Regeneration

UK scientists have grown fully functioning food pipes and successfully transplanted them into mini pigs, paving the way for human trials.

Animal studies often fail to predict human tissue responses to new drugs or newly developed therapies. Besides generating tremendous costs for clinical studies, it also raises significant ethical concerns. Therefore, novel approaches to mimicking natural human environments like vascular system growth control, are broadly developed to deliver a reproducible model to test novel drugs.

A new Tasmanian Institute of Agriculture (TIA) study has found that while regenerative agriculture practices can improve soil health and reduce emissions on sheep farms, farmers often face trade-offs between environmental and economic goals. The article, "Regenerative agriculture improves productivity and profitability while reducing greenhouse gas emissions on Australian sheep farms," has been published in Nature Food.

Species capable of exceptional regeneration also tend to have longer life spans and slowed aging relative to similar species with less proficient regenerative capabilities. Various closely related species of spiny mouse have been studied in the context of mammalian regeneration because of their ability to shed a large amount of skin and supporting tissues as a defensive mechanism, and later regrow that tissue without scarring. This exceptional regenerative capacity extends to at least some internal organs as well. Spiny mice have been used in past studies that pointed to differences in the activity of macrophage cells as one of the important determinants of complete regeneration versus scar formation. Macrophages are innate immune cells that are deeply involved in ongoing tissue maintenance and regeneration from injury. […]

Technologies that convert carbon dioxide (CO₂) emitted from factories and power plants into useful chemical feedstocks are considered key to achieving carbon neutrality. However, rapid degradation of catalyst performance has long hindered commercialization. KAIST researchers have now developed a "self-regenerating" catalyst that restores its activity during operation, offering a potential solution to this challenge.

Some of the organs in the body do not have to be in their current location, nor structured in a single mass of tissue, in order to carry out all of their functions. The liver is one of these organs. Many (not all, but many) of the functions of the liver could be carried out by small amounts of liver tissue distributed throughout the body. Thus the existence of companies like Lygenesis, shepherding clinical trials of liver tissue organoid transplantation into lymph nodes to help restore lost function. Here, researchers report on the early stages of development for an alternative approach that is even less like normal liver tissue, essentially just an injection of cells and hydrogel rather than any production of structured tissue for […]

Dental pulp injury caused by trauma or deep caries often leads to inflammation, tissue necrosis, and eventual loss of tooth vitality.

The world's first lab-based tick feeding system for bush ticks, developed by researchers at the University of Melbourne, has transformed the study of ticks and how they transmit disease. The novel, host-free technology reduces the need for animal experiments in tick studies, facilitating more ethical, reproducible research.

Scientists have discovered a key biological safeguard that helps one of nature's most impressive regenerators, the planarian flatworm, correctly rebuild its organs. The new research, published in Nature Communications, illuminates how these animals prevent their powerful stem cells from making mistakes during regeneration, a discovery that may eventually help scientists understand how to better control stem cell behavior in other species.

Aging muscles heal more slowly after injury — a frustrating reality familiar to many older adults. A new

A muscle-tissue engineering company, MUVON Therapeutics, is set to highlight the regulatory and technological challenges of bringing these novel therapies to the clinic. The post Bridging the Translation Gap for Regenerative Tissues appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers overcome key challenges in the mass production of enzymatic biofuel cells, paving the way for self-powered wearable sensor.

Sens. Diagn.DOI: 10.1039/D5SD00210A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vincent Vezza, Veerappan Mani, Niamh Docherty, Adrian Butterworth, David Alcorn, Paul A. Hoskisson, Damion CorriganSevere sepsis presents a critical healthcare challenge where rapid pathogen identification is vital for timely intervention.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Loss of specialized cells is a feature of aging, exhibited in tissues throughout the body. There are many examples of cell types that could in principle be replaced once lost, but in practice are not replaced. The underlying reasons for this selective lack of regenerative capacity are incompletely understood. Examples of highly specialized cell types that do not regenerate include sensory hair cells in the inner ear and the podocyte cells of the kidney that are the subject of today's research materials. Interestingly, some of the cell types that regenerate poorly or not at all in mammals are in fact restored when lost in other species. While comparative biology allows for an exploration of these differences, cells are enormously complex and expanding the understanding of […]

