Stem Cells

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07.05.2026
13:21 FightAging.org More Evidence for Muscle Stem Cell Activity to be Inhibited by the Aged Tissue Environment

Stem cells support tissues by generating a supply of daughter somatic cells to replace losses. A broad body of evidence points to reduced muscle stem cell activity as a major contributing cause of age-related loss of muscle mass and strength. Other evidence suggests that this stem cell population remains capable; when old muscle stem cells are removed from the aged tissue environment for assessment, they appear to be as capable as young muscle stem cells. Researchers are now interested in establishing how an aged environment interacts with muscle stem cells to reduce their activity, with an eye to developing therapies to interfere in specific mechanisms as they are uncovered. Frailty arising from loss of muscle function and mass is a significant health concern impacting quality […]

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06.05.2026
11:04 Technology.org Stem cell model of human embryo produces yolk sac without hypoblasts or genetic trickery

For the first time, a stem cell model has produced a structure resembling an early human embryo with

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05.05.2026
01:35 GenEngNews.com Blood Stem Cells Evade Immune Attack in Aplastic Anemia Through Gene Mutations

Among individuals with aplastic anemia, different blood stem cells in the same person independently acquire gene mutations allowing escape from immune attack, and for some people these “rescuing” stem cell clones are sufficient to restore blood production and enable long-term remission. The post Blood Stem Cells Evade Immune Attack in Aplastic Anemia Through Gene Mutations appeared first on GEN - Genetic Engineering and Biotechnology News.

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02.05.2026
07:23 News-Medical.Net Study shows eIF4G2 gene maintains adult intestinal stem cell identity

Years before he conducted the research that would earn him a Nobel Prize in Physiology and Medicine, Shinya Yamanaka, MD, PhD, was a postdoctoral scientist at Gladstone Institutes, studying genes.

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30.04.2026
04:25 GenEngNews.com Restoring Vision with Stem Cell–Derived Retinal Cells by Overcoming ILM Barrier

Disrupting the eye’s internal limiting membrane enables transplanted stem cell–derived retinal ganglion cells to survive, migrate, and form connections, offering a potential future treatment for optic nerve damage. The post Restoring Vision with Stem Cell–Derived Retinal Cells by Overcoming ILM Barrier appeared first on GEN - Genetic Engineering and Biotechnology News.

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29.04.2026
17:21 Drugs.com Pooled Umbilical Cord Blood Boosts Stem Cell Transplant Success, Trial Finds

WEDNESDAY, April 29, 2026 — A new way of using umbilical cord blood — by pooling blood from multiple donors — could make it easier to receive a stem cell transplant for leukemia, a new study says.Nearly everyone in a small group of patients who rece...

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27.04.2026
13:37 FightAging.org Evidence for MLKL to be Important in Hematopoietic Stem Cell Aging

Researchers here identify a common mechanism in the cellular responses to various forms of stress that appears to drive aspects of hematopoietic stem cell aging via impairment of mitochondrial function. Hematopoietic cells are responsible for generating immune cells and red blood cells. Aging produces alterations in the character and lineages of generated cells, contributing to dysfunction in the immune system and in platelet producing cells, among other issues. Suppressing some aspects of cellular stress responses, those that become maladaptive in the aged tissue environment, may prove to be useful as a basis for therapy. It nonetheless seems a poor alternative to instead repairing or otherwise addressing the forms of damage and dysfunction that provoke these excessive cell stress responses. Hematopoietic stem cells (HSCs) survive many […]

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26.04.2026
18:42 News-Medical.Net International consortia honored for advancing stem cell research collaboration

The International Society for Stem Cell Research (ISSCR) has named CorEUstem COST Action and Stem Cell COREdinates as the recipients of the 2026 ISSCR Public Service Award.

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25.04.2026
09:52 News-Medical.Net ISSCR urges NIH to continue support human embryonic stem cell research

The International Society for Stem Cell Research (ISSCR) has submitted a formal response to a Request for Information (RFI) issued by the National Institutes of Health (NIH) regarding its pause on new submissions to the NIH Human Embryonic Stem Cell (hESC) Registry and considerations to reduce reliance on hESCs in federally supported research.

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24.04.2026
14:21 NewScientist.Com Is stem cell therapy about to transform medicine and reverse ageing?

