Life Extension

Autophagy is the name given to a complex collection of processes responsible for identifying and recycling damaged or otherwise unwanted structures in the cell. Typically, a structure flagged for recycling is engulfed by an autophagosome, which is transported to and fuses with a lysosome, and the structure is broken down inside the lysosome by enzymes. An optimal level of autophagy for the maintenance of cell function only occurs in response to stress, including heat, cold, lack of nutrients, toxins, oxidative damage to important molecules, and so forth. Thus mild stresses that inflict relatively little damage to a cell can improve the function of cells, tissues, and organs, leading to a greater resistance to the damage and dysfunction of aging. Most of the well studied interventions […]

A new study by cell biologists at the University of California, Santa Cruz, suggests that an early first pregnancy may protect against breast cancer decades later by preventing age-related changes in breast cells that are linked to tumor formation.

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Microbes could extract the metal needed for cleantech In a pine forest on Michigan’s Upper Peninsula, the only active nickel mine in the US is nearing the end of its life. At a…

The loss of social connectedness as people age increases the odds of cognitive-related disorders and can worsen health outcomes in older populations. But is there a direct relationship between social behavior and cognition? Subhadeep Dutta Gupta, Peter Rapp, and colleagues, from the National Institute on Aging, developed a rat model to probe social cognition in the aging brain.

As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren't sure why.

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of life, but it is associated with a greatly increased incidence of most chronic diseases, including various cancers, diabetes, and Alzheimer's disease.

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health.

In today's open access paper, researchers review the evidence for exercise to slow the aging of muscle tissue in part because it improves DNA repair mechanisms. How exactly damage to nuclear DNA contributes to aging beyond creating a raised risk of cancer remains a debated topic, despite recent conceptual advances. Nuclear DNA damage occurs constantly, near all of which is repaired. Yet the remaining damage largely occurs in genes that are not used or that are not all that important, and in cells with few replications remaining. Thus the ability to cause harmful alterations to cellular metabolism throughout a tissue was thought to be limited. The first way in which nuclear DNA damage could meaningfully impact aging is via somatic mosaicism. When mutations occur in […]

Your organs are constantly talking to each other in ways we’re only beginning to understand. Tapping into these communication networks is opening up radical new ways to boost health

The most robust evidence to date shows that people with a type of lung cancer lived longer if they received immunotherapy before 3pm

Researchers have been publishing more data of late from the CALERIE trial of human calorie restriction that took place over the course of a few years. The participants aimed at a 25% reduction in calorie intake, and ended up achieving something more like 12-15%. The trial started nearly 20 years ago at this point. It is often the case that tissue samples and data remain intact and potentially useful long after the study is complete, awaiting greater funding and interest, as well as the existence of more advanced analysis technologies. Small non-coding RNAs (smRNAs), approximately 20-35 nucleotides in length, represent a diverse class of regulatory molecules that include microRNAs (miRs) and piwi-interacting RNAs (piRs). These nanoscale molecules are key regulators of gene expression, orchestrating complex […]

Elon Musk told Davos ageing is 'very solvable' and life extension 'highly likely' but cautioned immortality could create rigid, stagnant societies lacking vibrancy.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents ANGPT2 Encourages Blood-Brain Barrier Leakage and Consequent Neurodegeneration Results from the Immunis Phase 2 Trial of a Stem Cell Secretome Therapy Reviewing the […]

Researchers found that small doses of an antibiotic can coax gut bacteria into producing a life-extending compound. In worms, this led to longer lifespans, while mice showed healthier cholesterol and insulin changes. Because the drug stays in the gut, it avoids toxic side effects. The study points to a new way of promoting health by targeting microbes rather than the body itself.

Aging muscles heal more slowly after injury—a frustrating reality familiar to many older adults. A UCLA study conducted in mice reveals an unexpected cause: Stem cells in aged muscle accumulate higher levels of a protein that slows their ability to activate and repair tissue, but helps the cells survive longer in the harsh environment of aging tissue.

An analysis of twin cohort data suggests that human life span is far more heritable than previously believed.

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical substances. To counteract this, cells rely on an elaborate network of repair mechanisms. When these systems fail, DNA damage can accumulate, impair cellular function, and contribute to cancer, aging, and degenerative diseases.