An AI‑based method has been developed to detect subtle, hard‑to‑see changes in human pancreatic tissue linked to type 2 diabetes. Using gigapixel microscopy and explainable AI, the team identified key cellular features that may serve as early biomarkers of the disease. The post AI Maps Subtle Human Pancreatic Tissue Changes Linked to Type 2 Diabetes appeared first on GEN - Genetic Engineering and Biotechnology News.

Dr. Vadim Jucaud's lab at the Terasaki Institute has developed a vascularized liver tissueoid-on-a-chip (LToC) platform that recapitulates key structural, functional, and immunological features of human liver tissue, enabling the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system.

APOE is a component of the low density lipoprotein (LDL) particles that carry cholesterol from the liver to where it is needed in the body. Lowering circulating LDL-cholesterol levels to modestly slow the progression of atherosclerosis is the primary approach taken in cardiovascular medicine; in recent years, new forms of LDL-lowering therapy such as PCSK9 inhibitors have been used to dramatically reduce LDL-cholesterol to far below normal levels with no immediately apparent prohibitively negative effects on patients. In today's open access paper, researchers show that elevated APOE levels are a feature of old age and negatively affect bone regeneration, likely by suppressing the creation of osteoblast cells responsible for producing bone extracellular matrix structures. A near complete elimination of APOE production in the liver (which […]

Researchers have built a realistic human mini spinal cord in the lab and used it to simulate traumatic injury. The model reproduced key damage seen in real spinal cord injuries, including inflammation and scar formation. After treatment with fast moving “dancing molecules,” nerve fibers began growing again and scar tissue shrank. The results suggest the therapy could eventually help repair spinal cord damage.

Axolotls can completely rebuild their thymus, a key immune organ

Humans develop sharp vision during early fetal development thanks to an interplay between a vitamin A derivative and thyroid hormones in the retina, Johns Hopkins University scientists have found. The findings could upend decades of conventional understanding of how the eye grows light-sensing cells and could inform new research into treatments for macular degeneration, glaucoma, and other age-related vision disorders. Details of the study, which used lab-grown retinal tissue, are published today in Proceedings of the National Academy of Sciences.

Researchers in the College of Agriculture, Health and Natural Resources have developed a novel line of bovine embryonic stem cells, which have significant potential for a variety of new innovations, from lab-grown meat to models for human tissue replacement. This work, led by Xiuchun "Cindy" Tian, professor of biotechnology in the Department of Animal Science, and her former and current graduate students Yue Su, Jiaxi Liu, and Ruifeng Zhao, was published in Stem Cells.

Sens. Diagn.DOI: 10.1039/D5SD00210A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vincent Vezza, Veerappan Mani, Niamh Docherty, Adrian Butterworth, David Alcorn, Paul A Hoskisson, Damion CorriganSevere sepsis presents a critical healthcare challenge where rapid pathogen identification is vital for timely intervention. Current diagnostic methods, however, remain inadequate, often delaying targeted treatment. Using readily available printed...The content of this RSS Feed (c) The Royal Society of Chemistry

A University of Missouri researcher is pioneering an innovative solution to remove tiny bits of plastic pollution from our water. Mizzou's Susie Dai recently applied a revolutionary strain of algae toward capturing and removing harmful microplastics from polluted water. Driven by a mission to improve the world for both wildlife and humans, Dai also aims to repurpose the collected microplastics into safe, bioplastic products such as composite plastic films.

Relative to skin elsewhere on the body, facial skin is less prone to scarring following regeneration from injury. Researchers have identified how this difference is regulated, and here demonstrate that they can influence the relevant mechanisms in order to reduce scarring during regeneration of skin injuries elsewhere on the body. It is also possible that further investigation of this biochemistry may yield approaches to reduce scarring more generally. This is of interest in the context of aging, as tissue maintenance becomes dysfunctional in many organs in ways that lead to excessive formation of disruptive small-scale scar-like structures. Surgeons have known for decades that facial wounds heal with less scarring than injuries on other parts of the body. This phenomenon makes evolutionary sense: Rapid healing of […]

Researchers have developed a way to grow a highly specialized subset of brain nerve cells that are involved in motor neuron disease and damaged in spinal injuries.

