Regeneration

A University of Missouri researcher is pioneering an innovative solution to remove tiny bits of plastic pollution from our water. Mizzou's Susie Dai recently applied a revolutionary strain of algae toward capturing and removing harmful microplastics from polluted water. Driven by a mission to improve the world for both wildlife and humans, Dai also aims to repurpose the collected microplastics into safe, bioplastic products such as composite plastic films.

Relative to skin elsewhere on the body, facial skin is less prone to scarring following regeneration from injury. Researchers have identified how this difference is regulated, and here demonstrate that they can influence the relevant mechanisms in order to reduce scarring during regeneration of skin injuries elsewhere on the body. It is also possible that further investigation of this biochemistry may yield approaches to reduce scarring more generally. This is of interest in the context of aging, as tissue maintenance becomes dysfunctional in many organs in ways that lead to excessive formation of disruptive small-scale scar-like structures. Surgeons have known for decades that facial wounds heal with less scarring than injuries on other parts of the body. This phenomenon makes evolutionary sense: Rapid healing of […]

Researchers have developed a way to grow a highly specialized subset of brain nerve cells that are involved in motor neuron disease and damaged in spinal injuries.

Shark Tank star Kevin O'Leary recently shared how he undergoes an exotic procedure for rapid cell generation, tissue healing, and a stronger immune system.

Skeletal muscle stem cells in hibernating Syrian hamsters preserve their ability to function by suppressing their activation during the hibernation period, a research team led by Hiroshima University has shown. This insight may lead to a broader understanding of the maintenance of muscle tissue under prolonged low-temperature conditions and may eventually lead to therapeutic applications.

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have found that a key protein can help to regenerate neural stem cells, which may improve aging-associated decline in neuronal production of an aging brain.

The thymus is a small inner organ near the heart that is responsible for the maturation of T cells of the adaptive immune system. The supply of new T cells is critical to the maintenance of effective immune function over time. Unfortunately the thymus atrophies over the course of adult life, and in most people is largely made up of inactive fat tissue by as early as 50 years of age. The resulting diminished supply of replacement cells ensures that the T cell population thereafter becomes ever more made up of malfunctioning, exhausted, and senescent cells incapable of mounting an effective response. Given the pressing need for ways to restore lost immune function in older individuals, it is good to see that a fair number […]

As we age, we don't recover from injury or illness like we did when we were young. But new research from UCSF has found gene regulators—proteins that turn genes on and off—that could restore the aging body's ability to self-repair.

In Finland, farmers who have transitioned to regenerative agriculture are forming a regenerative professional partnership with nature in their decision-making, a new study from the University of Eastern Finland shows.

Yeast left over from brewing beer can be transformed into edible 'scaffolds' for cultivated meat – sometimes known as lab-grown meat – which could offer a more sustainable, cost-effective alternative to current methods, according to a new study from UCL (University College London) researchers.

Intestinal Stem Cells (ISCs) derived from a patient's own cells have garnered significant attention as a new alternative for treating intractable intestinal diseases due to their low risk of rejection.

Plants have an extraordinary ability to sense tissue damage and quickly rebuild their protective outer layers, a process vital for survival amid environmental stresses. The periderm—a specialized protective tissue found in many woody plants—serves as a crucial barrier against water loss, pathogens, and mechanical injury. However, understanding how gaseous molecules enable plants to rapidly detect surface disruptions has long remained elusive.

Like a phoenix rising from the ashes, our skin tissue—and in fact many types of epithelial tissue that lines and covers the body's organs—can respond to death and destruction with a burst of regeneration. This phenomenon, known as compensatory proliferation, was first described in the 1970s in fly larvae, which regrew fully functional wings after their epithelial tissue had been severely damaged by high-dose radiation. Since then, this surprising ability has been documented in many species, including humans, yet its molecular basis has remained unclear.

Scientists cultivating partnerships of fungi and algae believe their invention has far-out implications for how we create the buildings of the future

3D-printed meat in Brazil advances with CELLMEAT 3D project using biopsied cells for lab-grown protein, no slaughter needed

Researchers created pea-sized brain structures from stem cells to study neural firing patterns, correctly identifying bipolar disorder and schizophrenia.

The dental pulp is susceptible to microbial infection, which often results in inflammation, necrosis, and defects in the pulp-dentin complex. Traditional treatment strategies suffer from multiple limitations and do not promote neural regeneration.