Aging muscles heal more slowly after injury - a frustrating reality familiar to many older adults.

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic.

Relative to skin elsewhere on the body, facial skin is less prone to scarring following regeneration from injury. Researchers have identified how this difference is regulated, and here demonstrate that they can influence the relevant mechanisms in order to reduce scarring during regeneration of skin injuries elsewhere on the body. It is also possible that further investigation of this biochemistry may yield approaches to reduce scarring more generally. This is of interest in the context of aging, as tissue maintenance becomes dysfunctional in many organs in ways that lead to excessive formation of disruptive small-scale scar-like structures. Surgeons have known for decades that facial wounds heal with less scarring than injuries on other parts of the body. This phenomenon makes evolutionary sense: Rapid healing of […]

Morgan Freeman reveals how daily movement, simple eating habits and discipline keep him active and working at 88, defying retirement.

When DNA–protein crosslinks are not efficiently repaired during cell division, they accumulate and provoke inflammatory signaling with consequences for development and early aging. The post DNA-Protein Crosslinks Drive Inflammation Linked to Early Aging appeared first on GEN - Genetic Engineering and Biotechnology News.

The composition of the gut microbiome changes with age. A variety of factors likely contribute, including reduced physical activity, changes in diet, and a decline in the ability of the immune system to keep unwanted microbial populations in check. With age, microbes capable of provoking inflammation grow in number while microbes responsible for generating beneficial metabolites diminish in number. This is not an inevitable fate: the composition of the gut microbiome can be permanently changed by fecal microbiota transplantation. Studies have shown rejuvenation of the aged gut microbiome, improved health, and extended life span following fecal microbiota transplantation from young donor animals to old recipient animals. In human medicine, fecal microbiota transplantation was up until recently conducted in something of a gray area of regulation, […]

A new study suggests that those with long-lived families probably have the best prospects of making it to a very old age.

A new study suggests that those with long-lived families probably have the best prospects of making it to a very old age.

“Who here believes involuntary death is a good thing?”  Nathan Cheng has been delivering similar versions of this speech over the last couple of years, so I knew what was coming. He was about to try to convince the 80 or so people in the audience that death is bad. And that defeating it should…

A National Institute on Ageing survey reveals social isolation, financial stress, and a steep decline in positive feelings toward ageing among older Canadian adults.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

While scientists have long known that living in a disadvantaged neighborhood is associated with biological symptoms of accelerated aging, emotional distress accounts for a significant portion of these effects, researchers found in a recent study.

Confused by Kinji Hakari's domain in Jujutsu Kaisen Season 3? We explain his Idle Death Gamble, the Jackpot mechanics, and why he becomes effectively immortal.

Shark Tank star Kevin O'Leary recently shared how he undergoes an exotic procedure for rapid cell generation, tissue healing, and a stronger immune system.

Drinking tea, particularly green tea, is linked to better heart health, improved metabolism, and lower risks of chronic diseases like diabetes and cancer. It may also help protect the brain and preserve muscle strength as people age. However, processed teas—such as bottled and bubble varieties—often contain sugars and additives that may cancel out these benefits. Moderation and choosing freshly brewed tea appear key.

Research by an interdisciplinary team from McGill University and Université Laval provides new insights into the links between social factors and cognitive health among aging adults.

A new experimental study has found that perfluorooctanoic acid (PFOA), a widely used industrial chemical, can interfere with key biological processes required for successful embryo implantation, raising concerns about its potential impact on female fertility.

The therapies developed by Immunis represent the less well trodden path when it comes to the ongoing but still early stages in the replacement of stem cell therapies. This replacement is possible because the benefits provided by presently widespread forms of stem cell therapy result from the signals secreted by those cells in the short period of time before they die. Few such therapies have demonstrated any meaningful degree of long-term engraftment and survival of transplanted cells. Benefits are thus a matter of signals from the stem cells favorably adjusting the behavior of native cells for some extended period of time. The most reliable beneficial outcome of such therapies is a reduction in chronic inflammation. Most efforts to replace stem cell therapies with a logistically […]

When Elon Musk was at Davos last week, an interviewer asked him if he thought aging could be reversed. Musk said he hasn’t put much time into the problem but suspects it is “very solvable” and that when scientists discover why we age, it’s going to be something “obvious.” Not long after, the Harvard professor…

TUESDAY, Jan. 27, 2026 — Grandkids are a blessing in more ways than one for seniors, a new study says.Grandparenting is good for the aging brain, potentially serving as a buffer against cognitive decline, according to findings published Jan. 26 in t...

