Life Extension

A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues.

A study of long-lived families has identified rare genetic variants that may help people stay healthier for much longer as they age. One standout mutation appears to temper inflammation, potentially delaying disease and extending years of healthy living.

To function properly, neurons need to recycle cellular waste before it becomes toxic. When neurons can no longer

Influencers and ultra-rich people looking to extend their lifespan are trading tips and tricks on how to eke out extra years

Thrombospondin-1 is a component of the senescence-associated secretory phenotype (SASP) produced by senescent cells. It has been shown in the past to induce blood-brain barrier dysfunction, but here researchers show that it also degrades mitochondrial function in macrophages, biasing those cells into the inflammatory M1 state. This in turn contributes to chronic inflammation and dysfunctional bone regeneration. The accumulation of senescent cells with age is known to be an important aspect of degenerative aging, and the SASP is known to change bystander cell behavior for the worse. There are likely countless mechanisms of this nature taking place in the aging body, all of which could be suppressed via reduction of the burden of senescent cells. The aging bone marrow microenvironment is characterized by chronic low-grade […]

Across mammalian species, resting metabolic rate roughly inversely correlates with species life span and body weight. Larger species are on average longer lived and have lower metabolic rates. There are, of course, a number of interesting outliers that exhibit very long lives relative to similarly sized mammalian species, such as a few bat species and the naked mole-rats that are the subject of this paper. The prevalent thinking on the matter of metabolic rate and longevity is that this relationship says something about the amount of oxidative damage an individual's cells can sustain, or the capacity of those cells to resist that form of damage. Greater metabolic rate implies greater generation of oxidative molecules by mitochondria. The membrane pacemaker hypothesis on species life span suggests […]

Researchers here identify mechanisms downstream of faulty calcium metabolism that drive the harmful signaling of senescent cells that accumulate in aged tissues. Calcium metabolism is well studied in a number of contexts, and various drugs exist to adjust its operation in one way or another. Applying one of those drugs to aged mice results in a reduction in the harms done by senescent cells, improved health, and a 17% extension of life span. There will be many ways in which the presence of senescent cells in aged tissues could be made less harmful. At present most efforts are focused on the development of new drugs to selectively destroy senescent cells, but it seems likely that these research groups and companies will soon be joined by […]

Researchers here report on an interesting in vitro exercise in the comparative biology of aging. They took fibroblast cells from ten difference mammalian species with widely divergent life spans and chemically induced DNA damage in the cells. Modern DNA sequencing approaches allow an accurate measure of the amount of mutational damage produced by this chemical treatment, which in turn allows a comparison of the degree to which cells from different species can resist such damage via the operation of DNA repair systems. Long-lived species have more efficient DNA repair mechanisms, as determined by this approach. We test the hypothesis that excess mutations induced in primary fibroblasts by a low dose of N-ethyl-N-nitrosourea (ENU) are inversely correlated with species-specific maximum life span. To measure excess mutations […]

Adjusting the operation of metabolism to modestly slow aging has long formed the bulk of fundamental research into intervention in aging. All living organisms exhibit some plasticity of life span when subject to mild stresses, such as lack of nutrients, heat, cold, and so forth. Unfortunately this strategy seems unlikely to lead to therapies that greatly improve upon the effects of exercise and lifestyle choice, particularly given the evidence for metabolic adjustment to produce ever smaller gains in longevity as species life span increases. Nonetheless, this form of research persists, driven by the scientific urge to obtain complete understanding of the way in which aging progresses in detail. Here, for example, researchers provide evidence for there to be multiple options for the adjustment of metabolism […]

Producing new aging clocks is easier than overcoming the hurdles to the practical use of existing aging clocks, so the research community is generating new clocks at a fair pace while failing to make much concrete progress on the challenging problem of how to use clocks to assess novel potential rejuvenation therapies. An aging clock measures some combination of parameters that at least appears to reflect biological age. Given that clocks are reverse engineered from epidemiological data via machine learning techniques and the research community has not established clear links between biological age and any of the specific parameters used in a clock, it is entirely unclear as to whether any given clock will accurately reflect the outcome of an actual rejuvenation therapy. Will it […]