The axolotl, a type of salamander that stays in the tadpole form throughout its life, is a master of regeneration. Axolotls have been observed to regrow several body parts, including limbs, eyes, and even parts of their brains.

As we age, the muscles we rely on for daily activities tend to become less reliable. With enough decline, even normal movements such as getting out of bed become risky.

Sizable regeneration of damaged or lost cartilage remains impossible in practice, but also a highly desirable goal given the prevalence of osteoarthritis. The best that has been achieved to date in clinical practice results from one specific implementation of stem cell therapy, Cartistem. Other stem cell therapies haven't done as well in this context. You may recall that inhibition of 15-PGDH was shown to improve muscle function in old mice. That work has since moved on to initial clinical trials of a small molecule drug, developed by Epirium Bio. Here, researchers show that the same approach can produce some degree of cartilage regrowth, also in old mice. Blocking the function of 15-PGDH with a small molecule results in an increase in old animals' muscle mass […]

Microdroplet arrays store and conceal digital data through droplet composition, enabling reversible encoding, multi-layer QR patterns, error correction, and time-controlled messages using living cells.

Nerve damage is one of the most common and burdensome complications of diabetes. Millions of patients worldwide suffer from pain, numbness, and restricted movement, largely because damaged nerve fibres do not regenerate sufficiently.

Type 1 diabetes (T1D) is an autoimmune disorder characterized by the specific destruction of insulin-producing pancreatic β-cells.

With aging, the intestine gradually loses its ability to regenerate after damage. An international research team involving the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena and the University of Turin has now found that polyamines, small molecules produced naturally in the body, can play a decisive role in this process.

Former Campbell's employee leaks explosive recording and sues two company officers for wrongful termination.

In industrial pipes, mineral deposits build up the way limescale collects inside a kettle ⎯ only on a far larger and more expensive scale. Mineral scaling is a major issue in water and energy systems, where it slows flow, strains equipment and drives up costs.

Researchers at Wageningen University & Research (WUR), working in close collaboration with KeyGene, have developed a method that enables plant cells to regenerate into complete plants without the need for added hormones.

4D printed hydrogel expanders use controlled buckling and low pressure to generate new soft tissue while preserving viability and activating early remodeling pathways for personalized reconstruction.

Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology

Studying tail regeneration in tadpoles, researchers discovered that putative muscle stem cells produce a secreted protein, c1qtnf3, which shifts macrophages from immune to regenerative functions. The post Stem Cell Signal Redirects Macrophages to Promote Regeneration of Tadpole Tails appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers Sumika Kato, Takeo Kubo, and Taro Fukazawa of the University of Tokyo have discovered that c1qtnf3, a secreting factor, namely a protein molecule that is secreted by a cell and influences functions of other cells, is expressed in putative muscle stem cells and shifts macrophages from immune to regenerative functions in the regenerating tails of tadpoles.

Thin sheets of engineered artificial tissue can be readily manufactured because they do not require a vasculature, perfusion of fluids is sufficient to support the cells. For some years now, researchers have developed the capability to manufacture thin heart tissue patches. A number of preclinical studies in various animal models have demonstrated that applying these patches to an injured heart promotes greater regeneration and restoration of function than normally takes place. Here, the technique is combined with a minimally invasive form of surgery as a proof of concept, and used in rats following heart attack to promote greater regeneration. For years, scientists have been working on ways to replace damaged tissue with healthy heart cells derived from stem cells. Early efforts showed promise, but most […]

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A new research paper was published in Oncotarget (Volume 16) on November 6, 2025, titled "LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas."

A new study shows, for the first time, that cow cells can naturally become immortal—continuing to divide indefinitely without genetic modification or any abnormal transformation. This overturns long-held assumptions that bovine cells could only be immortalized through gene editing, providing a safe, stable, and scalable source of cells for cultivated beef production.

A research team in South Korea has successfully developed a novel technology that combines nanoparticles with stem cells to significantly improve 3D bone tissue regeneration. This advancement marks a step forward in the treatment of bone fractures and injuries, as well as in next-generation regenerative medicine.

Southwest Research Institute (SwRI) has demonstrated a new application for its cell-expansion bioreactor to advance tissue engineering and cell-based therapies for treatment of injuries and diseases.

A research team in South Korea has successfully developed a novel technology that combines nanoparticles with stem cells to significantly improve 3D bone tissue regeneration.

Researchers created a nanoparticle-stem cell technology that greatly enhances 3D bone regeneration, advancing treatment for fractures and regenerative medicine.