Shark Tank star Kevin O'Leary recently shared how he undergoes an exotic procedure for rapid cell generation, tissue healing, and a stronger immune system.

Skeletal muscle stem cells in hibernating Syrian hamsters preserve their ability to function by suppressing their activation during the hibernation period, a research team led by Hiroshima University has shown. This insight may lead to a broader understanding of the maintenance of muscle tissue under prolonged low-temperature conditions and may eventually lead to therapeutic applications.

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have found that a key protein can help to regenerate neural stem cells, which may improve aging-associated decline in neuronal production of an aging brain.

The thymus is a small inner organ near the heart that is responsible for the maturation of T cells of the adaptive immune system. The supply of new T cells is critical to the maintenance of effective immune function over time. Unfortunately the thymus atrophies over the course of adult life, and in most people is largely made up of inactive fat tissue by as early as 50 years of age. The resulting diminished supply of replacement cells ensures that the T cell population thereafter becomes ever more made up of malfunctioning, exhausted, and senescent cells incapable of mounting an effective response. Given the pressing need for ways to restore lost immune function in older individuals, it is good to see that a fair number […]

As we age, we don't recover from injury or illness like we did when we were young. But new research from UCSF has found gene regulators—proteins that turn genes on and off—that could restore the aging body's ability to self-repair.

In Finland, farmers who have transitioned to regenerative agriculture are forming a regenerative professional partnership with nature in their decision-making, a new study from the University of Eastern Finland shows.

Yeast left over from brewing beer can be transformed into edible 'scaffolds' for cultivated meat – sometimes known as lab-grown meat – which could offer a more sustainable, cost-effective alternative to current methods, according to a new study from UCL (University College London) researchers.

Intestinal Stem Cells (ISCs) derived from a patient's own cells have garnered significant attention as a new alternative for treating intractable intestinal diseases due to their low risk of rejection.

Plants have an extraordinary ability to sense tissue damage and quickly rebuild their protective outer layers, a process vital for survival amid environmental stresses. The periderm—a specialized protective tissue found in many woody plants—serves as a crucial barrier against water loss, pathogens, and mechanical injury. However, understanding how gaseous molecules enable plants to rapidly detect surface disruptions has long remained elusive.

Like a phoenix rising from the ashes, our skin tissue—and in fact many types of epithelial tissue that lines and covers the body's organs—can respond to death and destruction with a burst of regeneration. This phenomenon, known as compensatory proliferation, was first described in the 1970s in fly larvae, which regrew fully functional wings after their epithelial tissue had been severely damaged by high-dose radiation. Since then, this surprising ability has been documented in many species, including humans, yet its molecular basis has remained unclear.

Scientists cultivating partnerships of fungi and algae believe their invention has far-out implications for how we create the buildings of the future

3D-printed meat in Brazil advances with CELLMEAT 3D project using biopsied cells for lab-grown protein, no slaughter needed

Researchers created pea-sized brain structures from stem cells to study neural firing patterns, correctly identifying bipolar disorder and schizophrenia.

The dental pulp is susceptible to microbial infection, which often results in inflammation, necrosis, and defects in the pulp-dentin complex. Traditional treatment strategies suffer from multiple limitations and do not promote neural regeneration.

The axolotl, a type of salamander that stays in the tadpole form throughout its life, is a master of regeneration. Axolotls have been observed to regrow several body parts, including limbs, eyes, and even parts of their brains.

As we age, the muscles we rely on for daily activities tend to become less reliable. With enough decline, even normal movements such as getting out of bed become risky.

