Cancer

Cancer immunotherapy is built on a simple but powerful idea: the immune system can recognize and destroy cancer cells if it is properly activated. In many patients, however, this response is too weak or too slow to be effective.

Mayo Clinic's AI model identifies invisible signs of pancreatic cancer on routine CT scans, potentially transforming early detection and survival rates.

Hundreds of thousands of people diagnosed with cancer are still alive today but were never genetically tested, either because testing was not available or was not routinely offered at the time of their diagnosis. These patients are just as likely as those diagnosed today to carry a germline pathogenic variant (gPV) - a heritable genetic alteration - that increases cancer risk.

Not all cancer survivors face the same likelihood for a second cancer. New data show striking differences by age, cohort, and initial diagnosis.

For roughly forty years, oncologists have treated pancreatic cancer with the grim arithmetic of months gained, not years.

The targeted RAS inhibitor therapy daraxonrasib demonstrated the potential to improve patient outcomes over current standard treatments for patients with RAS-mutant pancreatic cancer, according to results of a Phase 1/2 trial led by researchers at The University of Texas MD Anderson Cancer Center.

Among the challenges in treating disease, including cancer, is wiping out malignancies, infection, contaminants or other pathologies, without destroying healthy tissue.

The review offers important insights for patients and families by explaining why pancreatic cancer has proven so resistant to treatment, and where new hope may emerge.

Researchers at the Icahn School of Medicine at Mount Sinai and the Mount Sinai Tisch Cancer Center have identified a promising new strategy to overcome resistance to immunotherapy in colorectal cancer, one of the leading causes of cancer-related deaths worldwide.

Researchers at The University of Texas MD Anderson Cancer Center and The University of Texas at Austin have identified specific blood-based genomic biomarkers that distinguish inflammatory breast cancer from other subtypes, providing a new and less invasive method for early diagnosis, disease progression monitoring and treatment development for patients with this aggressive disease.

A new trial will test whether a tool that harnesses Apple Watch health data and artificial intelligence can help protect children undergoing cancer treatment from infections.

New research shows that the same genes are active in pancreatic cancer, obesity and diabetes, helping to explain why people with metabolic disease often face poorer cancer outcomes and pointing to future ways to predict recurrence and develop more targeted treatments.

A new kind of CRISPR that destroys cells rather than gene editing them has shown potential for killing sick cells while leaving healthy cells untouched. The technology has largely been tested in cells in a dish, but if it can be applied to organisms, it could be a powerful tool to treat disease and advance research.

WEDNESDAY, May 6, 2026 — Children who live near a gas station are more likely to develop leukemia or other childhood cancers, a new study says.Living within 250 meters (820 feet) of a gas station raises childhood cancer risk, and the risk increases...

Global modeling reveals that without urgent action, cervical cancer inequalities will worsen, highlighting the need for enhanced vaccination and screening.

A short burst of immunotherapy before surgery is delivering surprisingly powerful results for a specific type of colorectal cancer. Patients in a UK-led trial who received just nine weeks of pembrolizumab prior to surgery have remained cancer-free nearly three years later—an outcome that challenges the standard approach of surgery followed by months of chemotherapy.

Most women requiring continued cervical cancer screening — including those at high risk — do not continue screening after 65 years of age.

Santaquin nurse Meggan Sundwall was sentenced to up to 15 years for manslaughter in the overdose death of Kacee Lyn Terry, who faked cancer. Explore the legal, ethical, and financial motives behind this case.

Researchers from The University of Texas MD Anderson Cancer Center have discovered that some cancer cells express the YAP1 protein only after treatment with chemotherapy, allowing them to survive by becoming more invasive and leading to treatment resistance with eventual relapse in patients with small cell lung cancer (SCLC).

Researchers at City of Hope® and TGen (part of City of Hope) have identified a significant correlation between a tumor's "splicing burden" and its clinical response to treatment for metastatic renal cell carcinoma (mRCC).

Breast cancer impacts over 2 million women around the world each year. Following radiotherapy or chemotherapy, breast-conserving surgery is the first line of intervention for early-stage breast cancer.

A biopsy of a woman's cancer seems to have triggered an immune response against the tumour, putting her into remission

Strenuous weight training after breast cancer surgery is not only safe but also improves women’s strength, mobility, and balance, a study of one program finds.

The number of family relatives, first-degree or not, who have pancreatic cancer does not appear to affect the risk for intermediate lesions.

The Alliance for Clinical Trials in Oncology is now enrolling patients in the ASPIRE trial (A032302)-a large-scale, phase III clinical study investigating whether adding chemotherapy to current standard treatments extends survival for men with advanced prostate cancer.

