Stem Cells

Aging muscles heal more slowly after injury—a frustrating reality familiar to many older adults. A UCLA study conducted in mice reveals an unexpected cause: Stem cells in aged muscle accumulate higher levels of a protein that slows their ability to activate and repair tissue, but helps the cells survive longer in the harsh environment of aging tissue.

Aging muscles heal more slowly after injury - a frustrating reality familiar to many older adults.

The composition of the gut microbiome changes with age. A variety of factors likely contribute, including reduced physical activity, changes in diet, and a decline in the ability of the immune system to keep unwanted microbial populations in check. With age, microbes capable of provoking inflammation grow in number while microbes responsible for generating beneficial metabolites diminish in number. This is not an inevitable fate: the composition of the gut microbiome can be permanently changed by fecal microbiota transplantation. Studies have shown rejuvenation of the aged gut microbiome, improved health, and extended life span following fecal microbiota transplantation from young donor animals to old recipient animals. In human medicine, fecal microbiota transplantation was up until recently conducted in something of a gray area of regulation, […]

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

The therapies developed by Immunis represent the less well trodden path when it comes to the ongoing but still early stages in the replacement of stem cell therapies. This replacement is possible because the benefits provided by presently widespread forms of stem cell therapy result from the signals secreted by those cells in the short period of time before they die. Few such therapies have demonstrated any meaningful degree of long-term engraftment and survival of transplanted cells. Benefits are thus a matter of signals from the stem cells favorably adjusting the behavior of native cells for some extended period of time. The most reliable beneficial outcome of such therapies is a reduction in chronic inflammation. Most efforts to replace stem cell therapies with a logistically […]

Scientists are developing a "sponge" that can soak up pain signals in the body before they reach the brain, potentially offering an alternative to painkillers.

A new study led by Hartmut Geiger at the University of Ulm, Germany, and Yi Zheng and Kodandaramireddy Nalapareddy, Cincinnati Children's Hospital Medical Center (CCHMC), USA reveals that age-related changes in the gut microbiota directly impair intestinal stem cell (ISC) function and that restoring a youthful microbial environment can reverse this decline.

The International Society for Stem Cell Research (ISSCR) today announced the upcoming release of "Charting the Translational Pathway: ISSCR Best Practices for the Development of Pluripotent Stem Cell (PSC)-Derived Therapies," a new paper highlighting some of the most critical aspects of the ISSCR's breakthrough interactive resource designed to transform how PSC-derived therapies are developed, evaluated, and advanced toward clinical and commercial success.

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have found that a key protein can help to regenerate neural stem cells, which may improve aging-associated decline in neuronal production of an aging brain.

In a study published in Cell Research, researchers have identified a fibrous-layer resident subpopulation of P-SSCs labeled by Angptl7. They found that these cells are crucial for bone fracture repair by mediating endochondral ossification, but exhibit minimal osteogenic capacity during postnatal bone development and maintenance.

Among allogeneic haematopoietic stem cell transplant recipients with influenza infection, seasonal influenza vaccination lowers the risk for progression to lower respiratory tract disease.

Study in mouse models of stroke showed how transplanted stem cell-derived neurons contain intrinsic codes for navigating and forming connections with the nervous system, which may help develop future cell therapies. The post Stem Cell-Derived Neurons Navigate to Form Connections in the Injured Brain appeared first on GEN - Genetic Engineering and Biotechnology News.

Some parts of our bodies bounce back from injury in fairly short order. The outer protective layer of the eye-called the cornea-can heal from minor scratches within a single day.

The California Institute for Regenerative Medicine (CIRM) has awarded $7.4 million to support a University of California San Diego team developing a first-of-its-kind stem cell-based gene therapy for Friedreich's ataxia, a rare inherited neurodegenerative disease that causes progressive loss of coordination, muscle strength, heart function and overall mobility.

For the first time, researchers at the University of British Columbia have demonstrated how to reliably produce an important type of human immune cell-known as helper T cells-from stem cells in a controlled laboratory setting.

Researchers at the Francis Crick Institute and AlveoliX have developed the first human 'lung-on-chip' model using stem cells taken from only one person.

