Regeneration

A comprehensive new review highlights the expanding importance of Lgr6, a member of the G protein-coupled receptor family, as a critical regulator of tissue homeostasis, injury repair, and disease development across multiple organ systems.

3D bioprinting allows scientists to build custom tissue structures for medicine, but printing soft tissues like the human brain remains a major challenge. The strong pushing forces required to squeeze biological materials through tiny printer nozzles often crush and damage sensitive cells, leading to low survival rates and weak printed structures.

In southeastern Madagascar, patches of forest that were once cut down to make way for farms are slowly regenerating naturally after being left to lie fallow. But recovering a native forest needs more than just gaining tree cover. The animals that once lived in these forests also need to make their way back so that the forest can function the way it used to.

A protein best known for protecting the ends of chromosomes also helps muscle stem cells preserve their identity and repair damaged tissue, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

A new study reveals that lignin - a natural plant polymer - can be transformed into a bioactive material that promotes the formation of bone-like minerals while supporting the growth of bone-forming cells.

A new collaborative research project between Murdoch University and Walailak University (WU) aims to restore seagrass meadows in Thailand using 3D-printed pods made from bioplastics.

Miniature brain models grown from patients’ cells revealed striking differences in how Alzheimer’s-related tissue responds to an antidepressant. The organoids and the particles they release could eventually guide more personalized treatments and provide new clues for diagnosing the disease.

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Microglia are innate immune cells of the brain, analogous to macrophages elsewhere in the body. Both cell types are deeply involved in the intricate processes of tissue maintenance and regeneration. The central nervous system has only limited regenerative capacity, but it can regain some lost function following injury, such as that caused by a stroke. Researchers here find a way to improve the regenerative activities of microglia, and demonstrate that this intervention can improve outcomes following stroke in animal models. After a stroke, the brain launches a coordinated repair program that involves several types of cells. Among these, microglia, the brain's resident immune cells, play a pivotal role. Immediately after an injury, microglia are activated to trigger inflammation, but thereafter, they rapidly transition into a […]

For decades, medicine has chased a simple but elusive goal of delivering the right drug to the right place at the right time.

Lab-grown meat, gene editing and extreme fire: researchers' predictions for life in the 2100s

After a typhoon surprised a research cruise, scientists took advantage of the unique sampling opportunity to reveal rapid changes in bacterioplankton communities and biogeochemical cycling.

IMDEA Materials Institute has developed mechanically tunable hydrogel membranes that closely mimic the mechanical environment of human skin while remaining highly biocompatible, representing an improved platform for skin tissue engineering and regenerative medicine.

A healthy bone marrow (BM) produces nearly all types of cells in our blood. Many blood disorders occur when hematopoietic stem cells (HSCs) in the BM malfunction.

Tooth enamel is the hardest substance in the human body, yet once damaged, it cannot regenerate naturally.

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Primary bone tumors, such as osteosarcoma, have seen stagnant survival rates over the past four decades. Surgical removal of the tumor is critical, but local recurrence may occur when tumours are close to vital structures, often resulting in amputation

Researchers at National Institute of Advanced Industrial Science and Technology (AIST), in collaboration with researchers from The University of Electro-Communications (UEC) and Akita Prefectural University, have discovered a new insect pathogen that invades the gut symbiotic organ of stink bugs by mimicking their symbiotic microorganism, ultimately killing the host bugs.

A study by a team of researchers from the Gray Faculty of Medical and Health Sciences at Tel Aviv University offers new hope to millions of people with irreversible hearing loss. The researchers identified a unique biological mechanism that could, in the future, enable the regeneration of sensory hair cells in the inner ear—a process previously thought impossible in humans.

Therapies that increase muscle tissue regeneration following injury, and possibly also normal maintenance and growth of muscle tissue, are of great interest at present. The widespread use of GLP-1 receptor agonists to induce calorie restriction causes loss of muscle mass as well as fat mass, and so there is a strong financial incentive for the research and development of means to force the body to build more muscle. There was already a strong financial incentive in the sense that everyone loses muscle with age, and frailty is a prevalent and harmful state of poor health, but for some reason that was never as motivating to the development community. Nonetheless, recent years have seen a number of interesting new discoveries in the regulation of muscle regeneration […]

Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine researchers have found.