The disruption of your gut microbiome is a major consequence, and possible cause, of ageing. Columnist Graham Lawton looks into recent trials examining whether it can be replenished through diet and prebiotics, probiotics or postbiotics

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

A new cutting-edge research team, led by Indiana University School of Medicine scientists and interdisciplinary experts from multiple universities, will investigate the role of immune cell aging on Parkinson's disease risk and progression.

Newly released US files suggest Russia and China may be reverse-engineering UFOs, sparking debate on national security and transparency. The files raise more questions than answers about extraterrestrial technology.

Aging Baby Boomers have brought cardiology to a critical juncture, fueling demand for minimally invasive procedures and AI tools to help meet the nuanced needs of older patients.

A first-in-human clinical trial of an immune rejuvenation therapy designed to restore the function of worn-out T cells is expected to begin later this year, building on research led by UCL scientists into the mechanisms of immune aging.

Donald Trump's visibly swollen ankles at the G7 summit in Évian-les-Bains have reignited doubts over the 80-year-old president's health, despite a White House memo declaring him 'in excellent' condition.

Honor has officially shown off its Android 17 update, MagicOS 11, which is easily the most blatant copy of Apple’s Liquid Glass design language we’ve seen to date.

Scientists have taken a surprising step toward unlocking regeneration in mammals, showing that the ability to rebuild complex body parts may not be lost after all—it may simply be switched off. Using a two-stage treatment, researchers redirected the body’s normal healing response away from scar formation and toward regrowth, successfully restoring bone, joints, ligaments, and tendons after amputation in animal studies.

Among the body's most crucial protective features are the brain barrier systems, including the blood-brain and blood-cerebrospinal fluid (CSF) barriers. These barriers are made of highly specialized cells that allow essential nutrients to enter, yet repel dangerous toxins and pathogens that may be circulating in the bloodstream. Scientists have long known what these barriers do, but less about how they are built during development.

A systematic review identified 41 human studies evaluating interventions targeting next-generation DNA methylation-based aging clocks. Pharmaceutical, lifestyle, supplement, clinical, and psychosocial interventions shifted some clock outputs, but these biomarkers remain investigational rather than proven clinical surrogates.

Using artificial intelligence, scammers can duplicate someone's voice with just seconds of audio, says the University of Cincinnati's Kimberly Hyun. Impostor scams are one of the most common forms of fraud, according to the Federal Trade Commission.

A cell becomes senescent given sufficient stress, molecular damage, or on reaching the Hayflick limit on replication. A senescent cell ceases replication, grows in size, and secretes a potent mix of pro-growth, pro-inflammatory signals. In a young individual, senescent cells are rapidly removed by the immune system, but this clearance slows with age. Senescent cells accumulate as a result in tissues throughout the aging body. The greater the number of senescent cells, the more disruptive their signaling becomes, changing the behavior of surrounding cells for the worse, degrading tissue structure, and rousing the immune system into a harmful state of constant inflammatory behavior. Studies have shown that selective clearance of senescent cells in older mice improves health, extends life, and turns back many aspects of […]

A drug previously developed at UCLA to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found.

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. This man with ALS is the first “power user” of a brain implant that lets him speak Casey Harrell has had a set of electrodes embedded in his brain for almost…

Machine learning approaches can be used to create aging clocks from near any set of biological data collected from people of various ages. The techniques are well established and many new clocks are published every year. A clock is really an age predictor (or a mortality predictor, or a predictor of some other outcome) trained on a single dataset. When the clock algorithm is applied to any given individual not in that data set, it is thought that the predicted age or mortality risk or other outcome is some reflection of biological age. It is hard to validate this proposition, as there is very little concrete connection between any easily measured biomarker and mechanisms of aging, and indeed all too little consensus on how to […]

Joe Alwyn and Sarah Pidgeon spark dating rumours after Brooklyn PDA photos, as TikTok users react with viral comments and Swift song references

Women who view TikTok videos of others comfortable with their gray hair and laugh lines start to feel more positive about their own aging the more they watch, a new UConn study has found, potentially influencing a woman's ability to age well later in life.