A clinical trial to reverse age-related vision conditions using stem cell treatment could finally deliver on the promise of a major discovery in ageing and regeneration made 20 years ago, says columnist Graham Lawton

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02:42 Phys.org New bioreactor turns stem cells into an immune-cell factory, producing 40 million human macrophages per week

Researchers at Hannover Medical School (MHH) have developed a method for the efficient production of human immune cells, such as macrophages, in medium-sized bioreactors. These immune cells can be derived from induced pluripotent stem cells and are important for disease research and the development of new therapeutic approaches. The method has now been published in the journal Nature Protocols.

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22.04.2026
04:38 News-Medical.Net Stem cell model recreates early human embryo with yolk sac

For the first time, a stem cell model has produced a structure resembling an early human embryo with a yolk-sac-like structure, from a single starting stem cell population and without direct genetic manipulation.

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21.04.2026
00:27 Phys.org Stem cell embryo model grows yolk sac without hypoblasts or gene editing

For the first time, a stem cell model has produced a structure resembling an early human embryo with a yolk-sac-like structure, from a single starting stem cell population and without direct genetic manipulation. The models were made at University of Michigan Engineering. Researchers at the Chinese Academy of Sciences provided monkey embryo data to help confirm that the Michigan team was indeed seeing a yolk-sac-like structure in their models. The work is published in the journal Nature Cell Biology.

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18.04.2026
08:11 News-Medical.Net Stem cell model identifies promising therapy for inflammatory bowel disease

A new study published today in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate for reducing intestinal inflammation and cell death.

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02:15 SingularityHub.Com Norwegian Man Cured of HIV by His Brother’s Stem Cells

Fewer than 10 people worldwide have eradicated the virus with stem cells. But this case was special—no one knew his brother's cells carried a protective mutation until transplant day. The post Norwegian Man Cured of HIV by His Brother’s Stem Cells appeared first on SingularityHub.

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17.04.2026
04:59 GenEngNews.com Stem Cell Editing Programs the Immune System to Make Own Therapeutic Proteins

A new gene‑editing strategy programs hematopoietic stem cells to produce therapeutic antibodies and other proteins. The approach generates long‑lasting immunity in mice and could point to single‑vaccine treatments for diverse diseases in the future. The post Stem Cell Editing Programs the Immune System to Make Own Therapeutic Proteins appeared first on GEN - Genetic Engineering and Biotechnology News.

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16.04.2026
21:29 GenEngNews.com Advances in Stem Cell‑Derived Insulin‑Producing Cells for Type 1 Diabetes

Researchers developed an improved method for creating insulin-producing cells from human stem cells, which effectively regulated blood sugar levels in laboratory tests and reversed diabetes in a mouse model. The post Advances in Stem Cell‑Derived Insulin‑Producing Cells for Type 1 Diabetes appeared first on GEN - Genetic Engineering and Biotechnology News.

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14.04.2026
00:20 LiveScience.com 'Oslo patient' likely cured of HIV after getting stem cell transplant from his brother, who is genetically resistant to the virus

A man known as the "Oslo patient" joins a short list of people in long-term remission from HIV following bone marrow transplants.

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12.04.2026
13:53 News-Medical.Net Pseudogene lncRNAs regulate cancer stem cell behavior and signaling

Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to therapy due to their innate capacity for self-renewal and differentiation.

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10.04.2026
05:44 News-Medical.Net Study maps DNA methylation changes driving MDS stem cell dysfunction

Published on April 01, 2026, in Volume 2, article number 19 of the journal Immunity & Inflammation, a collaborative team led by Prof. Cao at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, along with Dr. Liangding Hu at the Fifth Medical Center of Chinese PLA General Hospital, and Professors Qian Zhang and Yanmei Han at the National Key Laboratory of Immunity and Inflammation, Naval Medical University, has generated the first base-resolution DNA methylome of human MDS HSCs.

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09.04.2026
05:45 News-Medical.Net Stem cell study identifies universal checkpoint controlling cell identity

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages.

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03:12 Phys.org A 'stemness checkpoint' helps control stem cell identity

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages. For nearly two decades, scientists have understood that stem cell self-renewal depends on blocking differentiation signals—a concept described in earlier work, including Qi-Long Ying and Austin Smith's 2008 Nature paper titled "The ground state of embryonic stem cell self-renewal."

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08.04.2026
23:27 GenEngNews.com Scalable Embryonic Stem Cell Platform Enables Mitochondrial DNA Research in Mice

Researchers say the platform represents a strategically valuable foundation for accelerating therapeutic development through genetically precise mitochondrial disease models. The post Scalable Embryonic Stem Cell Platform Enables Mitochondrial DNA Research in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.

