnsonii, can enhance muscle strength in aging mice. Co-administration of these strains boosted muscle mass, performance, and reduced inflammation, pointing to a possible microbiome-based strategy for muscle health.

A device that has been likened to a pacemaker for the brain has given a man with severe depression great relief

TUESDAY, Aug. 19, 2025 — Want to keep your brain healthy as you age?Regularly volunteer some of your time to your community, neighborhood, friends or family, a new study suggests.People who regularly lend a hand slow their rate of aging-related b...

A new research paper was published in Volume 17, Issue 7 of Aging (Aging-US) on July 7, 2025, titled "Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer."

Aging is particularly harsh on the hippocampus - the brain region responsible for learning and memory.

Researchers here note that the state of research into the relationships between exercise, physical fitness, and epigenetic aging (or indeed, any other assessment of biological age provided by forms of aging clock) is patchy at best. There are at present too few studies and too little data for researchers to be able to confidently describe the degree to which various levels of exercise and fitness affect aging clocks, as compared to what it is possible to achieve for well-investigated outcomes such as risk of age-related disease and mortality. The concept of an epigenetic clock is a predictive model based on DNA methylation patterns that provides a more accurate estimate of biological age than chronological age. Physical activity has emerged as a modifiable lifestyle factor that […]

Metformin, rapamycin, and senolytics show multifaceted effects on aging biology that could transform how clinicians approach chronic disease prevention.

Reproductive timing matters when it comes to aging and age-related disease. In a study now online at eLife¸ Buck researchers determine that girls who go through puberty (the onset of menstruation) before the age of 11 or women who give birth before the age of 21 have double the risk of developing type 2 diabetes, heart failure and obesity and quadruple the risk of developing severe metabolic disorders.

A Mediterranean lifestyle survey of over 4,000 adults across seven countries found that while men and women scored similarly on overall adherence, they achieved this through different patterns of diet, exercise, and well-being. Tailored strategies may be needed to support gender-specific improvements in health behaviors.

As aging progresses, the quality of DNA and proteins inside cells declines, which is known to be the cause of various degenerative diseases. However, the connection between aging and RNA has remained largely unexplored.

As aging progresses, the quality of DNA and proteins inside cells declines, known to be the cause of various degenerative diseases.

The most recent issue of Journal of the American Medical Association includes a landmark review highlighting innovative strategies to slow the biological aging process, an emerging approach with significant potential to prevent or delay multiple chronic diseases at once, one of the most pressing challenges in modern medicine today.

When bones break and there is extreme tissue loss--such as after a car accident or a battlefield injury--current treatments don't often lead to effective healing.

Researchers have in the past identified the activities of CaMKII as potential issue in degenerative aging, particularly in muscle tissue. Species differences in its activities are in fact a good example of antagonistic pleiotropy, in that mammalian CaMKII exhibits specific structural differences versus the analogous proteins in lower species that act to produce both better muscle function in youth and worse harms to muscle function in later life. Unfortunately CaMKII has many functions in many different tissues, so it isn't a straightforward target for therapies. Here, researchers use a tissue-specific inhibition in aged muscle to demonstrate that reduced CaMKII expression can reverse some of the characteristic age-related changes in muscle cell biochemistry and improve aspects of muscle function in old mice. Sarcopenia, the age-related loss […]

The brain is a plastic organ throughout life, neural networks adapting to use and experience. Many of the changes that occur with age are taking place in response to patterns of use, not just in response to damage and dysfunction. It isn't entirely straightforward to determine which is which. The research noted here doesn't give any particular insight into how to address undesirable changes in the aging brain, but does provide an interesting view into how the brain strives and succeeds to retain function in capacities that receive constant use. The human cerebral cortex is only a few millimetres thick and arranged in numerous folds. This tissue usually becomes thinner with age. "This is a hallmark of aging. It is attributed, among other things, to […]

A Covid infection, particularly in women, may lead to blood vessels aging around five years, according to research published in the European Heart Journal on 18th August, 2025.

New research from the Charles Perkins Centre at the University of Sydney has uncovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing dangerous blood clots, potentially paving the way for future treatments that reduce their cardiovascular risk.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents GFI1 Inhibition as an Approach to Reduce T Cell Exhaustion Reviewing the Role of Inflammasomes in Aging Semaglutide Modestly Reduces Epigenetic Age in Overweight Individuals R-Loop DNA Provokes Chronic Inflammation via cGAS/STING Immunosenescence Framed as a Treatable Condition Effects […]

More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-quality fertility care for those in need but, importantly, also for new biomedical solutions that can address the root causes of infertility.

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres - regions of repetitive DNA sequences and a protein structure - protect the tips of chromosomes from damage.

A new nanotube-based RNA delivery system boosts plant regeneration by switching off a molecule that blocks shoot growth, without changing the plant's DNA.