MONDAY, May 4, 2026 — The U.S. Food and Drug Administration (FDA) granted expanded access for the use of an experimental pancreatic cancer drug, daraxonrasib.This means the drug will be available for early access to those who previously received...

Scientists at Oregon Health & Science University have developed a new technique using an electronic jolt and nanoparticles to reveal the telltale signal of an insidious form of cancer.

NHS rolls out 1-minute cancer immunotherapy jab, cutting treatment time and improving efficiency for thousands of patients across England.

MONDAY, May 4, 2026 — Misinformation is putting more than 16 million Americans at increased risk for skin cancer, a new American Academy of Dermatology (AAD) survey has concluded.Nearly 3 in 5 Americans (57%) regularly use sunscreen, the annual...

Using a powerful single-molecule imaging method they developed, a Broad Institute research team has unveiled a dynamic view of how some cancer-related proteins interact in living cells. The technique relies on highly stable nanoparticle probes that brightly illuminate individual molecules for long periods of time. The researchers used their method to observe, for the first time, individual receptors as they move around the cell membrane, attaching to and then letting go of other receptors to alter signaling within the cell.

Maintenance therapy with capecitabine prolongs progression-free survival in patients with advanced oesophagogastric adenocarcinoma after first-line chemotherapy.

Barry Manilow, 82, is pushing ahead with his June UK tour while pausing his May Las Vegas shows on doctors' advice, after surgery for early-stage lung cancer caught through what he calls 'pure luck.'

Human epidemiological data robustly indicates a trade-off between risk of cancer and risk of neurodegenerative conditions. Why is this the case? While all too little is understood of the precise details, at the high level it is thought that this is a reflection of the degree to which tissue maintenance activities decline with age. The less work undertaken by stem cells, the less cell replication in general, the lower the risk of a potentially cancerous combination of mutations occurring. But without that ongoing maintenance, the loss of tissue function accelerates, and neurodegenerative conditions are one of the more prominent outcomes. In essence one is forced to choose between cancer or regeneration. Not all species face that choice, of course. Some, like naked mole rats, can […]

New population studies suggest that tattoos may be associated with a higher risk for lymphoma and skin cancer, although causality remains unproven.

Low doses of the investigational medicinal product endoxifen reduce breast density to the same extent as the standard treatment tamoxifen, but without causing such troublesome side effects. This is shown by a new study from Karolinska Institutet published in the Journal of the National Cancer Institute. The results may have implications for future preventive treatment of breast cancer.

The American Academy of Dermatology (AAD) today released results from its annual Practice Safe Sun Survey, revealing many Americans still engage in risky sun behaviors driven by misinformation, social media, and persistent tanning myths despite their concerns about the long term aging effects of sun exposure. In recognition of Skin Cancer Awareness Month (May) and Melanoma Monday® on May 4, the AAD is encouraging the public to practice safe sun to reduce their risk of skin cancer.

Diaceutics, the intelligence and engagement company unlocking the full potential of diagnostic-driven therapies, has released new research revealing a critical shift in precision medicine. Despite major advances in biomarker testing, nearly two-thirds of eligible patients with advanced non-small cell lung cancer (aNSCLC) in the US are still not receiving the most appropriate treatment

May 01, 2026 -- Today, the U.S. Food and Drug Administration is announcing that it issued a “safe to proceed” letter to Revolution Medicines, allowing the sponsor to initiate an expanded access treatment protocol (EAP) for its...

For decades, the relationship between fat and cancer has been treated as a question of quantity: eat less

While high-income countries like Canada could eliminate cervical cancer by 2048 through human papillomavirus (HPV) vaccination and screening, the gap with lower-income countries is widening.

Artificial intelligence tools like ChatGPT are increasingly being explored in cancer care, but they can sometimes produce outdated or incorrect information. In medicine, where accuracy is critical, that risk is a serious concern.

A new pretargeted radioimmunotherapy (PRIT) technique has been shown to be safe and effective in eradicating tumors from a preclinical colorectal cancer model.

T cells are crucial components of our immune system, serving as critical protectors against infection and disease.

Approval was based on findings from the phase 3 VERITAC-2 trial showing significantly improved PFS for patients with ESR1-mutated disease.

FDA authorizes an expanded access treatment protocol after the oral RAS(ON) inhibitor doubled survival for metastatic patients in a phase 3 trial.