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20:45 News-Medical.Net New MRI method tracks transplanted heart stem cells for months

Researchers at the Institute of Biomedical Engineering at the University of Toronto have demonstrated a new way to monitor transplanted stem-cell-derived heart cells using magnetic resonance imaging (MRI).

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07.04.2026
23:26 Phys.org How stem cell descendants preserve flexibility while maintaining distinct identities

Stem cells are the body's ultimate shape-shifters, sustaining tissues by balancing two competing demands: maintaining their own population and generating specialized descendants. In many tissues, some early descendants can revert to a stem cell state through a process known as dedifferentiation. This ability can help replenish the stem cell pool when stem cells are lost.

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02.04.2026
00:43 GenEngNews.com Biological Complexity of ALS to Be Addressed by the Development of New Stem Cell Models

PRISM ALS aims to develop, evaluate, and make available a diverse panel of well-characterized, patient-derived induced pluripotent stem cell (iPSC) models that capture both genetic and sporadic forms of ALS. The post Biological Complexity of ALS to Be Addressed by the Development of New Stem Cell Models appeared first on GEN - Genetic Engineering and Biotechnology News.

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01.04.2026
09:01 News-Medical.Net PRISM ALS: A new global collaboration to expand patient-derived stem cell models and accelerate treatments

A new global initiative launched today aims to close a critical gap in ALS/MND drug discovery - current cell models used for testing treatments do not currently reflect the diverse nature of the disease - that affects both researchers developing therapies and the people urgently waiting for them.

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31.03.2026
22:11 News-Medical.Net New stem cell therapy offers permanent cure for Hirschsprung disease

Scientists are developing a revolutionary new stem cell therapy to treat a rare and life-threatening disease that leaves newborn babies unable to function without invasive surgery, thanks to a collaboration between UCL, the University of Sheffield and Queen's University Belfast.

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30.03.2026
04:46 News-Medical.Net Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.

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27.03.2026
18:23 GenEngNews.com Stem Cells at the Frontier: Breakthroughs, Barriers, and What’s Next

This GEN Live show will focus on new areas of stem cell research, including aging. It will bring together a panel of leading experts to unpack the latest advances and ongoing challenges in stem cells. The post Stem Cells at the Frontier: Breakthroughs, Barriers, and What’s Next appeared first on GEN - Genetic Engineering and Biotechnology News.

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25.03.2026
21:42 FightAging.org Aging Impairs Activation of Muscle Stem Cells, with MG53 as a Potential Target for Therapies

Researchers have identified many contributing issues leading to the characteristic loss of muscle mass and strength that takes place with age. Arguably the central problems are (a) the disruptions of cell behavior caused by chronic inflammation, (b) damage to neuromuscular junctions, depriving muscle tissue of signals it relies upon for normal maintenance to take place, and (c) loss of muscle stem cell activity, and thus a reduced supply of somatic muscle cells to replace losses. These central problems likely interact with one another, but in principle could be addressed distinctly to produce benefits in patients. Past studies have shown, rather convincingly, that muscle stem cells in older individuals retain their function when moved from an old environment to a young environment. The problem is not […]

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24.03.2026
22:03 News-Medical.Net CREB5 drives stem cell-like transcriptional programs in aggressive prostate cancer

A new research paper was published in Volume 17 of Oncotarget on March 17, 2026, titled "CREB5 regulates stem cell-like transcriptional programs to enhance tumor progression in prostate cancer."

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14.03.2026
12:19 MedicalNewsToday.com Japan becomes first to approve stem cell therapies for Parkinson’s and heart failure

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13.03.2026
05:59 News-Medical.Net ISSCR launches education program on stem cell treatments for Parkinson's

The International Society for Stem Cell Research (ISSCR) today announced the launch of Stem Cell Medicine: Parkinson's Disease, a new continuing education course designed to equip clinicians with an evidence-based understanding of emerging stem cell therapies for Parkinson's disease (PD).

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12.03.2026
12:02 Nanowerk.com Nanogel gives stem cells room to breathe

Nanogel integrated spheroids increase cell retention and repair injured swallowing muscles.