Everyone develops atherosclerotic plaque that narrows and weakens blood vessel walls in later life. A sizable fraction of all human mortality derives from the consequences of that plaque, such as rupture of unstable plaque to cause a stroke or heart attack. The maladaptive formation of blood clots within or attached to the plaque structure greatly reduces the stability of these structures, and is an important contribution to mortality. Here, researchers show that cells driven into a senescent state by the toxic plaque environment generate the circumstances that provoke inappropriate clot formation in and around an atherosclerotic plaque. Of note, other work has suggested that those same senescent cells may be structurally important to a plaque, and removing them may also cause loss of plaque stability. […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Mislocalization of Nucleic Acids in Cells as a Driver of Age-Related Inflammation Towards Artificial Gut Microbiomes as an Alternative to Fecal Microbiota Transplantation […]

Weight loss drugs are a major focus of the pharmaceutical industry at present. It remains to be seen as to what will emerge as the next big class of weight loss drugs following GLP-1 receptor agonists. Since the primary effect of GLP-1 receptor agonist drugs is a reduction in calorie intake, all of the gathered data in humans is really just a sizable confirmation of the harms done by the presence of excess visceral fat tissue, and the benefits gained from losing that fat via dieting. It wouldn't much matter how these patients achieved that outcome, the resulting benefits would look much the same - and have in the past as a result of other strategies for weight loss. Researchers analyzed data from a previously […]

Today's open access paper combines a few interesting topics. Firstly, the researchers involved describe a way to deliver a short-lived messenger RNA gene therapy selectively to the innate immune cells known as macrophages. Macrophages are normally responsible for engulfing all sorts of unwanted structures in the cell, and many of the specific features that induce that behavior have been identified. Encapsulating messenger RNA into lipid nanoparticles that mimic some of the surface features of cells undergoing programmed cell death results in aggressive uptake by macrophages. Macrophages arguably make a good target for gene therapies in which the goal is to manufacture a secreted molecule of some sort, such as an antibody, and have it fairly widely and evenly distributed throughout the body. For many secreted […]

Scientists have long known that being obese increases the risk of dementia and Alzheimer's disease. What remains unclear is how that risk develops in the brain.

Casey Harrell has had a set of electrodes embedded in his brain for almost three years. Harrell, who has amyotrophic lateral sclerosis (ALS) and is paralyzed, first used his brain-computer interface (BCI) to “speak” sentences with the help of a research team in 2023. Since then, Harrell has clocked thousands of hours of use. He…

Online sleuths have drawn uncanny parallels between Princess Lilibet's tightly controlled birthday photos and a San Francisco childrenswear campaign, fuelling 'clone' rumours around a mystery child model.

By integrating findings from 140 studies and nearly 66,000 individuals, researchers from the Biosocial team at the Max Planck Institute for Human Development in collaboration with Columbia University in New York have shown that lower socioeconomic status and exposure to discrimination are consistently associated with accelerated biological aging, measured in the epigenome.

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Why “reprogramming” is the buzziest approach to reversing aging right now Earlier this week, Life Biosciences, a biotech company focused on reversing age-related diseases, announced that it had dosed its first…

Earlier this week, Life Biosciences, a biotech company focused on reversing age-related diseases, announced that it had dosed its first volunteer. A person with glaucoma has had an experimental treatment injected straight into their eyeball. The idea is to try to treat the disease—which can cause vision loss—by regenerating healthy nerves in the eye. But…

Autologous hematopoietic stem cell transplant at experienced centers in the current era can include indefinite disease control with low relative risk, a new update suggests.