Vaccination status correlates with better health outcomes and lower risk of a range of age-related disease unrelated to the target of the vaccine. One possible contribution to this outcome is that people who make the effort to be vaccinated also tend to be more conscientious about other health practices. Another involves the trained immunity effect, in that many vaccinations have been demonstrated to both reduce maladaptive age-related inflammation and increase immune capabilities against a variety of unrelated targets. The data reported here argues more for the trained immunity effect, in that researchers note reduced inflammation as an outcome correlated with shingles vaccination status. Using data from the nationally representative U.S. Health and Retirement Study, researchers examined how shingles vaccination affected several aspects of biological aging […]

Across the world, water scarcity is emerging as one of the most pressing challenges of the 21st century. Climate change is pushing rivers and aquifers into unprecedented extremes, droughts and floods are intensifying, and demand for freshwater is rising with population growth and economic development.

Skeletal muscle stem cells in hibernating Syrian hamsters preserve their ability to function by suppressing their activation during the hibernation period, a research team led by Hiroshima University has shown. This insight may lead to a broader understanding of the maintenance of muscle tissue under prolonged low-temperature conditions and may eventually lead to therapeutic applications.

Astrocytes make up a sizable fraction of the cells in brain tissue, responsible for supporting the functions of neurons and the microenvironment of the brain. Cellular senescence in these supporting populations grows with age and is thought to provide an important contribution to the aging of the brain and onset of neurodegenerative conditions. Lingering senescent cells secrete inflammatory signals, disrupting the function and structure of tissue in proportion to their numbers. The research community continues to investigate the biochemistry of the senescent state and how cells become senescent, details that may differ meaningfully from cell population to cell population, in search of novel approaches that might lead to drugs that can prevent senescence, destroy senescent cells, or even reverse the normally irreversible senescent state. Astrocytes […]

Hemoglobin is the primary carrier for oxygen found in red blood cells. It preferentially binds oxygen in relatively high oxygen environments, such as lung tissue, and releases it in relatively low oxygen environments as it moves about the body. As is true of near all proteins, hemoglobin has many roles. Independently of its role in oxygen transport, it also interacts with a range of proteins involved in the regulation of inflammation, for example. Here find a discussion of the ways in which hemoglobin might be involved in the relationship between oxidative stress, inflammation, and the progression of degenerative aging. Oxidative stress is excessive alterations to cellular proteins caused by oxidative reactions; these take place constantly, and cells employ antioxidants and repair mechanisms to reduce their […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Exercise Improves the Aged Gut Microbiome, But Less Effectively as Aging Progresses PDI Overexpression Improves Vascular Contractility in Aged Blood Vessels A Brief […]

New research suggests that getting even just a few more minutes of sleep and exercise and eating an extra cup of vegetables every day can significantly boost longevity

Researchers have found that a natural aging-related molecule can repair key memory processes affected by Alzheimer’s disease. The compound improves communication between brain cells and restores early memory abilities that typically fade first. Because it already exists in the body and declines with age, boosting it may offer a safer way to protect the brain. The discovery hints at a new strategy for slowing cognitive ageing before severe damage sets in.

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FRIDAY, Jan. 23, 2026 — The shingles vaccine can do more than simply protect folks from a maddening skin disease, new research shows.Incredibly, the shingles jab also appears to slow down the aging process, contributing to slower biological aging i...

A pair of centenarian physicians and ancient recipes — how research into ‘Swedish Bitters’ underscores persistent unknowns in medicine.

Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.

Some stars appear to defy time itself. Nestled within ancient star clusters, they shine bluer and brighter than their neighbors, looking far younger than their true age. Known as blue straggler stars, these stellar oddities have puzzled astronomers for more than 70 years. Now, new results using the NASA/ESA Hubble Space Telescope are finally revealing how these "forever young" stars come to be and why they thrive in quieter cosmic neighborhoods.

