CRISPR

A new study suggests that novel CRISPR gene editing boosts natural killer cell function in cancer treatment.

Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified through a new genome-wide CRISPR screening tool, according to new research from The University of Texas MD Anderson Cancer Center.

A new generation of CRISPR technology developed at UNSW Sydney offers a safer path to treating genetic diseases like Sickle Cell, while also proving beyond doubt that chemical tags on DNA - often thought to be little more than genetic cobwebs - actively silence genes.

A new generation of CRISPR technology developed at UNSW Sydney offers a safer path to treating genetic diseases like sickle cell, while also proving beyond doubt that chemical tags on DNA—often thought to be little more than genetic cobwebs—actively silence genes.

A research team headed by the University of Zurich has developed a powerful new method to precisely edit DNA by combining cutting-edge genetic engineering with artificial intelligence. The work has been published in Nature Biotechnology.

Scientists developed an AI-powered DNA editing method, enabling precise disease modeling and paving the way for advanced next-generation gene therapies.

Sens. Diagn.DOI: 10.1039/D5SD00083A, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sakshi Seth, K. Sudhakara PrasadCirculating cell-free DNA (cfDNA) has been established as a minimally invasive liquid biopsy biomarker with utility in the diagnosis of cancer, monitoring of treatment response, and detection of minimal residual...The content of this RSS Feed (c) The Royal Society of Chemistry

Scientists reported a time-resolved analysis of molecular processes that unfold when macrophages respond to specific pathogens and infection-linked stimuli, identifying a network of regulators that share the responsibility of triggering the most appropriate immune response. The post CRISPR Screen Uncovers How Macrophages Respond to Pathogens appeared first on GEN - Genetic Engineering and Biotechnology News.

The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide.

Sens. Diagn.DOI: 10.1039/D5SD00080G, Tutorial Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ankush Kaushik, Yamini Saini, Saif Hameed, Jitendra Singh, Zeeshan FatimaTo address the problems linked with Mycobacterium tuberculosis (MTB) detection, we need an accurate, sensitive, and faster detection method for efficient epidemiological management for tuberculosis (TB) diagnosis. Nucleic acid-based diagnosis...The content of this RSS Feed (c) The Royal Society of Chemistry

Getting CRISPR experiments right in the lab isn’t simple. Scientists need specialized domain knowledge and must spend hours perfecting the experimental design. All of that can change soon, however, thanks to AI. The post “CRISPR Meets GPT” to Supercharge Gene Editing appeared first on GEN - Genetic Engineering and Biotechnology News.

In a keynote talk during ’s “The State of CRISPR & Genome Editing” virtual summit, originally broadcast on June 11, 2025, Fyodor Urnov PhD, discussed the future of curing disease with CRISPR. The post Fyodor Urnov Discusses CRISPR Cures appeared first on GEN - Genetic Engineering and Biotechnology News.

Although outbreaks of Ebola virus are rare, the disease is severe and often fatal, with few treatment options. Rather than targeting the virus itself, one promising therapeutic approach would be to interrupt proteins in the human host cell that the virus relies upon.

Editing a single amino acid in mosquitoes halts malaria transmission, spreading resistance through populations via a CRISPR-based allelic-drive system. The post Malaria Transmission Blocked by One-Amino-Acid Mosquito CRISPR Edit appeared first on GEN - Genetic Engineering and Biotechnology News.

A gene called SDR42E1 has been identified as a key player in how our bodies absorb and process vitamin D. Researchers found that disabling this gene in colorectal cancer cells not only crippled their survival but also disrupted thousands of other genes tied to cancer and metabolism. This opens the door to highly targeted cancer therapies—by either cutting off vitamin D supply to tumors or enhancing the gene’s activity to boost health. The findings hint at vast possibilities in treating diseases influenced by vitamin D, though long-term impacts remain uncertain.

Genes, fragments of DNA located on our chromosomes, control much of what happens in cells.