A large MRI study of more than 47,000 adults found that cerebellar aging is uneven, with posterior association regions and some motor-related areas showing steeper age-related changes. Larger cerebellar volumes were linked to better cognitive performance, supporting a threshold-reserve model in which the cerebellum may help sustain cognition before Alzheimer’s pathology becomes widespread.

A teardown reveals the Trump T1 Phone is a clone of the HTC U24 Pro, sharing design and internal components, raising questions about manufacturing transparency.

A review article now published in "Nature Reviews Genetics" brings together evolutionary theory, comparative genomics and large-scale human genetics to explain why we age and why aging rates differ among individuals and species.

Exosomes emerge as a potential alternative to stem cells in regenerative medicine, and early studies suggest roles in skin rejuvenation, alopecia, and wound healing.

It seems perhaps overly reductionist to summarize the panoply of current efforts to treat aging into two camps of (a) things that affect the burden of cellular senescence and (b) things that affect metabolism. One has to cut out or diminish the importance of a fair number of line items that may be useful irrespective of their effects on cellular senescence. An increased burden of cellular senescence is only one of the major issues that drive aging. Nonetheless, that is the approach to categorization taken in this review paper. Aging is a complex biological process characterized by progressive functional decline, driving the incidence of age-related diseases such as neurodegeneration, metabolic disorders, and cardiovascular diseases. Therapeutic strategies targeting aging hallmarks can delay aging and mitigate disease […]

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents HMGB1 as a Hormetic Stressor in the Response to Exercise Caveolin-1 Gene Therapy Reduces TDP-43 Related Neurodegeneration in a Mouse Model FAM162A Overexpression […]

A small number of humans with an inherited PAI-1 loss of function mutation live up to seven years longer than peers. PAI-1 appears involved in cellular senescence, and thus effects on health and life span may reflect a lower burden of harm resulting from the presence of increasing numbers of senescent cells with advancing age. Researchers have been developing small molecule drugs to inhibit PAI-1 activity, and here find a review paper covering these efforts. Recall that inhibition via a small molecule drug tends to have a much smaller effect than a loss of function mutation, as firstly the drug is only used for part of a life span, and secondly the drug does not produce complete inhibition of activity. This is nonetheless how research […]

Individuals are transient vehicles for the immortal lineage of germline cells. Incompletely understood processes firstly ensure that the germline remains relatively untouched by aging, and secondly ensure that new individuals generated from the cells of two aged individuals are born functionally young. In recent years, researchers have discovered some of the regulatory systems that drive rejuvenation in early embryonic development, the conversion of an old oocyte into a mass of young embryonic stem cells. This has given rise to the techniques of cell reprogramming to generate induced pluripotent stem cells, and of much greater interest at the present time, the techniques of partial reprogramming to restore more youthful function to adult tissues. Yet this is just a first step, and the methods used reflect only […]

Rapamycin is an immunosuppressant long used in transplant medicine at relatively high doses. At lower doses, it slows aging and extends life in animal studies by mimicking some of the beneficial metabolic reactions to calorie restriction, such as increased autophagy. A fair number of people use rapamycin with the hopes of achieving the same outcome, though the human data for this use case and dosage remains sparse. Normally rapamyin is taken once a week, but here researchers mix it in with the diet in a study of immune aging in mice. Aging is the gradual accumulation of structural and functional changes in an organism over time, including immune remodeling and a progressive increase in basal inflammation, or inflammaging. The mTOR pathway is a central driver […]

Biochemistry is enormously complex. The closer that researchers look, the more that they will find. Details remain incompletely mapped and understood at every level; there are only so many researchers and only so much funding. Much of the ongoing fundamental research into interventions to treat aging remains focused on the ability of mild stress to provoke beneficial changes in cell behavior, such as the way in which calorie restriction or heat produce increased cell maintenance activities. Here, researchers delve into the extremely complex landscape of RNA molecules in the cell to search for specific RNAs that are essential to beneficial stress responses that slow aging. Transfer RNA (tRNA) halves (tRHs) are generated via the cleavage of tRNAs, but their roles in aging and longevity remain […]