Scientists are developing a "sponge" that can soak up pain signals in the body before they reach the brain, potentially offering an alternative to painkillers.

Exposing cells to the Yamanaka transcription factors for a short period of time can produce rejuvenation of nuclear DNA structure, epigenetic regulation of that structure, and cell function. Cells in aged tissues become functionally younger following this partial reprogramming, expressing genes in the same way that younger cells do. Initial efforts to build treatments based on this finding have focused on gene therapy approaches, but gene therapy technologies come attached to thorny delivery issues. It remains somewhere between very difficult and impossible to deliver gene therapies to many of the tissues in the body, or to deliver systemically and evenly throughout the body. Small molecule drugs, on the other hand, can be much better at achieving body-wide distribution of effects. If looking to the near […]

A new study led by Hartmut Geiger at the University of Ulm, Germany, and Yi Zheng and Kodandaramireddy Nalapareddy, Cincinnati Children's Hospital Medical Center (CCHMC), USA reveals that age-related changes in the gut microbiota directly impair intestinal stem cell (ISC) function and that restoring a youthful microbial environment can reverse this decline.

Many mammal populations in European and North American zoos are aging—a trend that jeopardizes the long-term viability of so-called reserve populations and, with it, a core mission of modern zoos in global species conservation. This is the central finding of a new international study published in the journal Proceedings of the National Academy of Sciences.

The International Society for Stem Cell Research (ISSCR) today announced the upcoming release of "Charting the Translational Pathway: ISSCR Best Practices for the Development of Pluripotent Stem Cell (PSC)-Derived Therapies," a new paper highlighting some of the most critical aspects of the ISSCR's breakthrough interactive resource designed to transform how PSC-derived therapies are developed, evaluated, and advanced toward clinical and commercial success.

University of Queensland researchers say the discovery of a new stress reduction role for a naturally occurring molecule in the body could lead to new drugs and treatment for metabolic disorders and aging.

Regular aerobic activity significantly reduces brain-PAD, indicating that exercise is crucial for maintaining brain health and reducing dementia risk.

One of the world’s most extensive birth cohorts is now entering later adulthood. At the University of Oulu in Finland, the Northern Finland Birth Cohort 1966 (NFBC1966) is launching a major new follow-up combining decades of biological, social, and environmental data with modern digital health tools to examine how lifelong exposures and the genome shape health and aging.

Study reveals an 'aging cliff' in sperm RNA, linking age-related changes to early development and highlighting risks associated with advanced paternal age.

The aging of muscle tissue leading to loss of muscle mass (sarcopenia) and muscle strength (dynapenia) is a microcosm of aging in general, in that many different groups promote many different views of the relative importance of many different mechanisms. All of these mechanisms do in fact exist - muscle aging is a complex interplay of many interacting issues - but it is likely that any given view on the importance of any given specific mechanism will turn out to be wrong. The only practical way to establish the importance of a mechanism of muscle aging is to develop a means of blocking or repairing just that mechanism in isolation of all of the others, and observe the result. This applies as much to the […]

YouTube CEO Neal Mohan revealed what the video platform's priorities are for 2026, which specifically includes ridding it of AI slop.

Experts long have known that strong social networks and physical activity help older adults stay healthier. Until now, however, little has been known about how these two factors interact to affect the health and well-being of this group.

This population-based study of U.S. adults aged 70 and older found that shingles vaccination was associated with slower epigenetic and transcriptomic aging, as well as lower systemic inflammation. No significant associations were observed for neurodegeneration or cardiovascular biomarkers, highlighting domain-specific molecular effects rather than broad clinical changes.

Metabolism is complex, the interactions of countless molecules inside and outside cells. Evolution clearly does not optimize for the metabolism that provides individuals of a species with longer, more comfortable lives. We know this because any number of small tweaks to levels and interactions of specific proteins or metabolites have been shown to improve health and slow aging in multiple species. Success for a species is not necessarily aligned with success for any of the individuals making up that species. Today's open access review is a guided tour of a handful of metabolites that are present in the body and for which studies have shown that upregulation (or in a few cases downregulation) can modestly slow aging in animal studies. This actually encapsulates quite a […]

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have found that a key protein can help to regenerate neural stem cells, which may improve aging-associated decline in neuronal production of an aging brain.