Researchers here demonstrate a novel way of delivering stem cells as a therapy for bone fractures that occur in the context of osteoporosis, by forming spheroids of stem cells combined with a bone mineral scaffolding material. The approach appears to encourage the survival of a larger fraction of transplanted cells, producing a greater regeneration of bone tissue. More usually near all of the transplanted cells die shortly after a transplantation procedure, and whatever benefits are obtained are derived from the signaling generated by the stem cells prior to that point. Osteoporotic vertebral fractures substantially contribute to disability and often require surgical intervention. However, some challenges, such as implant failure and suboptimal bone regeneration, limit current treatments. Adipose-derived stem cells are promising for regenerative therapy because […]

What if scientists could build a realistic model of the human lung, not full-sized, but grown in the

Researchers here find a potential way to induce greater regeneration in injured heart muscle, normally a tissue that regenerates only poorly following damage, and particularly so in older individuals. Inducing CCNA2 expression appears to promote replication of the cardiomyocyte cells making up heart muscle. Still, a great deal of work remains in order to build a viable gene therapy based on this finding and assess it in a clinical trial. The direct delivery of a gene therapy to heart muscle is perhaps more viable than is the case for other internal organs given the range of established minimally invasive surgical procedures developed for use in the cardiovascular field. One can envisage a therapy that is delivered alongside the procedures normally carried out for patients following […]

Plant biologists have developed a method for growing transgenic and gene-edited plants that cuts the slow and expensive process down from months to weeks.

Exoplanet scientists are eagerly awaiting the discovery of an atmosphere around a terrestrial exoplanet. Not a thin, tenuous, barely perceptible collection of molecules, but a thick, robust, potentially life-supporting atmosphere. Due to the way we detect exoplanets, most of the terrestrial planets we find are orbiting red dwarfs (M dwarfs).

Rocky exoplanets orbiting red dwarfs are in a tough spot. Their stars are known for violent flaring that can destroy their atmospheres. But it's possible that asteroid impacts could later recreate their atmospheres.

A team of researchers from the National Institutes for Quantum Science and Technology (QST) and Tokyo Metropolitan University has developed a biomaterial that could change how we treat muscle degeneration and metabolic disorders.

As chronic liver disease becomes more widespread, researchers at Science Tokyo have developed a lab-grown organoid that replicates a regenerating liver, offering new hope for future treatments.

Human health is the Achilles heel of space travel. Researchers at ETH Zurich have now succeeded in printing complex muscle tissue in zero gravity. This will enable drugs for space missions to be tested in the future.

After vocal cord surgery, many patients develop stiff vocal folds that impact their ability to speak. Hydrogels can help prevent this by promoting healing, but delivering hydrogels to the vocal cords is difficult.

Biologists have long been fascinated by the ability of salamanders to regrow entire limbs. Now Harvard researchers have solved part of the mystery of how they accomplish this feat—by activating stem cells throughout the body, not just at the injury site.

Researchers here report on potential targets to enhance the regenerative capacity of alveolar type 2 cells, a population necessary for regeneration in lung tissue, but which falters in this duty in the context of progressive and age-related lung disease. Compensating for poorly understood mechanisms of damage and disease that direct alveolar type 2 cells away from regenerative activity can in principle be achieved by overriding the regulatory system that controls this aspect of cell behavior, provided enough is understood of how that regulatory system works. This approach to therapy doesn't fix the underlying issues, but may well prove to be beneficial enough to pursue. There are numerous examples in the present practice of medicine of compensatory approaches that succeed in producing benefits for patients. When […]

Solving telomerase gene mystery in has evolutionary significance and could lead to a better understanding of how telomerase is regulated in healthy cells, with implications for aging, fertility, and regenerative medicine research. The post Hitchhiking DNA in C. elegans Solves Telomerase Puzzle, with Regenerative Promise appeared first on GEN - Genetic Engineering and Biotechnology News.

When farmland is abandoned and allowed to return to nature, forests and grasslands naturally regrow and absorb carbon dioxide from the atmosphere—helping fight climate change.

Soft tissue injuries of the gastrointestinal tract, like ulcers or hemorrhages, can currently be treated only with some form of surgery, which is invasive and may not result in permanent repair.