CZI and the Innovative Genomics Institute announce the funding of the Center for Pediatric CRISPR Cures which will use CRISPR-based editing technology to advance cures for severe pediatric genetic diseases. The post Center for Pediatric CRISPR Therapies Founded by IGI, CZI appeared first on GEN - Genetic Engineering and Biotechnology News.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

CZI and the Innovative Genomics Institute announce the funding of the Center for Pediatric CRISPR Cures which will use CRISPR-based editing technology to advance cures for severe pediatric genetic diseases. The post Center for Pediatric CRISPR Therapies Funded by IGI, CZI appeared first on GEN - Genetic Engineering and Biotechnology News.

A Ph.D. student in biomolecular engineering at the University of California, Santa Cruz, has built a software program designed to facilitate the kind of precision genome editing involved in the development of cutting-edge therapeutics for genetic conditions such as certain metabolic or blood disorders, like sickle-cell anemia.

Personalized CRISPR cures for children born with rare genetic diseases are now a step closer to being more widely available.

Genome editing technologies like CRISPR-Cas9 have transformed biology, medicine, and agriculture, but concerns remain about unintended edits at off-target DNA sites. These off-target effects can cause harmful mutations and are difficult to predict, as they depend not only on the guide RNA but also on an organism's unique genetic makeup. Most existing prediction tools rely on a standard reference genome, ignoring key variations like SNPs, insertions, and deletions that differ across individuals and alleles.

A team at Kobe University has created a game-changing resource for autism research: 63 mouse embryonic stem cell lines, each carrying a genetic mutation strongly associated with the disorder. By pairing classic stem cell manipulation with precise CRISPR gene editing, they ve built a standardized platform that mirrors autism-linked genetic conditions in mice. These models not only replicate autism-related traits but also expose key dysfunctions, like the brain s inability to clean up faulty proteins.

CRISPR-Cas13, a powerful RNA-targeting technology is gaining increasing attention as a next-generation gene therapy platform due to its precision and reduced side effects.

RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in coronaviruses, or regulate the expression of disease-causing genes.

The study generated approximately 1,300 independent CRISPR lines to influence tomato traits, including fruit flavor, nutrient uptake, and pathogen response. According to the authors, the technology can be applied to a wide variety of crop species to support food security. The post Scalable CRISPR-Based Gene Editing Improves Tomato Crop Traits appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers from Tel Aviv University have developed a genetic editing method tailored to crop plants, which has influenced various traits in tomato plants, including the taste and shape of the fruit. The researchers believe this innovative technology can be applied to a wide variety of crop species and may eventually be used to cultivate new and improved plant varieties.

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Crypto billionaire Brian Armstrong is ready to invest in CRISPR baby tech Brian Armstrong, the billionaire CEO of the cryptocurrency exchange Coinbase, says he’s ready to fund a US startup focused on gene-editing…

Brian Armstrong, the billionaire CEO of the cryptocurrency exchange Coinbase, says he’s ready to fund a US startup focused on gene-editing human embryos. If he goes forward, it would be the first major commercial investment in one of medicine’s most fraught ideas. In a post on X June 2, Armstrong announced he was looking for…

We discuss the first patient to be treated with a personalized CRISPR therapy and new CRISPR research. On the business front, 10x settles with Bruker and Vizgen, Illumina sues Element, and Prime downsizes. The post Customized CRISPR for KJ, 10x and Illumina Lawsuits, Regeneron Bags 23andMe appeared first on GEN - Genetic Engineering and Biotechnology News.

When a neuron in our body gets damaged, segments of RNA produce proteins that can help repair the injury.

Using CRISPR and stem cell–derived neurons, researchers identified early mitochondrial dysfunction shared across ALS-linked mutations—pointing to common disease pathways and potential therapeutic targets, long before traditional signs of neurodegeneration appear. The post Potential ALS Mitochondrial Target Identified with CRISPR, scRNA-seq appeared first on GEN - Genetic Engineering and Biotechnology News.

The new CRISPR system uses laboratory engineered versions of transposases from Pseudoalteromonas bacteria that were evolved over several generations to efficiently insert copies of healthy genes into human cells at therapeutically useful levels. The post EvoCAST Harnesses CRISPR-Linked Bacterial Transposes to Insert Genes Into Human Cells appeared first on GEN - Genetic Engineering and Biotechnology News.