Sizable regeneration of damaged or lost cartilage remains impossible in practice, but also a highly desirable goal given the prevalence of osteoarthritis. The best that has been achieved to date in clinical practice results from one specific implementation of stem cell therapy, Cartistem. Other stem cell therapies haven't done as well in this context. You may recall that inhibition of 15-PGDH was shown to improve muscle function in old mice. That work has since moved on to initial clinical trials of a small molecule drug, developed by Epirium Bio. Here, researchers show that the same approach can produce some degree of cartilage regrowth, also in old mice. Blocking the function of 15-PGDH with a small molecule results in an increase in old animals' muscle mass […]

Microdroplet arrays store and conceal digital data through droplet composition, enabling reversible encoding, multi-layer QR patterns, error correction, and time-controlled messages using living cells.

Nerve damage is one of the most common and burdensome complications of diabetes. Millions of patients worldwide suffer from pain, numbness, and restricted movement, largely because damaged nerve fibres do not regenerate sufficiently.

Type 1 diabetes (T1D) is an autoimmune disorder characterized by the specific destruction of insulin-producing pancreatic β-cells.

With aging, the intestine gradually loses its ability to regenerate after damage. An international research team involving the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena and the University of Turin has now found that polyamines, small molecules produced naturally in the body, can play a decisive role in this process.

Former Campbell's employee leaks explosive recording and sues two company officers for wrongful termination.

In industrial pipes, mineral deposits build up the way limescale collects inside a kettle ⎯ only on a far larger and more expensive scale. Mineral scaling is a major issue in water and energy systems, where it slows flow, strains equipment and drives up costs.

Researchers at Wageningen University & Research (WUR), working in close collaboration with KeyGene, have developed a method that enables plant cells to regenerate into complete plants without the need for added hormones.

4D printed hydrogel expanders use controlled buckling and low pressure to generate new soft tissue while preserving viability and activating early remodeling pathways for personalized reconstruction.

Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology

Studying tail regeneration in tadpoles, researchers discovered that putative muscle stem cells produce a secreted protein, c1qtnf3, which shifts macrophages from immune to regenerative functions. The post Stem Cell Signal Redirects Macrophages to Promote Regeneration of Tadpole Tails appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers Sumika Kato, Takeo Kubo, and Taro Fukazawa of the University of Tokyo have discovered that c1qtnf3, a secreting factor, namely a protein molecule that is secreted by a cell and influences functions of other cells, is expressed in putative muscle stem cells and shifts macrophages from immune to regenerative functions in the regenerating tails of tadpoles.

Thin sheets of engineered artificial tissue can be readily manufactured because they do not require a vasculature, perfusion of fluids is sufficient to support the cells. For some years now, researchers have developed the capability to manufacture thin heart tissue patches. A number of preclinical studies in various animal models have demonstrated that applying these patches to an injured heart promotes greater regeneration and restoration of function than normally takes place. Here, the technique is combined with a minimally invasive form of surgery as a proof of concept, and used in rats following heart attack to promote greater regeneration. For years, scientists have been working on ways to replace damaged tissue with healthy heart cells derived from stem cells. Early efforts showed promise, but most […]

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A new research paper was published in Oncotarget (Volume 16) on November 6, 2025, titled "LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas."

A new study shows, for the first time, that cow cells can naturally become immortal—continuing to divide indefinitely without genetic modification or any abnormal transformation. This overturns long-held assumptions that bovine cells could only be immortalized through gene editing, providing a safe, stable, and scalable source of cells for cultivated beef production.

A research team in South Korea has successfully developed a novel technology that combines nanoparticles with stem cells to significantly improve 3D bone tissue regeneration. This advancement marks a step forward in the treatment of bone fractures and injuries, as well as in next-generation regenerative medicine.

Southwest Research Institute (SwRI) has demonstrated a new application for its cell-expansion bioreactor to advance tissue engineering and cell-based therapies for treatment of injuries and diseases.

A research team in South Korea has successfully developed a novel technology that combines nanoparticles with stem cells to significantly improve 3D bone tissue regeneration.

Researchers created a nanoparticle-stem cell technology that greatly enhances 3D bone regeneration, advancing treatment for fractures and regenerative medicine.

