Regeneration

A new critical review, published in the journal CABI Agriculture and Bioscience, highlights the emergence and scientific basis of regenerative agriculture—proposing a working definition centered on ecological cycles and farm system outcomes.

Scientists developed a 3D printing method that creates hydrogels with tissue-like properties, paving the way for personalized implants and adaptive soft robotics.

New research from the Charles Perkins Centre at the University of Sydney has uncovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing dangerous blood clots, potentially paving the way for future treatments that reduce their cardiovascular risk.

More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-quality fertility care for those in need but, importantly, also for new biomedical solutions that can address the root causes of infertility.

A new nanotube-based RNA delivery system boosts plant regeneration by switching off a molecule that blocks shoot growth, without changing the plant's DNA.

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated.

In the near term, the field of tissue engineering aims to produce artificial tissue structures that can support cells and integrate with native tissue when implanted into an injury, promoting regeneration that would not otherwise have taken place. In the longer term, the goal is to produce entirely artificial, fully functional organs - but first things first. Producing large sections of pseudo-tissue that can reliably promote regeneration is still a work in progress, with many projects at varying stages of development. As this paper makes clear, the fine details involved in sufficiently replicating tissue structural properties can be a challenge. Myocardial Infarction (MI) occurs when blood flow to the heart is restricted, causing cardiomyocyte death, scar tissue formation, and myocardial remodeling. These changes reduce the […]

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation that could lead to better regenerative therapies.

A research team from Shanghai Jiao Tong University has resulted in a significant advancement in the field of orthopedic implant materials.

The eye of the apple snail is unusually similar to a human eye-but, unlike human eyes, it can regrow itself if injured or even amputated.

It is well known that the formation of fat deposits within muscle tissue is a feature of aging, and is also associated with a variety of muscle disorders. Here, researchers explore how exactly this infiltration of fat into muscle harms muscle function, with a focus on regenerative capacity. At present physical activity is the most reliable approach to prevent or reduce fat infiltration of muscle tissue, but it seems likely that at least some of the growing number of weight loss drugs in development, many of which improve upon GLP-1 receptor agonists by neither reducing calorie intake nor causing loss of muscle mass, will also be effective. Adipose tissue acts as an energy storage as well as an endocrine organ. However, different fat depots, such […]

Stem cell research, alongside the rapidly advancing field of biotechnology, has led to remarkable innovations in regenerative medicine.

Cartilage is a poorly regenerative tissue, one of the reasons why cartilage damage is a feature of aging and persistent consequences of joint injury. Nonetheless, cartilage is formed during development so in principle there must exist programs of regeneration that might be activated via suitable forms of therapy. Here, researchers use a targeted nanoparticle approach to deliver a therapeutic cargo into chondrocytes in damaged cartilage tissue. This caused an improvement in both mitochondrial function and capacity for regeneration. Treating osteoarthritis (OA) presents a significant challenge due to the fact that conventional intra-articular injections only achieve superficial penetration and uncontrolled drug release. Here, amino-modified cationic mesoporous silica nanoparticles were covalently conjugated with cartilage-targeted peptides to form a Trojan horse-like architecture for enveloping the prochondrogenic fucoidan. The […]

Researchers supported by the U.S. National Science Foundation have discovered that it is not how much of a key molecule

Announcing a new article publication for BIO Integration journal. As a mechanical wave capable of transmitting thermal and mechanical energy, ultrasound has emerged as a pivotal tool in regenerative medicine due to its non-invasive nature.

Announcing a new article publication for BIO Integration journal. Osteochondral damage is primarily caused by degeneration of articular cartilage due to trauma, degenerative injury.

Beef is growing in the Petri dishes of ETH professor Ori Bar-Nur, an expert in regenerative and muscle biology. However, he hasn't yet tasted the cultivated meat because human consumption requires official approval in Switzerland. However, Bar-Nur has colleagues who have participated in approved tastings of lab-grown beef. They describe the taste and consistency as being similar to that of real meat. After all, it is beef, the only difference being that no cow needs to be slaughtered in order to obtain it.

Aging negatively impacts muscle regeneration for reasons that remain incompletely understood. This incomplete understanding exists in part because muscle regeneration involves a complex set of interactions between different cell types that shifts over time as the response to injury progresses. It requires a great deal of effort to build a clear picture at the level of cell biochemistry. Nonetheless, it is evidently the case that aging impairs the activity of muscle stem cells, it impairs the niches in which those cells reside, it alters the behavior of immune cells for the worse, and so forth. There are starting points. Similarly, one can point to the chronic inflammation of aging and its ability to impairs regeneration, interfering in the normal short-term inflammatory signaling that follows injury. […]

Investigating vegetable oils, this study reveals their effects on skin cell proliferation and migration, emphasizing the role of fatty acid composition.