Regenerative agriculture can deliver both economic and environmental benefits for European farmers, Wageningen University & Research (WUR) concludes in the research project Regenomics. Whether these benefits are actually present depends strongly on regional conditions, such as the availability of water and livestock manure. As a result, the transition to regenerative agriculture requires tailored, farm-specific approaches.

Taking a supplement before a hepatectomy, a surgery in which part of the liver is removed, may help the organ recover more quickly and become more resistant to further damage.

SCI often causes long-term motor and sensory deficits because the damaged tissue does not simply heal like many peripheral tissues.

Researchers here report on a novel a way to improve kidney regeneration following injury, using a technique that was developed as a treatment for an injured heart. It is interesting to consider whether it might work on other tissues as well. Perhaps more relevant is the question of whether the therapy would improve ongoing tissue maintenance in an aged organ in the absence of injury; that rather depends on the fine details of the biochemistry, and could go either way. A drug developed to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found. The drug, called AD-NP1, which was recently approved by the FDA for a Phase 1 clinical trial in humans, works in […]

Thrombospondin-1 is a component of the senescence-associated secretory phenotype (SASP) produced by senescent cells. It has been shown in the past to induce blood-brain barrier dysfunction, but here researchers show that it also degrades mitochondrial function in macrophages, biasing those cells into the inflammatory M1 state. This in turn contributes to chronic inflammation and dysfunctional bone regeneration. The accumulation of senescent cells with age is known to be an important aspect of degenerative aging, and the SASP is known to change bystander cell behavior for the worse. There are likely countless mechanisms of this nature taking place in the aging body, all of which could be suppressed via reduction of the burden of senescent cells. The aging bone marrow microenvironment is characterized by chronic low-grade […]

Scientists have taken a surprising step toward unlocking regeneration in mammals, showing that the ability to rebuild complex body parts may not be lost after all—it may simply be switched off. Using a two-stage treatment, researchers redirected the body’s normal healing response away from scar formation and toward regrowth, successfully restoring bone, joints, ligaments, and tendons after amputation in animal studies.

A drug previously developed at UCLA to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found.

Mayo Clinic researchers have identified a previously unrecognized way the kidneys regulate water balance - an advance that could lead to improved treatments for polycystic kidney disease (PKD) and other disorders. The study, led by Fouad Chebib, M.D., a nephrologist at Mayo Clinic, is published in the Journal of Clinical Investigation.

Variants in the DHDDS gene cause a severe neurodegenerative condition, characterized by tremors, seizures, coordination and learning difficulties, usually manifesting in early childhood. This Parkinson's-like condition is extremely rare, and until recently, parents were told that there was nothing that could be done to slow down its progression.

Before testing new therapies in animals, researchers now have a more efficient starting point—lab-grown canine muscle cells that can help identify what works and what doesn't.

Cambridge scientists have grown miniature circuits in the lab that mimic how the brain and spinal cord connect

Exosomes emerge as a potential alternative to stem cells in regenerative medicine, and early studies suggest roles in skin rejuvenation, alopecia, and wound healing.

A new study from the Tufts University Center for Cellular Agriculture (TUCCA), recently published in Food Quality & Preference, explores how terminology influences consumer perceptions of cultivated meat products in the United States and Germany.

Researchers have made a new biomaterial that has a similar tensile strength as a fruit roll-up and could help reduce waste produced from indoor decor.

A team of Israeli scientists at the Hebrew University of Jerusalem has developed a novel method to significantly lower the production costs of cultivated meat. The new study demonstrates that preloading plant-derived cellulose scaffolds with growth factors supports the cost-efficient proliferation and differentiation of bovine stem cells. By binding these vital proteins directly to an anisotropic, directionally frozen framework instead of dispersing them in liquid media, this method achieves high-quality tissue development using up to 10 times fewer expensive factors. Upon multi-week cultivation and subsequent pan-frying, the cell-bound constructs show partially similar mechanical and visual responses to traditional sirloin cuts.