Analyzing embryo movements in uteruslike environments could offer clues to improving the success rate of in vitro fertilization

Scientists have captured a video showing the implantation of a human embryo for the first time, using a laboratory model of a uterus.

Researchers at the Institute for Bioengineering of Catalonia (IBEC) in collaboration with the Dexeus University Hospital have captured unparalleled images of a human embryo implanting. This is the first time that the process has been recorded in real time and in 3D.

Recent advancements in cancer research are shedding light on a novel therapeutic strategy aimed at overcoming the formidable challenge of cancer stem cells (CSCs).

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated.

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Features of spaceflight such as gravitational changes and circadian rhythm disruption—not to mention radiation—take a toll on the body, including muscle wasting and decreased bone density. These may even affect the ability to produce healthy offspring.

The practice of calorie restriction involves eating fewer calories while still obtaining at least adequate levels of micronutrients. Mild calorie restriction might be a 10% reduction from recommended calorie levels, but as much as 40% is possible given sufficient diligence and attention to the details. Calorie restriction induces sweeping metabolic changes that collectively act to improve cell and tissue function. The present consensus is that the most important of these changes is enhanced autophagy. Autophagy is a collection of maintenance processes responsible for recycling damaged proteins and structures in the cell. In near all species assessed to date, calorie restriction slows aging and improves health. Diet influences disease progression, yet the effects of fasting on acute kidney injury (AKI) and its transition to chronic kidney […]

The immune system is meant to protect the body from infection and disease. But with age, it can become less capable of doing so.

A new measure of ageing says today's older people are the healthiest ever – keeping the trend going won't be easy, however

Aging clocks can be manufactured using machine learning techniques from any sufficiently complex set of biological data obtained from people of different ages. An algorithm is found that maps age-related changes in the data to chronological age, on average. When that algorithm is applied to an individual not in the data set, the predicted age is called a biological age. Higher biological ages predicted by a clock usually correlate fairly well to risk of disease and mortality. Given the relatively low cost involved in creating clocks, new clocks are being produced at a rapid pace. It remains to be seen as to which of the many clocks created over the past decade or so prove to be useful enough in some context to be broadly […]

Some long-lived proteins (such as components of nuclear pore structures) in some long-lived cells (such as neurons) may never be replaced across a normal life span, or at the very least have lifetimes of years. That suggests that damage to these molecules may be important in aging and age-related disease. Some research has taken place on this topic, but as noted here, issues of measurement ensure that damage to long-lived molecules remains a more speculative contribution to degenerative aging. It may be important relative to other mechanisms, or it may not. Neurons, unlike most other cell types, do not divide and are not replaced over an organism's lifetime. This lack of turnover necessitates robust mechanisms to maintain cellular integrity and function across prolonged periods of […]

Nicholas J. Schork, Ph.D., an international authority on human longevity and health maintenance, has joined HonorHealth Research Institute as Research Director of Longevity, Prevention and Interception.

The International Society for Stem Cell Research (ISSCR) released an update of its 2021 Guidelines for Stem Cell Research and Clinical Translation today.

A new study suggests that the mitochondria in human egg cells don't accumulate DNA mutations with age, which sets them apart from other tissues in the body.

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized by the excessive accumulation of extracellular matrix components, leading to a gradual decline in lung function and, ultimately, respiratory failure.

People who do not put on a lot of excess weight, and the excess visceral fat tissue that goes with it, are very unlikely to develop type 2 diabetes. It is a metabolic disease in which the primary, addressable cause is the presence of too much visceral fat. Adoption of a low calorie diet and undergoing the consequent weight loss is a curative strategy, and can reverse the course of type 2 diabetes even in late stages of the condition. With all that said, typically, overweight people develop type 2 diabetes later in life. It takes a great deal of visceral fat tissue to push someone into type 2 diabetes in earlier adulthood. So clearly the mechanisms and dysfunctions of degenerative aging do play a […]

The hundreds of mitochondria present in every cell are responsible for generating the chemical energy store molecule adenosine triphosphate to power cell processes. Dysfunction in the mitochondrial population is characteristic of aging and thought to be a meaningful contribution to loss of tissue function. This dysfunction arises in part because the quality control mechanisms that cull damaged mitochondria become less effective. When functioning correctly, the processes of mitophagy identify and flag damaged mitochondria, which are then conducted to a lysosome, engulfed, and broken down. The remaining mitochondria replicate to make up their numbers. Many interventions known to modestly slow aging or aspects of aging, exercise included, improve the operation of mitophagy and consequently improve mitochondrial function. How much of the overall benefit arises from improved […]

Researchers examined four regions in Western Finland to see if any met Blue Zone lifestyle principles and matched high longevity, finding that the most long-lived area, Åland, had top health but low lifestyle adherence, while Swedish-speaking Ostrobothnia showed promising, but unconfirmed potential.