The results of a study in flatworms challenging the textbook concept that stem cells reside in a defined niche may help explain the planarian’s regenerative capacity, and potentially offer clues for developing approaches to human tissue repair or replacement. The post Flatworm Stem Cells Offer Insights into Regenerative Biology appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers from New York’s Rensselaer Polytechnic Institute have developed a cellulose membrane for purifying mRNA therapies, which has improved performance over commercial chromatography. They believe it will reduce the cost of manufacturing these therapies. The post Regenerated Cellulose Membrane Shown to Outperform Chromatography Columns in Purifying mRNA Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.

The brain's mechanisms for repairing injuries caused by trauma or degenerative diseases are not yet known in detail.

University of Cambridge scientists have used human stem cells to create three-dimensional embryo-like structures that replicate certain aspects of very early human development - including the production of blood stem cells.

University of Cambridge scientists have used human stem cells to create three-dimensional embryo-like structures that replicate certain aspects of very early human development—including the production of blood stem cells. The findings are published in the journal Cell Reports.

Researchers in the University of Minnesota College of Science and Engineering have successfully 3D printed realistic human tissue

In the upper Abbay basin, cradle of the Blue Nile, a team of researchers have predicted soils of the future: what will happen to soil organic carbon if we bet on regenerative agriculture—returning residues, organic manure, cover crops, agroforestry?

The body's tissues can get injured in many ways, but while some injuries heal perfectly, others don't heal at all. A cut in the skin, for example, usually heals all on its own, while internal organs, such as the heart after a heart attack or the kidney after an acute injury, remain damaged, leading to diminished function.

Taste is one of our most vital senses, shaping appetite, nutrition, and quality of life. Yet taste buds are fragile, relying heavily on the nerves that connect them to the brain.

Hundreds of readers responded to our poll asking if it would be OK to experiment on lab-grown "brains" if they became conscious.

Artificial tissues that mimic the placenta, endometrium, ovary and vagina could point to treatments for common conditions such as preeclampsia and endometriosis

Why does the peripheral nervous system regenerate while the central nervous system does not? Both are composed of clusters of neurons linked by axons that can extend for as much as a few feet in the longest cases. Nerves are bundled axons. One of the approaches taken by researchers interested in applying regenerative medicine strategies to the central nervous system is to look for biochemical differences between peripheral nervous system neurons and axons versus central nervous system neurons and axons. There must exist specific differences that enable regeneration of peripheral nervous system axons or suppress regeneration of central nervous system axons. That doesn't mean those differences are easy to find, of course. Biology is exceptionally complex and present omics approaches are not well suited to […]

Researchers, reporting in ACS Nano, developed a 3D-printable bioactive glass that functions effectively as a bone replacement material.

Elastin is a vital component of flexible tissues, and poorly maintained in the adult body. Deterioration of elastin is an important component of the age-related structural alterations that take place in tissues such as skin and blood vessels. Elastin is also hard to obtain or manufacture for use in engineered tissues, which is the primary roadblock motivating the research noted here. While this is useful, a robust source of elastin (or as here, elastin-like proteins that suitably mimic the behavior of elastin) would probably do relatively little to enable therapies to restore elastin structures in aged tissues, as those elastin structures are complex and the configuration of elastin molecules relative to other components of the extracellular matrix matters. It is likely that some form of […]

A German-Austrian team led by Friedrich Schiller University Jena and Leibniz-HKI has been able to biochemically demonstrate for the first time that different types of mushrooms produce the same mind-altering active substance, psilocybin, in different ways.

Pea-sized brains grown in a lab have for the first time revealed the unique way neurons might misfire due to schizophrenia and bipolar disorder, psychiatric ailments that affect millions of people worldwide but are difficult to diagnose because of the lack of understanding of their molecular basis.

A perspective paper published this week argued that brain organoids could soon gain consciousness, and we should consider stricter regulations around them.

The innate immune cells known as macrophages adopt different packages of behaviors (known as polarizations) depending on circumstances. Most research is focused on the difference between the pro-inflammatory M1 polarization and the anti-inflammatory M2 polarization. M2 is considered to be more regenerative, and many issues in aging are thought to involve the presence of too many M1 macrophages. Yet M1 macrophages do play a role in regeneration, as noted here, and this contribution is also disrupted with age to inhibit the ability to regrow muscle in older individuals. This is one of the aspects of macrophage behavior that illustrates the limitations of the simple M1/M2 model; the underlying reality is more of a spectrum of behaviors, and one M1-like macrophage is not necessarily undertaking the […]

A joint research team from POSTECH and Inha University researchers has successfully developed a novel biomaterial that overcomes the limitations of natural elastin.