Newly discovered weapons of bacterial self-defense take different approaches to achieving the same goal: preventing a virus from spreading through the bacterial population.

A CRISPR treatment seems to have been effective for a baby’s devastating disease, but it is not clear whether such bespoke therapies can be widely applied

KJ was born with a metabolic disorder that kills up to 50% of infants.

Every living creature on Earth needs to protect itself from things that would do it harm. Bacteria are no different. And despite their relative simplicity, they deploy remarkably savvy defensive strategies against viral invaders. The most well-known is CRISPR-Cas9, adapted for human use as the first FDA-approved genetic editing technique.

An infant with a severe genetic condition has shown signs of improvement after receiving a gene-editing treatment tailored to his specific mutation

A new gene editor takes advantage of CRISPR-associated proteins to insert whole genes into the genome, scientists report.

A baby known as KJ is the first person in the world to receive a customized CRISPR therapy designed to fix a specific mutation.

In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children's Hospital of Philadelphia (CHOP) and Penn Medicine.

An infant patient with a severe urea cycle disorder shows strong signs of improvement after receiving an individualized gene editing therapy that corrects mutations directly on the genome. The post ASGCT 2025: World’s First Patient Treated with Personalized CRISPR Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.

Spearhead Bio’s TAHITI platform merges CRISPR/Cas gene editing technology with engineered transposable elements to achieve precise gene insertion in high-value agricultural crops. The post SpearHead Bio Offers Precise Plant Engineering Using CRISPR-Directed Jumping Genes appeared first on GEN - Genetic Engineering and Biotechnology News.

In this Revvity GENCast episode 2, experts will discuss applications of gene editing to improve scientists’ understanding of the relationship between variant and disease in functional genomics studies. They will also talk about the Dharmacon product suite which is designed for CRISPR-based targeted editing in a wide range of cells. The post From Functional Genomics to Cell Therapy: The Role of CRISPR-based Gene Editing appeared first on GEN - Genetic Engineering and Biotechnology News.

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. A US court just put ownership of CRISPR back in play The CRISPR patents are back in play. Yesterday, the US Court of Appeals for the Federal Circuit said scientists Jennifer Doudna and…

The CRISPR patents are back in play. On Monday, the US Court of Appeals for the Federal Circuit said scientists Jennifer Doudna and Emmanuelle Charpentier will get another chance to show they ought to own the key patents on what many consider the defining biotechnology invention of the 21st century. The pair shared a 2020…

The University of Bayreuth's Biomaterials research group has, for the first time, successfully applied the CRISPR-Cas9 gene-editing tool to spiders. Following the genetic modification, the spiders produced red fluorescent silk.

Early phase data from human trials of a single, low-dose gene editing therapy using CRISPR-Cas12 proves promising for improving DMD symptoms with no adverse effects, scientists say. The post ASGCT 2025: CRISPR-Cas12 Editing Shows Early Clinical Benefit in Duchenne Muscular Dystrophy appeared first on GEN - Genetic Engineering and Biotechnology News.

Although immunotherapeutic strategies have made huge strides in treatment for solid tumors, the promising results have not moved over into the treatment of gastrointestinal cancer. Now, a first-in-human clinical trial shows encouraging signs of safety and potential effectiveness of a CRISPR/Cas9 gene-editing technique to help TILs fight advanced colorectal cancer. The post CRISPR-Edited TILs Fight Advanced Colorectal Cancer in Patients appeared first on GEN - Genetic Engineering and Biotechnology News.

PIC's gene-edited pigs are highly resistant to one of the most harmful viruses affecting pig populations worldwide today.

Most pigs in the US are confined to factory farms where they can be afflicted by a nasty respiratory virus that kills piglets. The illness is called porcine reproductive and respiratory syndrome, or PRRS. A few years ago, a British company called Genus set out to design pigs immune to this germ using CRISPR gene…

Plant breeding plays a vital role in ensuring global food security by increasing crop yields, improving nutritional quality and creating crops that are adaptable to climate change. However, current plant transformation methods present significant hurdles—they're labor-intensive, costly and don't work for many important plant species.