Intestinal Stem Cells (ISCs) derived from a patient's own cells have garnered significant attention as a new alternative for treating intractable intestinal diseases due to their low risk of rejection.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

To date, more than 100 clinical trials with human pluripotent stem cell (hPSC)-derived products have been initiated worldwide and an increasing number of potential hPSC-derived clinical products have entered early developmental pipelines.

With a Kobe University-developed procedure, induced pluripotent stem cells can now be frozen directly in their dishes without losing their viability or undifferentiated state after thawing. This marks a significant step for research automation, personalized medicine and drug discovery research.

Imagine if our bodies could grow new organs throughout our entire lives. Plants do this constantly, thanks to tiny, powerful reservoirs of stem cells. But how do these cells know when to divide, and how do they ensure each division is perfectly oriented to build a leaf, a stem, or a flower?

From the moment an embryo starts to take shape, two-way communication is critical for making sure tissues and organs develop correctly.

Parkinson's disease (PD) is an age-related, progressive, neurodegenerative condition, caused by loss of dopamine-producing neurons.

SereNeuro Therapeutics revealed promising results for SN101, a first-in-class iPSC-derived therapy designed to treat chronic osteoarthritis pain while protecting joint tissue. Instead of blocking pain pathways, SN101 uses lab-grown nociceptors that act like sponges, soaking up inflammatory pain factors without sending pain signals. These cells also release regenerative molecules, offering disease-modifying potential that stands apart from traditional corticosteroids and single-target drugs like Nav1.8 inhibitors.

The aging of the extracellular matrix is not as well studied as is the case for cell biochemistry. There are likely many important changes that take place in the extracellular matrix over a lifetime that meaningfully affect cell function in aged tissues, but have yet to be discovered and understood. One example is outlined here, a matrix protein that declines with age but seems necessary to maintain the normal function of muscle stem cells. Declining muscle stem cell function is one of the important contributions to the characteristic loss of muscle mass and strength that occurs with age. Skeletal muscle regeneration occurs through the finely timed activation of resident muscle stem cells (MuSC). Following injury, MuSC exit quiescence, undergo myogenic commitment, and regenerate the muscle. […]

The production of cultured meat depends on the isolation, expansion, and differentiation of animal stem cells into edible tissues. Muscle stem cells, or satellite cells, are central to this process due to their ability to regenerate and form muscle fibers.

Leslie M. Thompson, Donald Bren Professor of psychiatry and human behavior as well as neurobiology and behavior at the University of California, Irvine, has received an $11,999,933 grant from the California Institute for Regenerative Medicine for an unprecedented clinical trial of a novel neural stem cell therapy for Huntington's disease.

Canine induced pluripotent stem (iPS) cells possess the ability to differentiate into any type of cell, making them a useful tool for investigating common canine diseases and disease states, including those of humans.

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation.

Much of the benefit of stem cell therapies results from the signals released by those cells in the short time they survive in the body following transplantation. Much of that signaling is carried by extracellular vesicles, membrane-wrapped packages of molecules. Extracellular vesicle therapies can in principle become considerably less costly than stem cell therapies, because manufacture can be centralized, and because extracellular vesicles are much more readily stored and transported, but we are not there yet. Thus while extracellular vesicle therapy is certainly available to those with the time and patience to navigate the medical tourism space, or find suppliers and a cooperative physician inside the US, the schedule of 36 doses over 18 months used in this study is beyond the financial reach of […]

For years, the search for a stem cell donor has felt like a quest for a rare key-one that fits a lock with eight intricate tumblers, each representing a genetic marker.

This study shows that vacancy-engineered MoS₂ nanoflowers drive mitochondrial biogenesis in human mesenchymal stem cells by activating SIRT1–PGC-1α signaling and reducing oxidative stress. These treated cells transfer more functional mitochondria to injured recipient cells, restoring energy metabolism and redox balance in multiple in vitro models.

Kylie Jenner posted about stem-cell therapy for chronic back pain and named Eterna Health; social media has speculated a BBL reversal, but no medical records or legal filings confirm the allegation.

Syntax Bio, a synthetic biology company programming the next generation of cell therapies, has published new research in Science Advances detailing the company's CRISPR-based Cellgorithm technology, which lays the groundwork for programmable control of gene activity in human stem cells and offers an alternative to the slow, variable manual processes researchers use today.