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11.03.2026
21:23 Phys.org Trouble swallowing? A nanogel tweak may keep therapeutic stem cells alive longer

Swallowing is a fundamental human function that supports nutrition and communication. Damage to swallowing muscles can reduce quality of life and even lead to aspiration pneumonia or malnutrition. Many patients suffer from swallowing difficulties after being treated for head or neck cancer, and swallowing disorders are also common in older adults, yet effective therapies have been limited.

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15:39 Nature.Com Author Correction: Gut stem cell necroptosis by genome instability triggers bowel inflammation

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

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00:14 SingularityHub.Com In a First, Researchers Use Stem Cells and Surgery to Treat Spina Bifida in the Womb

The study focused on safety, but the results offer hope the approach could give kids a chance to walk. The post In a First, Researchers Use Stem Cells and Surgery to Treat Spina Bifida in the Womb appeared first on SingularityHub.

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10.03.2026
22:13 News-Medical.Net New biotech partnership aims to accelerate stem cell therapies for heart disease

A new biotech company forged through an Australian and Danish partnership will accelerate treatments for children and adults with heart disease. Harnessing cellular therapies, the company aims to conduct human clinical trials within three to five years.

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05.03.2026
18:45 Nature.Com Inside Mexico’s stem-cell industry

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01:38 Phys.org Just three molecules can launch gene-silencing condensates in stem cells

A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large-scale gene-silencing structures inside cells, and what happens when that process breaks down. The findings, published today in Molecular Cell, identify a self-clustering mechanism in the Polycomb protein CBX2 that is essential for initiating the formation of gene-repressive condensates and guiding stem cells toward their proper fates.

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04.03.2026
15:37 News-Medical.Net Stem cells from human primary tooth pulp may help treat chronic-phase cerebral palsy

Cerebral palsy is a condition usually caused by brain damage before or during birth, resulting in impaired posture and movement.

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00:16 ScienceMag.org Stem cell therapies ‘come of age’ with two conditional approvals in Japan

Induced pluripotent stem cells could help treat diseased hearts and brains

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02.03.2026
14:45 Technology.org Muscle stem cells build resilience but lose regenerative power with age

Aging muscles heal more slowly after injury — a frustrating reality familiar to many older adults. A new

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28.02.2026
05:45 News-Medical.Net Scientists discover how muscle stem cells "flip a switch" to rebuild damaged muscle

Scientists at the University of California, Irvine's School of Pharmacy & Pharmaceutical Sciences have discovered how muscle stem cells "flip a switch" to rebuild damaged muscle – a finding that could help address muscle loss linked to aging, injury and widely used weight-loss medications.

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27.02.2026
20:15 Gizmodo.com Scientists Injected Stem Cells Into Fetuses to Treat a Birth Defect. Here’s What Happened

In a Phase I trial, the treatment appeared to be safe in children with spina bifida.

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18:52 NewScientist.Com Frailty can be eased with an infusion of stem cells from young people

Frailty can typically only be lessened through lifestyle changes, but a stem cell therapy seems to target the underlying causes of the condition, boosting the mobility of frail older people

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18:15 Nature.Com Daily briefing: Stem-cell treatment strengthens people with age-related frailty

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09:40 Medscape.Com Stem Cell Therapy Safe, Feasible in Spina Bifida

A first-in-human trial shows the feasibility and safety of delivering placenta-derived stem cells during prenatal myelomeningocele repair.

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04:54 NewScientist.Com Stem cell patch reverses brain damage in fetuses with spina bifida

The congenital condition spina bifida is often treated surgically in the womb, but many children still go on to have mobility issues. The addition of a patch made up of stem cells from donated placentas could improve their long-term outcomes

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04:05 Nature.Com World-first stem-cell therapy shows promise for treating spina bifida in the womb

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03:42 News-Medical.Net Combining stem cell therapy with fetal surgery shows promise for treating myelomeningocele

A phase 1 clinical trial published in The Lancet has shown that combining stem cell therapy with standard fetal surgery before birth is a safe and promising approach to treat myelomeningocele, a severe form of spina bifida.