Researchers here demonstrate a novel way of delivering stem cells as a therapy for bone fractures that occur in the context of osteoporosis, by forming spheroids of stem cells combined with a bone mineral scaffolding material. The approach appears to encourage the survival of a larger fraction of transplanted cells, producing a greater regeneration of bone tissue. More usually near all of the transplanted cells die shortly after a transplantation procedure, and whatever benefits are obtained are derived from the signaling generated by the stem cells prior to that point. Osteoporotic vertebral fractures substantially contribute to disability and often require surgical intervention. However, some challenges, such as implant failure and suboptimal bone regeneration, limit current treatments. Adipose-derived stem cells are promising for regenerative therapy because […]

What if scientists could build a realistic model of the human lung, not full-sized, but grown in the

Researchers here find a potential way to induce greater regeneration in injured heart muscle, normally a tissue that regenerates only poorly following damage, and particularly so in older individuals. Inducing CCNA2 expression appears to promote replication of the cardiomyocyte cells making up heart muscle. Still, a great deal of work remains in order to build a viable gene therapy based on this finding and assess it in a clinical trial. The direct delivery of a gene therapy to heart muscle is perhaps more viable than is the case for other internal organs given the range of established minimally invasive surgical procedures developed for use in the cardiovascular field. One can envisage a therapy that is delivered alongside the procedures normally carried out for patients following […]

Plant biologists have developed a method for growing transgenic and gene-edited plants that cuts the slow and expensive process down from months to weeks.

Exoplanet scientists are eagerly awaiting the discovery of an atmosphere around a terrestrial exoplanet. Not a thin, tenuous, barely perceptible collection of molecules, but a thick, robust, potentially life-supporting atmosphere. Due to the way we detect exoplanets, most of the terrestrial planets we find are orbiting red dwarfs (M dwarfs).

Rocky exoplanets orbiting red dwarfs are in a tough spot. Their stars are known for violent flaring that can destroy their atmospheres. But it's possible that asteroid impacts could later recreate their atmospheres.

A team of researchers from the National Institutes for Quantum Science and Technology (QST) and Tokyo Metropolitan University has developed a biomaterial that could change how we treat muscle degeneration and metabolic disorders.

As chronic liver disease becomes more widespread, researchers at Science Tokyo have developed a lab-grown organoid that replicates a regenerating liver, offering new hope for future treatments.

Human health is the Achilles heel of space travel. Researchers at ETH Zurich have now succeeded in printing complex muscle tissue in zero gravity. This will enable drugs for space missions to be tested in the future.

After vocal cord surgery, many patients develop stiff vocal folds that impact their ability to speak. Hydrogels can help prevent this by promoting healing, but delivering hydrogels to the vocal cords is difficult.

Biologists have long been fascinated by the ability of salamanders to regrow entire limbs. Now Harvard researchers have solved part of the mystery of how they accomplish this feat—by activating stem cells throughout the body, not just at the injury site.

Researchers here report on potential targets to enhance the regenerative capacity of alveolar type 2 cells, a population necessary for regeneration in lung tissue, but which falters in this duty in the context of progressive and age-related lung disease. Compensating for poorly understood mechanisms of damage and disease that direct alveolar type 2 cells away from regenerative activity can in principle be achieved by overriding the regulatory system that controls this aspect of cell behavior, provided enough is understood of how that regulatory system works. This approach to therapy doesn't fix the underlying issues, but may well prove to be beneficial enough to pursue. There are numerous examples in the present practice of medicine of compensatory approaches that succeed in producing benefits for patients. When […]

Solving telomerase gene mystery in has evolutionary significance and could lead to a better understanding of how telomerase is regulated in healthy cells, with implications for aging, fertility, and regenerative medicine research. The post Hitchhiking DNA in C. elegans Solves Telomerase Puzzle, with Regenerative Promise appeared first on GEN - Genetic Engineering and Biotechnology News.

When farmland is abandoned and allowed to return to nature, forests and grasslands naturally regrow and absorb carbon dioxide from the atmosphere—helping fight climate change.