FRIDAY, May 1, 2026 — After breast cancer surgery, many women are told to limit how much — and how soon — they exercise."Traditional guidelines question how soon women treated for breast cancer can exercise and how much weight they can safely lift...

Recent data from a single-arm trial suggest favorable-risk patients with HPV-associated oropharyngeal carcinoma may benefit from a deintensified regimen.

Childhood cancers are devastating. Even when the disease is not fatal, its long-term effects can be severe. Not enough is known about the risk factors. "Research suggests that only 5% to 10% of childhood cancers are attributable solely to genetics, while the rest are due to other factors, particularly environmental ones," explained Stéphane Buteau, a professor in the Department of Environmental and Occupational Health in the School of Public Health at Université de Montréal.

Patients with one of the deadliest cancers have been pleading for an unapproved treatment that may prolong their lives.

FRIDAY, May 1, 2026 — Many women might start breast cancer screening later than recommended because they aren’t up to date on the latest guidelines, a new survey says.Updated guidelines issued in 2024 lowered the age to start getting mammograms to 4...

We also report on a new use for artificial intelligence that could help eliminate some racial inequities in heart disease diagnoses.

Researchers have created a detailed map of a deadly childhood cancer, showing it uses ‘shields’ and ‘bodyguards’ to

Researchers here show that fecal microbiota transplantation from young mice to old mice suppresses age-related increase in MDM2 expression and reduces risk of liver cancer. The balance of microbial populations making up the gut microbiome changes with age in ways that promote chronic inflammation and reduce the production of beneficial metabolites. Fecal microbiota transplantation is one of the few approaches that can make a permanent change to the composition of the gut microbiome, rejuvenating it when the donor is younger than the recipient. Numerous animal studies have shown improved health and extended live to result from this restoration of a youthful gut microbiome, and the work here is another example of the same, focused on the health of the liver. Researchers collected fecal samples from […]

The study links facial aging rates to cancer outcomes, suggesting a new prognostic tool that could personalize treatment and enhance patient survival.

Immunotherapy has become a standard of care in treating high-risk, early-stage breast cancers, yet it has had limited success in shrinking tumors.

Scientists at The Wistar Institute and clinical researchers from ChristianaCare's Helen F. Graham Cancer Center & Research Institute have discovered a vulnerability in pancreatic cancer that could be targeted as a potential therapy.

King Charles, during a New York event, made a candid remark about his future, highlighting his ongoing battle with cancer and emphasizing the importance of supporting the next generation.

Counterintuitive findings hint that diets rich in fruit, vegetables, and whole grains may increase the risk of lung cancer in young nonsmokers, but experts are skeptical.

Patients with cardiovascular-kidney-metabolic syndrome, especially those in the advanced stages at baseline, show a significant risk for incident cancer, stressing the need for risk assessment.

A ‘target trial’ emulation study suggests that regular exercise can help breast cancer survivors live longer.

The use of mailed FIT-DNA kits in community health centers significantly increases colorectal cancer screening, though follow-up colonoscopy rates remain low.

The body’s “killer” T cells don’t just attack—they strike with astonishing precision, forming a tiny, highly organized contact zone that lets them destroy dangerous cells without harming their neighbors. Now, scientists have captured this process in unprecedented detail, revealing a hidden world of molecular choreography.

Scientists have pinpointed a mechanism that may explain heart cancer's rarity and point to new cancer treatments.

Changes in insulin prescriptions in primary care are observed prior to a pancreatic cancer diagnosis, with women experiencing an increase earlier than men.

Scientists have discovered how cells decide when to respond to physical forces, potentially opening new avenues for tackling diseases such as cancer and fibrosis.

A troubling new study from MIT reveals that a common environmental contaminant, NDMA—found in polluted water, certain medications, and even processed foods—may pose a far greater cancer risk to children than adults. In experiments with mice, young animals exposed to the chemical developed significantly more DNA damage and cancer, despite experiencing the same initial exposure as adults. The key difference lies in how rapidly children’s cells divide, which turns early DNA damage into dangerous mutations much more easily.

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access.

Researchers at the University of Illinois Chicago have developed an anti-cancer therapy inspired by bacteria found in cancer tumors.

A new review was published in Volume 13 of Oncoscience on March 11, 2026, titled "Associations among physical activity, diet, non-lifestyle characteristics and the gut microbiome of cancer patients: A scoping review and network analysis."

Activation of a specific part of the Dicer enzyme can change its shape in a way that affects its critical role in proper cell division, with implications for both cancer biology and fertility, according to researchers at The University of Texas MD Anderson Cancer Center.