Mitochondria are power plants, hundreds of these organelles working in every cell to manufacture the adenosine triphosphate (ATP) chemical energy store molecule used to power cell operations. The decline of mitochondrial function with age impacts this supply, with negative consequences, but other equally important issues arise from mitochondrial dysfunction. For example, an important realization in aging research was that dysfunctional mitochondria contribute meaningfully to the chronic inflammation of aging, a topic that is a primary focus of this paper. Mitochondria are increasingly recognized as master regulators of aging, integrating bioenergetics, redox control, stem cell fate, and innate immune signaling. This review synthesizes evidence that mitochondrial dysfunction is not only a hallmark but also an upstream driver of stem cell exhaustion and inflammaging. We discuss how […]

The powerful role of exercise in maintaining skeletal muscle could be the key to improving health and resilience in older age, according to new research from Monash University.

Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial dysfunction and loss of cellular energy. Remarkably, boosting this nutrient restored more youthful mitochondrial performance in aging organisms, suggesting some aspects of aging can be slowed or reversed.

Wearable and implantable biosensors have the potential to revolutionize health care by diagnosing, monitoring, and even treating a wide range of health conditions. Recent innovations in the lab of Wei Gao, professor of medical engineering at Caltech and a Heritage Medical Research Institute Investigator, are pushing the field forward through the creation of soft, stretchable, tissue-integrated bioelectronics for continuous sensing and adaptive therapy.

Tea may help protect against heart disease, diabetes, cancer, cognitive decline, and age related muscle loss, according to a major review. But the way you drink it matters, since bottled and bubble teas often contain ingredients that can diminish tea's health benefits.

Albert Einstein College of Medicine has launched the Batia and Idan Ofer program for Validation of Interventions Targeting Aging and Longevity (BIO-VITAL), a new initiative designed to help biotechnology and pharmaceutical companies advance therapies that target the biology of aging.

Donald Trump is facing renewed scrutiny over his health after a live C‑SPAN interview in New York showed him stumbling over the name of the Lincoln Memorial and hailing a crowd reaction that appeared largely hostile.

TUESDAY, June 9, 2026 — Elizabeth Bonker is a silent woman with a loud mission. She wants government agencies to cover the costs of training people with autism in a form of communication called assisted spelling. One problem: Leading professional...

Weight lifting and other forms of resistance training can increase bone density, lower diabetes risk and boost mental health

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. David Sinclair plans to test whole-body rejuvenation drugs in the XPrize competition The outspoken longevity scientist David Sinclair has predicted that, one day, you’ll go to the doctor and get a…

The outspoken longevity scientist David Sinclair has been predicting that one day, you’ll go to the doctor and get a prescription that will make you 10 years younger. Now MIT Technology Review has learned that he has plans to launch human tests of an oral “reprogramming” drug as part of a $101 million competition organized…

Similar to the way DNA damage can contribute to human diseases such as cancer, it can also disrupt growth, development and survival in plants. Every day, plants endure environmental stresses such as sunlight, radiation, drought and soil stress—all of which can damage their DNA. However, they cannot move away from danger. How do plants handle all that damage?

Researchers have made a new biomaterial that has a similar tensile strength as a fruit roll-up and could help reduce waste produced from indoor decor.

A new review was published in Volume 18 of Aging on May 15, 2026, titled "Blue period – features of senescence 30 years after beta-galactosidase."

Announcing a new publication for Acta Materia Medica journal. Chronic renal failure (CRF) is a progressive disease characterized by a sustained loss of kidney function, for which current therapies remain insufficient.

How we sleep may have lasting impacts for our brain health as we age. A new University of Arizona study has found that several common sleep behaviors may be linked to signs of brain aging.