Researchers have established a framework for the design of bioactive injectable hydrogels formulated with extracellular vesicles (EVs) for tissue engineering and regenerative medicine applications.

In a breakthrough for regenerative medicine, a new study from IMDEA Materials Institute researchers has demonstrated the potential of 3D-printed carbon microlattices as structurally tunable scaffolds for bone tissue engineering.

GNSC-001 is the first IL-1 inhibitor for osteoarthritis that has been shown to generate IL-1Ra expression levels that maintain therapeutic thresholds long-term following a single administration to inhibit pathogenic IL-1. The post FDA Grants Regenerative Medicine Advanced Therapy Designation to Gene Therapy for Osteoarthritis appeared first on GEN - Genetic Engineering and Biotechnology News.

Some species, such as salamanders and zebrafish, are capable of reactivating programs of embryonic development following injury in order to regrow limbs and even major portions of vital internal organs. Since mammals share the same ability to conduct embryonic development, it is hoped that all of the necessary biochemical machinery to also conduct complete regeneration of organs still exists in adult mammals, merely suppressed in some way. Researchers investigate the exceptional regeneration of species like zebrafish in search of controlling mechanisms that might be manipulated to turn on the same exceptional regeneration in humans and other mammals. It remains to be seen as to how long this will take, and whether the options will be as straightforward as hoped for. Humans can't regenerate heart muscle […]

Researchers identified that two cyclin D genes, ccndx and ccnd2a, independently regulate distinct stem and progenitor cell populations during zebrafish sensory organ regeneration. The findings reveal that regeneration can proceed via alternative pathways even when one gene is disrupted, providing new insight into tissue repair mechanisms.

UBC Okanagan researchers have developed a 3D bio-printed model that closely mimics the complexity of natural lung tissue, an innovation that could transform how scientists study lung disease and develop new treatments.

While humans can regularly replace certain cells, like those in our blood and gut, we cannot naturally regrow most other parts of the body. For example, when the tiny sensory hair cells in our inner ears are damaged, the result is often permanent hearing loss, deafness, or balance problems.

Cleaning products, candles, cribs, and cosmetics are just a few of the common household items that emit formaldehyde, a colorless, odorless chemical that, when present in the air at levels higher than 0.1 parts per million, has been found to be a risk to human health.

In today's open access paper, researchers argue that the regeneration of outer, visible ear tissue is a useful area of focus for understanding why mammals are limited in their regenerative capacity. Species such as salamanders and zebrafish can regenerate limbs and internal organs, and researchers would like to understand how to enable this capability in mammals. The ear is interesting in this respect because some mammals are capable of regeneration of ear tissue, while others are not, giving a starting point for a closer comparison of the relevant biochemistry between more similar species. Mice are incapable of ear tissue regeneration, which is why ear notching is a common means of animal identification used in laboratories. Interestingly, this is how the exceptional regenerative capacity of MRL […]

Scientists have developed a technique that aligns stem cells into a single sheet, resulting in a marked increase in the secretion of signaling proteins which help repair tissue and regulate the immune system. The new approach, described in the journal Materials Today Bio, could improve stem cell-based treatments for conditions such as heart disease, liver damage, and autoimmune illnesses.

Food scientists are paving the way for 3D-printed food and pharmaceuticals based on drought-tolerant grain sorghum protein that won't turn into a blob.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Advanced imaging technologies are uncovering surprising roles for CD8+ T cells—not just in immune defense, but also in supporting tissue repair and regeneration.

Research led by the National Institute of Biological Sciences in Beijing has discovered that switching on a single dormant gene enables mice to regenerate ear tissue.

By flipping an evolutionarily disabled genetic switch involved in retinoic acid metabolism, or by administering exogenous retinoic acid, researchers have enabled ear tissue regeneration in mice. The post Mice Regenerate Ear Tissue When Vitamin A Genetic Switch is Flipped appeared first on GEN - Genetic Engineering and Biotechnology News.

As trees grow larger, their heartwood proportion increases and eventually accounts for most of the biomass. Heartwood decay resistance depends on the type and amount of protective chemicals (extractives) deposited therein. Rates of heartwood accumulation and extractive content are major determinants of tree longevity and a forest's capacity for long-term carbon storage.