Protein composition of muscular extracellular matrix impacts the function of muscular stem cells in repair and regeneration of muscles during aging. The role of tenascin-C has been clarified in a new study in mice. The post Muscle Stem Cells Bolstered by ECM Protein Tenascin-C appeared first on GEN - Genetic Engineering and Biotechnology News.

Your skin is in a constant state of reinvention. Every month, your body sheds and regenerates its entire outer layer—a complete turnover powered by tiny, tireless stem cells. These same cells spring into action when you get a cut, healing wounds with remarkable speed.

Scientists in Melbourne have discovered how tiny electrical pulses can steer stem cells as they grow, opening the door to new improved ways of creating new tissues, organs, nerves and bones.

Scientists in Melbourne have discovered how tiny electrical pulses can steer stem cells as they grow, opening the door to new improved ways of creating new tissues, organs, nerves and bones.

Stem cells exist in order to minimize the number of cells capable of unrestricted replication; most cells in the body are limited in the number of times that they can divide. This limit serves to reduce the risk of cancer - and other severe disruptions that could result from unlimited replication of a malfunctioning cell - to an acceptably low level to enable evolutionary success. Stem cells provide a supply of daughter somatic cells to replace those that are lost over time, due to limited somatic cell replication. In actuality, stem cells spend much of their time in a state of quiescence, without replicating. This is necessary to preserve their function and minimize damage over the course of a lifetime. When forced into excessive activity, […]

Age-related loss of function in hematopoietic stem cells resident in the bone marrow is an important component of immune system aging, and thus important to aging as a whole. There is a tendency to think of cells only in terms of chemistry, but some of that chemistry is linked to structure, mechanical forces, and the physical properties of surrounding tissues. Researchers here find that RhoA, a key protein in a cell's response to mechanical stimulus, is important in loss of function in aged hematopoietic stem cells. It is something of an open question as to how much of this importance is driven by changes in the mechanical properties of surrounding tissues versus epigenetic changes inside the cell that affect its structure, but RhoA inhibition clearly […]

A new study, led by the University of Vienna and the Alfred Wegener Institute in Bremerhaven, shows how the eyes of adult marine bristleworms continue to grow throughout life – driven by a ring of neural stem cells reminiscent of vertebrate eyes.

A new study, led by the University of Vienna and the Alfred Wegener Institute in Bremerhaven, shows how the eyes of adult marine bristleworms continue to grow throughout life—driven by a ring of neural stem cells reminiscent of vertebrate eyes. What's more, these stem cells respond to environmental light.

Lysosomes are a vital component in the recycling systems of the cell, organelles that break down harmful or unwanted molecules in order to provide raw materials for manufacture of new molecules. As is the case for all cell components, lysosomes become dysfunctional with age. The buildup of persistent metabolic waste, such as lipofuscin, that cells struggle to break down is implicated in age-related lysosomal dysfunction in long-lived cells, such as neurons. Sweeping epigenetic and transcriptomic changes that alter the production of proteins occur with age in all cells, and it is likely that a subset of these changes contributes meaningfully to impaired lysosomal function. Today's open access paper is interesting not just for the connection between specific forms of lysosomal dysfunction and hematopoietic stem cell […]

A handful of people with HIV have been cured after receiving HIV-resistant stem cells – but a man who received non-resistant stem cells is also now HIV-free

One of the ways in which transplanted stem cells aid native cells in the short period of time before they die is by transferring mitochondria. This happens in much the same way as the cells also transfer signals via extracellular vesicles. A mitochondrion and a vesicle are both membrane-wrapped packages of molecules, albeit that the former is much more complex and functional. Mitochondria are important to cell function, as they generate the chemical energy store molecule adenosine triphosphate (ATP) required to power the cell. Unfortunately, loss of mitochondrial function occurs with age, and is thought to be an important component of degenerative aging. The roots of age-related mitochondrial dysfunction are complex, involving damage to mitochondrial DNA, epigenetic changes that alter the expression of important mitochondrial […]

In preclinical studies, researchers found that priming the immune system with a Treg-expanding therapy before stem cell transplant boosted survival, protected vital organs, and promoted a balanced gut microbiome-offering hope for safer, more effective treatment of blood cancers.