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03:07 ScienceMag.org Treating fetuses with stem cells proves safe in milestone spina bifida trial

The study is now scaling up to do more in utero procedures and evaluate effects on disability as children grow

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25.02.2026
22:48 FightAging.org A Review of Efforts to Develop Stem Cell Therapies for Neurodegenerative Conditions

A wide variety of stem cell therapies exist at various stages of development and clinical use. A broad range of cell sources and processing techniques are unprotected by intellectual property and are thus employed by clinics both within and outside the more heavily regulated regions of the world. Stem cell therapies have long been a staple of the medical tourism industry. These first generation stem cell therapies may be widely used but do not contribute much in the way of robust data to improve our understanding of how well they work. It appears to be the case, from what little we can see, that the benefits of treatment vary notably between patients and clinics. Even similar approaches can produce very different outcomes in different hands, […]

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19:57 Nature.Com Stem cells provide a potent treatment for frailty

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24.02.2026
14:17 FightAging.org Ube2g1 is Upregulated in Aged Hematopoietic Stem Cells

Hematopoietic stem cells are responsible for generating red blood cells and immune cells. With age, this production of cells becomes dysfunctional in a variety of ways, contributing to the aging of the immune system. For example, production of immune cells becomes biased to myeloid cells at the expense of lymphoid cells, a change that contributes indirectly to the more inflammatory behavior of the aged immune system. Identifying specific mechanisms involved in hemotopoietic aging is the first step on the road to finding ways to reverse these issues. Aged hematopoietic stem cells (HSCs) show diminished capacity of self-renewal, skewed lineage output and compromised proteostasis. Ubiquitin proteasomal systems are critical for maintaining protein homeostasis. We show that the levels of Ube2g1, a E2 ubiquitin-conjugating enzyme likely involved […]

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23.02.2026
19:27 Nature.Com First-of-a-kind stem cell therapies set for approval in Japan

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20.02.2026
18:22 ScienceDaily.com Doctors implant dopamine-producing stem cells in Parkinson’s patients

A groundbreaking clinical trial is testing whether specially engineered stem cells can help the brain restore its own dopamine production in people with Parkinson’s disease. Because the condition is driven by the gradual loss of dopamine-producing cells—leading to tremors, stiffness, and slowed movement—researchers are implanting lab-grown cells directly into the brain’s movement center to replace what’s been lost.

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18.02.2026
15:50 News-Medical.Net Researchers find new way to halt leukemia stem cell growth

In a new study published in Nature Communications, a research team at the University of Oslo have examined how cancer cells develop in the bone marrow and whether it might be possible to stop them.

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12:04 ScienceDaily.com One stem cell generates 14 million tumor-killing NK cells in major cancer breakthrough

Scientists in China have unveiled a breakthrough way to mass-produce powerful cancer-fighting immune cells in the lab. By engineering early-stage stem cells from cord blood—rather than trying to modify mature natural killer (NK) cells—they created a streamlined process that generates enormous numbers of highly potent NK cells, including CAR-equipped versions designed to hunt specific cancers.

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11.02.2026
04:50 Phys.org Researchers discover L1td1 maintains stem cell pluripotency by degrading totipotency-associated RNAs

A new study has found that L1td1, a protein evolutionarily co-opted from the Long interspersed nuclear element 1 (LINE1) retrotransposon, functions as a critical "gatekeeper" restricting pluripotent stem cells (PSCs) from reverting to a totipotent state. The research demonstrates that loss of L1td1 triggers the reactivation of totipotency-associated genes and endogenous retroviruses (ERVs), prompting cells to spontaneously regress to a totipotent-like (or 2-cell-like) state that mirrors the earliest stages of embryogenesis. Notably, the study identifies L1td1 as a key post-transcriptional regulator that suppresses endogenous viral elements to sustain pluripotency.

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09.02.2026
07:30 News-Medical.Net Cellares to expand automated manufacturing to gene-edited stem cell therapies

Cellares, the first Integrated Development and Manufacturing Organization (IDMO), today announced a collaboration with the Stanford Center for Definitive and Curative Medicine (CDCM) and Stanford Innovative Medicines Accelerator (IMA) to automate manufacturing and release testing for gene-edited hematopoietic stem cell (HSC) therapies, expanding the application of Cellares' automation platforms beyond T cell therapies into a new cell modality.

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05.02.2026
22:17 News-Medical.Net Stem cell implants aim to restore dopamine in Parkinson’s disease

Parkinson's disease is a progressive neurodegenerative disorder that affects more than one million people in the United States, with approximately 90,000 new cases diagnosed each year.

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05:47 Phys.org AI foundation model aims to make stem cell therapies more predictable

One of the most enduring goals in regenerative medicine is deceptively simple: replace a person's damaged or dying cells with healthy new ones grown in the laboratory.