The creation of effective regenerative therapies for the aging heart is an area of active research and development. Cell therapies based on delivery of cardiomyocytes proved to be challenging, as just as in every other early approach to cell therapy, near all transplanted cells fail to survive. More recently researchers have engineered tissue patches made up of cardiomyocytes and supporting artificial extracellular matrix structures made of hydrogels and other materials. When such a patch is applied to injured heart tissue, it allows more of the transplanted cells to survive, resulting in the generation of healthy tissue. The natural extracellular matrix of the heart undergoes change with age. This aging of the extracellular matrix is nowhere near as well studied as the aging of cells, yet […]

One of the primary goals in the field of comparative biology is to produce a sufficient understanding of the proficient regeneration exhibited by species such as salamanders and zebrafish to enable similar feats of complete regeneration from severe injury in mammals. Progress has been slow, as it is a challenging problem. While a number of lines of evidence suggest that mammals still possess the molecular machinery necessary to regenerate organs, such as the exceptional regenerative capacity of MRL mice, it remains unclear as to why this machinery is inactive in near all circumstances. Tissue regeneration requires a complex cellular choreography that results in restoration of missing structures. Salamander limb regeneration is no exception, where mesenchymal cells, including dermal fibroblasts and periskeletal cells, dedifferentiate into a […]

Tiny gel droplets enhanced with University of Queensland technology could open new pathways to repairing and replacing damaged organs.

With the aid of a 3D printer, researchers at Uppsala University have succeeded in creating a model that resembles human nerve tissue.

Thanks to lab-grown miniature intestines, researchers at Uppsala University have successfully mapped how aggressive Shigella bacteria infect the human gut.

Axolotls, with their signature smiles and pink gills, are the celebrities of the salamander world. But they are more than just cute: They might also hold the secret to regenerating human limbs.

A team of biomedical researchers led by Michael Mak, Ph.D., in the Renaissance School of Medicine at Stony Brook University, has developed a new method of bioprinting physiological materials. Called TRACE (Tunable Rapid Assembly of Collagenous Elements), the method solves previous problems of bioprinting natural materials of the body.

Engineering functional cellular tissue components holds promise in regenerative medicine. Collagen I, a scaffolding material in bodily tissues, presents challenges in controlling its assembly kinetics in a biocompatible manner . The post Novel Biofabrication Technique Could Advance Bioprinting and Tissue Engineering appeared first on GEN - Genetic Engineering and Biotechnology News.

Boise State University researchers have developed a new technique and platform to communicate with cells and help drive them toward cartilage formation. Their work leverages a 3D biocompatible form of carbon known as graphene foam and is featured on the cover of Applied Materials and Interfaces.

The mammalian liver has an extraordinary regenerative capacity, capable of fully restoring its mass and function after injury or partial resection.

A new study suggests that stem cells thought to be dormant may offer clues to why our sense of smell declines or is lost.

Salivary glands play an essential role in protecting oral health by secreting saliva to aid in digestion, speech, and immunity.

Since the COVID-19 pandemic, global interest in antiviral therapies has increased significantly. Recently, with the growing attention to peptide-based drugs such as Wegovy, demand for effective peptide therapeutics derived from natural substances is rapidly rising.

Since the COVID-19 pandemic, global interest in antiviral therapies has increased significantly. Recently, with the growing attention to peptide-based drugs such as Wegovy, demand for effective peptide therapeutics derived from natural substances is rapidly rising. In particular, peptide metabolites—which are generated when natural proteins break down in the body—are emerging as promising candidates for multifunctional drug development.

Millions of people are affected by chronic dry mouth, or xerostomia, an agonizing side effect of damaged salivary glands. Currently, there is no cure for it. Researchers have established the world's first biobank of human salivary gland tissue-organoids that opens the door to research to find a cure.

The axolotl is renowned for its extensive ability to regenerate organs and body parts, including its spinal cord. Studies on spinal cord regeneration, however, have focused on axolotl cells next to an injury site, leaving the brain's role in regeneration a relative mystery.

Researchers have developed a 3D micro-printed sensor for highly sensitive on-chip biosensing. The sensor, which is based on a polymer whispering-gallery-mode microlaser, opens new opportunities for developing high-performance, cost-effective lab-on-a-chip devices for early disease diagnosis.