Obesity might be to blame for part of the increase in cancer among young people, a study in the UK has found, but the causes largely remain a mystery

Cases of several cancers are rising in England among both younger and older adults, but rates of bowel and ovarian cancer are rising only among younger adults (under 50s), finds research published in the open access journal BMJ Oncology.

An AI model (REDMOD) can pick up the very early subtle tissue changes of pancreatic ductal adenocarcinoma, the most common form of pancreatic cancer, which conventional imaging and the human eye find difficult to detect, finds research published online in the journal Gut.

Mayo Clinic researchers have developed a blood-based method that may help detect germ cell tumors, the most common type of testicular cancer, including cases that do not show up on standard blood tests, according to a study published in Nature Communications.

Sentinel lymph node biopsy (SLNB) is critical to breast cancer staging, yet current assessment methods remain heavily dependent on pathology expertise and time-consuming tissue processing.

An international group of experts led by the Comprehensive Cancer Centre (CCC) at MedUni Vienna and University Hospital Vienna has established endpoints for clinical trials in patients with cancer and isolated metastases.

Independent, academic clinical cancer trials are essential to improving patient outcomes, reducing inequalities in care, and strengthening healthcare systems worldwide, according to a new initiative published in The Lancet Oncology.

The National Comprehensive Cancer Network® (NCCN®)-an alliance of leading cancer centers-has published a new book explaining the latest evidence and expert recommendations around prostate cancer screening.

Scientists have uncovered an unexpected way cells can generate cancer-driving proteins—by cutting RNA into shorter, functional fragments rather than following the standard blueprint.

A new study explores whether first-time seizures are associated with a higher risk for cancer in the short or long term.

The Mass General Brigham research team behind FaceAge, an artificial intelligence (AI) tool that can estimate a person's biological age from a single photo, is reporting in a new study that estimating biological age from multiple photos taken over time can provide even more information about how well a person with cancer will do with treatment.

A new study designs drugs that bind to intrinsically disordered proteins, which play a central role in cancer, neurodegenerative disorders, heart disease, and autoimmune conditions, but are extremely difficult to target due to their flexible nature. The post Prostate Cancer Therapy Targets Disordered Region of Androgen Receptor appeared first on GEN - Genetic Engineering and Biotechnology News.

TUESDAY, April 28, 2026 — Mail-in DNA tests for colon cancer can extend easy, affordable cancer screening to people who are struggling to get by, a new study says.Patients at community health centers were more likely to participate in colon cancer s...

TUESDAY, April 28, 2026 — People with metabolic health problems might also have an increased risk of cancer, a new study says.People with advanced CKM (cardiovascular-kidney-metabolic) syndrome have up to a 30% increased risk of developing cancer, r...

A daily vitamin D supplement may quietly supercharge chemotherapy. In a small study, women who took low doses alongside treatment were far more likely to see their cancer vanish than those who didn’t. Since vitamin D also supports immune function—and many patients are deficient—it could be playing a bigger role than expected. Scientists say this affordable approach deserves much deeper investigation.

Clobetasol reduces vulvar malignancy risk at 2 years after diagnosis; topical calcineurin inhibitors do not increase malignancy risk.

A clinical trial designed to test an AI-based skin cancer detection app has some surprising results.

In a National Institutes of Health (NIH)-funded study, researchers developed a cancer assessment tool that can identify high-risk patients and the tumor

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 mutations that heighten the risk for breast, ovarian and other cancers.

A cancer diagnosis can upend any life. For young adults already navigating a step into independence, it can be especially distressing.

A research team from the School of Biomedical Sciences at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has uncovered the mechanism underlying how cancer patients respond to a widely used cancer drug, known as paclitaxel, offering insights that may help overcome cancer drug resistance. The study found that small differences in microtubules, the structures inside cells that help the cells divide and move, can determine the efficacy of paclitaxel. This finding was published in Nature Chemical Biology.

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 mutations that heighten the risk for breast, ovarian and other cancers.

University of Houston biologists have contributed to a potential breakthrough in treating Crohn's disease by shifting the clinical focus from symptom management to addressing a primary underlying cause of the condition.

Researchers at VIB and VUB have developed a powerful new way to study how the immune system behaves inside lung tumors.

People with advanced heart, kidney and metabolic disease may face a higher risk of developing cancer, according to new research published today in the American Heart Association's peer-reviewed scientific journal Circulation: Population Health and Outcomes.

Colorectal cancer (CRC) is the second most common cause of cancer death in the United States and disproportionally impacts people who receive care in under-resourced settings.