This study enrolled 308 Chinese women aged 15–65 years to explore the relationship between chronological age, perceived age, and facial aging manifestations.

Hunter Biden's return to social media has stirred political debate with his provocative statements, criticisms of Republican figures, and hints at a potential 2028 campaign.

In each cell of your body, DNA is stored in structures called chromosomes. When cells divide, these chromosomes are copied, but over time, the copying process degrades. After many cycles of making copies, the ends of the chromosomes become shorter and can sometimes get damaged. Thankfully, we have telomeres, which are like protective caps on the ends of our chromosomes that help to decrease the damage when cells divide.

A new study identifies vgll3 as a key gene that promotes rapid growth and early reproduction while increasing the risk of aging and cancer later in life.

The average woman spends more than one-third of her life in menopause. Some women, however, must deal with menopause-related symptoms longer and face added health problems because of premature menopause (before age 40) or early menopause (before age 45).

Glucagon-like peptide-1 (GLP-1) receptor agonist medications have gained widespread attention for effectively treating obesity, lowering blood sugar and decreasing the risk of cardiovascular disease.

A group of researchers at the Medical University of South Carolina (MUSC) has recently developed a new stem cell therapy with a remarkable ability to reverse new-onset Type 1 diabetes (T1D) in a mouse model of the disease.

Stem cell transplantation is the most cost-effective option for long-term care of sickle cell disease in adults when compared with gene therapy and standard of care treatment, according to new research published in Blood.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Spinal cord injuries can have devastating consequences for those affected. Nerve cells in the spinal cord rarely regenerate naturally, while scarring often prevents the regrowth of nerve fibers. Modern therapies attempt to influence implanted stem cells using electrical stimulation to promote the growth of new nerve cells. This approach has several drawbacks: it requires implanted electrodes, and the transplanted cells do not always survive or integrate properly into the existing tissue.

A new study to be presented at the SLEEP 2026 annual meeting found that adults who feel older than their chronological age reported worse sleep outcomes, including more insomnia symptoms, greater sleep-related impairment, and lower sleep regularity, with those sleep outcomes in turn associated with poorer self-reported physical health.

A research team from ETH Zurich and the University of Zurich (UZH) has developed a novel approach to treating spinal cord injuries: controllable microrobots deliver stem cells directly to the site of an injury, where they promote nerve cell regeneration.

Findings reveal that the Mediterranean diet may reduce anxiety symptoms in adolescents, with maternal dietary habits also impacting offspring mental health.

People who vape regularly show altered activity in 3,124 genes across the genome compared with people who do not smoke or vape.

A huge analysis of gene expression across species revealed genetic hallmarks of aging and could accelerate anti-aging treatments. The post How Fast Are You Aging? New Genetic Clock May Have the Answer appeared first on SingularityHub.

What if a process we associate with aging actually helps the body heal? A study led by Mikolaj Ogrodnik, LBI Trauma, published in Nature Cell Biology, shows that cells enter a state of senescence within minutes to hours after an injury—and that this rapid response not only plays a key role in wound healing, but also changes the paradigm of how slowly senescence was expected to arise.

In a groundbreaking study, Stevens researchers show how colorectal cancers can evolve from mature intestinal cells that revert to stem cells.

A genomic study of Greenland sharks, thought to be the longest-lived vertebrates on the planet, is hinting at the secrets to their epic lifespan and cancer resistance.

A team of researchers led by Luigi Naldini at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) has developed a new strategy to significantly improve the precision and safety of CRISPR-Cas9 gene editing in human blood stem cells, potentially overcoming one of the major barriers limiting broader clinical application of genome editing therapies.

Mesenchymal drift may help explain how cells lose stable identity and acquire pro-fibrotic, inflammatory mesenchymal traits during aging. The review proposes MD as a unifying framework that links multiple hallmarks of aging and highlights partial reprogramming as a potential, but still preclinical, way to counteract this process.