People who vape regularly show altered activity in 3,124 genes across the genome compared with people who do not smoke or vape.

An early 1900s rail and tram depot abandoned for almost 20 years in Rome will become a mixed-use private development designed by Stefano Boeri Architetti. The 16,000-sq-m Depositi delle Vittorie… The post Abandoned depot in Rome to become “virtuous example of urban regeneration” appeared first on Global Construction Review.

Natural diamond prices have plummeted due to the rise of lab-grown alternatives, which now dominate the engagement ring market, offering cost-effective and customisable options for couples

Cambridge scientists have grown miniature circuits in the lab that mimic how the brain and spinal cord connect up, which underlies our movements. They used this model to show how damage to these connections previously considered 'irreversible' could, in fact, be reversible.

Men who do not produce sperm can’t be helped by existing fertility treatments, but a start-up is now claiming it can grow their sperm in the lab. Columnist Michael Le Page suspects this technique will have to be combined with gene editing if it is to help many men

A new review shines a spotlight on efferocytosis, a critical biological process responsible for the removal of dead cells, as a central force in promoting efficient wound repair and maintaining tissue balance.

It is known that the antiepileptic drug valproate increases the risk of developmental disorders in unborn children.

The new system, termed KGN@PB@CM, combines several advanced elements. Prussian blue (PB) nanozymes act as potent reactive oxygen species (ROS) scavengers, while kartogenin (KGN)-a small molecule that promotes stem cell migration and tenogenic differentiation-is loaded onto the PB core.

A new research paper was published in Volume 18 of Aging-US on May 5, 2026, titled "Methylene blue protects hair follicle stem cells from oxidative and metabolic stress to enhance hair regeneration."

The baby chicks were shifting and starting to pip—or trying to hatch. But not from an egg.  Instead, these chickens were growing inside transparent 3D-printed plastic cups at the Dallas headquarters of Colossal Biosciences. The biotech company today claimed it has developed a “fully artificial egg” as part of its effort to resurrect extinct avian…

As climate change intensifies, one of the key challenges facing forestry is how to balance efficient timber production with the preservation of forests' climate-regulating functions, biodiversity, and resilience. The growing public demand for recreation in forests, together with increasing opposition to clear-cutting, is also driving the search for more sustainable management approaches.

Researchers here report an surprising, interesting, but not immediately useful discovery relating to the interaction of the immune system with wound healing in aged skin. Regeneration in aged skin is impaired, and non-healing wounds are one consequence of this impairment. The researchers found that priming aged skin with a dose of lipopolysaccharide, a toxic bacterial product that the immune system reacts to, improves skin regeneration after later injury. In the real world injuries are hard to predict ahead of time, so a better understanding how the observed changes in immune cell behavior provoked by this intervention are regulated is required in order to develop a form of therapy that usefully recreates the effects. Tissue repair is often hampered during aging. Worldwide, chronic wounds in elderly […]

A team led by USC Stem Cell scientist Zhongwei Li, PhD, has produced some of the most complex and mature lab-grown kidney models to date.

An international research group recently demonstrated that the antibody NG101 promotes the regeneration of damaged spinal cord tissue.

A team led by researchers from Tokyo Metropolitan University, in collaboration with Tohoku University and Orbray Co., Ltd., using heteroepitaxial diamond materials developed by Orbray, have shown that lab-grown diamonds might realize a radiation dosimeter compatible with both medical diagnosis and radiation therapy.

A team led by researchers from Tokyo Metropolitan University, in collaboration with Tohoku University and Orbray Co., Ltd., using heteroepitaxial diamond materials developed by Orbray, have shown that lab-grown diamonds might realize a radiation dosimeter compatible with both medical diagnosis and radiation therapy.

A recent mouse model based study suggests that blocking TGF-β may improve osteoporosis treatment by helping quiescent osteoblasts in inactive bone surfaces return to an active state.

Scientists in Sweden have taken a major step toward a potential cure for type 1 diabetes by developing a more reliable way to create insulin-producing cells from human stem cells. These lab-grown cells not only respond strongly to glucose but were also able to restore blood sugar control when transplanted into diabetic mice.