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04.02.2026
23:06 Phys.org Lab-grown beef: Novel line of bovine embryonic stem cells shows promise

Researchers in the College of Agriculture, Health and Natural Resources have developed a novel line of bovine embryonic stem cells, which have significant potential for a variety of new innovations, from lab-grown meat to models for human tissue replacement. This work, led by Xiuchun "Cindy" Tian, professor of biotechnology in the Department of Animal Science, and her former and current graduate students Yue Su, Jiaxi Liu, and Ruifeng Zhao, was published in Stem Cells.

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31.01.2026
20:27 Phys.org Sprint or marathon? Aging muscle stem cells shift from rapid repair to long-term survival

Aging muscles heal more slowly after injury—a frustrating reality familiar to many older adults. A UCLA study conducted in mice reveals an unexpected cause: Stem cells in aged muscle accumulate higher levels of a protein that slows their ability to activate and repair tissue, but helps the cells survive longer in the harsh environment of aging tissue.

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30.01.2026
19:46 News-Medical.Net Research uncovers trade-offs in aging muscle stem cell functionality

Aging muscles heal more slowly after injury - a frustrating reality familiar to many older adults.

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29.01.2026
22:38 FightAging.org Fecal Microbiota Transplantation from Young Mice to Old Mice Improves Intestinal Stem Cell Function

The composition of the gut microbiome changes with age. A variety of factors likely contribute, including reduced physical activity, changes in diet, and a decline in the ability of the immune system to keep unwanted microbial populations in check. With age, microbes capable of provoking inflammation grow in number while microbes responsible for generating beneficial metabolites diminish in number. This is not an inevitable fate: the composition of the gut microbiome can be permanently changed by fecal microbiota transplantation. Studies have shown rejuvenation of the aged gut microbiome, improved health, and extended life span following fecal microbiota transplantation from young donor animals to old recipient animals. In human medicine, fecal microbiota transplantation was up until recently conducted in something of a gray area of regulation, […]

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13:26 Nature.Com Developmental convergence and divergence in human stem cell models of autism

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

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27.01.2026
22:18 FightAging.org Results from the Immunis Phase 2 Trial of a Stem Cell Secretome Therapy

The therapies developed by Immunis represent the less well trodden path when it comes to the ongoing but still early stages in the replacement of stem cell therapies. This replacement is possible because the benefits provided by presently widespread forms of stem cell therapy result from the signals secreted by those cells in the short period of time before they die. Few such therapies have demonstrated any meaningful degree of long-term engraftment and survival of transplanted cells. Benefits are thus a matter of signals from the stem cells favorably adjusting the behavior of native cells for some extended period of time. The most reliable beneficial outcome of such therapies is a reduction in chronic inflammation. Most efforts to replace stem cell therapies with a logistically […]

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23.01.2026
00:53 LiveScience.com 'Pain sponge' derived from stem cells could soak up pain signals before they reach the brain

Scientists are developing a "sponge" that can soak up pain signals in the body before they reach the brain, potentially offering an alternative to painkillers.

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22.01.2026
20:11 News-Medical.Net Age-related changes in the gut microbiota impair intestinal stem cell function

A new study led by Hartmut Geiger at the University of Ulm, Germany, and Yi Zheng and Kodandaramireddy Nalapareddy, Cincinnati Children's Hospital Medical Center (CCHMC), USA reveals that age-related changes in the gut microbiota directly impair intestinal stem cell (ISC) function and that restoring a youthful microbial environment can reverse this decline.

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19:56 News-Medical.Net New ISSCR guidance charts path for pluripotent stem cell therapies

The International Society for Stem Cell Research (ISSCR) today announced the upcoming release of "Charting the Translational Pathway: ISSCR Best Practices for the Development of Pluripotent Stem Cell (PSC)-Derived Therapies," a new paper highlighting some of the most critical aspects of the ISSCR's breakthrough interactive resource designed to transform how PSC-derived therapies are developed, evaluated, and advanced toward clinical and commercial success.

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21.01.2026
19:47 Phys.org Key protein can restore aging neural stem cells' ability to regenerate

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have found that a key protein can help to regenerate neural stem cells, which may improve aging-associated decline in neuronal production of an aging brain.

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20.01.2026
00:42 Phys.org Stem cell subpopulation found to be essential for bone fracture repair

In a study published in Cell Research, researchers have identified a fibrous-layer resident subpopulation of P-SSCs labeled by Angptl7. They found that these cells are crucial for bone fracture repair by mediating endochondral ossification, but exhibit minimal osteogenic capacity during postnatal bone development and maintenance.