Studies found that amputated tissue from a sea cucumber remains viable for years in natural seawater, providing evidence of diversifying cells, immune activity, and tissue reorganization, and potentially “compelling a redefinition of what it means for tissue to be alive.” The post Sea Cucumber Tissues Demonstrate Natural Immortality in Seawater appeared first on GEN - Genetic Engineering and Biotechnology News.

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents The Hallmarks of Aging and the Scientific Endeavor An Update on Progress at Repair Biotechnologies, Developing Means to Regress Atherosclerotic Plaque Granzyme K […]

Scientists at Stanford may have uncovered a hidden reason our brains decline with age. Studying the ultra-short-lived turquoise killifish, researchers discovered that the cellular machinery responsible for building proteins begins to jam and malfunction over time. Tiny structures called ribosomes start colliding and stalling while reading genetic instructions, triggering a chain reaction that leads to faulty proteins and harmful clumps linked to diseases like Alzheimer’s.

Emerging data suggest Western dietary patterns may promote inflammatory gut changes, whereas traditional diets appear linked to more favorable metabolic effects.

Higher abdominal fat is associated with accelerated biological aging across multiple measures, and metabolic aging explains much of the increased risks for heart disease and death.

Teeth do age, becoming more brittle and prone to fracture as the cell populations of the dental pulp become less capable of conducting the necessary maintenance processes. This has only relatively recently become a topic of interest in the dental community, and so relatively little is understood in detail of the mechanisms of tooth aging. Researchers here identify loss of NFATC1 in dental pulp cells as a driver of age-related dysfunction in the maintenance of tooth structural properties, and show that this mechanism is in large part a downstream consequence of the presence of senescent cells in that tissue. Clearance of senescent cells via senolytic therapies reduces the impact of aging on teeth. Although tooth aging is causally linked to age-associated dental degeneration and regenerative […]

An early 1900s rail and tram depot abandoned for almost 20 years in Rome will become a mixed-use private development designed by Stefano Boeri Architetti. The 16,000-sq-m Depositi delle Vittorie… The post Abandoned depot in Rome to become “virtuous example of urban regeneration” appeared first on Global Construction Review.

Transposable elements (TEs), also called transposons, are DNA sequences capable of moving or replicating from one location to another within a genome.

A tiny sea creature might hold the secret to reversing the aging process. When treated with a brief series of electrical pulses, sea squirts experience dramatic and long-lasting health improvements that can significantly extend their lifespans, according to a new study by researchers at Stanford and other institutions.

A sizable proportion of past gains in human life expectancy arose from public health strategies to better control the burden of infectious disease. Exposure to pathogens doesn't just increase the risk of an earlier death due to fatal infection, but also places a burden of damage on the survivors that increases late life mortality. Researchers here discuss what the future of public health strategies might look like in the context of the present great shift from medicine that does not even consider the causes of aging to a medical community that will increasingly proficiently and deliberately target the causes of aging to slow and reverse age-related degeneration. Over the past century, the most transformative gains in human health and longevity did not arise from high-technology […]

Machine learning techniques can be used to generate aging clocks from any sufficiently complex set of biological data obtained from individuals of varying chronological ages. The research community is generating new clocks at a fair pace, most of which are doomed to vanish into obscurity, while trying to better understand best use cases and limitations of the small number of very well-studied clocks. As researchers here point out, when omics data is used as the foundation for a clock, it is typically only one type of omics data, most commonly epigenomic data. It is suggested that new clocks should be developed that employ multiple omics sources, not just one. While I'm sympathetic to this view, it seems to me that the priority remains to make […]

Announcing a new publication for Acta Materia Medica journal. Vicatia thibetica de Boiss (V. thibetica), a traditional medicinal and edible plant used by the Bai ethnic group in China, is known for its effects in tonifying qi, nourishing the blood, dispelling dampness, and relieving itching.