Last week, a legal battle over lab-grown meat kicked off in Texas. On September 1, a two-year ban on the technology went into effect across the state; the following day, two companies filed a lawsuit against state officials. The two companies, Wildtype Foods and Upside Foods, are part of a growing industry that aims to…

Why do some applications of electric fields appear to enhance regeneration from injury? The study of the effects of electromagnetism on cell behavior lags far behind the study of biochemistry, the effects of proteins and small molecules. Here, researchers provide evidence for electrical stimulation to be able to shift macrophage cells into a more pro-regenerative state. Macrophages are innate immune cells resident in tissue that conduct a wide range of tasks relating to defense against pathogens, destruction of harmful cells, and coordination of tissue maintenance. Macrophages adopt packages of behaviors dependent on circumstances; the most prominent model for describing those behaviors is the distinction between M1 macrophages (aggressive, inflammatory) and M2 macrophages (regenerative, anti-inflammatory). A fair amount of research effort has been directed towards ways […]

Organ donors can save lives, for example, those of patients with kidney failure. Unfortunately, there are too few donors, and the waiting lists are long. 3D bioprinting of (parts of) organs may offer a solution to this shortage in the future. But printing living tissues, bioprinting, is extremely complex and challenging.

Women of reproductive age seem to be less susceptible to CKD than men, but the molecular mechanisms were not well understood. Paola Romagnani, MD, PhD, speaks with about the estrogen-driven protective effect against CDK. The post Estrogen Signaling Impacts Kidney Cell Regeneration with Links to Preeclampsia appeared first on GEN - Genetic Engineering and Biotechnology News.

A new study in mice provides insights into why females in their reproductive years appear to be relatively protected from chronic kidney disease, a leading public health concern.

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes.

Researchers in McGill's Department of Mechanical Engineering have discovered a safe and low-cost method of engineering living materials such as tissues, organs and blood clots. By simply vibrating these materials as they form, scientists can dramatically influence how strong or weak they become.

For the first time, a research team at the University of Minnesota Twin Cities demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery.

A new critical review, published in the journal CABI Agriculture and Bioscience, highlights the emergence and scientific basis of regenerative agriculture—proposing a working definition centered on ecological cycles and farm system outcomes.

Scientists developed a 3D printing method that creates hydrogels with tissue-like properties, paving the way for personalized implants and adaptive soft robotics.

New research from the Charles Perkins Centre at the University of Sydney has uncovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing dangerous blood clots, potentially paving the way for future treatments that reduce their cardiovascular risk.

More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-quality fertility care for those in need but, importantly, also for new biomedical solutions that can address the root causes of infertility.

A new nanotube-based RNA delivery system boosts plant regeneration by switching off a molecule that blocks shoot growth, without changing the plant's DNA.

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated.

In the near term, the field of tissue engineering aims to produce artificial tissue structures that can support cells and integrate with native tissue when implanted into an injury, promoting regeneration that would not otherwise have taken place. In the longer term, the goal is to produce entirely artificial, fully functional organs - but first things first. Producing large sections of pseudo-tissue that can reliably promote regeneration is still a work in progress, with many projects at varying stages of development. As this paper makes clear, the fine details involved in sufficiently replicating tissue structural properties can be a challenge. Myocardial Infarction (MI) occurs when blood flow to the heart is restricted, causing cardiomyocyte death, scar tissue formation, and myocardial remodeling. These changes reduce the […]

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation that could lead to better regenerative therapies.

A research team from Shanghai Jiao Tong University has resulted in a significant advancement in the field of orthopedic implant materials.

The eye of the apple snail is unusually similar to a human eye-but, unlike human eyes, it can regrow itself if injured or even amputated.

It is well known that the formation of fat deposits within muscle tissue is a feature of aging, and is also associated with a variety of muscle disorders. Here, researchers explore how exactly this infiltration of fat into muscle harms muscle function, with a focus on regenerative capacity. At present physical activity is the most reliable approach to prevent or reduce fat infiltration of muscle tissue, but it seems likely that at least some of the growing number of weight loss drugs in development, many of which improve upon GLP-1 receptor agonists by neither reducing calorie intake nor causing loss of muscle mass, will also be effective. Adipose tissue acts as an energy storage as well as an endocrine organ. However, different fat depots, such […]

Stem cell research, alongside the rapidly advancing field of biotechnology, has led to remarkable innovations in regenerative medicine.