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12.01.2026
15:10 Medscape.Com Do Flu Shots Cut Severe Illness After Stem Cell Transplant?

Among allogeneic haematopoietic stem cell transplant recipients with influenza infection, seasonal influenza vaccination lowers the risk for progression to lower respiratory tract disease.

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09.01.2026
00:50 GenEngNews.com Stem Cell-Derived Neurons Navigate to Form Connections in the Injured Brain

Study in mouse models of stroke showed how transplanted stem cell-derived neurons contain intrinsic codes for navigating and forming connections with the nervous system, which may help develop future cell therapies. The post Stem Cell-Derived Neurons Navigate to Form Connections in the Injured Brain appeared first on GEN - Genetic Engineering and Biotechnology News.

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08.01.2026
21:27 News-Medical.Net Scientists discover how stem cells navigate and repair brain damage after stroke

Some parts of our bodies bounce back from injury in fairly short order. The outer protective layer of the eye-called the cornea-can heal from minor scratches within a single day.

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20:28 News-Medical.Net CIRM awards $7.4 million to advance stem cell-based gene therapy for Friedreich's ataxia

The California Institute for Regenerative Medicine (CIRM) has awarded $7.4 million to support a University of California San Diego team developing a first-of-its-kind stem cell-based gene therapy for Friedreich's ataxia, a rare inherited neurodegenerative disease that causes progressive loss of coordination, muscle strength, heart function and overall mobility.

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20:28 News-Medical.Net UBC researchers crack code to grow helper t cells from stem cells

For the first time, researchers at the University of British Columbia have demonstrated how to reliably produce an important type of human immune cell-known as helper T cells-from stem cells in a controlled laboratory setting.

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02.01.2026
13:59 News-Medical.Net First human 'lung-on-chip' model developed using stem cells from a single donor

Researchers at the Francis Crick Institute and AlveoliX have developed the first human 'lung-on-chip' model using stem cells taken from only one person.

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31.12.2025
03:27 News-Medical.Net Advancing stem cell regeneration through animal-free culture systems

Intestinal Stem Cells (ISCs) derived from a patient's own cells have garnered significant attention as a new alternative for treating intractable intestinal diseases due to their low risk of rejection.

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24.12.2025
05:02 Nature.Com Author Correction: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

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19.12.2025
05:22 News-Medical.Net Researchers provide a global catalog of human pluripotent stem cell lines for clinical use

To date, more than 100 clinical trials with human pluripotent stem cell (hPSC)-derived products have been initiated worldwide and an increasing number of potential hPSC-derived clinical products have entered early developmental pipelines.

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18.12.2025
23:36 Phys.org Induced pluripotent stem cells: From dish to freezer and back

With a Kobe University-developed procedure, induced pluripotent stem cells can now be frozen directly in their dishes without losing their viability or undifferentiated state after thawing. This marks a significant step for research automation, personalized medicine and drug discovery research.

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17.12.2025
02:12 Phys.org Scientists discover how plant cell walls guide stem cells

Imagine if our bodies could grow new organs throughout our entire lives. Plants do this constantly, thanks to tiny, powerful reservoirs of stem cells. But how do these cells know when to divide, and how do they ensure each division is perfectly oriented to build a leaf, a stem, or a flower?

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16.12.2025
20:55 Phys.org Uncovering early embryonic communications using new stem cell model

From the moment an embryo starts to take shape, two-way communication is critical for making sure tissues and organs develop correctly.

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14:27 News-Medical.Net Combining stem cell therapy and BDNF enhancement to manage Parkinson’s disease

Parkinson's disease (PD) is an age-related, progressive, neurodegenerative condition, caused by loss of dopamine-producing neurons.

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15.12.2025
16:29 ScienceDaily.com Stem cell pain sponge soaks up osteoarthritis joint pain and protects cartilage

SereNeuro Therapeutics revealed promising results for SN101, a first-in-class iPSC-derived therapy designed to treat chronic osteoarthritis pain while protecting joint tissue. Instead of blocking pain pathways, SN101 uses lab-grown nociceptors that act like sponges, soaking up inflammatory pain factors without sending pain signals. These cells also release regenerative molecules, offering disease-modifying potential that stands apart from traditional corticosteroids and single-target drugs like Nav1.8 inhibitors.