George R.R. Martin addresses health rumours and the toll of aging at 77. Discover the latest on The Winds of Winter progress and the WorldCon 2025 incident.

In the history of digital image processing, few advancements have been as mathematically disruptive as the transition from

The days can seem endless in Canadian prisons—and yet, inside, inmates actually age faster than on the outside. Why?

Any individual transcription factor influences the expression of many different genes. Researchers have established that some transcription factors can induce radical changes in cell state and behavior, such as the Yamanaka factors used in reprogramming studies. For any specific desirable change in the behavior of aged cells, it is possible that one or more specific transcription factors exist to create that change - the challenge lies in identifying those transcription factors. Researchers are thus working to assess and catalog the many transcription factors present in the human genome. It is a large task. The work noted here covers just one cell type and by no means all of the space of possibilities even there. Nonetheless, that the researchers found potentially useful transcription factors suggests that […]

Increasing paternal age has been linked to elevated health risks for the next generation, including higher risks of obesity and stillbirth. But what drives this increased risk remains unknown.

Shingles vaccination not only protects against the disease but may also contribute to slower biological aging in older adults, according to a new USC Leonard Davis School of Gerontology study.

A randomized crossover feeding trial in adults aged 65 years or older found that plant-forward diets incorporating either minimally processed lean pork or lentils produced similar short-term improvements in cardiometabolic and neuroactive biomarkers. Both diets supported metabolic health and functional stability, with no overall adverse biomarker effects attributable to including minimally processed red meat within a Dietary Guidelines–aligned pattern.

In a study published in Cell Research, researchers have identified a fibrous-layer resident subpopulation of P-SSCs labeled by Angptl7. They found that these cells are crucial for bone fracture repair by mediating endochondral ossification, but exhibit minimal osteogenic capacity during postnatal bone development and maintenance.

The balance of microbial populations making up the gut microbiome changes for the worse with aging. Populations that provoke inflammation increase in size at the expense of populations that manufacture beneficial metabolites. We have some idea of the size of the resulting contribution to degenerative aging as a result of fecal microbiota transplantation studies, from young donor to old recipient, carried out in killifish and mice. Old recipients provided with a young gut microbiome composition exhibit improved health and extended life. Sustained programs of exercise are known to improve the composition of the gut microbiome, reducing the magnitude of some of the changes known to occur with age. This may be the result of improved immune function, and thus a greater ability of the immune […]

As people age, structural brain changes influence their ability to adapt to the environment. New from eNeuro, Tatiana Wolfe and colleagues at the University of Arkansas characterized changes in the brain across two periods of adulthood that may correspond to changes in adaptive behavior.

Researchers here review the evidence for chronic inflammation to contribute to the vascular dysfunction of hypertension, in which blood pressure increases to harmful levels. The particular focus is on the feedback loop in which inflammatory immune dysfunction contributes to dysfunction in the regulation of hematopoiesis, the manufacture of new immune cells by hematopoietic cells resident in bone marrow, which in turn causes greater inflammatory immune dysfunction. Sustained inflammatory signaling is harmful to tissue structure and function throughout the body, including the vasculature and systems that regulate blood pressure. Hypertension is a highly prevalent chronic disease all around the world, and the pathogenic mechanism is complicated. The early and rapid decline of the function of human vascular system due to the aging of human body are […]

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Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN was disabled, tau vanished from neurons and brain cells remained healthy. The findings challenge long-held assumptions about tau’s necessity and highlight a promising new path for fighting Alzheimer’s and brain aging. Scientists now believe OTULIN may act as a master switch for inflammation and age-related brain decline.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Arguing for Sirtuins to be Involved in Known Interventions to Modestly Slow Vascular Calcification Reviewing the Use of Fecal Microbiota Transplantation to Treat […]

Abiraterone will be available in a matter of weeks and will be offered to 7,000 men a year.

A large international study reveals that mammals tend to live longer when reproduction is suppressed. On average, lifespan increases by about 10 percent, though the reasons differ for males and females. Castrated males avoid the harmful effects of testosterone, while females gain longevity by sidestepping the intense physical demands of pregnancy and nursing. The results underscore a powerful biological trade-off between making offspring and staying alive longer.