Texas A&M researchers found a way to make stem cells produce double the normal number of mitochondria using nanoflower particles. These energized stem cells then transfer their surplus “power packs” to weakened cells, reviving their energy production and resilience. The method bypasses many limitations of current mitochondrial therapies and could offer long-lasting effects. It may open the door to treatments for aging tissues and multiple degenerative diseases.

Scientists have discovered a method of helping human stem cells thrive in an animal embryo—a key development in efforts to grow human organs in animals for medical transplants.

Researchers use nanoflower-enhanced stem cells to supply extra mitochondria to damaged cells, restoring energy production and cell function without genetic modification.

Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell's lysosomes.

A first-of-its-kind trial is testing adult stem cell transplants for advanced dry macular degeneration. Early results show the treatment is safe and can significantly improve vision, even in severely affected patients. Participants gained measurable sight improvements in the treated eye. Researchers are now monitoring higher-dose groups as the therapy advances toward later trial phases.

In research, induced pluripotent stem (iPS) cells are derived from skin, urine, or blood samples and developed into other cells, like heart tissue, that researchers want to study.

The selection of suitable donors is crucial for the long-term recovery of patients after an allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Studying tail regeneration in tadpoles, researchers discovered that putative muscle stem cells produce a secreted protein, c1qtnf3, which shifts macrophages from immune to regenerative functions. The post Stem Cell Signal Redirects Macrophages to Promote Regeneration of Tadpole Tails appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers Sumika Kato, Takeo Kubo, and Taro Fukazawa of the University of Tokyo have discovered that c1qtnf3, a secreting factor, namely a protein molecule that is secreted by a cell and influences functions of other cells, is expressed in putative muscle stem cells and shifts macrophages from immune to regenerative functions in the regenerating tails of tadpoles.

A leading bioethicist at Hiroshima University is calling for an anticipatory, rather than reactive, approach to ethics after a Japanese government panel in August backed a report that brings the country a step closer to becoming the first in the world to allow research on human embryos created from stem cell–derived sperm and eggs.

For the first time, the International Society for Stem Cell Research (ISSCR), the Society for Developmental Biology (SDB), and the Allen Institute are collaborating to present a three-day scientific symposium led by early-career scientists.

Platelets are small, disc-shaped cell fragments in the blood that are essential to stop bleeding and to initiate blood clotting after injury.

Scientists at the University of Osaka have developed a novel hydrogel that enables the efficient, three-dimensional (3D) culture of human induced pluripotent stem cells (iPSCs).

A research team in South Korea has successfully developed a novel technology that combines nanoparticles with stem cells to significantly improve 3D bone tissue regeneration. This advancement marks a step forward in the treatment of bone fractures and injuries, as well as in next-generation regenerative medicine.

Southwest Research Institute (SwRI) has demonstrated a new application for its cell-expansion bioreactor to advance tissue engineering and cell-based therapies for treatment of injuries and diseases.

Researchers at the Technical University of Munich (TUM) have used nanorobots to precisely stimulate stem cells, leading to their consistent transformation into bone cells.

A research team in South Korea has successfully developed a novel technology that combines nanoparticles with stem cells to significantly improve 3D bone tissue regeneration.

Researchers created a nanoparticle-stem cell technology that greatly enhances 3D bone regeneration, advancing treatment for fractures and regenerative medicine.

Researchers here demonstrate a novel way of delivering stem cells as a therapy for bone fractures that occur in the context of osteoporosis, by forming spheroids of stem cells combined with a bone mineral scaffolding material. The approach appears to encourage the survival of a larger fraction of transplanted cells, producing a greater regeneration of bone tissue. More usually near all of the transplanted cells die shortly after a transplantation procedure, and whatever benefits are obtained are derived from the signaling generated by the stem cells prior to that point. Osteoporotic vertebral fractures substantially contribute to disability and often require surgical intervention. However, some challenges, such as implant failure and suboptimal bone regeneration, limit current treatments. Adipose-derived stem cells are promising for regenerative therapy because […]

A new chimera protein creates a potent, xeno-free fibrin scaffold with strong cell adhesion, paving the way for reproducible and medically applicable stem cell therapies.