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14:18 FightAging.org Extracellular Matrix Protein Tenascin-C is Important to Muscle Stem Cell Function, But Declines with Age

The aging of the extracellular matrix is not as well studied as is the case for cell biochemistry. There are likely many important changes that take place in the extracellular matrix over a lifetime that meaningfully affect cell function in aged tissues, but have yet to be discovered and understood. One example is outlined here, a matrix protein that declines with age but seems necessary to maintain the normal function of muscle stem cells. Declining muscle stem cell function is one of the important contributions to the characteristic loss of muscle mass and strength that occurs with age. Skeletal muscle regeneration occurs through the finely timed activation of resident muscle stem cells (MuSC). Following injury, MuSC exit quiescence, undergo myogenic commitment, and regenerate the muscle. […]

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13.12.2025
10:23 News-Medical.Net Engineering muscle stem cells for sustainable cultured meat production

The production of cultured meat depends on the isolation, expansion, and differentiation of animal stem cells into edible tissues. Muscle stem cells, or satellite cells, are central to this process due to their ability to regenerate and form muscle fibers.

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05:37 News-Medical.Net UC Irvine receives funding for clinical trial of neural stem cell therapy for Huntington's disease

Leslie M. Thompson, Donald Bren Professor of psychiatry and human behavior as well as neurobiology and behavior at the University of California, Irvine, has received an $11,999,933 grant from the California Institute for Regenerative Medicine for an unprecedented clinical trial of a novel neural stem cell therapy for Huntington's disease.

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12.12.2025
21:48 Phys.org A new medium for canine stem cells that doesn't contain any human components

Canine induced pluripotent stem (iPS) cells possess the ability to differentiate into any type of cell, making them a useful tool for investigating common canine diseases and disease states, including those of humans.

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16:58 News-Medical.Net Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation.

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11.12.2025
14:34 FightAging.org Long Term Treatment with Mesenchymal Stem Cell Extracellular Vesicles Improves Cognitive Function in Rhesus Monkeys

Much of the benefit of stem cell therapies results from the signals released by those cells in the short time they survive in the body following transplantation. Much of that signaling is carried by extracellular vesicles, membrane-wrapped packages of molecules. Extracellular vesicle therapies can in principle become considerably less costly than stem cell therapies, because manufacture can be centralized, and because extracellular vesicles are much more readily stored and transported, but we are not there yet. Thus while extracellular vesicle therapy is certainly available to those with the time and patience to navigate the medical tourism space, or find suppliers and a cooperative physician inside the US, the schedule of 36 doses over 18 months used in this study is beyond the financial reach of […]

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05:31 News-Medical.Net Expanded donor matching makes stem cell transplants accessible

For years, the search for a stem cell donor has felt like a quest for a rare key-one that fits a lock with eight intricate tumblers, each representing a genetic marker.

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10.12.2025
05:03 News-Medical.Net Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

This study shows that vacancy-engineered MoS₂ nanoflowers drive mitochondrial biogenesis in human mesenchymal stem cells by activating SIRT1–PGC-1α signaling and reducing oxidative stress. These treated cells transfer more functional mitochondria to injured recipient cells, restoring energy metabolism and redox balance in multiple in vitro models.

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06.12.2025
18:13 IbTimes.co.uk Kylie Jenner Accused of Lying About BBL Removal; Claims It Was 'Stem Cell Therapy'

Kylie Jenner posted about stem-cell therapy for chronic back pain and named Eterna Health; social media has speculated a BBL reversal, but no medical records or legal filings confirm the allegation.

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05.12.2025
22:03 Phys.org Programmable CRISPR platform can reduce stem cell differentiation from months to weeks

Syntax Bio, a synthetic biology company programming the next generation of cell therapies, has published new research in Science Advances detailing the company's CRISPR-based Cellgorithm technology, which lays the groundwork for programmable control of gene activity in human stem cells and offers an alternative to the slow, variable manual processes researchers use today.

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13:48 GenEngNews.com Muscle Stem Cells Bolstered by ECM Protein Tenascin-C

Protein composition of muscular extracellular matrix impacts the function of muscular stem cells in repair and regeneration of muscles during aging. The role of tenascin-C has been clarified in a new study in mice. The post Muscle Stem Cells Bolstered by ECM Protein Tenascin-C appeared first on GEN - Genetic Engineering and Biotechnology News.

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