Researchers have developed a method to confidently produce blood cell precursors from stem cells in mice, by activating a set of seven key genes in the laboratory. The team takes a step forward towards the production of precursor cells able to restore the bone marrow of blood cancer patients, in a successful example of regenerative medicine.

Collagen, a prevalent and predominant part of the structure of bodies, still has some mystique surrounding the finer aspects of its existence. In a new study, researchers look into the mechanism of orientation within collagen to elucidate some of the lesser-known aspects of this protein and how it can be used in future applications.

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed a technique that could help advance treatments in tissue engineering.

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed a technique that could help advance treatments in tissue engineering. The study, published in the journal Small, introduces a technique for producing tissues with precise cellular organization designed to mimic the natural structure of human tissue.

A new bioprinter uses ultrasound to print tissues, biosensors, and medication depots deep in the body. The post Scientists Can Now 3D Print Tissues Directly Inside the Body—No Surgery Needed appeared first on SingularityHub.

A major long-term study presented at EuroPerio11, the world's leading congress on gum health and implant dentistry by the European Federation of Periodontology (EFP), reveals that saving teeth with severe bone loss through periodontal regeneration (PR) offers benefits equal to - if not greater than - replacing them with dental implants or bridges.

Dental caries, or tooth decay, is a common oral health condition that often causes significant pain and discomfort and may even lead to tooth loss.

Acetaminophen is the most frequently taken fever and pain medication worldwide, but overdosing can be toxic to liver cells. In the United States, about 1,600 cases of acute liver failure and 500 deaths occur each year due to acetaminophen overuse and liver failure.

An ultrasound-guided 3D printing technique could make it possible to fabricate medical implants in vivo and deliver tailored therapies to tissues deep inside the body—all without invasive surgery. The post In Vivo Bioprinting Shows Promise for 3D Printed Implants Without Surgery appeared first on GEN - Genetic Engineering and Biotechnology News.

Adipose-derived stem cells may offer a way to slow the progression of mild to moderate Alzheimer’s. Early-phase data from five patients shows lower p-tau and better cognitive scores. The post Regeneration Biomedical’s Cell Therapy Reduces Tau, Boosts Cognition in Alzheimer’s Cases appeared first on GEN - Genetic Engineering and Biotechnology News.

The authors of this review paper have a positive view of the future of regenerative medicine built on the ability to generate induced pluripotent stem cells from any patient cell sample. That should be tempered by a realistic expectation on timelines. At this point almost two decades have passed since the discovery of the first approach to reprogramming adult cells into induced pluripotent stem cells, but relatively little progress has been made on bringing therapies into even initial clinical trials. Perhaps the biggest challenge is that working with cells is very expensive and very challenging, far more so than development of small molecule drugs. Higher costs means fewer programs, slower progress. Aging-related diseases often involve the dysfunction or loss of specific cell types, leading to […]

One of the less frequently discussed aspects of aging, perhaps because it is seen as a less critical function, is the progressive loss of the sense of smell. When arising from the underlying cell and tissue damage of aging, this can be considered a form of neurodegeneration. Strategies in the development of regenerative medicine that are aimed at regrowth of neurons and axonal connections between neurons are applicable to this form of age-related dysfunction, and here find a review of some of this ongoing work. Olfactory loss impacts more than 12% of the population and increases with aging. Multiple conditions can cause loss of smell (hyposmia or anosmia), including post-viral damage from COVID-19 or influenza, head injuries, sinusitis, or neurodegenerative conditions such as Alzheimer's or […]

In this interview, Sir Prof. Cato T. Laurencin, the 2025 Coulter Lecturer, discusses how he is addressing today’s medical challenges using the technology of the future.

Researchers convert red marker ink into graphene circuits using laser-induced graphene, paving the way for innovative, cost-effective electronic applications.

Researchers are growing the food of the future in this laboratory: meat that uses kelp as an alternative to animal-based ingredients.

Scientists in the U.K. have developed a new material that may allow them to grow teeth in the lab, which could provide an alternative to fillings and dental implants someday.

Scientists at the National Cancer Institute and partnering institutions have discovered that Schmidtea polychroa, a flatworm capable of regenerating lost tissue, develops this ability progressively during early life stages. Whole-body regeneration emerges during specific embryonic and juvenile stages, with head regeneration limited until the organism gains the capacity to reset its body's main axis. Stem-like cells are necessary for tissue growth yet insufficient on their own to trigger full regeneration.