For the first time, researchers at the Technical University of Munich (TUM) have succeeded in using nanorobots to stimulate stem cells with such precision that they are reliably transformed into bone cells. To achieve this, the robots exert external pressure on specific points in the cell wall. The new method offers opportunities for faster treatments in the future.

Researchers used nanorobots to precisely stimulate stem cells into bone cells by applying pressure to cell walls, enabling faster future treatments.

MONDAY, Nov. 10, 2025 — A Mayo Clinic team has developed a new way to repair damaged hearts without open-heart surgery, and early results suggest it could one day help people with severe heart failure.The team created a thin patch of lab-grown h...

This herculean effort could help scientists unravel the causes of autism, schizophrenia, and even a deadly form of cancer. The post Scientists Map the Brain’s Construction From Stem Cells to Early Adolescence appeared first on SingularityHub.

Southwest Research Institute (SwRI) has demonstrated a new application for its cell-expansion bioreactor to advance tissue engineering and cell-based therapies for treatment of injuries and diseases.

A Stanford-led team has replaced toxic pre-transplant chemotherapy with a targeted antibody, allowing children with Fanconi anemia to receive stem cell transplants safely. The antibody, briquilimab, removes diseased stem cells without radiation, enabling nearly complete donor cell replacement. The approach also widens donor eligibility and could soon be applied to other bone marrow failure diseases.

Mayo Clinic researchers have developed a pioneering method to mend damaged hearts without open-heart surgery, an advance that could one day transform the treatment of heart failure.

An Osaka Metropolitan University team has used stem cells extracted from adipose, the body's fatty tissue, to treat spine fractures in rats similar to those caused by osteoporosis in humans.

A major trend in the world of stem cell therapies is the replacement of stem cell transplantation with the use of extracellular vesicles derived from those stem cells. Extracellular vesicles are much more easily managed as a basis for therapy, they are more easily stored and transported, and their production can be more centralized. Since stem cell therapies produce their benefits largely via the signals generated by the transplanted cells in the short period before they die, the use of stem cell derived extracellar vesicles appears a good substitute. The availability of extracellular vesicle therapies is spreading in the medical tourism community, where good data on outcomes is very hard to come by, and the more mainstream medical development community has started towards clinical trials […]

Today's open access paper links a number of different areas of research and development of interest. Firstly, that senescent cells accumulate with age to disrupt tissue structure and function with their inflammatory secretions. Secondly, that the innate immune cells known as microglia become overly active and inflammatory in the aging brain, and a growing body of evidence supports a significant role for these inflammatory microglia in the development of neurodegenerative conditions. Some of these inflammatory microglia are senescent. Thirdly, the stem cell therapies pioneered over the last thirty years, and the more modern use of extracellular vesicles such as exosomes derived from stem cell cultures, appear to largely produce benefits via a sustained reduction in chronic inflammation in older individuals. The transplanted cells do not […]

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Patients with weak heart function who receive stem cell therapy shortly after a heart attack are at lower risk of developing heart failure and related hospital stays compared with standard care, finds a clinical trial published by The BMJ today.

People who receive stem cell therapy within a week of their first heart attack have nearly a 60 per cent lower risk of developing heart failure years later

Liver cells are indispensable for research—for drug testing, to better understand diseases such as hepatitis, fatty liver, cirrhosis, or liver cancer and for development of future cell therapies. However, obtaining human liver cells from biopsies and donor organs is challenging. Therefore, research requires alternative sources of liver cells.

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message (mRNA), which is then converted into a protein. Although DNA remains the same in all cells, how it is read depends on specific signals that can change the DNA itself, mRNA or proteins. These signals are often in the form of chemical modifications.

In this episode of 's , we discuss a conversation on the hype and the reality of AI-driven protein design and using machine learning to target cancer stem cells. The post Artificial Intelligence in the Emerald City and Targeting Colon Cancer Stem Cells appeared first on GEN - Genetic Engineering and Biotechnology News.