Polluted lakes and lab experiments highlight harms of chronic exposure to chlorpyrifos

The thymus is a small inner organ near the heart that is responsible for the maturation of T cells of the adaptive immune system. The supply of new T cells is critical to the maintenance of effective immune function over time. Unfortunately the thymus atrophies over the course of adult life, and in most people is largely made up of inactive fat tissue by as early as 50 years of age. The resulting diminished supply of replacement cells ensures that the T cell population thereafter becomes ever more made up of malfunctioning, exhausted, and senescent cells incapable of mounting an effective response. Given the pressing need for ways to restore lost immune function in older individuals, it is good to see that a fair number […]

Long-term exposure to low levels of a common agricultural pesticide can accelerate physiological aging and shorten lifespan in fish—a finding from new research led by University of Notre Dame biologist Jason Rohr with potentially far-reaching implications for environmental regulations and human health.

Author(s): Feng Wang, Yihong Du, Xueyi Xie, Enrico Calzavarini, and Chao SunIn this work, we experimentally investigate the freezing and ice aging dynamics in saline water under natural convection. We show that the rapid formation of a mushy ice layer is followed by desalination processes that might lead to a slow asymptotic decrease of the ice thickness. Desalination of mushy ice reduces its porosity, which alters the dynamic thermal equilibrium and ice thickness by weakening buoyancy-driven convection within mushy ice. In turn, changes in brine convection and ice thickness further affect the desalination process. The long-term dynamics can be predicted by a one-dimensional model based on appropriate parameterizations of global heat and mass transfer properties. [Phys. Rev. Fluids 11, 013504] Published Thu Jan 15, 2026

Flagship phones have gotten expensive enough that a small discount barely moves the needle. This one does. The Google Pixel 10 Pro XL (unlocked, 256GB) is down to $949.00, which is $250 off the $1,199.00 compared value. If you’ve been sitting on an older phone because you didn’t want to pay full price for a […] The post This Pixel 10 Pro XL sale is ideal if you’re ready to replace an aging phone appeared first on Digital Trends.

New research suggests statins may protect adults with type 2 diabetes regardless of how low their predicted heart risk appears. In a large UK study, statin use was linked to fewer deaths and major cardiac events across all risk levels. Even those labeled “low risk” benefited, challenging long-held assumptions about who should receive preventive therapy. Side effects were rare and generally mild.

Cells become senescent constantly throughout the body and throughout life, near all as the result of reaching the Hayflick limit on replication, but also due to excessive cell stress, damage, or a toxic environment. A senescent cell ceases replication, enlarges, and secretes a pro-inflammatory, pro-growth mix of signals that attracts the attention of the immune system. In youth senescent cells are efficiently destroyed by the immune system, but this clearance slows down with age. Senescent cells thus accumulate in later life to cause chronic inflammation and disruption to tissue structure and function. The immune system also accumulates senescent cells, and researchers here investigate the epigenetic regulation of gene expression in these cells, with an eye to finding ways to reduce the burden of senescence in […]

Much of the research into TGF-β signaling show that raised circulating levels of TGF-β drive chronic inflammation and related dysfunctions. Researchers have shown that reducing TGF-β levels can be used to improve health and extend life in mice, for example. Yet nothing is simple and straightforward when it comes to cellular biochemistry. Here, researchers provide evidence for a beneficial function of TGF-β, in that its presence restrains the inflammatory activity of the innate immune cells known as microglia to better preserve myelin structure in the aged spinal cord. Microglia survey and regulate central nervous system myelination during embryonic development and adult homeostasis. However, whether microglia-myelin interactions are spatiotemporally regulated remains unexplored. Here, by examining spinal cord white matter tracts in mice, we determined that myelin […]

The article I'll point out today manages to capture much of the gist of the present state of interactions between two opposing viewpoints on aging: firstly that aging is the consequence of an accumulation of cell and tissue damage, a byproduct of evolutionary focus on early life success, and secondly that aging is an evolved program in its entirety. In essence, the trend is now towards some form of synthesis of these two viewpoints, that the panoply of mechanisms making up degenerative aging contain something of both stochastic damage and programmed functions. One might look at the present state of the hyperfunction theory of aging as an at times confusing and contradictory effort to produce such a synthesis. At the time that these views emerged […]