A new study from researchers at the University of Illinois Chicago reveals how the blood-brain barrier gets leakier with age, contributing to memory deficits.

Constant, unresolved inflammatory signaling is a feature of aging. It occurs in absence of the usual provocations of infection and injury, and is disruptive to tissue structure and function. Normal, short-term inflammation is useful and necessary, but long-term inflammation is harmful. It changes cell behavior for the worse, causes the normal processes of tissue maintenance to run awry, degrades the effectiveness of the immune system, encourages growth of cancers, and contributes to the onset and progression of all of the common fatal diseases of aging. Much of this unwanted inflammation of aging is caused by the reaction of inflammasomes to the molecular damage present in an aged cell. Inflammasomes are protein complexes that evolved to react to the presence of molecules characteristic of infectious agents […]

A new research perspective was published in Aging (Aging-US) on July 8, 2025, titled "Exercise as a geroprotector: focusing on epigenetic aging."

Life expectancy has increased dramatically over the past century, but our years of good health appear not to have kept pace. Now, a new lens on what it means to age well is reshaping our view of our golden years

The human brain ages less than thought and in layers – at least in the area of the cerebral cortex responsible for the sense of touch.

Metabolic dysfunction-associated steatohepatitis (MASH) follows a fatty liver, largely a consequence of obesity, but made worse by aging, in which fat-induced dysfunction of liver tissue maintenance leads to an increasing burden of fibrosis and loss of function. In fibrosis, the normal mechanisms of tissue maintenance run awry and excessive collagen is deposited to form scar-like structures that disrupt tissue function. At present fibrosis is largely irreversible, despite some potentially promising lines of research and development. In recent years, aging and cellular senescence have triggered an increased interest in corresponding research fields. Evidence shows that the complex aging process is involved in the development of many chronic liver diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). In fact, aging has […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Chronological Age Doesn't Correlate Well with Cognitive Decline Early Life Intestinal Injury in Fruit Flies Delays Intestinal Aging and Mortality Measuring the Quality of Death Senescent Macrophages Accelerate Tumor Growth Sestrin 1 is Required for Calorie Restriction to Extend […]

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It took Amazon several years to overcome technical hurdles as it remade its voice assistant with new artificial intelligence technology.

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

An international research team involving the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, the Scuola Normale Superiore Pisa, and Stanford University has discovered that in the aging brain, certain proteins are lost even though their mRNA blueprints remain intact.

A common approach taken by researchers when investigating how a specific aspect of cellular biochemistry functions is to disable genes one by one to observe whether they are necessary or not. This isn't exactly straightforward, as cells typically have several ways of achieving a given goal, and removing one of those ways may or may not appear to do anything, depending on how exactly the researcher chooses to measure the outcome. This is the curse of engaging with complex systems. Nonetheless, sometimes one does find that one gene is critical, and that usually helps to advance the understanding of how the biochemistry of interest functions. Today's open access paper is an example of this sort of research applied to calorie restriction, an incremental advance in […]

For 25 years, scientists at Northwestern Medicine have been studying individuals aged 80 and older - dubbed "SuperAgers" - to better understand what makes them tick.

The process of aging happens to everyone, but the visible fine lines and wrinkles often show up earlier

Senescent cells accumulate with age and contribute to degenerative aging by provoking inflammation and disrupting tissue structure and function. Targeting cellular senescence for the treatment of age-related disease is presently in the slow, optimistic phase of research and development that comes after the initial hype has died down, but before a large number of attempts have been made at definitive, sizable clinical trials. This can last for years. The clinical development of new therapies is a very slow business. It has been something like fifteen years since the first flush of real excitement about senescent cells as a mechanism of aging captured the research community, and while a dozen or more life science companies are developing drugs to destroy or alter the behavior of senescent […]

A recent relationship resembles his ex, prompting social media criticism amid ongoing tension and provocative behaviour from Bryan.

Scientists discovered that jewel wasp larvae that undergo a developmental "pause" live longer and age more slowly at the molecular level by nearly 30%. This slowdown is tied to conserved biological pathways, hinting at possible applications for human aging.

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation that could lead to better regenerative therapies.

Chronic wounds, especially those caused by diabetes, are notoriously difficult to heal. These wounds are characterized by prolonged inflammation, impaired collagen production, and poor tissue regeneration.