Researchers at the University of Toronto's Institute of Biomedical Engineering have developed a new method to mature lab-grown heart cells, so they more closely resemble adult human heart tissue.

New research has shown that single blood vessel cells that appear in the earliest stages of lab-grown skin organoids have the ability to form complex microvascular networks that grow and mature over time.

Palmyra Atoll, a remote, uninhabited speck of land, coral and sea halfway between Hawaii and American Samoa, is one of the healthiest, intact atolls on the planet—so ecologically sensitive that visiting researchers freeze their clothes at night to kill invasive species.

A host of positive "tipping points" can spark rapid nature recovery, a leading expert says. Action to protect and restore nature must accelerate radically to meet global goals for 2030 and beyond. Writing in the journal Nature Sustainability, Professor Tim Lenton says positive tipping points are key to achieving this.

By studying and engineering heart tissue in the unique low-gravity environment of space, the laboratory of Arun Sharma, PhD, is uncovering new ways to protect and repair the failing heart.

Regenerative therapy is any treatment therapy that improves tissue health or function. With that definition, we can include platelet-rich plasma (PRP), stem cells, and autologous conditioned serum (ACS). The post Regenerative Medicine: Promise, Hype, and What Actually Works appeared first on GEN - Genetic Engineering and Biotechnology News.

Using engineered liver tissue as a proof-of-concept application, researchers integrated synthetic biology and tissue engineering tools to build liver tissues that can be expanded on-demand after implantation . The post Synthetic Biology and Tissue Engineering Grow Liver Tissue In‑Body appeared first on GEN - Genetic Engineering and Biotechnology News.

One of the major projects within the study of comparative biology is the attempt to understand why adult individuals of some species can fully regenerate lost tissues following injury, while mammals such as our own species cannot. A variety of modest inroads into identifying potentially important differences in cellular biochemistry and activity have been made, such as work focused on senescent cells and macrophages, but it remains an unsolved challenge. Researchers here present more data to add to that already under consideration, focused on the role of oxygen sensing in the initial response to injury. It is unclear as to whether it can lead to dramatic improvements in mammalian regeneration, but the work suggests that regeneration could be improved via manipulation of oxygen sensing in […]

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.

Researchers here describe a novel approach to encourage greater regeneration in heart tissue following the injury and lost function incurred during a heart attack. Their work falls into the growing category of practical gene therapies in which a small amount of easily accessible tissue, such as fat or muscle, is transfected to form a factory that generates and releases a beneficial circulating protein. Only a low dose of gene therapy vector is needed, and all of the present challenges in broader delivery of gene therapy are bypassed. The scope of possible uses is restricted to situations in which benefits can be derived from increased amounts of a specific protein in circulation, but this is still a large enough set of possibilities to support a broad […]

Some animals can regrow lost body parts. Salamanders and frog tadpoles can rebuild entire limbs after amputation. Mammals cannot. For decades, biologists have tried to understand why.

Oxygen and hyaluronic acid may play a role in tissue recovery and regeneration, two new studies suggest

Cartilage tissue exhibits a relatively poor capacity for regeneration even in youth, but this capacity for maintenance and repair diminishes with age. There are thus some gains to be made in understanding why this happens and developing means of rejuvenation, but ultimately some form of regenerative medicine above and beyond natural degrees of healing will be needed in order to completely address the very prevalent joint issues that occur in later life and culminate in disabling degrees of cartilage loss and osteoarthritis. While this is widely studied, cartilage has so far proven to be a difficult tissue for the tissue engineering community to reproduce and manipulate. The load-bearing capacity and resilience necessary for its function in the body requires an accurate recreation of the complex […]

Some animals can regrow lost body parts. Salamanders and frog tadpoles can rebuild entire limbs after amputation. Mammals cannot. For decades, biologists have tried to understand why. Now a team led by Can Aztekin at EPFL (now at the Friedrich Miescher Laboratory of the Max Planck Society) has discovered that oxygen plays a crucial role in limb regeneration. By comparing amputated limbs from frog tadpoles and embryonic mice, the researchers found that the way cells sense oxygen determines whether regeneration can even begin. The study is published in Science.