The medical tourism industry has adopted the therapeutic use of exosomes derived from stem cells in much the same way as it adopted the use of stem cell therapies. Transplanted stem cells produce benefits via signaling, and most signaling is carried via extracellular vesicles such as exosomes. From a logistics point of view, exosomes are more easily stored, transported, and used, while all of the tools needed to harvest exosomes from stem cell cultures already existed. Meanwhile, the regulated medical industry lags years behind, given the large costs and lengthy development programs required to satisfy regulatory requirements for manufacturing consistency and data on outcomes. Lack of consistency is certainly a long-standing issue in stem cell therapies, and will likely continue to be an issue for […]

Scientists at University of California San Diego have developed a new approach to destroying cancer stem cells – hard-to-find cells that help cancers spread, come back after treatment and resist therapy.

Researchers developed an AI strategy, CANDiT, that identifies, reprograms and ultimately triggers colon cancer stem cells to self-destruct. The team suggests the ability to track and selectively kill CSCs brings scientists “closer to rewriting the rules of cancer treatment.” The post AI Treatment Reprograms and Triggers Cancer Stem Cells to Self-Destruct appeared first on GEN - Genetic Engineering and Biotechnology News.

Multiple viral infections are common after stem cell transplants, especially in patients with CMV exposure, haploidentical donors, or acute graft-vs-host disease or those receiving T-cell depletion.

The results of a study in flatworms challenging the textbook concept that stem cells reside in a defined niche may help explain the planarian’s regenerative capacity, and potentially offer clues for developing approaches to human tissue repair or replacement. The post Flatworm Stem Cells Offer Insights into Regenerative Biology appeared first on GEN - Genetic Engineering and Biotechnology News.

The brain's mechanisms for repairing injuries caused by trauma or degenerative diseases are not yet known in detail.

For families of children with severe epilepsy, controlling seizures is often just the beginning of their challenges. Even

Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture.

There is a sizable literature of animal studies in which researchers increase or decrease intake of one specific dietary amino acid and observe the outcomes. Despite this, there are a lot of gaps and contradictory results in the understanding of the long term effects of increased intake of specific single amino acids, even for the smaller number of essential amino acids. Here, researchers find that increased cysteine intake can improve intestinal stem cell function in mice, and thus promote tissue health in the small intestine. While the context of the research is injury, such as the consequences of radiotherapy, this may be able to somewhat compensate for the loss of intestinal stem cell function that occurs with age. A fundamental question in physiology is understanding […]

The Cell and Gene Therapy Catapult site is the first of several planned global sites aimed at building the manufacturing backbone needed to bring regenerative medicines to millions of patients worldwide. The post Mytos Launches Automated CDMO for Manufacturing Stem-Cell Derived Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.

Chronic kidney disease (CKD) affects more than 700 million people worldwide and is caused by genetic and environmental factors, as well as existing medical conditions. Known genetic risk factors for CKD include mutations in a gene called APOL1.

Authentic embryonic stem cells have been derived from chickens and seven other bird species using egg yolk-based culture. This breakthrough offers promising applications in development, biotechnology, and species conservation. The post Avian Embryonic Stem Cells Derived Using Egg Yolk-Based Culture appeared first on GEN - Genetic Engineering and Biotechnology News.

Tissues in the body are supported by distinct stem cell populations that reside within structures of supporting helper cells known as stem cell niches. The primary purpose of stem cells is to deliver a supply of daughter somatic cells to replace lost cells, though they also provide signaling that affects cell behavior. All tissues undergo a slow turnover of cells as there is a limit to the number of times a somatic cell can replicate. Telomeres are lengths of repeated DNA sequences at the end of chromosomes that shorten with each cell division. When telomeres become too short, a cell reaches what is known as the Hayflick limit and either becomes senescent and is destroyed by the immune system or undergoes programmed cell death. Stem […]

Egg whites may be perfect for a health-conscious breakfast, but egg yolks turned out to be the key ingredient for cultivating bird embryonic stem cells (ESCs) in the lab. Using a growing medium of egg yolk along with a few other key factors, a USC Stem Cell-led team of scientists has succeeded in deriving and maintaining authentic ESCs from chickens and seven other bird species.

An international workshop of scientists, regulators, and industry experts led by Prof Ivana Barbaric convened to address the risks of genetic mutations in stem cell therapy.