Biodesix, Inc, a leading diagnostics solutions company, and Bio-Rad Laboratories, a global leader in life science research and diagnostics products, contributed to new research findings from Friends of Cancer Research's (Friends') ctMoniTR Project, recently published in Clinical Cancer Research (CCR). The findings demonstrate a strong association between changes in levels of circulating tumor DNA (ctDNA) and treatment outcomes, offering the potential for integration of ctDNA analysis in therapeutic development programs, and clinical cancer care.

The pedunculate oaks typical of Leipzig's floodplain forest and other German oak forests are struggling to regenerate in the understorey due to a lack of light. One reason for this is the absence of flooding in floodplain forests. In a two-year oak experiment in Leipzig's floodplain forest, researchers found that the current tree dieback -- caused by drought and pest outbreaks -- combined with the thinning of certain understorey species, can actually support oak regeneration.

The pedunculate oaks typical of Leipzig's floodplain forest and other German oak forests are struggling to regenerate in the understory due to a lack of light. One reason for this is the absence of flooding in floodplain forests.

Scientists have used an artificial circulatory system to create lab-grown chicken, which may improve its texture

Queensland is widely known as the land clearing capital of Australia. But what's not so well known is many of the cleared trees can grow back naturally.

We’ve now figured out how to culture chocolate in the lab. The breakthrough could help with spiralling cocoa costs, and may even lead to tastier treats with more nutritional value

Scientists from King's College London manage to grow a human tooth under laboratory conditions.

Research can be interesting even if the future development of therapies based on that research seems challenging. Today's open access paper is chiefly interesting for its outline of the developmental and ongoing relationship between skin and the brain, and the signaling that passes between the two. It is intriguing that this relationship means that one can harvest extracellular vesicles generated by cells in the brain and use them to change skin cell behavior in order to produce scar free regeneration from injury. However, to make this into a therapy would require either (a) a much greater understanding of the specific signaling mechanisms involved, in order to replace the vesicles with some other way to manipulate those mechanisms, or (b) the ability to maintain human organoid […]

Bone regeneration continues to be a critical challenge in tissue engineering, with unpredictable outcomes often hindering clinical application. Current strategies overlook key factors such as donor differences and biological sex, both of which play a significant role in fracture healing.

Research in a mouse model of Huntington’s disease showed that the adult brain can be stimulated to generate new neurons that integrate into key motor circuits, pointing to a potential regenerative strategy. The post Huntington’s Disease Progression May Be Slowed by Regenerative Strategy appeared first on GEN - Genetic Engineering and Biotechnology News.

As you age you naturally lose neurons and muscle mass and experience a decline in fertility and wound healing ability. Previous research in animals has offered several potential techniques for turning back the biological clock in specific tissues, including exercise and calorie restriction. However, age reversal of blood cells or at whole organism level has so far been elusive.

Vision is one of the most crucial human senses, yet over 300 million people worldwide are at risk of vision loss due to various retinal diseases.

The same genes could hold the key to regenerating cells in the ear and eye, according to a new mouse study from the USC Stem Cell laboratory of Ksenia Gnedeva, PhD, published in the Proceedings of the National Academy of Sciences (PNAS).

Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer.

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, regeneration, which allows it to replace liver cells damaged by the very toxins that these cells eliminate.

For millions of people, losing muscle isn't just about weakness; it's about losing independence. Whether caused by Duchenne muscular dystrophy, aging or other degenerative conditions, muscle loss can make everyday activities – like walking, climbing stairs or even standing up – a daily struggle

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation—the process by which stem cells give rise to specialized cells that make up all the body's tissues.

The Field Museum in Chicago and the Foundation for Scientific Advancement reported that sediment-encased maturation of pine resin produces a hardened, translucent substance that closely mimics natural copal and amber in appearance, texture, and chemical signature.

Researchers have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. A professor of pediatrics-developmental biology and an assistant professor of molecular, cellular, and developmental biology have shown the importance of the H3K36 methylation process in regulating plasticity and regeneration in intestinal cells.

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

Researchers have shed new light on how tissues in the body are repaired following the damage and premature death of tissue cells.

Researchers at MIT created synthetic muscle tissue that flexes in multiple directions, advancing the development of biohybrid robots for diverse applications.

London was the place where the world's first lab-grown burger was eaten in 2013.

Mississippi became the third state to ban cell-derived meat, a product not for sale in the United States. But not all livestock producers are opposed to cultivated protein.

Inside the human eye, the retina is made up of several types of cells, including the light-sensing photoreceptors that initiate the cascade of events that lead to vision.