Sustainability has become something of a buzzword over the years. From the clothes we wear and the energy that powers our homes to the way we live our lives, the idea of sustainable production and consumption has become commonplace.

The capacity for neurons to regrow the axons that connect them is relatively limited. The tissue of large nerves, largely made up of axons, does not readily regenerate; the closer to the central nervous system one comes, the less the capacity for regrowth following injury. This is not the case for all species, and thus - in principle at least - there must be regulatory controls in cellular biochemistry that can be adjusted to encourage lesser degrees of obstructive scarring and greater regrowth of axons. Here, researchers report on one recently discovered way to enhance axon regrowth that works in both peripheral nerves and the spinal cord. Axon regeneration is limited in the mammalian central nervous system. Neurons must balance stress responses with regenerative demands […]

Cell cultures—single layers of cells grown in a small dish—have enabled researchers to study biological growth, develop or test drugs and even discover what causes some diseases. Cell spheroids, 3D versions of cell cultures built using a process known as cell aggregation, are the next step in advancing this work, capable of more closely modeling real tissue. A new technology, invented by researchers from Penn State and detailed in a paper published in Advanced Science, could breathe fresh air into bottom-up tissue fabrication and potentially large-scale tissue engineering by addressing these issues.

In a preclinical animal study, implantation of lab-grown esophageal grafts restored swallowing, offering hope for infants with long-gap esophageal atresia.

Inhibiting AhR, a xenobiotic sensor protein, lifts a molecular brake on axon regeneration and pushes injured neurons from stress management towards growth in nerve and spinal cord injury models, scientists say. The post Blocking AhR Sensor Activates Regenerative Program in Injured Neurons appeared first on GEN - Genetic Engineering and Biotechnology News.

Experiments conducted in Brazil using laboratory rats have shown that graphene-based structures can act as a powerful ally in bone regeneration. These structures are made of sheets of the chemical element carbon that are just one atom thick. They can help heal fractures or bone loss. In the tests, the biocompatible matrix containing graphene facilitated nearly 90% repair of the damage sustained by the test subjects one month after the fracture was induced in the laboratory—a superior performance to that of other materials used in the research.

In chemical processes for producing pharmaceuticals, catalysts are a core technology that determines production speed and cost. However, until now, there has been a trade-off between "precise but disposable catalysts" and "reusable catalysts." A KAIST research team has developed an eco-friendly catalytic technology that combines these two types, operating solely with light and air. This opens a pathway to producing pharmaceutical ingredients more cheaply and cleanly, with expected reductions in carbon emissions and environmental pollution. The study is published in the Journal of the American Chemical Society.

If responsibly developed and thoughtfully integrated into healthcare systems, regenerative therapies could help shift medicine toward a more proactive model, i.e., one focused on preserving health, maintaining function, and extending healthy lifespan. The post Leveraging the Full Potential of Regenerative Medicine Requires a Proactive Approach appeared first on GEN - Genetic Engineering and Biotechnology News.

A new method can regenerate skin without scars by unblocking a healing mechanism that shuts off after birth. Demonstrated on mice, the study suggests a potential means to develop similar therapies in human patients.  The post Skin Regeneration Enabled by Embryonic Healing Mechanism in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.

Scientists from Great Ormond Street Hospital (GOSH) and University College London (UCL) have created the first lab‑grown esophagus - the food pipe - shown to safely replace a full section of the organ and restore normal function, including swallowing, in a growing animal without the need for immunosuppression.

Could wounded skin someday regrow perfectly without scars?

UK scientists have grown fully functioning food pipes and successfully transplanted them into mini pigs, paving the way for human trials.

Animal studies often fail to predict human tissue responses to new drugs or newly developed therapies. Besides generating tremendous costs for clinical studies, it also raises significant ethical concerns. Therefore, novel approaches to mimicking natural human environments like vascular system growth control, are broadly developed to deliver a reproducible model to test novel drugs.