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions—but there is always room for improvement. A new paper by investigators from Mass General Brigham showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy.

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions-but there is always room for improvement.

In  virtual summit, brings together an outstanding line-up of pioneers and practitioners in genome editing to provide a compelling and candid overview of the field. The post The State of CRISPR and Genome Editing appeared first on GEN - Genetic Engineering and Biotechnology News.

The arrangement allows EditCo to incorporate Promega’s bioluminescent and protein-labeling technologies into its CRISPR-engineered cell lines. The combined solution will let customers generate precise gene edits in cell lines with functional validation. The post EditCo, Promega to Combine CRISPR Knock-In Capabilities with Protein-Labeling Tech appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers present a strategy to improve editing efficiency in human immune cells for therapeutic applications by leveraging new constructs for nuclear localization signal (NLS) sequences that can be produced at high purity and yield.   The post New Strategy Enhances CRISPR Editing Efficiency for Therapeutic Use appeared first on GEN - Genetic Engineering and Biotechnology News.

A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also carry such variants do not. The prevailing theory has suggested additional genetic factors may play a role. To address this question, a new study used modern technology, called CRISPR interference, to systematically examine every gene in the human genome. The scientists identified a new set of genes that contribute to the risk of Parkinson's disease, which opens the door to previously untapped drug targets for treating PD.

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency. The research is published in the journal Science Advances.

Like a good workbench, proper data systems can help keep gene editing tools organized and accessible, providing the scaffold on which to build better science and better medicines for a range of human diseases. The post Why CRISPR R&D Needs to Think About Data Workflows appeared first on GEN - Genetic Engineering and Biotechnology News.

By enabling the CRISPR-edited GD2 CAR-T project at University of Wisconsin–Madison to achieve clinical-scale manufacturing earlier, the partnership aims to unlock potential investment into the experimental therapy and expedite its path to initial human trials. The post Cellares and University of Wisconsin Agree to Automate Clinical-Scale Production of CRISPR-Edited CAR-T appeared first on GEN - Genetic Engineering and Biotechnology News.

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes—demonstrated successfully in living mouse models that are blind due to a mutation.

Collaborative research led by investigators at Dana-Farber/Boston Children's Cancer and Blood Disorders Center defines a novel approach to understanding how certain proteins called transcription factors determine which genetic programs will drive cell growth and maturation.

A team of researchers at Karolinska Institutet has developed a novel tool for genetic research. The study, published in Nucleic Acids Research, introduces BLU-VIPR, a method that allows researchers to control the gene-editing tool CRISPR using light. This innovation could significantly enhance our understanding of gene functions in complex organisms.

CRISPR leaders across the Innovative Genomics Institute (IGI) ecosystem, which spans multiple California institutes and hospitals including UCSF, Benioff Children’s Hospital, and UCLA, came together to celebrate the one-year anniversary of the Danaher-IGI Beacon for CRISPR Cures collaboration, 10 years after IGI’s founding. The post Danaher-IGI Beacon for CRISPR Cures Celebrates One-Year Anniversary appeared first on GEN - Genetic Engineering and Biotechnology News.

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this technology -- which allows scientists to use a 'guide' RNA to modify DNA sequences and evaluate the effects -- is able to target, delete, replace, or modify only single gene sequences with a single guide RNA and has limited ability to assess multiple genetic changes simultaneously. Now, however, scientists have developed a series of sophisticated mouse models using CRISPR ('clustered regularly interspaced short palindromic repeats') technology that allows them to simultaneously assess genetic interactions on a host of immunological responses to multiple diseases, including cancer.

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases.

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this technology—which allows scientists to use a "guide" RNA to modify DNA sequences and evaluate the effects—is able to target, delete, replace, or modify only single gene sequences with a single guide RNA and has limited ability to assess multiple genetic changes simultaneously.

Bioengineering professor and The Grainger College of Engineering's Dean, Rashid Bashir, led a team of researchers in a project that's resulted in new technology that offers rapid, highly sensitive detection of multi-drug-resistant bacteria and other pathogens at low concentrations.