The innate immune cells known as macrophages are found in tissues throughout the body, and their activities are important in tissue maintenance and regeneration. Macrophages can adopt different packages of behavior in response to circumstances. There are a number of ways to define these behaviors, but researchers usually refer to (a) M1 macrophages that are inflammatory and aggressive, focused on destroying pathogens and errant cells, versus (b) M2 macrophages that are anti-inflammatory and more focused on tissue maintenance. This split of activities becomes particularly important in aged, damaged, or cancerous tissue. Cancers are known to reprogram and subvert immune cells in order to fuel growth, and the macrophages present in cancerous tissue, known as tumor-associated macrophages, are front and center in that process. In today's […]

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Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria that have their own DNA, replicate to maintain their numbers, and are responsible for generating the chemical energy store molecule adenosine triphosphate (ATP) to power the cell. Mitochondria, like all cell structures, are constantly damaged. Damaged and dysfunctional mitochondria are removed via the cell maintenance process of mitophagy. With age, this quality control falters, while the expression of genes necessary for mitochondrial function change for the worse. Mitochondrial DNA becomes damaged in ways that further degrade function. As a result, cell and tissue function also becomes disrupted, contributing to the many manifestations of degenerative aging. The focus here is on muscle tissue, but analogous stories can be told for any tissue in the […]

A Mediterranean diet during pregnancy significantly alters the maternal gut microbiome, increasing beneficial bacteria, while a mindfulness-based stress reduction program shows more limited effects. Neither intervention affected the vaginal microbiome, and the clinical significance of these changes requires further study.

A research team from Shanghai Jiao Tong University has resulted in a significant advancement in the field of orthopedic implant materials.

Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell failure.

Discover interesting facts about what happens to the body as it ages.

The eye of the apple snail is unusually similar to a human eye-but, unlike human eyes, it can regrow itself if injured or even amputated.

It is well known that the formation of fat deposits within muscle tissue is a feature of aging, and is also associated with a variety of muscle disorders. Here, researchers explore how exactly this infiltration of fat into muscle harms muscle function, with a focus on regenerative capacity. At present physical activity is the most reliable approach to prevent or reduce fat infiltration of muscle tissue, but it seems likely that at least some of the growing number of weight loss drugs in development, many of which improve upon GLP-1 receptor agonists by neither reducing calorie intake nor causing loss of muscle mass, will also be effective. Adipose tissue acts as an energy storage as well as an endocrine organ. However, different fat depots, such […]

Researchers at the University of California, Irvine have identified a promising nonpharmaceutical treatment that rejuvenates aging brain cells and clears away the buildup of harmful proteins associated with Alzheimer's disease.

Fruit flies are used as a model of intestinal aging primarily because this aspect of aging drives mortality in that species. We can say that flies die from intestinal dysfunction in the same way that we can say that humans die from cardiovascular dysfunction; it isn't the whole story by any means, but it is a sizable chunk of the story and the most common cause of mortality. So whenever one reads research materials on the topic of the aging of intestinal tissue, it is reasonable to expect fruit flies to be involved in that work at some point. In today's open access paper, researchers present an interesting finding regarding mechanisms of intestinal tissue maintenance and aging. Because enterocyte cells in the intestinal epithelium do […]

A recent study led by a team of researchers at The Johns Hopkins University School of Medicine examining aging mice has provided what is believed to be the first evidence that amyloid beta protein-small, sticky protein fragment found in people with Alzheimer's disease (AD)-particles build up in the bone marrow of the animals, although not in the exact same form as the large, dense plaques found in the brains of people with Alzheimer's disease.

A research team led by Professor Takuya Yamamoto and Assistant Professor Ryusaku Matsumoto (Department of Life Science Frontiers) has developed a machine learning model that enables early prediction of hypothalamus–pituitary organoid formation from human iPS cells to aid in organoid research and regenerative medicine.

Specific receptors on the surface of immune cells enable these cells to ingest and clear specific forms of metabolic waste. Receptors are proteins that are produced via the usual mechanisms of gene expression. The amount produced can change with age and circumstances, as epigenetic regulation of gene expression changes, and this will affect the ability of immune cells to act against specific targets. Researchers here report on the ability of the innate immune cells known as microglia to clear excess amyloid-β from the brain, and show that it is dependent on expression of the ADGRG1 receptor. In severe Alzheimer's disease, microglia lack sufficient ADGRG1 to effectively clear plaque. Whether this is a contributing cause of Alzheimer's disease rather than a side-effect remains to be demonstrated […]

A comprehensive genetic analysis of nearly one million people has identified 53 independent lead variants associated with frailty, a condition in which the body becomes more vulnerable to falls, infections and other stresses, to support aging-related therapies. The post Genetic Variants Linked to Frailty Unlock Aging-Related Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.

In a first-of-its-kind clinical trial, UCLA scientists have shown it's possible to reprogram a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents.

Once-weekly semaglutide significantly slowed epigenetic aging in adults with HIV-associated lipohypertrophy, as measured by multiple DNA methylation clocks in a randomized controlled trial. These exploratory findings suggest GLP-1 receptor agonists could impact biological aging but require further validation in broader populations.

The lowdown on the Environmental Protection Agency’s move to repeal of the “endangerment” finding. Also, how did a juicy ketchup ingredient help create a starchy tuber?