A new Tasmanian Institute of Agriculture (TIA) study has found that while regenerative agriculture practices can improve soil health and reduce emissions on sheep farms, farmers often face trade-offs between environmental and economic goals. The article, "Regenerative agriculture improves productivity and profitability while reducing greenhouse gas emissions on Australian sheep farms," has been published in Nature Food.

Species capable of exceptional regeneration also tend to have longer life spans and slowed aging relative to similar species with less proficient regenerative capabilities. Various closely related species of spiny mouse have been studied in the context of mammalian regeneration because of their ability to shed a large amount of skin and supporting tissues as a defensive mechanism, and later regrow that tissue without scarring. This exceptional regenerative capacity extends to at least some internal organs as well. Spiny mice have been used in past studies that pointed to differences in the activity of macrophage cells as one of the important determinants of complete regeneration versus scar formation. Macrophages are innate immune cells that are deeply involved in ongoing tissue maintenance and regeneration from injury. […]

Technologies that convert carbon dioxide (CO₂) emitted from factories and power plants into useful chemical feedstocks are considered key to achieving carbon neutrality. However, rapid degradation of catalyst performance has long hindered commercialization. KAIST researchers have now developed a "self-regenerating" catalyst that restores its activity during operation, offering a potential solution to this challenge.

Some of the organs in the body do not have to be in their current location, nor structured in a single mass of tissue, in order to carry out all of their functions. The liver is one of these organs. Many (not all, but many) of the functions of the liver could be carried out by small amounts of liver tissue distributed throughout the body. Thus the existence of companies like Lygenesis, shepherding clinical trials of liver tissue organoid transplantation into lymph nodes to help restore lost function. Here, researchers report on the early stages of development for an alternative approach that is even less like normal liver tissue, essentially just an injection of cells and hydrogel rather than any production of structured tissue for […]

Dental pulp injury caused by trauma or deep caries often leads to inflammation, tissue necrosis, and eventual loss of tooth vitality.

The world's first lab-based tick feeding system for bush ticks, developed by researchers at the University of Melbourne, has transformed the study of ticks and how they transmit disease. The novel, host-free technology reduces the need for animal experiments in tick studies, facilitating more ethical, reproducible research.

Scientists have discovered a key biological safeguard that helps one of nature's most impressive regenerators, the planarian flatworm, correctly rebuild its organs. The new research, published in Nature Communications, illuminates how these animals prevent their powerful stem cells from making mistakes during regeneration, a discovery that may eventually help scientists understand how to better control stem cell behavior in other species.

Aging muscles heal more slowly after injury — a frustrating reality familiar to many older adults. A new

A muscle-tissue engineering company, MUVON Therapeutics, is set to highlight the regulatory and technological challenges of bringing these novel therapies to the clinic. The post Bridging the Translation Gap for Regenerative Tissues appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers overcome key challenges in the mass production of enzymatic biofuel cells, paving the way for self-powered wearable sensor.

Sens. Diagn.DOI: 10.1039/D5SD00210A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vincent Vezza, Veerappan Mani, Niamh Docherty, Adrian Butterworth, David Alcorn, Paul A. Hoskisson, Damion CorriganSevere sepsis presents a critical healthcare challenge where rapid pathogen identification is vital for timely intervention.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Loss of specialized cells is a feature of aging, exhibited in tissues throughout the body. There are many examples of cell types that could in principle be replaced once lost, but in practice are not replaced. The underlying reasons for this selective lack of regenerative capacity are incompletely understood. Examples of highly specialized cell types that do not regenerate include sensory hair cells in the inner ear and the podocyte cells of the kidney that are the subject of today's research materials. Interestingly, some of the cell types that regenerate poorly or not at all in mammals are in fact restored when lost in other species. While comparative biology allows for an exploration of these differences, cells are enormously complex and expanding the understanding of […]

An AI‑based method has been developed to detect subtle, hard‑to‑see changes in human pancreatic tissue linked to type 2 diabetes. Using gigapixel microscopy and explainable AI, the team identified key cellular features that may serve as early biomarkers of the disease. The post AI Maps Subtle Human Pancreatic Tissue Changes Linked to Type 2 Diabetes appeared first on GEN - Genetic Engineering and Biotechnology News.