Soft tissue injuries of the gastrointestinal tract, like ulcers or hemorrhages, can currently be treated only with some form of surgery, which is invasive and may not result in permanent repair.

The results of a study in flatworms challenging the textbook concept that stem cells reside in a defined niche may help explain the planarian’s regenerative capacity, and potentially offer clues for developing approaches to human tissue repair or replacement. The post Flatworm Stem Cells Offer Insights into Regenerative Biology appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers from New York’s Rensselaer Polytechnic Institute have developed a cellulose membrane for purifying mRNA therapies, which has improved performance over commercial chromatography. They believe it will reduce the cost of manufacturing these therapies. The post Regenerated Cellulose Membrane Shown to Outperform Chromatography Columns in Purifying mRNA Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.

The brain's mechanisms for repairing injuries caused by trauma or degenerative diseases are not yet known in detail.

University of Cambridge scientists have used human stem cells to create three-dimensional embryo-like structures that replicate certain aspects of very early human development - including the production of blood stem cells.

University of Cambridge scientists have used human stem cells to create three-dimensional embryo-like structures that replicate certain aspects of very early human development—including the production of blood stem cells. The findings are published in the journal Cell Reports.

Researchers in the University of Minnesota College of Science and Engineering have successfully 3D printed realistic human tissue

In the upper Abbay basin, cradle of the Blue Nile, a team of researchers have predicted soils of the future: what will happen to soil organic carbon if we bet on regenerative agriculture—returning residues, organic manure, cover crops, agroforestry?

The body's tissues can get injured in many ways, but while some injuries heal perfectly, others don't heal at all. A cut in the skin, for example, usually heals all on its own, while internal organs, such as the heart after a heart attack or the kidney after an acute injury, remain damaged, leading to diminished function.

Taste is one of our most vital senses, shaping appetite, nutrition, and quality of life. Yet taste buds are fragile, relying heavily on the nerves that connect them to the brain.

Hundreds of readers responded to our poll asking if it would be OK to experiment on lab-grown "brains" if they became conscious.

Artificial tissues that mimic the placenta, endometrium, ovary and vagina could point to treatments for common conditions such as preeclampsia and endometriosis

Why does the peripheral nervous system regenerate while the central nervous system does not? Both are composed of clusters of neurons linked by axons that can extend for as much as a few feet in the longest cases. Nerves are bundled axons. One of the approaches taken by researchers interested in applying regenerative medicine strategies to the central nervous system is to look for biochemical differences between peripheral nervous system neurons and axons versus central nervous system neurons and axons. There must exist specific differences that enable regeneration of peripheral nervous system axons or suppress regeneration of central nervous system axons. That doesn't mean those differences are easy to find, of course. Biology is exceptionally complex and present omics approaches are not well suited to […]

Researchers, reporting in ACS Nano, developed a 3D-printable bioactive glass that functions effectively as a bone replacement material.

Elastin is a vital component of flexible tissues, and poorly maintained in the adult body. Deterioration of elastin is an important component of the age-related structural alterations that take place in tissues such as skin and blood vessels. Elastin is also hard to obtain or manufacture for use in engineered tissues, which is the primary roadblock motivating the research noted here. While this is useful, a robust source of elastin (or as here, elastin-like proteins that suitably mimic the behavior of elastin) would probably do relatively little to enable therapies to restore elastin structures in aged tissues, as those elastin structures are complex and the configuration of elastin molecules relative to other components of the extracellular matrix matters. It is likely that some form of […]

A German-Austrian team led by Friedrich Schiller University Jena and Leibniz-HKI has been able to biochemically demonstrate for the first time that different types of mushrooms produce the same mind-altering active substance, psilocybin, in different ways.

Pea-sized brains grown in a lab have for the first time revealed the unique way neurons might misfire due to schizophrenia and bipolar disorder, psychiatric ailments that affect millions of people worldwide but are difficult to diagnose because of the lack of understanding of their molecular basis.

A perspective paper published this week argued that brain organoids could soon gain consciousness, and we should consider stricter regulations around them.