University of Illinois at Urbana-Champaign researchers have developed a CRISPR-based diagnostic tool capable of detecting bloodstream infections in minutes without the need for nucleic acid amplification. The CRISPR-Cascade assay achieves attomolar sensitivity and incorporates an OR-gated logic function to identify multiple pathogens simultaneously through DNA from pathogens associated with bloodstream infections.

A recent review published in the journal Engineering delves into the significant advancements and potential of CRISPR technologies in the field of regenerative medicine.

Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular genes and measure the impact on the expression of other genes. These methods, however, fail to capture spatial information such as the effects from, or on, neighboring cells, which can provide important clues to a cell or gene's role in health and disease.

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and animals.

Tulane University researchers have developed a CRISPR-based test that diagnoses Pneumocystis jirovecii pneumonia (PJP) - a life-threatening fungal infection primarily affecting children and immunocompromised patients - more quickly and less invasively, according to a new study published in the Journal of Clinical Investigation.

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and animals. To better monitor the emergence and spread of resistance, researchers at the Carl R. Woese Institute for Genomic Biology have developed a CRISPR-enriched metagenomics method for the enhanced surveillance of antibiotic resistance genes (ARGs) in wastewater.

When Vijay Sankaran was an MD-PhD student at Harvard Medical School in the mid-2000s, one of his first clinical encounters was with a 24-year-old patient whose sickle cell disease left them with almost weekly pain episodes.

Humans have appreciated the beauty of flowers for centuries. Yet, flowers aren't just aesthetically pleasing. They also play a crucial role in plant reproduction. In all plants, a well-studied gene with a curious name, Unusual Floral Organs (UFO), orchestrates the flowering process. UFO expression hinges on another complex process called cis-regulation. And this one has remained a "black box" of plant biology research for years.

The CRISPR-Cas gene scissors offer a wide range of potential applications, from the treatment of genetic diseases to antiviral therapies and diagnostics. However, to safely harness their powers, scientists are searching for mechanisms that can regulate or inhibit the systems' activity. Enter the anti-CRISPR protein AcrVIB1, a promising inhibitor whose exact function has remained a mystery—until now.

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform gene editing in non-liver tissues, including skeletal muscle, using a single adeno-associated virus (AAV) vector. Experiments in non-human primates (NHPs) resulted in editing efficiencies exceeding 30% in muscle tissues.

On the premiere of Season 2, editors discussed some interesting and developing stories around AI, including an in-depth dialogue about what Recursion has been doing lately. They also discussed gene editing updates in delivery systems, Cas12 preclinical work, and AgBio. The discussion was rounded out with a look forward into takeover targets for 2025. The post Recursion Clinical Trial, CRISPR Delivery Methods, Preclinical Cas12 Use, Gene Editing in AgBio, Top 10 Takeover Targets appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.

The new tool, NanoCas, could extend gene therapies throughout the body. The post Miniaturized CRISPR Packs a Mighty Gene Editing Punch appeared first on SingularityHub.

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume. They also have a "superpower" in the field: they are able to fix nitrogen to the soil, so they reduce the need for nitrogen fertilizers (and their associated pollution) for them and the crops with which they are planted.

The downsized DNA-slicing machinery may reach more tissues to take aim at more diseases

It’s a new way to create same-sex biological offspring—but the approach is not ready for humans. The post Mice With Two Dads Reach Adulthood Thanks to CRISPR appeared first on SingularityHub.

The epigenetic state of chromatin, gene activity, and chromosomal positions are interrelated. A research team from the IPK Leibniz Institute (IPK) and the Karlsruhe Institute of Technology (KIT) has investigated how the chromosomal location affects epigenetic stability and gene expression through chromosome engineering. The results are published in the journal New Phytologist.

Researchers in Germany say their study is reportedly the first in the plant scientific community which shows the effect of structural variations on the epigenetic state of chromatin in the following generations after the occurrence of an inversion. The post Epigenetic Chromosomal State Remains Stable in Plants after Inversion by CRISPR/Cas Technology appeared first on GEN - Genetic Engineering and Biotechnology News.